Published in Int J Biochem Cell Biol on January 19, 2008
Choline metabolism in malignant transformation. Nat Rev Cancer (2011) 2.85
Choline kinase inhibition in rheumatoid arthritis. Ann Rheum Dis (2014) 2.17
Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells. Mol Cancer (2009) 1.13
Intakes of meat, fish, poultry, and eggs and risk of prostate cancer progression. Am J Clin Nutr (2009) 1.01
Pharmacodynamic markers for choline kinase down-regulation in breast cancer cells. Neoplasia (2009) 0.94
Yeast and cancer cells - common principles in lipid metabolism. Biochim Biophys Acta (2012) 0.92
Metabolomics in rheumatic diseases: desperately seeking biomarkers. Nat Rev Rheumatol (2016) 0.88
Identification of potential synthetic lethal genes to p53 using a computational biology approach. BMC Med Genomics (2013) 0.87
Admixture mapping and subsequent fine-mapping suggests a biologically relevant and novel association on chromosome 11 for type 2 diabetes in African Americans. PLoS One (2014) 0.86
Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity. J Biol Chem (2010) 0.84
Discovery of co-occurring driver pathways in cancer. BMC Bioinformatics (2014) 0.84
Transcriptomic analysis to elucidate the molecular mechanisms that underlie feed efficiency in meat-type chickens. Mol Genet Genomics (2015) 0.84
Choline kinase β mutant mice exhibit reduced phosphocholine, elevated osteoclast activity, and low bone mass. J Biol Chem (2014) 0.80
Influence of multidrug resistance on (18)F-FCH cellular uptake in a glioblastoma model. Eur J Nucl Med Mol Imaging (2009) 0.79
Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors. Medchemcomm (2013) 0.78
Choline phosphorylation and regulation of transcription of choline kinase α in hypoxia. J Lipid Res (2011) 0.78
Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells. Oncotarget (2016) 0.77
Phorbol ester stimulates ethanolamine release from the metastatic basal prostate cancer cell line PC3 but not from prostate epithelial cell lines LNCaP and P4E6. Br J Cancer (2014) 0.77
Human prostate cell lines from normal and tumourigenic epithelia differ in the pattern and control of choline lipid headgroups released into the medium on stimulation of protein kinase C. Br J Cancer (2011) 0.76
Human Choline Kinase-α Promotes Hepatitis C Virus RNA Replication through Modulation of Membranous Viral Replication Complex Formation. J Virol (2016) 0.75
Phosphorylation of Human Choline Kinase Beta by Protein Kinase A: Its Impact on Activity and Inhibition. PLoS One (2016) 0.75
Genetic Variation in Choline-Metabolizing Enzymes Alters Choline Metabolism in Young Women Consuming Choline Intakes Meeting Current Recommendations. Int J Mol Sci (2017) 0.75
Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study. Lancet Oncol (2007) 2.35
Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy. Oncogene (2002) 2.09
Rho GTPase expression in tumourigenesis: evidence for a significant link. Bioessays (2005) 1.97
Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia. Cancer Res (2009) 1.95
Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth. Mol Cancer Res (2008) 1.94
Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas. PLoS One (2011) 1.57
Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression. Cancer Res (2004) 1.53
Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2. Genome Biol (2013) 1.47
Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation. Biochim Biophys Acta (2004) 1.45
Orthotopic microinjection of human colon cancer cells in nude mice induces tumor foci in all clinically relevant metastatic sites. Am J Pathol (2007) 1.44
Gene expression profile of omental adipose tissue in human obesity. FASEB J (2003) 1.42
A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool. Neuro Oncol (2014) 1.40
[Association between microsatellite instability and clinico-pathological characteristics in sporadic colon cancer]. Med Clin (Barc) (2005) 1.38
Inhibition of tumor angiogenesis by cannabinoids. FASEB J (2003) 1.36
Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment. PLoS One (2009) 1.23
Rho GTPases: potential candidates for anticancer therapy. Cancer Lett (2004) 1.23
Altered patterns of expression of members of the heterogeneous nuclear ribonucleoprotein (hnRNP) family in lung cancer. Lung Cancer (2003) 1.22
Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism. Int J Oncol (2008) 1.19
Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K. Oncogene (2002) 1.19
Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability. Mol Biol Cell (2002) 1.18
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. PLoS Biol (2012) 1.16
Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action. Oncogene (2004) 1.16
Glyceraldehyde-3-phosphate dehydrogenase regulates endothelin-1 expression by a novel, redox-sensitive mechanism involving mRNA stability. Mol Cell Biol (2008) 1.15
Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells. Mol Cancer (2009) 1.13
Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells. Oncogene (2003) 1.13
Choline kinase is a novel oncogene that potentiates RhoA-induced carcinogenesis. Cancer Res (2005) 1.12
Pharmacogenomic approach for the identification of novel determinants of acquired resistance to oxaliplatin in colorectal cancer. Mol Cancer Ther (2009) 1.12
Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells. Development (2013) 1.11
Deregulation of miR-200b, miR-200c and miR-429 indicates its potential relevant role in patients with colorectal cancer liver metastasis. J Surg Oncol (2014) 1.10
Clinical significance of miR-126 in colorectal cancer. Genes Chromosomes Cancer (2014) 1.09
ROCK and nuclear factor-kappaB-dependent activation of cyclooxygenase-2 by Rho GTPases: effects on tumor growth and therapeutic consequences. Mol Biol Cell (2003) 1.08
TWIST1 overexpression is associated with nodal invasion and male sex in primary colorectal cancer. Ann Surg Oncol (2008) 1.06
Epidermal growth factor receptor (EGFR) polymorphisms and survival in head and neck cancer patients. Oral Oncol (2006) 1.05
Choline kinase alpha depletion selectively kills tumoral cells. Curr Cancer Drug Targets (2008) 1.03
Involvement of human choline kinase alpha and beta in carcinogenesis: a different role in lipid metabolism and biological functions. Adv Enzyme Regul (2010) 1.02
Epigenetic regulation of microRNAs in acute lymphoblastic leukemia. J Clin Oncol (2009) 1.01
Inhibition of choline kinase renders a highly selective cytotoxic effect in tumour cells through a mitochondrial independent mechanism. Int J Oncol (2005) 1.00
PP2A inhibition is a common event in colorectal cancer and its restoration using FTY720 shows promising therapeutic potential. Mol Cancer Ther (2014) 1.00
Role of endothelin in the cardiovascular system. Pharmacol Res (2011) 1.00
A novel missense mutation in the CYLD gene in a Spanish family with multiple familial trichoepithelioma. Arch Dermatol (2007) 0.99
Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway. Cancer Res (2013) 0.98
18F-choline images murine atherosclerotic plaques ex vivo. Arterioscler Thromb Vasc Biol (2005) 0.97
Lineage specific methylation of the Elf5 promoter in mammary epithelial cells. Stem Cells (2011) 0.97
miR-326 associates with biochemical markers of bone turnover in lung cancer bone metastasis. Bone (2012) 0.97
Polymorphisms in the thymidylate synthase and dihydropyrimidine dehydrogenase genes predict response and toxicity to capecitabine-raltitrexed in colorectal cancer. Oncol Rep (2007) 0.96
Toxic epidermal necrolysis related to pemetrexed and carboplatin with vitamin B12 and folic acid supplementation for advanced non-small cell lung cancer. Onkologie (2009) 0.96
Biological profile of new apoptotic agents based on 2,4-pyrido[2,3-d]pyrimidine derivatives. Bioorg Med Chem (2006) 0.96
Inhibitor of differentiation-1 as a novel prognostic factor in NSCLC patients with adenocarcinoma histology and its potential contribution to therapy resistance. Clin Cancer Res (2011) 0.95
Differential expression of Rac1 identifies its target genes and its contribution to progression of colorectal cancer. Int J Biochem Cell Biol (2007) 0.95
Approaches for the study of cancer: towards the integration of genomics, proteomics and metabolomics. Clin Transl Oncol (2011) 0.94
A critical role for Rac1 in tumor progression of human colorectal adenocarcinoma cells. Am J Pathol (2007) 0.93
From Ras signalling to ChoK inhibitors: a further advance in anticancer drug design. Cancer Lett (2004) 0.92
Patterns of response after preoperative treatment in gastric cancer. Int J Radiat Oncol Biol Phys (2010) 0.91
