Published in Circulation on March 24, 2008
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol (2009) 6.11
Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3. Ann Intern Med (2009) 6.00
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA (2009) 5.32
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat Genet (2011) 5.23
Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. Nat Genet (2009) 5.13
New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet (2009) 5.12
Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature (2010) 3.77
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ Cardiovasc Genet (2010) 3.15
INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis. PLoS One (2009) 2.77
Large scale association analysis of novel genetic loci for coronary artery disease. Arterioscler Thromb Vasc Biol (2009) 2.71
Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke. Ann Neurol (2009) 2.55
Association of variation in the chromosome 9p21 locus with myocardial infarction versus chronic coronary artery disease. Circ Cardiovasc Genet (2008) 2.50
Sequential methods for random-effects meta-analysis. Stat Med (2010) 2.33
Dysfunctional nitric oxide signalling increases risk of myocardial infarction. Nature (2013) 2.24
Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol (2010) 2.17
The chromosome 9p21 risk locus is associated with angiographic severity and progression of coronary artery disease. Eur Heart J (2010) 2.04
A variant at chromosome 9p21 is associated with recurrent myocardial infarction and cardiac death after acute coronary syndrome: the GRACE Genetics Study. Eur Heart J (2010) 1.90
Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis. PLoS Genet (2009) 1.80
Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. Eur Heart J (2008) 1.80
Impact of adding a single allele in the 9p21 locus to traditional risk factors on reclassification of coronary heart disease risk and implications for lipid-modifying therapy in the Atherosclerosis Risk in Communities study. Circ Cardiovasc Genet (2009) 1.80
Chromosome 9p21 haplotypes and prognosis in white and black patients with coronary artery disease. Circ Cardiovasc Genet (2011) 1.69
Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease. Circ Cardiovasc Genet (2010) 1.64
Heterogeneity of the phenotypic definition of coronary artery disease and its impact on genetic association studies. Circ Cardiovasc Genet (2010) 1.62
A common variant at 9p21 is associated with sudden and arrhythmic cardiac death. Circulation (2009) 1.59
Lack of association of chromosome 9p21.3 genotype with cardiovascular structure and function in persons with stable coronary artery disease: The Heart and Soul Study. Atherosclerosis (2008) 1.45
The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts. Genet Epidemiol (2009) 1.43
The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study. PLoS Med (2011) 1.36
Gender differences in genetic risk profiles for cardiovascular disease. PLoS One (2008) 1.31
The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. Circ Cardiovasc Genet (2009) 1.27
Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circ Cardiovasc Genet (2011) 1.26
Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells. Hum Mol Genet (2012) 1.24
Variant on 9p21 strongly associates with coronary heart disease, but lacks association with common stroke. Eur J Hum Genet (2009) 1.22
The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis. BMC Cardiovasc Disord (2009) 1.18
Genetic cardiovascular risk prediction: will we get there? Circulation (2010) 1.17
Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. J Clin Periodontol (2013) 1.12
Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease. Genome Med (2009) 1.12
A genetic variant on chromosome 9p21 and incident heart failure in the ARIC study. Eur Heart J (2009) 1.07
Chromosome 9p21 in ischemic stroke: population structure and meta-analysis. Stroke (2010) 1.06
Utility of genetic determinants of lipids and cardiovascular events in assessing risk. Nat Rev Cardiol (2011) 1.04
Rationale and design of the Leipzig (LIFE) Heart Study: phenotyping and cardiovascular characteristics of patients with coronary artery disease. PLoS One (2011) 1.03
Chromosome 9p21 single nucleotide polymorphisms are not associated with recurrent myocardial infarction in patients with established coronary artery disease. Circ J (2012) 1.02
Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. J Am Coll Cardiol (2013) 1.02
Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry. BMC Cardiovasc Disord (2011) 1.01
The genetics of ischaemic stroke. J Intern Med (2010) 1.01
Genetics of coronary artery disease. Circulation (2013) 1.00
Genome-wide association studies of coronary artery disease and heart failure: where are we going? Pharmacogenomics (2009) 1.00
