Published in Immunol Today on February 01, 1991
Antiviral immune responses of lymphocytic choriomeningitis virus-infected mice lacking CD8+ T lymphocytes because of disruption of the beta 2-microglobulin gene. J Virol (1993) 1.76
CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx. EMBO J (1992) 1.29
Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains. J Exp Med (1994) 1.28
Revenge of the microbes. Superantigens of the T and B cell lineage. Am J Pathol (1994) 1.04
Functional anatomy of the thymic microenvironment. J Anat (1991) 1.00
Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases. Biochem J (1994) 0.97
A Raf-1-related p110 polypeptide associates with the CD4-p56lck complex in T cells. Mol Cell Biol (1992) 0.88
Paleo-immunology: evidence consistent with insertion of a primordial herpes virus-like element in the origins of acquired immunity. PLoS One (2009) 0.88
Cellular signalling mechanisms in B lymphocytes. Biochem J (1993) 0.84
CD26 induces T-cell proliferation by tyrosine protein phosphorylation. Immunology (1992) 0.81
IL-4 is able to reverse the CD2-mediated negative apoptotic signal to CD4-CD8- alpha beta and/or gamma delta T lymphocytes. Immunology (1995) 0.80
In vitro transfection of fresh thymocytes and T cells shows subset-specific expression of viral promoters. Mol Cell Biol (1992) 0.79
The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes. J Immunol (1994) 4.37
Interleukin-induced increase in Ia expression by normal mouse B cells. J Exp Med (1984) 4.14
Several common HLA-DR types share largely overlapping peptide binding repertoires. J Immunol (1998) 3.95
Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules. Cell (1993) 3.80
Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. Science (1995) 3.24
Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit. Science (1994) 2.98
Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides. Immunity (1994) 2.90
The small subunit of HL-A antigens is beta 2-microglobulin. J Exp Med (1973) 2.68
The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors. Science (1992) 2.41
Thymus-derived (T) cell immunoglobulins. Presence of a receptor site for IgG and absence of large amounts of "buried" Ig determinants on T cells. J Exp Med (1972) 2.35
B lymphocyte antigen receptors (mIg) are non-covalently associated with a disulfide linked, inducibly phosphorylated glycoprotein complex. EMBO J (1990) 2.24
Molecular mechanisms of transmembrane signaling in B lymphocytes. Annu Rev Immunol (1987) 2.22
Resident pulmonary lymphocytes expressing the gamma/delta T-cell receptor. Nature (1989) 2.16
Role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins. J Immunol (1994) 2.07
In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes. J Immunol (1991) 2.00
Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes. Nature (1987) 1.93
The thymus has two functionally distinct populations of immature alpha beta + T cells: one population is deleted by ligation of alpha beta TCR. Cell (1989) 1.91
Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases. J Immunol (1996) 1.90
The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells. Immunity (2000) 1.88
Studies on receptors for IgG on epithelial cells of the rat intestine. J Immunol (1977) 1.82
Peptide binding to the most frequent HLA-A class I alleles measured by quantitative molecular binding assays. Mol Immunol (1994) 1.80
Immunological identity of the small subunit of HL-A antigens and beta2-microglobulin and its turnover on the cell membrane. Proc Natl Acad Sci U S A (1974) 1.80
Practical, biochemical and evolutionary implications of the discovery of HLA class I supermotifs. Immunol Today (1996) 1.79
Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell (1998) 1.78
B cell activation. III. B cell plasma membrane depolarization and hyper-Ia antigen expression induced by receptor immunoglobulin cross-linking are coupled. J Exp Med (1983) 1.77
Limited receptor repertoire in a mycobacteria-reactive subset of gamma delta T lymphocytes. Nature (1989) 1.77
The B-cell antigen receptor complex. Immunol Today (1991) 1.74
Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J Exp Med (1995) 1.73
IgM antigen receptor complex contains phosphoprotein products of B29 and mb-1 genes. Proc Natl Acad Sci U S A (1991) 1.67
B cell activation. VIII. Membrane immunoglobulins transduce signals via activation of phosphatidylinositol hydrolysis. J Immunol (1984) 1.66
Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45. Science (1991) 1.66
Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice. Cell (1989) 1.66
New nomenclature for the Reth motif (or ARH1/TAM/ARAM/YXXL) Immunol Today (1995) 1.65
Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant. Science (1992) 1.63
Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling. J Exp Med (1995) 1.62
Identification and characterization of a loss-of-function human MPYS variant. Genes Immun (2011) 1.60
IgD: a major immunoglobulin on the surface of lymphocytes from patients with chronic lymphatic leukemia. J Immunol (1974) 1.56
B cell activation. I. Anti-immunoglobulin-induced receptor cross-linking results in a decrease in the plasma membrane potential of murine B lymphocytes. J Exp Med (1983) 1.56
B cell development: signal transduction by antigen receptors and their surrogates. Curr Opin Immunol (1999) 1.55
Level of mIa expression on mitogen-stimulated murine B lymphocytes is dependent on position in cell cycle. J Immunol (1983) 1.54
Activation and anergy in bone marrow B cells of a novel immunoglobulin transgenic mouse that is both hapten specific and autoreactive. Immunity (2001) 1.54
The B-cell antigen receptor complex: structure and signal transduction. Immunol Today (1994) 1.53
Definition of an HLA-A3-like supermotif demonstrates the overlapping peptide-binding repertoires of common HLA molecules. Hum Immunol (1996) 1.52
Mitogen activation of human chronic lymphatic leukemia cells. I. Synthesis and secretion of immunoglobulin. J Immunol (1977) 1.52
Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases. J Immunol (1995) 1.51
Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance. J Exp Med (1976) 1.50
Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha. Proc Natl Acad Sci U S A (1994) 1.49
Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses. J Exp Med (1998) 1.47
Translocation of protein kinase C during membrane immunoglobulin-mediated transmembrane signaling in B lymphocytes. J Immunol (1986) 1.45
Regulation of catabolism of IgM heavy chains in a B lymphoma cell line. J Biol Chem (1982) 1.44
Anti-Ig induces release of inositol 1,4,5-trisphosphate, which mediates mobilization of intracellular Ca++ stores in B lymphocytes. J Immunol (1986) 1.43
Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity. EMBO J (1994) 1.43
Peptide sequences of T-cell receptor delta and gamma chains are identical to predicted X and gamma proteins. Nature (1988) 1.41
Surface expression of a T cell receptor beta (TCR-beta) chain in the absence of TCR-alpha, -delta, and -gamma proteins. J Exp Med (1991) 1.39
mu-Chains from a nonsecretor B cell line differ from secreted mu-chains at the C-terminal end. J Immunol (1978) 1.36
Binding of a peptide antigen to multiple HLA alleles allows definition of an A2-like supertype. J Immunol (1995) 1.35
Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP). J Exp Med (2000) 1.34
Several HLA alleles share overlapping peptide specificities. J Immunol (1995) 1.33
B-cell tolerance. III. Effect of papain-mediated cleavage of cell surface IgD on tolerance susceptibility of murine B cells. J Exp Med (1977) 1.32
Transmembrane signals and intracellular "second messengers" in the regulation of quiescent B-lymphocyte activation. Immunol Rev (1987) 1.32
TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-alpha/beta dimers. Science (2001) 1.31
Physical association of CD4 with the T cell receptor. J Immunol (1992) 1.28
Fc epsilon receptor I-associated lyn-dependent phosphorylation of Fc gamma receptor IIB during negative regulation of mast cell activation. J Immunol (1998) 1.28
Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking. Nature (1987) 1.25
Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization. J Exp Med (1997) 1.25
