Published in J Biol Chem on March 15, 2008
Transport of lipopolysaccharide across the cell envelope: the long road of discovery. Nat Rev Microbiol (2009) 2.07
Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation. Nat Struct Mol Biol (2012) 1.66
Mapping daunorubicin-binding Sites in the ATP-binding cassette transporter MsbA using site-specific quenching by spin labels. J Biol Chem (2009) 0.99
Transporter-mediated biofuel secretion. Proc Natl Acad Sci U S A (2013) 0.98
Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein. Acta Crystallogr D Biol Crystallogr (2015) 0.96
The Arabidopsis peroxisomal ABC transporter, comatose, complements the Saccharomyces cerevisiae pxa1 pxa2Delta mutant for metabolism of long-chain fatty acids and exhibits fatty acyl-CoA-stimulated ATPase activity. J Biol Chem (2010) 0.96
Optimized purification of a heterodimeric ABC transporter in a highly stable form amenable to 2-D crystallization. PLoS One (2011) 0.94
The ABC transporter MsbA interacts with lipid A and amphipathic drugs at different sites. Biochem J (2009) 0.94
Substrate binding stabilizes a pre-translocation intermediate in the ATP-binding cassette transport protein MsbA. J Biol Chem (2013) 0.91
Outer membrane biogenesis in Escherichia coli, Neisseria meningitidis, and Helicobacter pylori: paradigm deviations in H. pylori. Front Cell Infect Microbiol (2012) 0.89
Characterization of the E506Q and H537A dysfunctional mutants in the E. coli ABC transporter MsbA. Biochemistry (2011) 0.89
Distinct conformational spectrum of homologous multidrug ABC transporters. Structure (2015) 0.88
The reconstituted Escherichia coli MsbA protein displays lipid flippase activity. Biochem J (2010) 0.87
A multidrug ABC transporter with a taste for salt. PLoS One (2009) 0.87
Asymmetry in the homodimeric ABC transporter MsbA recognized by a DARPin. J Biol Chem (2012) 0.87
Molecular disruption of the power stroke in the ATP-binding cassette transport protein MsbA. J Biol Chem (2013) 0.85
The DrrAB efflux system of Streptomyces peucetius is a multidrug transporter of broad substrate specificity. J Biol Chem (2014) 0.85
Time-resolved Fourier transform infrared spectroscopy of the nucleotide-binding domain from the ATP-binding Cassette transporter MsbA: ATP hydrolysis is the rate-limiting step in the catalytic cycle. J Biol Chem (2012) 0.81
The Lipid Bilayer Modulates the Structure and Function of an ATP-binding Cassette Exporter. J Biol Chem (2016) 0.79
The Heterodimeric ABC Transporter EfrCD Mediates Multidrug Efflux in Enterococcus faecalis. Antimicrob Agents Chemother (2016) 0.78
Sequential Action of MalE and Maltose Allows Coupling ATP Hydrolysis to Translocation in the MalFGK2 Transporter. J Biol Chem (2015) 0.77
ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled. Nat Commun (2016) 0.77
Molten globule-like partially folded state of Bacillus licheniformis α-amylase at low pH induced by 1,1,1,3,3,3-hexafluoroisopropanol. ScientificWorldJournal (2014) 0.75
Coupled ATPase-adenylate kinase activity in ABC transporters. Nat Commun (2016) 0.75
Unidirectional Transport Mechanism in an ATP Dependent Exporter. ACS Cent Sci (2017) 0.75
Attenuation of Phosphorylation-dependent Activation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Disease-causing Mutations at the Transmission Interface. J Biol Chem (2016) 0.75
Structural basis of MsbA-mediated lipopolysaccharide transport. Nature (2017) 0.75
ABC efflux pump-based resistance to chemotherapy drugs. Chem Rev (2009) 1.92
Fluorescent probe partitioning in giant unilamellar vesicles of 'lipid raft' mixtures. Biochem J (2010) 1.58
Characterization of an asymmetric occluded state of P-glycoprotein with two bound nucleotides: implications for catalysis. J Biol Chem (2010) 1.12
Interaction of LDS-751 and rhodamine 123 with P-glycoprotein: evidence for simultaneous binding of both drugs. Biochemistry (2005) 1.10
The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids. Biochem J (2005) 1.09
Interaction of LDS-751 with P-glycoprotein and mapping of the location of the R drug binding site. Biochemistry (2005) 1.07
Isolation and characterization of lipid rafts with different properties from RBL-2H3 (rat basophilic leukaemia) cells. Biochem J (2004) 1.04
Phenotypic variability in hyperphosphatasia with seizures and neurologic deficit (Mabry syndrome). Am J Med Genet A (2012) 1.02
Characterization of fluorescent sterol binding to purified human NPC1. J Biol Chem (2008) 1.01
