Published in Infect Immun on March 10, 2008
Antibody-profiling technologies for studying humoral responses to infectious agents. Expert Rev Vaccines (2010) 1.67
Syphilis: using modern approaches to understand an old disease. J Clin Invest (2011) 1.58
Validation of serological tests for the detection of antibodies against Treponema pallidum in nonhuman primates. PLoS Negl Trop Dis (2015) 1.49
Molecular typing of Treponema pallidum in the Czech Republic during 2011 to 2013: increased prevalence of identified genotypes and of isolates with macrolide resistance. J Clin Microbiol (2014) 1.45
The Structure of Treponema pallidum Tp0751 (Pallilysin) Reveals a Non-canonical Lipocalin Fold That Mediates Adhesion to Extracellular Matrix Components and Interactions with Host Cells. PLoS Pathog (2016) 1.40
Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays. BMC Microbiol (2008) 1.29
Whole genome sequences of three Treponema pallidum ssp. pertenue strains: yaws and syphilis treponemes differ in less than 0.2% of the genome sequence. PLoS Negl Trop Dis (2012) 1.27
Yaws: a second (and maybe last?) chance for eradication. PLoS Negl Trop Dis (2008) 1.26
Cellular architecture of Treponema pallidum: novel flagellum, periplasmic cone, and cell envelope as revealed by cryo electron tomography. J Mol Biol (2010) 1.22
Borrelia burgdorferi RevA antigen binds host fibronectin. Infect Immun (2009) 1.21
Cryo-electron tomography elucidates the molecular architecture of Treponema pallidum, the syphilis spirochete. J Bacteriol (2009) 1.18
Surface immunolabeling and consensus computational framework to identify candidate rare outer membrane proteins of Treponema pallidum. Infect Immun (2010) 1.17
Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws. Infect Genet Evol (2011) 1.15
Complete genome sequence of Treponema paraluiscuniculi, strain Cuniculi A: the loss of infectivity to humans is associated with genome decay. PLoS One (2011) 1.05
Comparative investigation of the genomic regions involved in antigenic variation of the TprK antigen among treponemal species, subspecies, and strains. J Bacteriol (2012) 1.05
Fine analysis of genetic diversity of the tpr gene family among treponemal species, subspecies and strains. PLoS Negl Trop Dis (2013) 0.93
Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains: most of the genetic differences are localized in six regions. PLoS One (2010) 0.93
Current status of syphilis vaccine development: need, challenges, prospects. Vaccine (2013) 0.92
That's my story, and I'm sticking to it--an update on B. burgdorferi adhesins. Front Cell Infect Microbiol (2014) 0.91
Complete genome sequence of Treponema pallidum strain DAL-1. Stand Genomic Sci (2012) 0.88
Activation and proteolytic activity of the Treponema pallidum metalloprotease, pallilysin. PLoS Pathog (2012) 0.86
Characterization of a novel family of fibronectin-binding proteins with M23 peptidase domains from Treponema denticola. Mol Oral Microbiol (2010) 0.84
Whole genome sequence of the Treponema pallidum subsp. endemicum strain Bosnia A: the genome is related to yaws treponemes but contains few loci similar to syphilis treponemes. PLoS Negl Trop Dis (2014) 0.80
Treponema pallidum subsp. pallidum TP0136 protein is heterogeneous among isolates and binds cellular and plasma fibronectin via its NH2-terminal end. PLoS Negl Trop Dis (2015) 0.79
Recombinant Treponema pallidum protein Tp0965 activates endothelial cells and increases the permeability of endothelial cell monolayer. PLoS One (2014) 0.79
Rabbit Models for Studying Human Infectious Diseases. Comp Med (2015) 0.78
Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections. Small GTPases (2015) 0.78
Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen. Nat Rev Microbiol (2016) 0.78
Fibronectin binding to the Treponema pallidum adhesin protein fragment rTp0483 on functionalized self-assembled monolayers. Bioconjug Chem (2012) 0.78
A Retrospective Study on Genetic Heterogeneity within Treponema Strains: Subpopulations Are Genetically Distinct in a Limited Number of Positions. PLoS Negl Trop Dis (2015) 0.78
