Published in Cancer Res on March 15, 2008
New wirings in the survivin networks. Oncogene (2008) 1.76
Importazole, a small molecule inhibitor of the transport receptor importin-β. ACS Chem Biol (2011) 1.39
Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex. Clin Cancer Res (2012) 1.11
RHAMM promotes interphase microtubule instability and mitotic spindle integrity through MEK1/ERK1/2 activity. J Biol Chem (2010) 1.06
A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis. Cancer Cell (2015) 0.97
PPAR signaling pathway and cancer-related proteins are involved in celiac disease-associated tissue damage. Mol Med (2010) 0.94
Tumor suppressor function of miR-483-3p on squamous cell carcinomas due to its pro-apoptotic properties. Cell Cycle (2013) 0.94
Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis. J Cell Biol (2010) 0.94
An essential role for Ran GTPase in epithelial ovarian cancer cell survival. Mol Cancer (2010) 0.93
Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways. Clin Cancer Res (2011) 0.92
A survivin-ran complex regulates spindle formation in tumor cells. Mol Cell Biol (2008) 0.91
RAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 are new prognostic biomarkers in serous epithelial ovarian cancer. PLoS One (2014) 0.90
Establishment and mitotic characterization of new Drosophila acentriolar cell lines from DSas-4 mutant. Biol Open (2013) 0.86
Differentially Expressed Genes and Signature Pathways of Human Prostate Cancer. PLoS One (2015) 0.82
A novel strategy for targeted killing of tumor cells: Induction of multipolar acentrosomal mitotic spindles with a quinazolinone derivative mdivi-1. Mol Oncol (2014) 0.81
Screening of potential molecular targets for colorectal cancer therapy. Int J Gen Med (2009) 0.80
Molecular resistance fingerprint of pemetrexed and platinum in a long-term survivor of mesothelioma. PLoS One (2012) 0.80
RanGTPase: A Key Regulator of Nucleocytoplasmic Trafficking. Mol Cell Pharmacol (2009) 0.79
In vitro transcriptomic prediction of hepatotoxicity for early drug discovery. J Theor Biol (2011) 0.79
Comment re: Ran-GTP control of tumor cell mitosis. Cancer Res (2009) 0.79
The acute transcriptomic and proteomic response of HC-04 hepatoma cells to hepatocyte growth factor and its implications for Plasmodium falciparum sporozoite invasion. Mol Cell Proteomics (2014) 0.78
Ran Involved in the Development and Reproduction Is a Potential Target for RNA-Interference-Based Pest Management in Nilaparvata lugens. PLoS One (2015) 0.78
Genetic variants in RAN, DICER and HIWI of microRNA biogenesis genes and risk of cervical carcinoma in a Chinese population. Chin J Cancer Res (2013) 0.77
Inter-cellular transport of ran GTPase. PLoS One (2015) 0.77
Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design. ChemMedChem (2015) 0.77
Hemocyanin from Shrimp Litopenaeus vannamei Has Antiproliferative Effect against HeLa Cell In Vitro. PLoS One (2016) 0.76
Two-dimensional gel proteome reference map of human small intestine. Proteome Sci (2009) 0.76
Essential role of the small GTPase Ran in postnatal pancreatic islet development. PLoS One (2011) 0.75
Ran GTPase promotes cancer progression via Met receptormediated downstream signaling. Oncotarget (2016) 0.75
Ran signaling in melanoma: implications for the development of alternative therapeutic strategies. Cancer Lett (2014) 0.75
Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. Cell (2007) 3.00
An IAP-IAP complex inhibits apoptosis. J Biol Chem (2004) 2.82
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis. J Clin Invest (2004) 2.59
IAP regulation of metastasis. Cancer Cell (2010) 2.47
Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function. J Cell Sci (2002) 2.40
Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J Clin Invest (2005) 2.32
Survivin and molecular pathogenesis of colorectal cancer. Lancet (2003) 2.25
Full-length dominant-negative survivin for cancer immunotherapy. Clin Cancer Res (2003) 2.00
A p34(cdc2) survival checkpoint in cancer. Cancer Cell (2002) 1.99