Interaction of the P-glycoprotein multidrug efflux pump with cholesterol: effects on ATPase activity, drug binding and transport. Biochemistry (2008) 1.00
Stoichiometry and affinity of nucleotide binding to P-glycoprotein during the catalytic cycle. Biochemistry (2003) 0.95
The ABC transporter MsbA interacts with lipid A and amphipathic drugs at different sites. Biochem J (2009) 0.94
P-Glycoprotein is localized in intermediate-density membrane microdomains distinct from classical lipid rafts and caveolar domains. FEBS J (2005) 0.93
Transition state P-glycoprotein binds drugs and modulators with unchanged affinity, suggesting a concerted transport mechanism. Biochemistry (2003) 0.93
Conformational and functional characterization of trapped complexes of the P-glycoprotein multidrug transporter. Biochem J (2006) 0.92
Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance. Cancer Res (2004) 0.92
PI-specific phospholipase C cleavage of a reconstituted GPI-anchored protein: modulation by the lipid bilayer. Biochemistry (2002) 0.92
Oligomerization of the E5 protein of human papillomavirus type 16 occurs through multiple hydrophobic regions. Virology (2003) 0.91
Proximity of bound Hoechst 33342 to the ATPase catalytic sites places the drug binding site of P-glycoprotein within the cytoplasmic membrane leaflet. Biochemistry (2002) 0.90
Quantitative characterization of coexisting phases in DOPC/DPPC/cholesterol mixtures: comparing confocal fluorescence microscopy and deuterium nuclear magnetic resonance. Biochim Biophys Acta (2009) 0.90
Proteins that bind and move lipids: MsbA and NPC1. Crit Rev Biochem Mol Biol (2011) 0.88
Proximity of the protein moiety of a GPI-anchored protein to the membrane surface: a FRET study. Biochemistry (2002) 0.88
Combined chemical and enzymatic stable isotope labeling for quantitative profiling of detergent-insoluble membrane proteins isolated using Triton X-100 and Brij-96. J Proteome Res (2006) 0.88
The reconstituted Escherichia coli MsbA protein displays lipid flippase activity. Biochem J (2010) 0.87
Overexpression, purification, and structural analysis of the hydrophobic E5 protein from human papillomavirus type 16. Protein Expr Purif (2003) 0.87
Fluorescent probe partitioning in GUVs of binary phospholipid mixtures: implications for interpreting phase behavior. Biochim Biophys Acta (2011) 0.87
Overcoming tumor drug resistance with high-affinity taxanes: a SAR study of C2-modified 7-acyl-10-deacetyl cephalomannines. ChemMedChem (2007) 0.86
P-glycoprotein (ABCB1) interacts directly with lipid-based anti-cancer drugs and platelet-activating factors. Biochem Cell Biol (2006) 0.85
Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents. Int J Cancer (2010) 0.83
Interaction of insecticides with mammalian P-glycoprotein and their effect on its transport function. Biochim Biophys Acta (2007) 0.83
Lipid bilayer properties control membrane partitioning, binding, and transport of p-glycoprotein substrates. Biochemistry (2013) 0.82
Time-resolved fluorescence resonance energy transfer shows that the bacterial multidrug ABC half-transporter BmrA functions as a homodimer. Biochemistry (2005) 0.81
15N,(1)H Heteronuclear correlation NMR of gramicidin A in DMPC-d(67). J Am Chem Soc (2002) 0.79
Interaction of LDS-751 with the drug-binding site of P-glycoprotein: a Trp fluorescence steady-state and lifetime study. Arch Biochem Biophys (2009) 0.79
Determining P-glycoprotein-drug interactions: evaluation of reconstituted P-glycoprotein in a liposomal system and LLC-MDR1 polarized cell monolayers. J Pharmacol Toxicol Methods (2012) 0.79
The transmembrane domain of Neu in a lipid bilayer: molecular dynamics simulations. Eur Biophys J (2004) 0.79
A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and β-III tubulin mediated tumor drug resistance in vitro. Cancer Lett (2013) 0.77
Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport. Bioorg Med Chem Lett (2011) 0.76
Reversible dimers of the atypical antipsychotic quetiapine inhibit p-glycoprotein-mediated efflux in vitro with increased binding affinity and in situ at the blood-brain barrier. ACS Chem Neurosci (2014) 0.75
Characterization of the proto-oncogenic and mutant forms of the transmembrane region of Neu in micelles. J Biol Chem (2004) 0.75
Comparison of proto-oncogenic and mutant forms of the transmembrane region of the Neu receptor in TFE. FEBS Lett (2003) 0.75