Carriage of the V279F null allele within the gene encoding Lp-PLA₂ is protective from coronary artery disease in South Korean males. PLoS One (2011) 0.99
Implications of discoveries from genome-wide association studies in current cardiovascular practice. World J Cardiol (2011) 0.97
Family history of peripheral artery disease is associated with prevalence and severity of peripheral artery disease: the San Diego population study. J Am Coll Cardiol (2011) 0.96
Genomic approaches to coronary artery disease. Indian J Med Res (2010) 0.96
Genetics of common polygenic ischaemic stroke: current understanding and future challenges. Stroke Res Treat (2011) 0.96
Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study. BMC Med (2008) 0.95
Chromosome 9p21.3 polymorphism in a Chinese Han population is associated with angiographic coronary plaque progression in non-diabetic but not in type 2 diabetic patients. Cardiovasc Diabetol (2010) 0.93
The chromosome 9p21.3 coronary heart disease risk allele is associated with altered gene expression in normal heart and vascular tissues. PLoS One (2012) 0.91
Molecular genetics of myocardial infarction. Genomic Med (2008) 0.91
Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease. Hum Genet (2011) 0.91
Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes. BMC Med Genet (2013) 0.90
Common genetic variants on chromosome 9p21 predict perioperative myocardial injury after coronary artery bypass graft surgery. J Thorac Cardiovasc Surg (2009) 0.90
Genetic causes of myocardial infarction: new insights from genome-wide association studies. Dtsch Arztebl Int (2010) 0.90
Chapter 11: challenges in and principles for conducting systematic reviews of genetic tests used as predictive indicators. J Gen Intern Med (2012) 0.90
CXCL12: a new player in coronary disease identified through human genetics. Trends Cardiovasc Med (2010) 0.90
Higher incidence of death in multi-vessel coronary artery disease patients associated with polymorphisms in chromosome 9p21. BMC Cardiovasc Disord (2012) 0.89
Identification of quantitative trait loci for fibrin clot phenotypes: the EuroCLOT study. Arterioscler Thromb Vasc Biol (2009) 0.89
The Geisinger MyCode community health initiative: an electronic health record-linked biobank for precision medicine research. Genet Med (2016) 0.89
Evaluation of single-nucleotide polymorphism imputation using random forests. BMC Proc (2009) 0.88
Using Hamming Distance as Information for SNP-Sets Clustering and Testing in Disease Association Studies. PLoS One (2015) 0.88
The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) Study. Atherosclerosis (2012) 0.87
Unravelling the genetics of ischaemic stroke. PLoS Med (2010) 0.87
Association Study between Coronary Artery Disease and rs1333049 and rs10757274 Polymorphisms at 9p21 Locus in South-West Iran. Cell J (2015) 0.86
Genetic predisposition to coronary heart disease and stroke using an additive genetic risk score: a population-based study in Greece. Atherosclerosis (2012) 0.86
The relationship between polymorphisms on chromosome 9p21 and age of onset of coronary heart disease in black and white women. Genet Test Mol Biomarkers (2011) 0.85
HapMap and mapping genes for cardiovascular disease. Circ Cardiovasc Genet (2008) 0.85
Cardiovascular genomics. J Nurs Scholarsh (2013) 0.85
Meta-analysis of low density lipoprotein receptor (LDLR) rs2228671 polymorphism and coronary heart disease. Biomed Res Int (2014) 0.84
The coronary artery disease-associated 9p21 variant and later life 20-year survival to cohort extinction. Circ Cardiovasc Genet (2011) 0.84
The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease. EMBO Mol Med (2016) 0.83
Two chromosome 9p21 haplotype blocks distinguish between coronary artery disease and myocardial infarction risk. Circ Cardiovasc Genet (2013) 0.83
Genome-wide association study of coronary artery disease. Int J Hypertens (2010) 0.83
Genetics of coronary artery disease: focus on genome-wide association studies. Am J Transl Res (2009) 0.83
Replication of putative susceptibility loci from genome-wide association studies associated with coronary atherosclerosis in Chinese Han population. PLoS One (2011) 0.82
Smoking modifies the associated increased risk of future cardiovascular disease by genetic variation on chromosome 9p21. PLoS One (2014) 0.82
Additive influence of genetic predisposition and conventional risk factors in the incidence of coronary heart disease: a population-based study in Greece. BMJ Open (2014) 0.82
Replication of the association of chromosomal region 9p21.3 with generalized aggressive periodontitis (gAgP) using an independent case-control cohort. BMC Med Genet (2010) 0.82
Interaction of type 2 diabetes mellitus with chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction: a case-control study in Chinese population. BMC Cardiovasc Disord (2014) 0.81
