Published in Proc Natl Acad Sci U S A on March 05, 2008
Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. Nat Rev Immunol (2008) 2.98
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell (2012) 1.71
Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development. Mol Cell Biol (2009) 1.31
Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling. Proc Natl Acad Sci U S A (2009) 1.06
The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish. Blood (2009) 1.05
A novel genetic strategy reveals unexpected roles of the Swi-Snf-like chromatin-remodeling BAF complex in thymocyte development. J Exp Med (2008) 0.91
Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene. Proc Natl Acad Sci U S A (2011) 0.90
Tenuous paths in unexplored territory: From T cell receptor signaling to effector gene expression during thymocyte selection. Semin Immunol (2010) 0.88
Molecular basis of CD4 repression by the Swi/Snf-like BAF chromatin remodeling complex. Eur J Immunol (2009) 0.87
The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression. Curr Top Microbiol Immunol (2012) 0.84
Notch signalling inhibits CD4 expression during initiation and differentiation of human T cell lineage. PLoS One (2012) 0.79
LMO2 induces T-cell leukemia with epigenetic deregulation of CD4. Exp Hematol (2014) 0.79
Maintaining CD4-CD8 lineage integrity in T cells: where plasticity serves versatility. Semin Immunol (2011) 0.78
Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor. J Immunol (2012) 0.78
A general approach for controlling transcription and probing epigenetic mechanisms: application to the CD4 locus. J Immunol (2013) 0.78
Inducible mouse models illuminate parameters influencing epigenetic inheritance. Development (2013) 0.76
Transcriptional control of CD4 and CD8 coreceptor expression during T cell development. Cell Mol Life Sci (2013) 0.76
Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice. Front Immunol (2017) 0.75
Distinct requirement of Runx complexes for TCRβ enhancer activation at distinct developmental stages. Sci Rep (2017) 0.75
Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A (2002) 25.47
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature (2007) 5.14
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell (2002) 5.07
Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response. Genes Dev (2006) 4.61
The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med (2007) 2.84
Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. Immunity (2003) 2.56
The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development. Immunity (2004) 2.54
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature (2002) 2.41
Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med (2007) 2.39
Histone modification and the control of heterochromatic gene silencing in Drosophila. Chromosome Res (2006) 2.28
Early thymocyte development is regulated by modulation of E2A protein activity. J Exp Med (2001) 2.05
Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage. Nat Genet (2001) 1.95
Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes. Immunity (2005) 1.91
CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals. Nat Rev Immunol (2004) 1.69
Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors. Immunity (2007) 1.68
Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells. J Immunol (2005) 1.57
An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus. J Immunol (2002) 1.52
Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation. Nat Rev Immunol (2002) 1.49
The control of histone lysine methylation in epigenetic regulation. Biochimie (2006) 1.48
Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression. Immunity (2007) 1.45
Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation. Mol Cell (2002) 1.43
CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision. Adv Immunol (2004) 1.42
Mechanism of transcriptional silencing in yeast. Cell (2005) 1.31
T cell development: better living through chromatin. Nat Immunol (2007) 1.24
Localization of the domains in Runx transcription factors required for the repression of CD4 in thymocytes. J Immunol (2004) 1.23
The CD4/CD8 lineage choice: new insights into epigenetic regulation during T cell development. Adv Immunol (2004) 1.22
A role for a pre-T-cell receptor in T-cell development. Immunol Today (1993) 1.17
Transcriptional regulation of CD4 gene expression by T cell factor-1/beta-catenin pathway. J Immunol (2006) 1.13
Negative regulation of CD4 gene expression by a HES-1-c-Myb complex. Mol Cell Biol (2001) 1.06
Purification and functional analysis of the mammalian SWI/SNF-family of chromatin-remodeling complexes. Methods Enzymol (2004) 1.02
A Myc-associated zinc finger protein binding site is one of four important functional regions in the CD4 promoter. Mol Cell Biol (1995) 0.97
Assembly of silent chromatin during thymocyte development. Semin Immunol (2005) 0.94
The E47 transcription factor negatively regulates CD5 expression during thymocyte development. Proc Natl Acad Sci U S A (2004) 0.92
Molecular basis of transcriptional silencing in budding yeast. Biochem Cell Biol (2004) 0.92
Replacement of pre-T cell receptor signaling functions by the CD4 coreceptor. J Exp Med (1997) 0.87
A potential role for Elf-1 in CD4 promoter function. J Biol Chem (1999) 0.86
The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol (2006) 30.90
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A (2006) 8.01
