Published in Nature on March 27, 2008
Geochemical evidence for widespread euxinia in the later Cambrian ocean. Nature (2011) 3.01
Biochemistry and evolution of anaerobic energy metabolism in eukaryotes. Microbiol Mol Biol Rev (2012) 2.65
Devonian rise in atmospheric oxygen correlated to the radiations of terrestrial plants and large predatory fish. Proc Natl Acad Sci U S A (2010) 2.50
Rapid evolutionary innovation during an Archaean genetic expansion. Nature (2010) 2.34
Two-phase increase in the maximum size of life over 3.5 billion years reflects biological innovation and environmental opportunity. Proc Natl Acad Sci U S A (2008) 2.01
Fluctuations in Precambrian atmospheric oxygenation recorded by chromium isotopes. Nature (2009) 2.01
History of biological metal utilization inferred through phylogenomic analysis of protein structures. Proc Natl Acad Sci U S A (2010) 1.71
The evolution of the marine phosphate reservoir. Nature (2010) 1.69
Oceanic nickel depletion and a methanogen famine before the Great Oxidation Event. Nature (2009) 1.62
Anoxygenic photosynthesis modulated Proterozoic oxygen and sustained Earth's middle age. Proc Natl Acad Sci U S A (2009) 1.58
Widespread iron-rich conditions in the mid-Proterozoic ocean. Nature (2011) 1.55
Proterozoic ocean redox and biogeochemical stasis. Proc Natl Acad Sci U S A (2013) 1.54
Aerobic bacterial pyrite oxidation and acid rock drainage during the Great Oxidation Event. Nature (2011) 1.29
Paleobiological perspectives on early eukaryotic evolution. Cold Spring Harb Perspect Biol (2014) 1.21
Ocean oxygenation in the wake of the Marinoan glaciation. Nature (2012) 1.19
Large spinose microfossils in Ediacaran rocks as resting stages of early animals. Proc Natl Acad Sci U S A (2009) 1.11
Trace metal requirements for microbial enzymes involved in the production and consumption of methane and nitrous oxide. Front Microbiol (2012) 1.09
Red and green algal origin of diatom membrane transporters: insights into environmental adaptation and cell evolution. PLoS One (2011) 1.05
The ineluctable requirement for the trans-iron elements molybdenum and/or tungsten in the origin of life. Sci Rep (2012) 0.99
Mineralogical constraints on the paleoenvironments of the Ediacaran Doushantuo Formation. Proc Natl Acad Sci U S A (2009) 0.96
Early oxygenation of the terrestrial environment during the Mesoproterozoic. Nature (2010) 0.94
Molybdenum limitation of microbial nitrogen assimilation in aquatic ecosystems and pure cultures. Front Microbiol (2012) 0.94
Interplay between oxygen and Fe-S cluster biogenesis: insights from the Suf pathway. Biochemistry (2014) 0.92
Rise to modern levels of ocean oxygenation coincided with the Cambrian radiation of animals. Nat Commun (2015) 0.91
Chlorophyll biosynthesis gene evolution indicates photosystem gene duplication, not photosystem merger, at the origin of oxygenic photosynthesis. Genome Biol Evol (2013) 0.91
Rapid oxygenation of Earth's atmosphere 2.33 billion years ago. Sci Adv (2016) 0.87
Isotopic evidence for biological nitrogen fixation by molybdenum-nitrogenase from 3.2 Gyr. Nature (2015) 0.85
Redox chemistry of molybdenum in natural waters and its involvement in biological evolution. Front Microbiol (2012) 0.83
Phototrophic sulfide oxidation: environmental insights and a method for kinetic analysis. Front Microbiol (2013) 0.82
Evolution of the global phosphorus cycle. Nature (2016) 0.81
Nitrogen isotope fractionation by alternative nitrogenases and past ocean anoxia. Proc Natl Acad Sci U S A (2014) 0.81
Origin of marine planktonic cyanobacteria. Sci Rep (2015) 0.81
Photosynthetic Versatility in the Genome of Geitlerinema sp. PCC 9228 (Formerly Oscillatoria limnetica 'Solar Lake'), a Model Anoxygenic Photosynthetic Cyanobacterium. Front Microbiol (2016) 0.80
Open Questions on the Origin of Eukaryotes. Trends Ecol Evol (2015) 0.80
Low-oxygen waters limited habitable space for early animals. Nat Commun (2016) 0.79
An early productive ocean unfit for aerobics. Proc Natl Acad Sci U S A (2009) 0.79
The role of biology in planetary evolution: cyanobacterial primary production in low-oxygen Proterozoic oceans. Environ Microbiol (2015) 0.78