Effect of 9p21 genetic variation on coronary heart disease is not modified by other risk markers. The Atherosclerosis Risk in Communities (ARIC) Study. Atherosclerosis (2012) 0.81
Genomic variant in CAV1 increases susceptibility to coronary artery disease and myocardial infarction. Atherosclerosis (2016) 0.79
The association between variants on chromosome 9p21 and inflammatory biomarkers in ethnically diverse women with coronary heart disease: a pilot study. Biol Res Nurs (2011) 0.79
Genomic markers to tailor treatments: waiting or initiating? Hum Genet (2011) 0.79
The methodology for developing a prospective meta-analysis in the family planning community. Trials (2011) 0.79
Stroke Risk Factors, Genetics, and Prevention. Circ Res (2017) 0.78
CDKN2B expression and subcutaneous adipose tissue expandability: possible influence of the 9p21 atherosclerosis locus. Biochem Biophys Res Commun (2014) 0.78
Parental intermittent claudication as risk factor for claudication in adults. Am J Cardiol (2011) 0.78
Analysis of Genomic Regions Associated With Coronary Artery Disease Reveals Continent-Specific Single Nucleotide Polymorphisms in North African Populations. J Epidemiol (2016) 0.78
The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts. Age (Dordr) (2013) 0.78
The Relation between eNOS -786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, -384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease. Dis Markers (2015) 0.78
Genome-wide association analysis and replication of coronary artery disease in South Korea suggests a causal variant common to diverse populations. Heart Asia (2010) 0.78
South Asian Heart Risk Assessment (SAHARA): Randomized Controlled Trial Design and Pilot Study. JMIR Res Protoc (2013) 0.77
MRAS Genetic Variation Is Associated with Atherothrombotic Stroke in the Han Chinese Population. J Clin Neurol (2013) 0.77
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
A haplotype map of the human genome. Nature (2005) 105.70
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
Replicating genotype-phenotype associations. Nature (2007) 16.11
Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med (1994) 7.47
Nonvalidation of reported genetic risk factors for acute coronary syndrome in a large-scale replication study. JAMA (2007) 7.12
White cell telomere length and risk of premature myocardial infarction. Arterioscler Thromb Vasc Biol (2003) 5.04
PopGen: population-based recruitment of patients and controls for the analysis of complex genotype-phenotype relationships. Community Genet (2006) 4.72
Trend tests for case-control studies of genetic markers: power, sample size and robustness. Hum Hered (2002) 4.64
A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat Genet (2002) 3.19
Traditional reviews, meta-analyses and pooled analyses in epidemiology. Int J Epidemiol (1999) 2.85
Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction. Circulation (2005) 2.81
A new JAVA interface implementation of THESIAS: testing haplotype effects in association studies. Bioinformatics (2007) 2.11
The choice of a genetic model in the meta-analysis of molecular association studies. Int J Epidemiol (2005) 1.88
Specific haplotypes of the P-selectin gene are associated with myocardial infarction. Hum Mol Genet (2002) 1.51
Association of polymorphisms of the apolipoprotein(a) gene with lipoprotein(a) levels and myocardial infarction. Circulation (2003) 1.49
The population-based acute myocardial infarction (AMI) registry of the MONICA/KORA study region of Augsburg. Gesundheitswesen (2005) 1.39
A method for meta-analysis of case-control genetic association studies using logistic regression. Stat Appl Genet Mol Biol (2007) 1.33
Five-year incidence of angina pectoris and other forms of coronary heart disease in healthy men aged 50-59 in France and Northern Ireland: the Prospective Epidemiological Study of Myocardial Infarction (PRIME) Study. Int J Epidemiol (2001) 1.17
Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular risk. Circ Res (2006) 1.08
Distribution of tissue plasminogen activator insertion/deletion polymorphism in myocardial infarction and control subjects. Thromb Haemost (1998) 1.01
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Population genomics of human gene expression. Nat Genet (2007) 24.49
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
The fine-scale structure of recombination rate variation in the human genome. Science (2004) 17.05
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
Structural variation of chromosomes in autism spectrum disorder. Am J Hum Genet (2008) 15.51
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet (2006) 15.14
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 13.74
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25