Transcription of TP0126, Treponema pallidum putative OmpW homolog, is regulated by the length of a homopolymeric guanosine repeat. Infect Immun (2015) 0.78
Vaccine development for syphilis. Expert Rev Vaccines (2016) 0.78
Characterizing the Syphilis-Causing Treponema pallidum ssp. pallidum Proteome Using Complementary Mass Spectrometry. PLoS Negl Trop Dis (2016) 0.77
Mapping the ligand-binding region of Borrelia hermsii fibronectin-binding protein. PLoS One (2013) 0.77
Conservation of the Host-Interacting Proteins Tp0750 and Pallilysin among Treponemes and Restriction of Proteolytic Capacity to Treponema pallidum. Infect Immun (2015) 0.77
Treponema pallidum Lipoprotein TP0435 Expressed in Borrelia burgdorferi Produces Multiple Surface/Periplasmic Isoforms and mediates Adherence. Sci Rep (2016) 0.77
Novel Treponema pallidum Recombinant Antigens for Syphilis Diagnostics: Current Status and Future Prospects. Biomed Res Int (2017) 0.75
T-Coffee: A novel method for fast and accurate multiple sequence alignment. J Mol Biol (2000) 57.88
Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Protein Eng (1997) 38.38
From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection. Sex Transm Infect (1999) 17.95
Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science (1998) 7.96
Prediction of lipoprotein signal peptides in Gram-negative bacteria. Protein Sci (2003) 6.85
Treponema pallidum (Nichols strain) in tissue cultures: cellular attachment, entry, and survival. Infect Immun (1975) 4.41
The univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes. Curr Biol (1998) 4.14
Parasitism by virulent Treponema pallidum of host cell surfaces. Infect Immun (1977) 4.05
A single amino acid determinant of the membrane localization of lipoproteins in E. coli. Cell (1988) 4.03
Immunity in experimental syphilis. VI. Successful vaccination of rabbits with Treponema pallidum, Nichols strain, attenuated by -irradiation. J Immunol (1973) 3.45
Outer membrane ultrastructure explains the limited antigenicity of virulent Treponema pallidum. Proc Natl Acad Sci U S A (1989) 3.17
Characterization of the attachment of Treponema pallidum (Nichols strain) to cultured mammalian cells and the potential relationship of attachment to pathogenicity. Infect Immun (1977) 2.95
Treponema pallidum receptor binding proteins interact with fibronectin. J Exp Med (1983) 2.90
MatGAT: an application that generates similarity/identity matrices using protein or DNA sequences. BMC Bioinformatics (2003) 2.70
Purification of Treponema pallidum, Nichols strain, by Percoll density gradient centrifugation. Sex Transm Dis (1985) 2.63
Superfibronectin is a functionally distinct form of fibronectin. Nature (1994) 2.38
Antigens of Treponema pallidum recognized by IgG and IgM antibodies during syphilis in humans. J Infect Dis (1985) 2.29
Purification of Treponema pallidum from Infected Rabbit Tissue: Resolution into Two Treponemal Populations. Infect Immun (1974) 2.23
Role of fibronectin-binding MSCRAMMs in bacterial adherence and entry into mammalian cells. Matrix Biol (1999) 2.23
Lipoprotein computational prediction in spirochaetal genomes. Microbiology (2006) 1.98
Gene conversion: a mechanism for generation of heterogeneity in the tprK gene of Treponema pallidum during infection. Mol Microbiol (2004) 1.94
Intrinsically unstructured proteins evolve by repeat expansion. Bioessays (2003) 1.88
Outer membrane proteins of pathogenic spirochetes. FEMS Microbiol Rev (2004) 1.87
The PE-PGRS glycine-rich proteins of Mycobacterium tuberculosis: a new family of fibronectin-binding proteins? Microbiology (1999) 1.73
Characterization, cloning, and binding properties of the major 53-kilodalton Treponema denticola surface antigen. Infect Immun (1992) 1.61
Treponema pallidum in gel microdroplets: a novel strategy for investigation of treponemal molecular architecture. Mol Microbiol (1995) 1.54