Comparison of trace element concentration in bone and intervertebral disc tissue by atomic absorption spectrometry techniques. J Orthop Surg Res (2014) 0.78
Proterozoic oxygen rise linked to shifting balance between seafloor and terrestrial weathering. Proc Natl Acad Sci U S A (2014) 0.78
Molybdenum isotope fractionation by cyanobacterial assimilation during nitrate utilization and N₂ fixation. Geobiology (2010) 0.77
Symbiosis in eukaryotic evolution. J Theor Biol (2017) 0.76
Ediacaran Marine Redox Heterogeneity and Early Animal Ecosystems. Sci Rep (2015) 0.76
Cyanobacterial Diazotrophy and Earth's Delayed Oxygenation. Front Microbiol (2016) 0.75
Breathing room for early animals. Proc Natl Acad Sci U S A (2016) 0.75
Atmospheric oxygen regulation at low Proterozoic levels by incomplete oxidative weathering of sedimentary organic carbon. Nat Commun (2017) 0.75
Iron Isotope Fractionation during Fe(II) Oxidation Mediated by the Oxygen-Producing Marine Cyanobacterium Synechococcus PCC 7002. Environ Sci Technol (2017) 0.75
The Cosmic Zoo: The (Near) Inevitability of the Evolution of Complex, Macroscopic Life. Life (Basel) (2016) 0.75
The worm turned, and the ocean followed. Proc Natl Acad Sci U S A (2009) 0.75
High Molybdenum availability for evolution in a Mesoproterozoic lacustrine environment. Nat Commun (2015) 0.75
Selenium isotopes record extensive marine suboxia during the Great Oxidation Event. Proc Natl Acad Sci U S A (2017) 0.75
Inflammation and Alzheimer's disease. Neurobiol Aging (2000) 12.56
The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med (2000) 7.54
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol (1999) 7.16
Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats. Nature (1993) 4.87
Human cytomegalovirus IE1 and IE2 proteins block apoptosis. J Virol (1995) 4.22
Recovery from psychotic illness: a 15- and 25-year international follow-up study. Br J Psychiatry (2001) 4.13
Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders. J Med Genet (2008) 3.87
Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia. J Med Genet (2004) 3.45
Incidence and origin of "null" alleles in the (AC)n microsatellite markers. Am J Hum Genet (1993) 3.18
'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737. Oncogene (2006) 3.10
Chinese SF-36 Health Survey: translation, cultural adaptation, validation, and normalisation. J Epidemiol Community Health (2003) 2.90
White matter damage on diffusion tensor imaging correlates with age-related cognitive decline. Neurology (2006) 2.42
DSPP mutation in dentinogenesis imperfecta Shields type II. Nat Genet (2001) 2.39
Molybdenum isotope evidence for widespread anoxia in mid-Proterozoic oceans. Science (2004) 2.28
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther (1994) 2.27
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome Res (2000) 2.21
Post-earthquake quality of life and psychological well-being: longitudinal evaluation in a rural community sample in northern China. Psychiatry Clin Neurosci (2000) 2.20
Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. Genome Res (1997) 2.17
Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism. Neuron (1999) 2.16
Identification and characterization of the gene causing type 1 spinocerebellar ataxia. Nat Genet (1994) 2.13
Configurational diffusion down a folding funnel describes the dynamics of DNA hairpins. Proc Natl Acad Sci U S A (2001) 2.08
Characterization of 16S rRNA genes from oil field microbial communities indicates the presence of a variety of sulfate-reducing, fermentative, and sulfide-oxidizing bacteria. Appl Environ Microbiol (1996) 2.05
Simultaneous shotgun sequencing of multiple cDNA clones. DNA Seq (1997) 2.04
Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma. Leukemia (2007) 2.03
Isolation and characterisation of (AC)n microsatellite genetic markers from human chromosome 16. Genomics (1992) 2.00
Ordered assembly of roX RNAs into MSL complexes on the dosage-compensated X chromosome in Drosophila. Curr Biol (2000) 1.98
Antirotation proximal femoral nail versus dynamic hip screw for intertrochanteric fractures: a meta-analysis of randomized controlled studies. Orthop Traumatol Surg Res (2013) 1.97
