Published in Naunyn Schmiedebergs Arch Pharmacol on February 26, 2008
Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects. J Biol Chem (2010) 1.14
Potent anti-inflammatory activity of pyrenocine A isolated from the marine-derived fungus Penicillium paxilli Ma(G)K. Mediators Inflamm (2014) 0.77
Adjusting the balance between effective loading and vector migration of macrophage vehicles to deliver nanoparticles. PLoS One (2013) 0.76
Inflammatory resolution: new opportunities for drug discovery. Nat Rev Drug Discov (2004) 5.08
Src kinase regulation by phosphorylation and dephosphorylation. Biochem Biophys Res Commun (2005) 3.31
Macrophages in inflammation. Curr Drug Targets Inflamm Allergy (2005) 2.85
IkappaB kinases: key regulators of the NF-kappaB pathway. Trends Biochem Sci (2004) 2.61
Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages. Eur J Immunol (2003) 2.47
Nuclear factor-kappa B and cancer: its role in prevention and therapy. Biochem Pharmacol (2002) 2.27
IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide. J Immunol (1999) 2.05
Physiological functions of protein kinase B/Akt. Biochem Soc Trans (2004) 2.00
Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts. Biochem Biophys Res Commun (2003) 1.93
The aging innate immune system. Curr Opin Immunol (2005) 1.81
Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6. J Biol Chem (1997) 1.78
Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors. J Immunol (1996) 1.75
Reactive nitrogen intermediates and the pathogenesis of Salmonella and mycobacteria. Curr Opin Microbiol (2000) 1.73
In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. Eur J Pharmacol (2000) 1.70
The ubiquitin-dependent proteolytic system and other potential targets for the modulation of nuclear factor-kB (NF-kB). Curr Drug Targets (2000) 1.61
Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells. Eur J Pharmacol (2006) 1.51
Redox signaling in vascular angiogenesis. Free Radic Biol Med (2002) 1.45
Role of the NF-kappaB pathway in the pathogenesis of human disease states. Curr Mol Med (2001) 1.44
Natural products as targeted modulators of the nuclear factor-kappaB pathway. J Pharm Pharmacol (2002) 1.40
The functional interactions between CD98, beta1-integrins, and CD147 in the induction of U937 homotypic aggregation. Blood (2001) 1.39
Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival. Mol Cancer Ther (2005) 1.37
Arginase II downregulates nitric oxide (NO) production and prevents NO-mediated apoptosis in murine macrophage-derived RAW 264.7 cells. J Cell Biol (1999) 1.35
Identification of cooperative monomeric Brachyury sites conferring T-bet responsiveness to the proximal IFN-gamma promoter. Int Immunol (2003) 1.29
Macrophages in host defense against Histoplasma capsulatum. Trends Microbiol (1999) 1.29
Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia. Life Sci (2006) 1.28
Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. Am J Respir Cell Mol Biol (2007) 1.26
Signal transduction via the NF-kappaB pathway: a targeted treatment modality for infection, inflammation and repair. Cell Biochem Funct (2004) 1.18
Inhibition of nuclear factor kappaB by phenolic antioxidants: interplay between antioxidant signaling and inflammatory cytokine expression. Mol Pharmacol (2003) 1.17
Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin. J Biol Chem (2001) 1.11
PPAR-gamma agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathways. Blood (2005) 1.09
Calling in the troops: regulation of inflammatory cell trafficking through innate cytokine/chemokine networks. Viral Immunol (2003) 1.04
Rengyolone inhibits inducible nitric oxide synthase expression and nitric oxide production by down-regulation of NF-kappaB and p38 MAP kinase activity in LPS-stimulated RAW 264.7 cells. Biochem Pharmacol (2006) 1.03
Savinin, a lignan from Pterocarpus santalinus inhibits tumor necrosis factor-alpha production and T cell proliferation. Biol Pharm Bull (2001) 1.00
CD98-dependent homotypic aggregation is associated with translocation of protein kinase Cdelta and activation of mitogen-activated protein kinases. Exp Cell Res (2003) 0.99
Anti-inflammatory properties of lipid oxidation products. J Mol Med (Berl) (2003) 0.99
Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells. Biochem Pharmacol (2006) 0.98
Inducible nitric oxide synthase and Salmonella infection. Microbes Infect (2001) 0.95
Regulatory effects of Codonopsis lanceolata on macrophage-mediated immune responses. J Ethnopharmacol (2007) 0.94
Inflammatory response and the endothelium. Thromb Res (2004) 0.94
In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists. Planta Med (2001) 0.94
Melittin inhibits inflammatory target gene expression and mediator generation via interaction with IkappaB kinase. Biochem Pharmacol (2006) 0.88
Pure lipopolysaccharide or synthetic lipid A induces activation of p21Ras in primary macrophages through a pathway dependent on Src family kinases and PI3K. J Immunol (2005) 0.87
Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design. J Med Chem (2007) 0.87
Regulation of CD43-induced U937 homotypic aggregation. Exp Cell Res (2003) 0.85
The anti-inflammatory sesquiterpene lactone parthenolide suppresses IL-4 gene expression in peripheral blood T. Eur J Immunol (2002) 0.84
Proteolytic signaling by TNFalpha: caspase activation and IkappaB degradation. Cytokine (2003) 0.83
Differential effect of phosphodiesterase IV inhibitor RP73401 on various inflammatory and immune responses relevent to rheumatoid arthritis. Pharmacol Res (2004) 0.83
Stimulation of tumour necrosis factor release by cytotoxic analogues of platelet-activating factor. Immunology (1992) 0.82
Enhanced v-Src-induced oncogenic transformation in the absence of focal adhesion kinase is mediated by phosphatidylinositol 3-kinase. Biochem Biophys Res Commun (2005) 0.81
In vitro antiinflammatory effects of neolignan woorenosides from the rhizomes of Coptis japonica. J Nat Prod (2000) 0.79
Phosphatidic acid positively regulates LPS-induced differentiation of RAW264.7 murine macrophage cell line into dendritic-like cells. Biochem Biophys Res Commun (2004) 0.78
Coupling of C3bi to IgG inhibits the tyrosine phosphorylation signaling cascade downstream Syk and reduces cytokine induction in monocytes. J Leukoc Biol (2006) 0.78
Induction of inducible nitric oxide synthase and apoptosis by LPS and TNF-alpha in nasal microvascular endothelial cells. Acta Otolaryngol (2008) 0.77
In vitro antitumour activity of the novel imidazoisoquinoline SDZ 62-434. Br J Cancer (1993) 0.77
Antitumor activity of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinolines. J Med Chem (1995) 0.77
Preclinical pharmacology and possible mechanism of action of the novel antitumor agent 5-(4'-piperidinomethylphenyl)-2,3-dihydroimidazo [2,1-a]isoquinoline. Arzneimittelforschung (1995) 0.77
Lipopolysaccharide prevents apoptosis induced by brefeldin A, an endoplasmic reticulum stress agent, in RAW 264.7 cells. Biochem Biophys Res Commun (2005) 0.76
Lack of therapeutic effects of platelet activating factor antagonists in WEHI-3B leukemia, human xenotransplanted colorectal and lung cancer and Lewis-lung tumor in vivo. Cancer Lett (1992) 0.75
The role of Src kinase in macrophage-mediated inflammatory responses. Mediators Inflamm (2012) 1.30
Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia. Life Sci (2006) 1.28
Ginsenoside Rp1, a Ginsenoside Derivative, Blocks Promoter Activation of iNOS and COX-2 Genes by Suppression of an IKKβ-mediated NF-кB Pathway in HEK293 Cells. J Ginseng Res (2011) 1.26
In vitro anti-inflammatory and anti-oxidative effects of Cinnamomum camphora extracts. J Ethnopharmacol (2005) 1.25
Molecular mechanism of macrophage activation by red ginseng acidic polysaccharide from Korean red ginseng. Mediators Inflamm (2012) 1.24
Anti-hyperlipidemic effects of red ginseng acidic polysaccharide from Korean red ginseng. Biol Pharm Bull (2010) 1.23
The pivotal role of TBK1 in inflammatory responses mediated by macrophages. Mediators Inflamm (2012) 1.19
Korean Red Ginseng Saponin Fraction Downregulates Proinflammatory Mediators in LPS Stimulated RAW264.7 Cells and Protects Mice against Endotoxic Shock. J Ginseng Res (2012) 1.18
Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects. J Biol Chem (2010) 1.14
Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells. Immunobiology (2013) 1.13
Distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of kappaB alpha via activation of the phosphoinositide-3-kinase and Akt pathways. Int J Biochem Cell Biol (2008) 1.09
Functional role of Akt in macrophage-mediated innate immunity. Front Biosci (Landmark Ed) (2011) 1.08
Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression. FEBS Lett (2007) 1.07
Src-mediated regulation of inflammatory responses by actin polymerization. Biochem Pharmacol (2009) 1.06
20S-dihydroprotopanaxatriol modulates functional activation of monocytes and macrophages. J Ginseng Res (2013) 1.06
Inhibitory effect of saponin fraction from Codonopsis lanceolata on immune cell-mediated inflammatory responses. Arch Pharm Res (2009) 1.04
Inhibitory mechanisms of dihydroginsenoside Rg3 in platelet aggregation: critical roles of ERK2 and cAMP. J Pharm Pharmacol (2008) 1.03
Surfactin blocks NO production in lipopolysaccharide-activated macrophages by inhibiting NF-kappaB activation. J Microbiol Biotechnol (2008) 1.03
20S-dihydroprotopanaxadiol, a ginsenoside derivative, boosts innate immune responses of monocytes and macrophages. J Ginseng Res (2013) 1.01
In vitro and in vivo anti-inflammatory effects of ethanol extract from Acer tegmentosum. J Ethnopharmacol (2010) 1.01
Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans. J Ethnopharmacol (2011) 1.01
p-Terphenyls from the fruiting bodies of Paxillus curtisii and their antioxidant properties. Bioorg Med Chem (2009) 1.01
Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Acta Pharmacol Sin (2008) 0.99
BAY 11-7082 is a broad-spectrum inhibitor with anti-inflammatory activity against multiple targets. Mediators Inflamm (2012) 0.98
In vitro and in vivo anti-inflammatory activities of Polygonum hydropiper methanol extract. J Ethnopharmacol (2011) 0.97
Inhibition of 2,4-dinitrofluorobenzene-induced atopic dermatitis by topical application of the butanol extract of Cordyceps bassiana in NC/Nga mice. J Ethnopharmacol (2010) 0.96
Total saponin from korean red ginseng inhibits thromboxane A2 production associated microsomal enzyme activity in platelets. J Ginseng Res (2012) 0.96
The TRIF/TBK1/IRF-3 activation pathway is the primary inhibitory target of resveratrol, contributing to its broad-spectrum anti-inflammatory effects. Pharmazie (2011) 0.95
Anti-metastatic potential of ginsenoside Rp1, a novel ginsenoside derivative. Biol Pharm Bull (2008) 0.95
Inhibitory effect of Sanguisorba officinalis ethanol extract on NO and PGE₂ production is mediated by suppression of NF-κB and AP-1 activation signaling cascade. J Ethnopharmacol (2010) 0.95
Cell-permeable ceramides act as novel regulators of U937 cell-cell adhesion mediated by CD29, CD98, and CD147. Immunobiology (2009) 0.95
The expression patterns of RGS transcripts in platelets. Platelets (2006) 0.95
AP-1/IRF-3 Targeted Anti-Inflammatory Activity of Andrographolide Isolated from Andrographis paniculata. Evid Based Complement Alternat Med (2013) 0.94
A noble function of BAY 11-7082: Inhibition of platelet aggregation mediated by an elevated cAMP-induced VASP, and decreased ERK2/JNK1 phosphorylations. Eur J Pharmacol (2009) 0.94
Flavonoids differentially modulate nitric oxide production pathways in lipopolysaccharide-activated RAW264.7 cells. Arch Pharm Res (2005) 0.94
Regulatory effects of Codonopsis lanceolata on macrophage-mediated immune responses. J Ethnopharmacol (2007) 0.94
Cordycepin (3'-deoxyadenosine) inhibits human platelet aggregation in a cyclic AMP- and cyclic GMP-dependent manner. Eur J Pharmacol (2006) 0.93
Ginsenoside Rp1, a ginsenoside derivative, blocks lipopolysaccharide-induced interleukin-1beta production via suppression of the NF-kappaB pathway. Planta Med (2009) 0.93
Ginsenoside Rp1 from Panax ginseng exhibits anti-cancer activity by down-regulation of the IGF-1R/Akt pathway in breast cancer cells. Plant Foods Hum Nutr (2011) 0.93
The mechanism of anti-platelet activity of davallialactone: involvement of intracellular calcium ions, extracellular signal-regulated kinase 2 and p38 mitogen-activated protein kinase. Eur J Pharmacol (2008) 0.93
Hydroquinone regulates hemeoxygenase-1 expression via modulation of Src kinase activity through thiolation of cysteine residues. Free Radic Biol Med (2013) 0.93