Attachment of Treponema pallidum to fibronectin, laminin, collagen IV, and collagen I, and blockage of attachment by immune rabbit IgG. Br J Vener Dis (1984) 1.51
Protection against syphilis correlates with specificity of antibodies to the variable regions of Treponema pallidum repeat protein K. Infect Immun (2003) 1.49
Systematic cloning of Treponema pallidum open reading frames for protein expression and antigen discovery. Genome Res (2003) 1.44
Borrelia burgdorferi lipoproteins are secreted to the outer surface by default. Mol Microbiol (2006) 1.38
Putative Treponema pallidum cytadhesins share a common functional domain. Infect Immun (1985) 1.35
Transcriptome of Treponema pallidum: gene expression profile during experimental rabbit infection. J Bacteriol (2005) 1.30
Subfamily I Treponema pallidum repeat protein family: sequence variation and immunity. Microbes Infect (2004) 1.28
Lack of endotoxin in Borrelia hispanica and Treponema pallidum. Proc Soc Exp Biol Med (1983) 1.26
TprK sequence diversity accumulates during infection of rabbits with Treponema pallidum subsp. pallidum Nichols strain. Infect Immun (2006) 1.26
Reduced amino acid alphabet is sufficient to accurately recognize intrinsically disordered protein. FEBS Lett (2004) 1.25
Fibronectin-binding activity in Borrelia burgdorferi1. Biochim Biophys Acta (1998) 1.17
Biology of Treponema pallidum: correlation of functional activities with genome sequence data. J Mol Microbiol Biotechnol (2001) 1.15
Treponema pallidum fibronectin-binding proteins. J Bacteriol (2004) 1.14
Genome scale identification of Treponema pallidum antigens. Infect Immun (2005) 1.14
Virulent Treponema pallidum, lipoprotein, and synthetic lipopeptides induce CCR5 on human monocytes and enhance their susceptibility to infection by human immunodeficiency virus type 1. J Infect Dis (2000) 1.13
Reactivity of antibodies from syphilis patients to a protein array representing the Treponema pallidum proteome. J Clin Microbiol (2006) 1.11
Genome differences between Treponema pallidum subsp. pallidum strain Nichols and T. paraluiscuniculi strain Cuniculi A. Infect Immun (2007) 1.04
Fibronectin-binding proteins of a human oral spirochete Treponema denticola. Microbiol Immunol (1993) 1.03
Defining the interaction of the Treponema pallidum adhesin Tp0751 with laminin. Infect Immun (2005) 1.01
Progress towards an effective syphilis vaccine: the past, present and future. Expert Rev Vaccines (2006) 0.96
ProtRepeatsDB: a database of amino acid repeats in genomes. BMC Bioinformatics (2006) 0.93
Malaria: therapy, genes and vaccines. Curr Mol Med (2006) 0.93
An intramolecular disulphide bond reduces the efficacy of a lipoprotein plasma membrane sorting signal. Mol Microbiol (2003) 0.89
A monoclonal antibody that conveys in vitro killing and partial protection in experimental syphilis binds a phosphorylcholine surface epitope of Treponema pallidum. Infect Immun (2005) 0.86
PepTool and GeneTool: platform-independent tools for biological sequence analysis. Methods Mol Biol (2000) 0.79
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
The complete genome of an individual by massively parallel DNA sequencing. Nature (2008) 52.81
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res (2005) 44.08
Somatic mutations affect key pathways in lung adenocarcinoma. Nature (2008) 30.02
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature (2010) 19.68
Direct selection of human genomic loci by microarray hybridization. Nat Methods (2007) 17.73
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Characterizing the cancer genome in lung adenocarcinoma. Nature (2007) 16.48
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
VarScan: variant detection in massively parallel sequencing of individual and pooled samples. Bioinformatics (2009) 16.04
The Atlas genome assembly system. Genome Res (2004) 9.78
A high-resolution map of human evolutionary constraint using 29 mammals. Nature (2011) 8.67
Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. Genome Res (2005) 8.38
The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science (2009) 8.23