601 octogenarians undergoing cardiac surgery: outcome and comparison with younger age groups. Ann Thorac Surg (1999) 1.96
Fragile X syndrome: diagnosis using highly polymorphic microsatellite markers. Am J Hum Genet (1991) 1.95
Duplication of a gene-rich cluster between 16p11.1 and Xq28: a novel pericentromeric-directed mechanism for paralogous genome evolution. Hum Mol Genet (1996) 1.93
Antibiotic treatment of gastric lymphoma of mucosa-associated lymphoid tissue. An uncontrolled trial. Ann Intern Med (1999) 1.88
Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytes/macrophages. J Immunol (1995) 1.86
A role for complement in antibody-mediated inflammation: C5-deficient DBA/1 mice are resistant to collagen-induced arthritis. J Immunol (2000) 1.82
Crystallographic findings on the internally uncoupled and near-rigor states of myosin: further insights into the mechanics of the motor. Proc Natl Acad Sci U S A (2002) 1.81
The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells. Oncogene (2008) 1.79
Association study of an SNP combination pattern in the dopaminergic pathway in paranoid schizophrenia: a novel strategy for complex disorders. Mol Psychiatry (2004) 1.79
Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. Proc Natl Acad Sci U S A (1998) 1.78
Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts. J Cell Biol (1997) 1.78
Longitudinal study of earthquake-related PTSD in a randomly selected community sample in north China. Am J Psychiatry (2000) 1.75
238U/235U variations in meteorites: extant 247Cm and implications for Pb-Pb dating. Science (2009) 1.70
Gamma-S crystallin gene (CRYGS) mutation causes dominant progressive cortical cataract in humans. J Med Genet (2005) 1.68
A distinct spectrum of SLC26A4 mutations in patients with enlarged vestibular aqueduct in China. Clin Genet (2007) 1.66
Is the dementia rate increasing in Beijing? Prevalence and incidence of dementia 10 years later in an urban elderly population. Acta Psychiatr Scand (2007) 1.65
Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy. Kidney Int (2007) 1.63
Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol (1993) 1.59
Quantitative reverse sample genome probing of microbial communities and its application to oil field production waters. Appl Environ Microbiol (1993) 1.56
A semiflexible polymer model applied to loop formation in DNA hairpins. Biophys J (2001) 1.54
The vascular biology of the glycoprotein Ib-IX-V complex. Thromb Haemost (2001) 1.53
Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia (2001) 1.53
Value of CSF beta-amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment. Mol Psychiatry (2004) 1.53
Radiation dose and cancer risk in retrospectively and prospectively ECG-gated coronary angiography using 64-slice multidetector CT. Br J Radiol (2010) 1.53
Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island. Nat Genet (1996) 1.52
Propofol EC50 for inducing loss of consciousness is lower in the luteal phase of the menstrual cycle. Br J Anaesth (2013) 1.50
Characterization of telomerase-immortalized, non-neoplastic, human Barrett's cell line (BAR-T). Dis Esophagus (2007) 1.47
Mechanism of the systemic, left ventricular, and coronary vascular tolerance to a binge of cocaine in conscious dogs. Circulation (1996) 1.41
Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases. J Thromb Haemost (2007) 1.41
Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family. J Neurochem (1995) 1.40
beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1. Am J Physiol Cell Physiol (2000) 1.40
Artificial neural network to assist psychiatric diagnosis. Br J Psychiatry (1996) 1.39
Experimental characterization of superradiance in a single-pass high-gain laser-seeded free-electron laser amplifier. Phys Rev Lett (2007) 1.39
Glycoprotein Ib-IX-V. Int J Biochem Cell Biol (2003) 1.38
Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively. Proc Natl Acad Sci U S A (1999) 1.32
A population genetic test of selection at the molecular level. Science (1995) 1.32