An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron (2007) 5.35
VisANT: data-integrating visual framework for biological networks and modules. Nucleic Acids Res (2005) 3.24
The role of DNA methylation in setting up chromatin structure during development. Nat Genet (2003) 3.06
VisANT: an online visualization and analysis tool for biological interaction data. BMC Bioinformatics (2004) 2.88
Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. Immunity (2003) 2.56
The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies. BMC Bioinformatics (2008) 2.54
The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult. Cell Rep (2012) 2.45
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature (2002) 2.41
p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells. PLoS Biol (2006) 2.39
Association of leukocyte telomere length with breast cancer risk: nested case-control findings from the Shanghai Women's Health Study. Am J Epidemiol (2013) 2.34
Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol Cell Biol (2005) 2.31
Towards zoomable multidimensional maps of the cell. Nat Biotechnol (2007) 2.20
Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network. Blood (2013) 2.05
Effects of therapeutic mild hypothermia on patients with severe traumatic brain injury after craniotomy. J Crit Care (2007) 2.00
Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol (2006) 1.98
Potent inhibition of platelet-derived growth factor-induced responses in vascular smooth muscle cells by BMS-354825 (dasatinib). Mol Pharmacol (2006) 1.95
Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. Proc Natl Acad Sci U S A (2007) 1.83
Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation. Hum Mutat (2004) 1.80
P2X7 receptor antagonism inhibits p38 mitogen-activated protein kinase activation and ameliorates neuronal apoptosis after subarachnoid hemorrhage in rats. Crit Care Med (2013) 1.76
A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression. Genes Dev (2009) 1.73
Effect of atorvastatin on SR-BI expression and HDL-induced cholesterol efflux in adipocytes of hypercholesterolemic rabbits. Clin Chim Acta (2005) 1.71
Systemic spread and propagation of a plant-pathogenic virus in European honeybees, Apis mellifera. MBio (2014) 1.71
Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor. J Biol Chem (2003) 1.68
Intraerythrocytic Plasmodium falciparum utilizes only a fraction of the amino acids derived from the digestion of host cell cytosol for the biosynthesis of its proteins. Mol Biochem Parasitol (2002) 1.59
Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis. Hepatology (2015) 1.55
Functional rundown of gamma-aminobutyric acid(A) receptors in human hypothalamic hamartomas. Ann Neurol (2011) 1.48
Problematic Internet Use in high school students in Guangdong Province, China. PLoS One (2011) 1.47
Cross-priming amplification for rapid detection of Mycobacterium tuberculosis in sputum specimens. J Clin Microbiol (2008) 1.47
Regulation of the mitogen-activated protein kinase signaling pathway by SHP2. J Biol Chem (2002) 1.47
Role of DNA methylation in stable gene repression. J Biol Chem (2007) 1.45
The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells. Cancer Res (2004) 1.42
Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90. Clin Cancer Res (2007) 1.42
3D coordination framework with uncommon two-fold interpenetrated {3(3)5(9)6(3)}-lcy net and coordinated anion exchange. Chemistry (2009) 1.40
Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells. Oncogene (2002) 1.38
Combined effects of novel tyrosine kinase inhibitor AMN107 and histone deacetylase inhibitor LBH589 against Bcr-Abl-expressing human leukemia cells. Blood (2006) 1.36
Impact of cigarette smoking in type 2 diabetes development. Acta Pharmacol Sin (2009) 1.34
A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides. J Neurosci (2009) 1.33
Identification of a signalling molecule involved in bacterial intergeneric communication. Microbiology (2007) 1.32
Prediction of estrogen receptor binding for 58,000 chemicals using an integrated system of a tree-based model with structural alerts. Environ Health Perspect (2002) 1.31
Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells. J Biol Chem (2005) 1.31
Shifts in replication timing actively affect histone acetylation during nucleosome reassembly. Mol Cell (2009) 1.27
Hypermethylation of homeobox A10 by in utero diethylstilbestrol exposure: an epigenetic mechanism for altered developmental programming. Endocrinology (2009) 1.25
Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824. Mol Cancer Ther (2005) 1.24
Comparative assessment of performance and genome dependence among phylogenetic profiling methods. BMC Bioinformatics (2006) 1.22
Why do pathological stage IA lung adenocarcinomas vary from prognosis?: a clinicopathologic study of 176 patients with pathological stage IA lung adenocarcinoma based on the IASLC/ATS/ERS classification. J Thorac Oncol (2013) 1.21
A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration. Genes Dev (2010) 1.21
HIV impairs TNF-alpha mediated macrophage apoptotic response to Mycobacterium tuberculosis. J Immunol (2007) 1.19
Correction of aberrant imprinting of IGF2 in human tumors by nuclear transfer-induced epigenetic reprogramming. EMBO J (2006) 1.19
Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells. Blood (2004) 1.18
Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors. J Biol Chem (2002) 1.17