Regulation of survivin function by Hsp90. Proc Natl Acad Sci U S A (2003) 1.86
Regulation of microtubule stability and mitotic progression by survivin. Cancer Res (2002) 1.74
Rational design of shepherdin, a novel anticancer agent. Cancer Cell (2005) 1.74
Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90. J Clin Invest (2009) 1.72
Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection. Mol Cell (2007) 1.60
Fibronectin protects prostate cancer cells from tumor necrosis factor-alpha-induced apoptosis via the AKT/survivin pathway. J Biol Chem (2003) 1.59
Hsp60 regulation of tumor cell apoptosis. J Biol Chem (2007) 1.57
Survivin modulates microtubule dynamics and nucleation throughout the cell cycle. Mol Biol Cell (2006) 1.57
Therapeutic targeting of the survivin pathway in cancer: initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis. Clin Cancer Res (2003) 1.54
Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein. J Biol Chem (2011) 1.54
Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis. Cancer Res (2003) 1.54
Survival responses of human embryonic stem cells to DNA damage. J Cell Physiol (2009) 1.51
A functional Notch-survivin gene signature in basal breast cancer. Breast Cancer Res (2008) 1.46
Inhibitor of apoptosis protein survivin regulates vascular injury. Nat Med (2002) 1.42
Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells. J Clin Invest (2011) 1.41
Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis. J Biol Chem (2003) 1.37
Survivin as a global target of intrinsic tumor suppression networks. Cell Cycle (2009) 1.36
Landscape of the mitochondrial Hsp90 metabolome in tumours. Nat Commun (2013) 1.29
Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells. J Clin Invest (2013) 1.28
Molecular mechanism of inhibition of survivin transcription by the GC-rich sequence-selective DNA binding antitumor agent, hedamycin: evidence of survivin down-regulation associated with drug sensitivity. J Biol Chem (2005) 1.27
Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer. Am J Pathol (2009) 1.26
Molecular dependence of estrogen receptor-negative breast cancer on a notch-survivin signaling axis. Cancer Res (2008) 1.24
Heat shock protein 60 regulation of the mitochondrial permeability transition pore in tumor cells. Cancer Res (2010) 1.19
A survivin gene signature predicts aggressive tumor behavior. Cancer Res (2005) 1.17
Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase-3beta in colorectal cancer cells. Clin Cancer Res (2005) 1.17
Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s. Cancer Cell (2012) 1.17
Dendritic cell-based full-length survivin vaccine in treatment of experimental tumors. J Immunother (2007) 1.13
Mitosis-independent survivin gene expression in vivo and regulation by p53. Cancer Res (2006) 1.13
Activated checkpoint kinase 2 provides a survival signal for tumor cells. Cancer Res (2006) 1.12
Sorafenib exerts anti-glioma activity in vitro and in vivo. Neurosci Lett (2010) 1.12
Endogenous tumor suppression mediated by PTEN involves survivin gene silencing. Cancer Res (2009) 1.11
Induction and regulation of tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand-mediated apoptosis in renal cell carcinoma. Cancer Res (2002) 1.10
Bone morphogenetic protein 7 protects prostate cancer cells from stress-induced apoptosis via both Smad and c-Jun NH2-terminal kinase pathways. Cancer Res (2006) 1.07
Antileukemic activity of shepherdin and molecular diversity of hsp90 inhibitors. J Natl Cancer Inst (2006) 1.06
Regulation of survivin stability by the aryl hydrocarbon receptor-interacting protein. J Biol Chem (2006) 1.05
Small-molecule targeting of heat shock protein 90 chaperone function: rational identification of a new anticancer lead. J Med Chem (2006) 1.03
Regulation of vein graft hyperplasia by survivin, an inhibitor of apoptosis protein. Arterioscler Thromb Vasc Biol (2005) 1.01
Preclinical characterization of mitochondria-targeted small molecule hsp90 inhibitors, gamitrinibs, in advanced prostate cancer. Clin Cancer Res (2010) 1.01
Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression. Cancer Res (2003) 1.00
Postnatal expansion of the pancreatic beta-cell mass is dependent on survivin. Diabetes (2008) 0.99
Global targeting of subcellular heat shock protein-90 networks for therapy of glioblastoma. Mol Cancer Ther (2010) 0.94
Survivin expression is up-regulated in vascular injury and identifies a distinct cellular phenotype. J Vasc Surg (2005) 0.94
The cancer-related Runx2 protein enhances cell growth and responses to androgen and TGFbeta in prostate cancer cells. J Cell Biochem (2010) 0.94
Survivin family proteins as novel molecular determinants of doxorubicin resistance in organotypic human breast tumors. Breast Cancer Res (2014) 0.93
Effect of intravesical treatment of transitional cell carcinoma with bacillus Calmette-Guerin and mitomycin C on urinary survivin levels and outcome. J Urol (2003) 0.93
Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors. J Clin Invest (2016) 0.93
Inhibition of apoptosis by survivin improves transplantation of pancreatic islets for treatment of diabetes in mice. EMBO Rep (2006) 0.92
Regulation of lung cancer metastasis by Klf4-Numb-like signaling. Cancer Res (2013) 0.91
Aberrant overexpression of the cell polarity module scribble in human cancer. Am J Pathol (2011) 0.91
IL-11 protects human microvascular endothelium from alloinjury in vivo by induction of survivin expression. J Immunol (2004) 0.91
A survivin-ran complex regulates spindle formation in tumor cells. Mol Cell Biol (2008) 0.91
Bladder cancer detection with urinary survivin, an inhibitor of apoptosis. Front Biosci (2002) 0.87
α(V)β(6) integrin expression is induced in the POET and Pten(pc-/-) mouse models of prostatic inflammation and prostatic adenocarcinoma. Am J Transl Res (2012) 0.87
Cyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility. J Biol Chem (2013) 0.87
4-Hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers in mice: characterization of FHIT and survivin expression and chemopreventive effects of indomethacin. Carcinogenesis (2004) 0.86
Identification of accrual barriers onto breast cancer prevention clinical trials: a case-control study. Cancer (2010) 0.86
Survivin regulation of vascular injury. Trends Cardiovasc Med (2006) 0.85
β1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1. J Cell Physiol (2013) 0.83
Survivin blockade sensitizes rhabdomyosarcoma cells for lysis by fetal acetylcholine receptor-redirected T cells. Am J Pathol (2013) 0.82
Chk2 phosphorylation of survivin-DeltaEx3 contributes to a DNA damage-sensing checkpoint in cancer. Cancer Res (2012) 0.82
PSA regulates androgen receptor expression in prostate cancer cells. Prostate (2011) 0.81
SIRTing through breast cancer is just a survivin' game. Mol Cell (2008) 0.81
microRNA-mediated survivin control of pluripotency. J Cell Physiol (2015) 0.78
Mitochondrial heat shock protein-90 modulates vascular smooth muscle cell survival and the vascular injury response in vivo. Am J Pathol (2012) 0.77
Endothelium derived nitric oxide synthase negatively regulates the PDGF-survivin pathway during flow-dependent vascular remodeling. PLoS One (2012) 0.77
Mitochondrial dynamics of survivin and "four dimensional" control of tumor cell apoptosis. Cell Cycle (2005) 0.77
Combined in silico and experimental approach for drug design: the binding mode of peptidic and non-peptidic inhibitors to hsp90 N-terminal domain. Chem Biol Drug Des (2010) 0.76
Essential role of the small GTPase Ran in postnatal pancreatic islet development. PLoS One (2011) 0.75
The search for a better prostate cancer biomarker. J Urol (2011) 0.75
Corrigendum: Landscape of the mitochondrial Hsp90 metabolome in tumours. Nat Commun (2015) 0.75
Mitochondrial Hsp90 chaperones as novel molecular targets in prostate cancer. Future Oncol (2010) 0.75
Erratum: Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts. Oncotarget (2015) 0.75
A retrogen plasmid-based vaccine generates high titer antibody responses against the autologous cancer antigen survivin and demonstrates anti-tumor efficacy. Cancer Lett (2005) 0.75