Prospective randomised evaluation of traditional Chinese medicine combined with chemotherapy: a randomised phase II study of wild toad extract plus gemcitabine in patients with advanced pancreatic adenocarcinomas. Br J Cancer (2012) 1.31
Effect of time to complete remission on subsequent survival and disease-free survival time in AML, RAEB-t, and RAEB. Blood (2000) 1.31
Treatment of moderate mitral regurgitation and coronary disease by coronary bypass alone: late results. Ann Thorac Surg (1999) 1.29
Advances in photoacoustic noninvasive glucose testing. Clin Chem (1999) 1.27
Y-linked inheritance of non-syndromic hearing impairment in a large Chinese family. J Med Genet (2004) 1.26
Intraepithelial CD8-positive T lymphocytes predict survival for patients with serous stage III ovarian carcinomas: relevance of clonal selection of T lymphocytes. Br J Cancer (2009) 1.25
Familial Mediterranean fever (FMF) in Moroccan Jews: demonstration of a founder effect by extended haplotype analysis. Am J Hum Genet (1993) 1.25
Stress-induced neuroendocrine modulation of viral pathogenesis and immunity. Ann N Y Acad Sci (1998) 1.24
High prevalence of albuminuria in population-based patients diagnosed with type 2 diabetes in the Shanghai downtown. Diabetes Res Clin Pract (2006) 1.22
Isolation and characterization of a zebrafish homologue of the cone rod homeobox gene. Invest Ophthalmol Vis Sci (2001) 1.21
Immune biology of macaque lymphocyte populations during mycobacterial infection. Clin Exp Immunol (2003) 1.20
Redox redux. Geobiology (2009) 1.20
The extracellular signal-regulated kinase pathway contributes to the control of behavioral excitement. Mol Psychiatry (2008) 1.19
Antibacterial and smear layer removal ability of a novel irrigant, QMiX. Int Endod J (2011) 1.19
No evidence of a role for mutations or polymorphisms of the follicle-stimulating hormone receptor in ovarian granulosa cell tumors. J Clin Endocrinol Metab (1998) 1.18
A late methanogen origin for molybdenum-dependent nitrogenase. Geobiology (2011) 1.18
Permutation tests for comparing marginal survival functions with clustered failure time data. Stat Med (2000) 1.18
Detection of elevated reactive oxygen species level in cultured rat hepatocytes treated with aflatoxin B1. Free Radic Biol Med (1996) 1.17
Refined mapping of the gene causing familial Mediterranean fever, by linkage and homozygosity studies. Am J Hum Genet (1993) 1.16
Multidrug resistant gram-negative bacilli as predominant bacteremic pathogens in liver transplant recipients. Transpl Infect Dis (2009) 1.15
Human transcription factor IIIC box B binding subunit. Proc Natl Acad Sci U S A (1994) 1.15
Arsenic trioxide induces multiple myeloma cell apoptosis via disruption of mitochondrial transmembrane potentials and activation of caspase-3. Chin Med J (Engl) (2001) 1.15
TBX6 null variants and a common hypomorphic allele in congenital scoliosis. N Engl J Med (2015) 1.15
High resolution mapping of interstitial long arm deletions of chromosome 16: relationship to phenotype. J Med Genet (1993) 1.14
Long-term treatment efficacy in primary inflammatory breast cancer by hormonal receptor- and HER2-defined subtypes. Ann Oncol (2013) 1.14
Rifampin's acute inhibitory and chronic inductive drug interactions: experimental and model-based approaches to drug-drug interaction trial design. Clin Pharmacol Ther (2010) 1.14
Haloperidol concentrations elevated in Chinese patients. Psychiatry Res (1984) 1.14
Distinct types of T-cell help for the induction of a humoral immune response to Streptococcus pneumoniae. Trends Immunol (2001) 1.13
Estrogen enhances uptake of amyloid beta-protein by microglia derived from the human cortex. J Neurochem (2000) 1.13
Elevated soluble Fas (sFas) levels in nonhematopoietic human malignancy. Cancer Res (1996) 1.13
B7 requirements for primary and secondary protein- and polysaccharide-specific Ig isotype responses to Streptococcus pneumoniae. J Immunol (2000) 1.11
High-throughput peptide identification from protein digests using data-dependent multiplexed tandem FTICR mass spectrometry coupled with capillary liquid chromatography. Anal Chem (2001) 1.11
Regulation of miRNA expression by Src and contact normalization: effects on nonanchored cell growth and migration. Oncogene (2009) 1.11