A catalog of reference genomes from the human microbiome. Science (2010) 8.10
Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds. Science (2009) 7.64
Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications. Nat Biotechnol (2011) 7.53
Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome. Genome Res (2007) 7.05
The genome of the model beetle and pest Tribolium castaneum. Nature (2008) 6.50
28-way vertebrate alignment and conservation track in the UCSC Genome Browser. Genome Res (2007) 6.42
The genome of the sea urchin Strongylocentrotus purpuratus. Science (2006) 6.41
Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol (2009) 6.10
A SNP discovery method to assess variant allele probability from next-generation resequencing data. Genome Res (2009) 4.78
Genomic variation landscape of the human gut microbiome. Nature (2012) 4.38
Creating a honey bee consensus gene set. Genome Biol (2007) 4.17
Comparative and demographic analysis of orang-utan genomes. Nature (2011) 3.83
Comparison of the respiratory microbiome in healthy nonsmokers and smokers. Am J Respir Crit Care Med (2013) 3.65
Propionibacterium acnes strain populations in the human skin microbiome associated with acne. J Invest Dermatol (2013) 3.32
Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus. BMC Microbiol (2007) 3.25
Genetic basis for in vivo daptomycin resistance in enterococci. N Engl J Med (2011) 3.20
A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host. Mol Microbiol (2003) 3.17
The complete genome sequence of Escherichia coli DH10B: insights into the biology of a laboratory workhorse. J Bacteriol (2008) 2.97
Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF. Genome Biol (2008) 2.71
Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes. Proc Natl Acad Sci U S A (2004) 2.60
Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations. Nature (2013) 2.53
Complete genome sequence of Rickettsia typhi and comparison with sequences of other rickettsiae. J Bacteriol (2004) 2.44
Phylogenomic analysis reveals bees and wasps (Hymenoptera) at the base of the radiation of Holometabolous insects. Genome Res (2006) 2.42
Novel bacterial taxa in the human microbiome. PLoS One (2012) 2.35
The genome sequence of the leaf-cutter ant Atta cephalotes reveals insights into its obligate symbiotic lifestyle. PLoS Genet (2011) 2.16
Optimizing read mapping to reference genomes to determine composition and species prevalence in microbial communities. PLoS One (2012) 2.09
BBE02 disruption mutants of Borrelia burgdorferi B31 have a highly transformable, infectious phenotype. Infect Immun (2004) 2.08
Characteristic male urine microbiomes associate with asymptomatic sexually transmitted infection. PLoS One (2010) 2.02
Community annotation: procedures, protocols, and supporting tools. Genome Res (2006) 1.91
Clinical isolates of Enterococcus faecium exhibit strain-specific collagen binding mediated by Acm, a new member of the MSCRAMM family. Mol Microbiol (2003) 1.85
Bos taurus genome assembly. BMC Genomics (2009) 1.83
Decreased electroporation efficiency in Borrelia burgdorferi containing linear plasmids lp25 and lp56: impact on transformation of infectious B. burgdorferi. Infect Immun (2002) 1.83
Inflammatory bowel diseases phenotype, C. difficile and NOD2 genotype are associated with shifts in human ileum associated microbial composition. PLoS One (2012) 1.82
Genome sequencing reveals widespread virulence gene exchange among human Neisseria species. PLoS One (2010) 1.81
An Enterococcus faecalis ABC homologue (Lsa) is required for the resistance of this species to clindamycin and quinupristin-dalfopristin. Antimicrob Agents Chemother (2002) 1.79
Chromosome rearrangement and diversification of Francisella tularensis revealed by the type B (OSU18) genome sequence. J Bacteriol (2006) 1.75
Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032. PLoS One (2007) 1.71
Widespread colonization of the lung by Tropheryma whipplei in HIV infection. Am J Respir Crit Care Med (2013) 1.66
