Syk/Src pathway-targeted inhibition of skin inflammatory responses by carnosic acid.

PubWeight™: 0.87‹?›

🔗 View Article (PMC 3337681)

Published in Mediators Inflamm on April 10, 2012

Authors

Jueun Oh1, Tao Yu, Soo Jeong Choi, Yanyan Yang, Heung Soo Baek, Soon Ae An, Lee Kyoung Kwon, Jinsol Kim, Ho Sik Rho, Song Seok Shin, Wahn Soo Choi, Sungyoul Hong, Jae Youl Cho

Author Affiliations

1: Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea.

Articles cited by this

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds. J Virol Methods (1988) 7.74

Macrophages in rheumatoid arthritis. Arthritis Res (2000) 3.40

A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest (1999) 2.65

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat Immunol (2010) 2.58

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector. Arch Biochem Biophys (2010) 2.27

New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol (2009) 2.16

Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J Neurochem (2007) 1.90

Mononuclear phagocytes and rheumatoid synovitis. Mastermind or workhorse in arthritis? Arthritis Rheum (1997) 1.89

In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. Eur J Pharmacol (2000) 1.70

Pathogenesis of joint damage in rheumatoid arthritis. J Rheumatol (1999) 1.69

Antioxidant activity, lipid peroxidation and skin diseases. What's new. J Eur Acad Dermatol Venereol (2003) 1.67

Roles of Toll-like receptors in innate immune responses. Genes Cells (2001) 1.56

Review of the innate immune response in acne vulgaris: activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses. Dermatology (2005) 1.48

Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid. Xenobiotica (1992) 1.44

Abnormal skin barrier in the etiopathogenesis of atopic dermatitis. Curr Opin Allergy Clin Immunol (2009) 1.43

Skin and soft tissue infection: microbiology and epidemiology. Int J Antimicrob Agents (2009) 1.29

Ginsenoside Rp1, a Ginsenoside Derivative, Blocks Promoter Activation of iNOS and COX-2 Genes by Suppression of an IKKβ-mediated NF-кB Pathway in HEK293 Cells. J Ginseng Res (2011) 1.26

Infective endocarditis due to Propionibacterium species. Clin Microbiol Infect (2009) 1.25

Toll-like receptor 2 ligands activate human basophils for both IgE-dependent and IgE-independent secretion. J Allergy Clin Immunol (2005) 1.25

Photoprotective potential of lycopene, beta-carotene, vitamin E, vitamin C and carnosic acid in UVA-irradiated human skin fibroblasts. Free Radic Biol Med (2002) 1.15

Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects. J Biol Chem (2010) 1.14

Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes. Biochem Pharmacol (2008) 1.14

Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages. Carcinogenesis (2002) 1.13

Distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of kappaB alpha via activation of the phosphoinositide-3-kinase and Akt pathways. Int J Biochem Cell Biol (2008) 1.09

Cytokine and chemokine inter-regulation in the inflamed or injured CNS. Brain Res Brain Res Rev (2005) 1.07

Src-mediated regulation of inflammatory responses by actin polymerization. Biochem Pharmacol (2009) 1.06

Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages. J Immunol (2006) 1.05

Surfactin blocks NO production in lipopolysaccharide-activated macrophages by inhibiting NF-kappaB activation. J Microbiol Biotechnol (2008) 1.03

Protective effect of polygoni cuspidati radix and emodin on Vibrio vulnificus cytotoxicity and infection. J Microbiol (2008) 1.00

Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium. Chem Biol Interact (2010) 0.99

Mast cells as regulators of skin inflammation and immunity. Acta Derm Venereol (2011) 0.98

Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma. Planta Med (2006) 0.97

In vitro and in vivo anti-inflammatory activities of Polygonum hydropiper methanol extract. J Ethnopharmacol (2011) 0.97

The TRIF/TBK1/IRF-3 activation pathway is the primary inhibitory target of resveratrol, contributing to its broad-spectrum anti-inflammatory effects. Pharmazie (2011) 0.95

Inhibitory effect of Sanguisorba officinalis ethanol extract on NO and PGE₂ production is mediated by suppression of NF-κB and AP-1 activation signaling cascade. J Ethnopharmacol (2010) 0.95

Immunology of allergic contact dermatitis. Acta Dermatovenerol Croat (2011) 0.94

Modulation of the Fcepsilon receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases. Curr Pharm Des (2004) 0.92

Preclinical evaluation of local JAK1 and JAK2 inhibition in cutaneous inflammation. J Invest Dermatol (2011) 0.92

Human skin in organ culture and human skin cells (keratinocytes and fibroblasts) in monolayer culture for assessment of chemically induced skin damage. Toxicol Pathol (2007) 0.91

