PubRank

James R Trudell

Author PubWeight™ 59.36‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol Sci 2005 2.91
2 Coupling of agonist binding to channel gating in the GABA(A) receptor. Nature 2003 2.89
3 Ethanol's molecular targets. Sci Signal 2008 2.06
4 Structural basis for alcohol modulation of a pentameric ligand-gated ion channel. Proc Natl Acad Sci U S A 2011 1.52
5 Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor. Biophys J 2011 1.42
6 Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors. J Neurochem 2007 1.26
7 Charged residues in the beta2 subunit involved in GABAA receptor activation. J Biol Chem 2003 1.18
8 Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity. J Biol Chem 2009 1.16
9 Sites of excitatory and inhibitory actions of alcohols on neuronal alpha2beta4 nicotinic acetylcholine receptors. J Pharmacol Exp Ther 2003 1.14
10 The common chemical motifs within anesthetic binding sites. Anesth Analg 2007 1.13
11 Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics. J Biol Chem 2004 1.10
12 A novel hyperekplexia-causing mutation in the pre-transmembrane segment 1 of the human glycine receptor alpha1 subunit reduces membrane expression and impairs gating by agonists. J Biol Chem 2004 1.09
13 Tryptophan scanning mutagenesis in TM4 of the GABA(A) receptor alpha1 subunit: implications for modulation by inhaled anesthetics and ion channel structure. Neuropharmacology 2002 1.08
14 Accessibility to residues in transmembrane segment four of the glycine receptor. Neuropharmacology 2005 1.08
15 Cross-linking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activation. J Neurochem 2007 1.08
16 Modeling anesthetic binding sites within the glycine alpha one receptor based on prokaryotic ion channel templates: the problem with TM4. J Chem Inf Model 2010 1.05
17 General anesthetics have additive actions on three ligand gated ion channels. Anesth Analg 2008 1.03
18 Molecular targets and mechanisms for ethanol action in glycine receptors. Pharmacol Ther 2010 1.03
19 Endothelial fate mapping in mice with pulmonary hypertension. Circulation 2013 1.02
20 Targets for ethanol action and antagonism in loop 2 of the extracellular domain of glycine receptors. J Neurochem 2008 1.02
21 Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptors. J Pharmacol Exp Ther 2010 1.01
22 Homology modeling of a human glycine alpha 1 receptor reveals a plausible anesthetic binding site. J Chem Inf Model 2005 1.01
23 Anesthetic and ethanol effects on spontaneously opening glycine receptor channels. J Neurochem 2002 1.00
24 Zinc enhances ethanol modulation of the alpha1 glycine receptor. Neuropharmacology 2009 0.99
25 Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols. J Pharmacol Exp Ther 2011 0.99
26 Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution. Alcohol Clin Exp Res 2011 0.99
27 Cross-linking of glycine receptor transmembrane segments two and three alters coupling of ligand binding with channel opening. J Neurochem 2004 0.97
28 Normal-mode analysis of the glycine alpha1 receptor by three separate methods. J Chem Inf Model 2007 0.96
29 Molecular mechanism for the dual alcohol modulation of Cys-loop receptors. PLoS Comput Biol 2012 0.95
30 Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism. J Neurochem 2004 0.95
31 A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics. J Pharmacol Exp Ther 2010 0.94
32 Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure. Alcohol Clin Exp Res 2003 0.94
33 Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation. Proc Natl Acad Sci U S A 2010 0.93
34 Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation. Biochemistry 2004 0.93
35 Evaluation of a proposed mechanism of ligand-gated ion channel activation in the GABAA and glycine receptors. Neurosci Lett 2004 0.93
36 Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics. Pharmacol Rev 2014 0.90
37 Roles for loop 2 residues of alpha1 glycine receptors in agonist activation. J Biol Chem 2008 0.90
38 Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors. J Pharmacol Exp Ther 2012 0.90
39 Assessment of homology templates and an anesthetic binding site within the γ-aminobutyric acid receptor. Anesthesiology 2013 0.90
40 Stabilization of the GluCl ligand-gated ion channel in the presence and absence of ivermectin. Biophys J 2013 0.90
41 Molecular mechanisms and binding site location for the noncompetitive antagonist crystal violet on nicotinic acetylcholine receptors. Biochemistry 2006 0.89
42 Are sobriety and consciousness determined by water in protein cavities? Alcohol Clin Exp Res 2004 0.89
43 GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites. J Neurochem 2013 0.88
44 Noncompetitive antagonist binding sites in the torpedo nicotinic acetylcholine receptor ion channel. Structure-activity relationship studies using adamantane derivatives. Biochemistry 2003 0.88
45 Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol. Alcohol Clin Exp Res 2013 0.88
46 Effect of cobratoxin binding on the normal mode vibration within acetylcholine binding protein. J Chem Inf Model 2008 0.86
47 Mutation of a zinc-binding residue in the glycine receptor α1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivo. J Pharmacol Exp Ther 2012 0.86
48 Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites. Structure 2013 0.85
49 Zinc-dependent modulation of α2- and α3-glycine receptor subunits by ethanol. Alcohol Clin Exp Res 2013 0.85
50 Identifying the binding site(s) for antidepressants on the Torpedo nicotinic acetylcholine receptor: [3H]2-azidoimipramine photolabeling and molecular dynamics studies. Biochim Biophys Acta 2008 0.84
51 Unique general anesthetic binding sites within distinct conformational states of the nicotinic acetylcholine receptor. Int Rev Neurobiol 2003 0.84
52 The TM2 6' position of GABA(A) receptors mediates alcohol inhibition. J Pharmacol Exp Ther 2011 0.82
53 Normal mode gating motions of a ligand-gated ion channel persist in a fully hydrated lipid bilayer model. ACS Chem Neurosci 2010 0.79
54 The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms. Anesth Analg 2006 0.76
55 Molecular modeling of a tandem two pore domain potassium channel reveals a putative binding site for general anesthetics. ACS Chem Neurosci 2014 0.76
56 Induced changes in protein receptors conferring resistance to anesthetics. Curr Opin Anaesthesiol 2012 0.75