Molecular characterization of a widespread, pathogenic, and antibiotic resistance-receptive Enterococcus faecalis lineage and dissemination of its putative pathogenicity island. J Bacteriol (2005) 1.66
A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement. Eur J Hum Genet (2011) 1.66
Identification of disease-causing mutations in autosomal dominant retinitis pigmentosa (adRP) using next-generation DNA sequencing. Invest Ophthalmol Vis Sci (2011) 1.63
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi. J Biol Chem (2002) 1.62
Intact flagellar motor of Borrelia burgdorferi revealed by cryo-electron tomography: evidence for stator ring curvature and rotor/C-ring assembly flexion. J Bacteriol (2009) 1.61
The binary protein interactome of Treponema pallidum--the syphilis spirochete. PLoS One (2008) 1.59
Targeted high-throughput DNA sequencing for gene discovery in retinitis pigmentosa. Adv Exp Med Biol (2010) 1.58
Sequence analysis of the human virome in febrile and afebrile children. PLoS One (2012) 1.56
The genome sequence of Mannheimia haemolytica A1: insights into virulence, natural competence, and Pasteurellaceae phylogeny. J Bacteriol (2006) 1.55
Coverage theories for metagenomic DNA sequencing based on a generalization of Stevens' theorem. J Math Biol (2012) 1.49
Biogeography of the ecosystems of the healthy human body. Genome Biol (2013) 1.48
Identification and phenotypic characterization of a second collagen adhesin, Scm, and genome-based identification and analysis of 13 other predicted MSCRAMMs, including four distinct pilus loci, in Enterococcus faecium. Microbiology (2008) 1.47
Graph accordance of next-generation sequence assemblies. Bioinformatics (2011) 1.47
Involvement of PhoP-PhoS homologs in Enterococcus faecalis virulence. Infect Immun (2002) 1.46
The protein network of bacterial motility. Mol Syst Biol (2007) 1.45
Systematic cloning of Treponema pallidum open reading frames for protein expression and antigen discovery. Genome Res (2003) 1.44
Complete genome sequence of Enterococcus faecium strain TX16 and comparative genomic analysis of Enterococcus faecium genomes. BMC Microbiol (2012) 1.43
Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum. J Med Microbiol (2009) 1.42
Pooled genomic indexing of rhesus macaque. Genome Res (2005) 1.41
Evidence that the enterococcal polysaccharide antigen gene (epa) cluster is widespread in Enterococcus faecalis and influences resistance to phagocytic killing of E. faecalis. Infect Immun (2002) 1.39
Probing regulon of ArcA in Shewanella oneidensis MR-1 by integrated genomic analyses. BMC Genomics (2008) 1.38
Dynamic building of a BAC clone tiling path for the Rat Genome Sequencing Project. Genome Res (2004) 1.36
Daptomycin-resistant Enterococcus faecalis diverts the antibiotic molecule from the division septum and remodels cell membrane phospholipids. MBio (2013) 1.35
Bacterial communities of the coronal sulcus and distal urethra of adolescent males. PLoS One (2012) 1.34
Pan-genome and comparative genome analyses of propionibacterium acnes reveal its genomic diversity in the healthy and diseased human skin microbiome. MBio (2013) 1.33
LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation. EMBO J (2002) 1.31
Transcriptome of Treponema pallidum: gene expression profile during experimental rabbit infection. J Bacteriol (2005) 1.30
Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays. BMC Microbiol (2008) 1.29
Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi. PLoS Pathog (2010) 1.29
Whole genome sequences of three Treponema pallidum ssp. pertenue strains: yaws and syphilis treponemes differ in less than 0.2% of the genome sequence. PLoS Negl Trop Dis (2012) 1.27
Whole-genome analysis of a daptomycin-susceptible enterococcus faecium strain and its daptomycin-resistant variant arising during therapy. Antimicrob Agents Chemother (2012) 1.25
Detailed analysis of sequence changes occurring during vlsE antigenic variation in the mouse model of Borrelia burgdorferi infection. PLoS Pathog (2009) 1.24