Carnosic acid prevents the migration of human aortic smooth muscle cells by inhibiting the activation and expression of matrix metalloproteinase-9. Br J Nutr (2008) 0.88

Skin clues in the diagnosis of life-threatening infections. Rev Infect Dis (1986) 0.88

Modulation of the IL-1 cytokine network in keratinocytes by intracellular IL-1 alpha and IL-1 receptor antagonist. Clin Exp Immunol (1995) 0.86

Antihistamines in the treatment of dermatitis. J Cutan Med Surg (2005) 0.86

Carnosic acid reduces cytokine-induced adhesion molecules expression and monocyte adhesion to endothelial cells. Eur J Nutr (2009) 0.86

Synthesis and microbiological evaluation of honokiol derivatives as new antimicrobial agents. Arch Pharm Res (2010) 0.85

Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia. Biochem Biophys Res Commun (2011) 0.85

Syntheses of carnosic acid and carnosol, anti-oxidants in Rosemary, from pisiferic acid, the major constituent of Sawara. Chem Pharm Bull (Tokyo) (2010) 0.83

In vitro antimicrobial and antioxidant activity of commercial rosemary extract formulations. J Food Prot (2009) 0.82

Polygoni cuspidati radix inhibits the activation of Syk kinase in mast cells for antiallergic activity. Exp Biol Med (Maywood) (2007) 0.82

Analysis of the mechanism for the development of allergic skin inflammation and the application for its treatment: aspirin modulation of IgE-dependent mast cell activation: role of aspirin-induced exacerbation of immediate allergy. J Pharmacol Sci (2009) 0.81

Antiangiogenic effect of carnosic acid and carnosol, neuroprotective compounds in rosemary leaves. Biosci Biotechnol Biochem (2012) 0.81

Anti-inflammatory activity of Sorbus commixta water extract and its molecular inhibitory mechanism. J Ethnopharmacol (2010) 0.79

Relevance of carnosic acid concentrations to the selection of rosemary, Rosmarinus officinalis (L.), accessions for optimization of antioxidant yield. J Agric Food Chem (2004) 0.78

Retracted Chemical stabilization of oils rich in long-chain polyunsaturated fatty acids during storage. Food Sci Technol Int (2011) 0.76

Articles by these authors

Pyran annulation: asymmetric synthesis of 2,6-disubstituted-4-methylene tetrahydropyrans. Org Lett (2002) 1.96

Dynamics connect substrate recognition to catalysis in protein kinase A. Nat Chem Biol (2010) 1.95

cAMP-dependent protein kinase A selects the excited state of the membrane substrate phospholamban. J Mol Biol (2011) 1.90

Th9 cells promote antitumor immune responses in vivo. J Clin Invest (2012) 1.80

Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Nat Neurosci (2002) 1.69

Port-wine vascular malformations and glaucoma risk in Sturge-Weber syndrome. J AAPOS (2009) 1.65

A DNA nanostructure platform for directed assembly of synthetic vaccines. Nano Lett (2012) 1.64

Myeloma cell line-derived, pooled heat shock proteins as a universal vaccine for immunotherapy of multiple myeloma. Blood (2009) 1.61

Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis. Blood (2009) 1.58

Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities. Hum Mol Genet (2007) 1.57

MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted-cell viability. Nat Mater (2013) 1.53

Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells. Clin Exp Metastasis (2002) 1.53

Global functional connectivity reveals highly significant differences between the vegetative and the minimally conscious state. J Neurol (2012) 1.50

The effects of epinephrine on outcomes of normothermic and therapeutic hypothermic cardiopulmonary resuscitation. Crit Care Med (2010) 1.49

The chromatin-remodeling enzyme BRG1 coordinates CIITA induction through many interdependent distal enhancers. Nat Immunol (2008) 1.44

Surface maturation scoring for oesophageal squamous intraepithelial neoplasia: a novel diagnostic approach inspired by first endomicroscopic 3-dimensional reconstruction. Gut (2012) 1.44

Microalterations of esophagus in patients with non-erosive reflux disease: in-vivo diagnosis by confocal laser endomicroscopy and its relationship with gastroesophageal reflux. Am J Gastroenterol (2012) 1.43

Pharmacologically induced hypothermia with cannabinoid receptor agonist WIN55, 212-2 after cardiopulmonary resuscitation. Crit Care Med (2010) 1.40

Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell (2013) 1.31

The role of Src kinase in macrophage-mediated inflammatory responses. Mediators Inflamm (2012) 1.30

Optimizing immunotherapy in multiple myeloma: Restoring the function of patients' monocyte-derived dendritic cells by inhibiting p38 or activating MEK/ERK MAPK and neutralizing interleukin-6 in progenitor cells. Blood (2006) 1.30