Evidence of p38γ and p38δ involvement in cell transformation processes. Carcinogenesis (2011) 0.91
LOXL4 is induced by transforming growth factor β1 through Smad and JunB/Fra2 and contributes to vascular matrix remodeling. Mol Cell Biol (2013) 0.91
A new palliative care consultation team at the oncology department of a university hospital: an assessment of initial efficiency and effectiveness. Support Care Cancer (2012) 0.90
Characterization of cisplatin cytotoxicity delivered from PLGA-systems. Eur J Pharm Biopharm (2007) 0.90
Combined 5-FU and ChoKα inhibitors as a new alternative therapy of colorectal cancer: evidence in human tumor-derived cell lines and mouse xenografts. PLoS One (2013) 0.90
Primary bone lymphoma of the mandible and thyroid incidentaloma identified by FDG PET/CT: a case report. Cases J (2009) 0.90
Four-week neoadjuvant intensity-modulated radiation therapy with concurrent capecitabine and oxaliplatin in locally advanced rectal cancer patients: a validation phase II trial. Int J Radiat Oncol Biol Phys (2011) 0.89
Upregulation of trefoil factor 3 (TFF3) after rectal cancer chemoradiotherapy is an adverse prognostic factor and a potential therapeutic target. Int J Radiat Oncol Biol Phys (2012) 0.88
BCL-2 hypermethylation is a potential biomarker of sensitivity to antimitotic chemotherapy in endocrine-resistant breast cancer. Mol Cancer Ther (2013) 0.88
MicroRNA-21 predicts response to preoperative chemoradiotherapy in locally advanced rectal cancer. Int J Colorectal Dis (2015) 0.88
STAT5a activation mediates the epithelial to mesenchymal transition induced by oncogenic RhoA. Mol Biol Cell (2003) 0.87
Treatment recommendations for metastatic colorectal cancer. Clin Transl Oncol (2011) 0.85
Acquired potential N-glycosylation sites within the tumor-specific immunoglobulin heavy chains of B-cell malignancies. Haematologica (2004) 0.85
Guidelines for biomarker testing in colorectal carcinoma (CRC): a national consensus of the Spanish Society of Pathology (SEAP) and the Spanish Society of Medical Oncology (SEOM). Clin Transl Oncol (2012) 0.84
Phospholipase D and choline kinase: their role in cancer development and their potential as drug targets. Prog Cell Cycle Res (2003) 0.84
The mammary cellular hierarchy and breast cancer. Cell Mol Life Sci (2014) 0.84
Proteomic analysis in cancer research: potential application in clinical use. Clin Transl Oncol (2006) 0.84
Moving forward in colorectal cancer research, what proteomics has to tell. World J Gastroenterol (2007) 0.84
Selection of extreme phenotypes: the role of clinical observation in translational research. Clin Transl Oncol (2010) 0.83
Improving disease control in advanced colorectal cancer: Panitumumab and cetuximab. Crit Rev Oncol Hematol (2009) 0.83
A case of capecitabine-induced coronary microspasm in a patient with rectal cancer. World J Gastroenterol (2007) 0.83
Irinotecan, oxaliplatin, and 5-fluorouracil/leucovorin combination chemotherapy in advanced colorectal carcinoma: a phase II study. Clin Colorectal Cancer (2002) 0.83
The multimodal management of locally advanced N2 non-small cell lung cancer: is there a role for surgical resection? A single institution's experience. Clin Transl Oncol (2012) 0.83
KRAS mutational status analysis of peripheral blood isolated circulating tumor cells in metastatic colorectal patients. Oncol Lett (2013) 0.83
Comparative disease pattern of a patient with a novel BRCA2 truncation and knockout models for BRCA2. Breast Cancer Res Treat (2010) 0.82
Influence of the linker in bispyridium compounds on the inhibition of human choline kinase. J Med Chem (2004) 0.82
Association of steroid and xenobiotic receptor (SXR) and multidrug resistance 1 (MDR1) gene expression with survival among patients with invasive bladder carcinoma. BJU Int (2010) 0.82
Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer. Int J Oncol (2006) 0.82
Downregulation of miR-214 is specific of liver metastasis in colorectal cancer and could play a role determining the metastatic niche. Int J Colorectal Dis (2014) 0.81
Up-regulation of c-Cbl suggests its potential role as oncogene in primary colorectal cancer. Int J Colorectal Dis (2014) 0.81
Adult onset Still's disease after first cycle of pemetrexed and gemcitabine for non-small cell lung cancer. Lung Cancer (2008) 0.81