Negative regulation of FcepsilonRI signaling by FcgammaRII costimulation in human blood basophils. J Allergy Clin Immunol (2000) 1.24
Antigen receptor signaling: integration of protein tyrosine kinase functions. Oncogene (1998) 1.24
Induction of c-fos and c-myc expression during B cell activation by IL-4 and immunoglobulin binding ligands. J Immunol (1989) 1.22
Transmembrane signaling through B cell MHC class II molecules: anti-Ia antibodies induce protein kinase C translocation to the nuclear fraction. J Immunol (1987) 1.21
B-cell tolerance. IV. Differential role of surface IgM and IgD in determining tolerance susceptibility of murine B cells. J Exp Med (1977) 1.21
Altered I-A protein-mediated transmembrane signaling in B cells that express truncated I-Ak protein. Proc Natl Acad Sci U S A (1989) 1.21
Specificity and degeneracy in peptide binding to HLA-B7-like class I molecules. J Immunol (1996) 1.21
B cell activation. IV. Induction of cell membrane depolarization and hyper-I-A expression by phorbol diesters suggests a role for protein kinase C in murine B lymphocyte activation. J Immunol (1984) 1.21
Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis. J Exp Med (2001) 1.19
mIgM:mIgD ratios on B cells: mean mIgD expression exceeds mIgM by 10-fold on most splenic B cells. J Immunol (1984) 1.17
The role of receptor IgM and IgD in determining triggering and induction of tolerance in murine B cells. Immunol Rev (1979) 1.15
Analysis of the interaction site for the self superantigen Mls-1a on T cell receptor V beta. J Exp Med (1991) 1.13
B-cell antigen receptor competence regulates B-lymphocyte selection and survival. Immunol Rev (2000) 1.12
Alpha beta T cell receptor and CD3 transduce different signals in immature T cells. Implications for selection and tolerance. J Immunol (1989) 1.12
Unique signaling properties of B cell antigen receptor in mature and immature B cells: implications for tolerance and activation. J Immunol (2001) 1.12
B cell activation. V. Differentiation signaling of B cell membrane depolarization, increased I-A expression, G0 to G1 transition, and thymidine uptake by anti-IgM and anti-IgD antibodies. J Immunol (1984) 1.11
Antigen-stimulated dissociation of BCR mIg from Ig-alpha/Ig-beta: implications for receptor desensitization. Immunity (1999) 1.10
Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD. Proc Natl Acad Sci U S A (1978) 1.10
Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase. J Immunol (1999) 1.09
Transforming growth factor beta 1 has differential effects on B cell proliferation and activation antigen expression. J Immunol (1990) 1.09
B lymphocyte activation: entry into cell cycle is accompanied by decreased expression of IgD but not IgM. Eur J Immunol (1983) 1.08
Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: regulators of B cell signal transduction. Curr Opin Immunol (2000) 1.08
B cell antigen receptor cross-linking triggers rapid protein kinase C independent activation of p21ras1. J Immunol (1993) 1.08
Differential association of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based inhibition motifs. Eur J Immunol (1997) 1.07
Fc gammaRIIB1 inhibition of BCR-mediated phosphoinositide hydrolysis and Ca2+ mobilization is integrated by CD19 dephosphorylation. Immunity (1997) 1.07
Prominent roles of secondary anchor residues in peptide binding to HLA-A24 human class I molecules. J Immunol (1995) 1.06
Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells. J Exp Med (1999) 1.06
Derivation of HLA-A11/Kb transgenic mice: functional CTL repertoire and recognition of human A11-restricted CTL epitopes. J Immunol (1997) 1.06
Potent immunogenic short linear peptide constructs composed of B cell epitopes and Pan DR T helper epitopes (PADRE) for antibody responses in vivo. Vaccine (1997) 1.05
Signaling-defective mutants of the B lymphocyte antigen receptor fail to associate with Ig-alpha and Ig-beta/gamma. J Biol Chem (1993) 1.04
Alpha-chains of IgM and IgD antigen receptor complexes are differentially N-glycosylated MB-1-related molecules. J Immunol (1991) 1.04