Classification of inflammation activity in ulcerative colitis by confocal laser endomicroscopy. Am J Gastroenterol (2009) 1.30

Apical role for BRG1 in cytokine-induced promoter assembly. Proc Natl Acad Sci U S A (2005) 1.30

A severe combined immunodeficient-hu in vivo mouse model of human primary mantle cell lymphoma. Clin Cancer Res (2008) 1.29

Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia. Life Sci (2006) 1.28

Fused phenanthridines: domino cyclization of 1,6-diynes with bromo(iso)quinoline. Chem Asian J (2011) 1.26

Dickkopf-1 (DKK1) is a widely expressed and potent tumor-associated antigen in multiple myeloma. Blood (2007) 1.26

Ginsenoside Rp1, a Ginsenoside Derivative, Blocks Promoter Activation of iNOS and COX-2 Genes by Suppression of an IKKβ-mediated NF-кB Pathway in HEK293 Cells. J Ginseng Res (2011) 1.26

Antibiotic resistance characteristics of environmental bacteria from an oxytetracycline production wastewater treatment plant and the receiving river. Appl Environ Microbiol (2010) 1.26

In vitro anti-inflammatory and anti-oxidative effects of Cinnamomum camphora extracts. J Ethnopharmacol (2005) 1.25

Molecular mechanism of macrophage activation by red ginseng acidic polysaccharide from Korean red ginseng. Mediators Inflamm (2012) 1.24

Anti-hyperlipidemic effects of red ginseng acidic polysaccharide from Korean red ginseng. Biol Pharm Bull (2010) 1.23

Cross talk between the bone and immune systems: osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells. Blood (2010) 1.23

Classification of gastric pit patterns by confocal endomicroscopy. Gastrointest Endosc (2008) 1.21

Norepinephrine induces VEGF expression and angiogenesis by a hypoxia-inducible factor-1α protein-dependent mechanism. Int J Cancer (2010) 1.21

The pivotal role of TBK1 in inflammatory responses mediated by macrophages. Mediators Inflamm (2012) 1.19

Korean Red Ginseng Saponin Fraction Downregulates Proinflammatory Mediators in LPS Stimulated RAW264.7 Cells and Protects Mice against Endotoxic Shock. J Ginseng Res (2012) 1.18

The inhibition of T-cells proliferation by mouse mesenchymal stem cells through the induction of p16INK4A-cyclin D1/cdk4 and p21waf1, p27kip1-cyclin E/cdk2 pathways. Cell Immunol (2007) 1.17

Diagnostic value of confocal laser endomicroscopy for gastric superficial cancerous lesions. Gut (2010) 1.15

Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects. J Biol Chem (2010) 1.14

Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells. Immunobiology (2013) 1.13

Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells. J Biol Chem (2001) 1.13

Proteomic profiling and identification of cofilin responding to oxidative stress in vascular smooth muscle. Proteomics (2006) 1.11

Enantio- and diastereoselective additions to aldehydes using the bifunctional reagent 2-(chloromethyl)-3-(tributylstannyl)propene: application to a synthesis of the C16-C27 segment of bryostatin 1. J Org Chem (2005) 1.10

Effect of acupuncture treatment on spastic states of stroke patients. J Neurol Sci (2008) 1.10

Tumor necrosis factor alpha-induced interleukin-32 is positively regulated via the Syk/protein kinase Cdelta/JNK pathway in rheumatoid synovial fibroblasts. Arthritis Rheum (2009) 1.10

Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone. J Mol Med (Berl) (2011) 1.10

Distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of kappaB alpha via activation of the phosphoinositide-3-kinase and Akt pathways. Int J Biochem Cell Biol (2008) 1.09

Confocal endomicroscopy for in vivo detection of microvascular architecture in normal and malignant lesions of upper gastrointestinal tract. J Gastroenterol Hepatol (2007) 1.08

Functional role of Akt in macrophage-mediated innate immunity. Front Biosci (Landmark Ed) (2011) 1.08

Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression. FEBS Lett (2007) 1.07

Characterisation of allergen-specific responses of IL-10-producing regulatory B cells (Br1) in Cow Milk Allergy. Cell Immunol (2010) 1.07

Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Int J Oncol (2012) 1.07

Src-mediated regulation of inflammatory responses by actin polymerization. Biochem Pharmacol (2009) 1.06

20S-dihydroprotopanaxatriol modulates functional activation of monocytes and macrophages. J Ginseng Res (2013) 1.06

Limitations of minimal incision technique for tibiotalocalcaneal arthrodesis. Foot Ankle Int (2014) 1.06

The imprinted H19 gene regulates human placental trophoblast cell proliferation via encoding miR-675 that targets Nodal Modulator 1 (NOMO1). RNA Biol (2012) 1.05

miRNA-200c inhibits invasion and metastasis of human non-small cell lung cancer by directly targeting ubiquitin specific peptidase 25. Mol Cancer (2014) 1.05