P2X7R/cryopyrin inflammasome axis inhibition reduces neuroinflammation after SAH. Neurobiol Dis (2013) 1.17
Porphyromonas gingivalis minor fimbriae are required for cell-cell interactions. Infect Immun (2006) 1.17
Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation. J Hum Genet (2009) 1.17
Association between embB codon 306 mutations and drug resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother (2007) 1.17
Coupled modelling of tumour angiogenesis, tumour growth and blood perfusion. J Theor Biol (2011) 1.16
Investigation of Frizzled-5 during embryonic neural development in mouse. Dev Dyn (2008) 1.16
TAZ induces growth factor-independent proliferation through activation of EGFR ligand amphiregulin. Cell Cycle (2012) 1.15
Whole-genome sequencing identifies genomic heterogeneity at a nucleotide and chromosomal level in bladder cancer. Proc Natl Acad Sci U S A (2014) 1.14
Association of leukocyte telomere length with colorectal cancer risk: nested case-control findings from the Shanghai Women's Health Study. Cancer Epidemiol Biomarkers Prev (2012) 1.14
Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons. J Physiol (2008) 1.14
Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking. J Biol Chem (2002) 1.13
An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus. J Pathol (2005) 1.12
A molecular epidemiological study targeting the glycoprotein gene of rabies virus isolates from China. Virus Res (2006) 1.12
The tumor suppressor WTX shuttles to the nucleus and modulates WT1 activity. Proc Natl Acad Sci U S A (2009) 1.10
Targeting protein tyrosine phosphatases for anticancer drug discovery. Curr Pharm Des (2010) 1.10
Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor. Biochem J (2005) 1.09
Phenotype variability in patients carrying KCNJ2 mutations. Circ Cardiovasc Genet (2012) 1.09
Human adenovirus infection in children with acute respiratory tract disease in Guangzhou, China. APMIS (2012) 1.08
Pneumocystis-mediated IL-8 release by macrophages requires coexpression of mannose receptors and TLR2. J Leukoc Biol (2006) 1.08
Functional nicotinic acetylcholine receptors containing α6 subunits are on GABAergic neuronal boutons adherent to ventral tegmental area dopamine neurons. J Neurosci (2011) 1.08
GABAA receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas. Epilepsia (2007) 1.08
Chikungunya outbreak in Guangdong Province, China, 2010. Emerg Infect Dis (2012) 1.07
Cyclophilin A/Cluster of Differentiation 147 Interactions and Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage. Crit Care Med (2015) 1.07
HIV impairs TNF-alpha release in response to Toll-like receptor 4 stimulation in human macrophages in vitro. Am J Respir Cell Mol Biol (2005) 1.07
Label-free measuring and mapping of binding kinetics of membrane proteins in single living cells. Nat Chem (2012) 1.06
Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling. Proc Natl Acad Sci U S A (2009) 1.06
The use of chitosan based hydrogel for enhancing the therapeutic benefits of adipose-derived MSCs for acute kidney injury. Biomaterials (2012) 1.05
Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis. J Mammary Gland Biol Neoplasia (2004) 1.05
Attenuation of CNS inflammatory responses by nicotine involves α7 and non-α7 nicotinic receptors. Exp Neurol (2010) 1.05
Mechanisms involved in systemic nicotine-induced glutamatergic synaptic plasticity on dopamine neurons in the ventral tegmental area. J Neurosci (2010) 1.04
Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl(+) K562 leukemic cells by Gab2. Blood (2002) 1.03
Palladium-catalyzed Suzuki-Miyaura cross-couplings of aryl tosylates with potassium aryltrifluoroborates. J Org Chem (2007) 1.03
Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem (2008) 1.03
Negative correlation of distributions of Streptococcus cristatus and Porphyromonas gingivalis in subgingival plaque. J Clin Microbiol (2009) 1.02
Virological and epidemiological evidence of avian influenza virus infections among feral dogs in live poultry markets, china: a threat to human health? Clin Infect Dis (2014) 1.02
Circulation of reassortant influenza A(H7N9) viruses in poultry and humans, Guangdong Province, China, 2013. Emerg Infect Dis (2014) 1.02
Direct cloning of double-stranded RNAs from RNase protection analysis reveals processing patterns of C/D box snoRNAs and provides evidence for widespread antisense transcript expression. Nucleic Acids Res (2011) 1.01
Factors associated with the age of natural menopause and menopausal symptoms in Chinese women. Maturitas (2012) 1.01
SARS coronavirus 7a protein blocks cell cycle progression at G0/G1 phase via the cyclin D3/pRb pathway. Virology (2005) 1.01
B-cell responses in patients who have recovered from severe acute respiratory syndrome target a dominant site in the S2 domain of the surface spike glycoprotein. J Virol (2005) 1.01
Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro. J Med Chem (2004) 1.01
Room-temperature implementation of the Deutsch-Jozsa algorithm with a single electronic spin in diamond. Phys Rev Lett (2010) 1.01
A splice donor mutation in NAA10 results in the dysregulation of the retinoic acid signalling pathway and causes Lenz microphthalmia syndrome. J Med Genet (2014) 1.01
Purification and characterization of a surfactant-stable high-alkaline protease from Bacillus sp. B001. Bioresour Technol (2010) 1.01
Serologic survey of the pandemic H1N1 2009 virus in Guangdong Province, China: a cross sectional study. PLoS One (2011) 1.01