Biological and antibacterial activities of the natural herb Houttuynia cordata water extract against the intracellular bacterial pathogen salmonella within the RAW 264.7 macrophage. Biol Pharm Bull (2008) 0.92
Cynaropicrin, a sesquiterpene lactone, as a new strong regulator of CD29 and CD98 functions. Biochem Biophys Res Commun (2004) 0.92
In vitro and in vivo anti-inflammatory effect of Rhodomyrtus tomentosa methanol extract. J Ethnopharmacol (2013) 0.92
In vitro anti-inflammatory and pro-aggregative effects of a lipid compound, petrocortyne A, from marine sponges. Naunyn Schmiedebergs Arch Pharmacol (2003) 0.90
Epigallocatechin-3-gallate has an anti-platelet effect in a cyclic AMP-dependent manner. J Atheroscler Thromb (2012) 0.90
Ischemia induces regulator of G protein signaling 2 (RGS2) protein upregulation and enhances apoptosis in astrocytes. Am J Physiol Cell Physiol (2009) 0.89
Process development for mycelial growth and polysaccharide production in Tricholoma matsutake liquid culture. J Biosci Bioeng (2009) 0.89
Dual Roles of Quercetin in Platelets: Phosphoinositide-3-Kinase and MAP Kinases Inhibition, and cAMP-Dependent Vasodilator-Stimulated Phosphoprotein Stimulation. Evid Based Complement Alternat Med (2012) 0.88
Structural characteristics of immunostimulating polysaccharides from lentinus edodes. J Microbiol Biotechnol (2009) 0.88
3-(4-(tert-Octyl)phenoxy)propane-1,2-diol suppresses inflammatory responses via inhibition of multiple kinases. Biochem Pharmacol (2012) 0.88
Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines. Eur J Pharmacol (2004) 0.88
Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein. BMC Cell Biol (2009) 0.88
Effect of Korean red ginseng extract on liver damage induced by short-term and long-term ethanol treatment in rats. J Ginseng Res (2013) 0.88
Phellinus baumii ethyl acetate extract inhibits lipopolysaccharide-induced iNOS, COX-2, and proinflammatory cytokine expression in RAW264.7 cells. J Nat Med (2011) 0.87
Involvement of Src and the actin cytoskeleton in the antitumorigenic action of adenosine dialdehyde. Biochem Pharmacol (2013) 0.87
Inhibition of cytokine expression by a butanol extract from Cordyceps bassiana. Pharmazie (2011) 0.87
Radical scavenging activity-based and AP-1-targeted anti-inflammatory effects of lutein in macrophage-like and skin keratinocytic cells. Mediators Inflamm (2013) 0.87
Molecular mechanism of macrophage activation by Exopolysaccharides from liquid culture of Lentinus edodes. J Microbiol Biotechnol (2008) 0.87
p38-targeted inhibition of interleukin-12 expression by ethanol extract from Cordyceps bassiana in lipopolysaccharide-activated macrophages. Immunopharmacol Immunotoxicol (2010) 0.87
Syk/Src pathway-targeted inhibition of skin inflammatory responses by carnosic acid. Mediators Inflamm (2012) 0.87
Immunomodulatory effect of Hibiscus cannabinus extract on macrophage functions. J Ethnopharmacol (2007) 0.86
Red ginseng saponin fraction a isolated from korean red ginseng by ultrafiltration on the porcine coronary artery. J Ginseng Res (2011) 0.86
Nuclear factor-kappaB/signal transducers and activators of transcription-1-mediated inflammatory responses in lipopolysaccharide-activated macrophages are a major inhibitory target of kahweol, a coffee diterpene. Biol Pharm Bull (2010) 0.86
Toll-like receptor 4-linked Janus kinase 2 signaling contributes to internalization of Brucella abortus by macrophages. Infect Immun (2013) 0.86
Inhibitory effects of total saponin from Korean red ginseng via vasodilator-stimulated phosphoprotein-Ser(157) phosphorylation on thrombin-induced platelet aggregation. J Ginseng Res (2013) 0.86
Inhibitory effects of Bulnesia sarmienti aqueous extract on agonist-induced platelet activation and thrombus formation involves mitogen-activated protein kinases. J Ethnopharmacol (2010) 0.85
The ability of an ethanol extract of Cinnamomum cassia to inhibit Src and spleen tyrosine kinase activity contributes to its anti-inflammatory action. J Ethnopharmacol (2011) 0.85
Hydroquinone, a reactive metabolite of benzene, reduces macrophage-mediated immune responses. Mol Cells (2007) 0.85