Inhibitory effect of saponin fraction from Codonopsis lanceolata on immune cell-mediated inflammatory responses. Arch Pharm Res (2009) 1.04

Prospectively versus retrospectively ECG-gated 256-slice coronary CT angiography: image quality and radiation dose over expanded heart rates. Int J Cardiovasc Imaging (2010) 1.04

Inhibitory mechanisms of dihydroginsenoside Rg3 in platelet aggregation: critical roles of ERK2 and cAMP. J Pharm Pharmacol (2008) 1.03

Allergen-specific responses of CD19(+)CD5(+)Foxp3(+) regulatory B cells (Bregs) and CD4(+)Foxp3(+) regulatory T cell (Tregs) in immune tolerance of cow milk allergy of late eczematous reactions. Cell Immunol (2012) 1.03

Surfactin blocks NO production in lipopolysaccharide-activated macrophages by inhibiting NF-kappaB activation. J Microbiol Biotechnol (2008) 1.03

In vitro selection of DNA aptamer against abrin toxin and aptamer-based abrin direct detection. Biosens Bioelectron (2006) 1.03

Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk. J Allergy Clin Immunol (2008) 1.03

Gene transfer of redox factor-1 inhibits neointimal formation: involvement of platelet-derived growth factor-beta receptor signaling via the inhibition of the reactive oxygen species-mediated Syk pathway. Circ Res (2008) 1.03

Effects of a life skills intervention for increasing physical activity in adolescent girls. Arch Pediatr Adolesc Med (2006) 1.02

Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents. J Med Chem (2005) 1.02

Synthesis and structure-activity relationship of ethacrynic acid analogues on glutathione-s-transferase P1-1 activity inhibition. Bioorg Med Chem (2005) 1.02

Cooperation of H2O2-mediated ERK activation with Smad pathway in TGF-beta1 induction of p21WAF1/Cip1. Cell Signal (2005) 1.01

In vitro and in vivo anti-inflammatory effects of ethanol extract from Acer tegmentosum. J Ethnopharmacol (2010) 1.01

20S-dihydroprotopanaxadiol, a ginsenoside derivative, boosts innate immune responses of monocytes and macrophages. J Ginseng Res (2013) 1.01

Active vaccination with Dickkopf-1 induces protective and therapeutic antitumor immunity in murine multiple myeloma. Blood (2011) 1.01

Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans. J Ethnopharmacol (2011) 1.01

Theoretical study on the structure and stability of [1,2,5] oxadiazolo [3,4-e] [1,2,3,4]-tetrazine-4,6-Di-N-dioxide (FTDO). J Mol Model (2014) 1.00

Diabetes mellitus and increased risk of biliary tract cancer: systematic review and meta-analysis. Cancer Causes Control (2011) 1.00

Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Acta Pharmacol Sin (2008) 0.99

MULTIPLE TESTING VIA FDR FOR LARGE SCALE IMAGING DATA. Ann Stat (2011) 0.99

Hypoxia enhances LPA-induced HIF-1alpha and VEGF expression: their inhibition by resveratrol. Cancer Lett (2007) 0.99

Spinal angiolipoma: etiology, imaging findings, classification, treatment, and prognosis. Eur Spine J (2013) 0.98

BAY 11-7082 is a broad-spectrum inhibitor with anti-inflammatory activity against multiple targets. Mediators Inflamm (2012) 0.98

Transthoracic impedance for the monitoring of quality of manual chest compression during cardiopulmonary resuscitation. Resuscitation (2012) 0.98

WormFarm: a quantitative control and measurement device toward automated Caenorhabditis elegans aging analysis. Aging Cell (2013) 0.98

An MEC-MFC-coupled system for biohydrogen production from acetate. Environ Sci Technol (2008) 0.98

ANK3 as a risk gene for schizophrenia: new data in Han Chinese and meta analysis. Am J Med Genet B Neuropsychiatr Genet (2012) 0.97

Genetic analysis of Down syndrome-associated heart defects in mice. Hum Genet (2011) 0.97

True or false? Activations of language-related areas in patients with disorders of consciousness. Curr Pharm Des (2014) 0.97

In vitro and in vivo anti-inflammatory activities of Polygonum hydropiper methanol extract. J Ethnopharmacol (2011) 0.97

Characterization and identification of gastric hyperplastic polyps and adenomas by confocal laser endomicroscopy. Surg Endosc (2009) 0.97

A fast cell loading and high-throughput microfluidic system for long-term cell culture in zero-flow environments. Biotechnol Bioeng (2008) 0.96

COMP-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice. Am J Physiol Endocrinol Metab (2009) 0.96