Published in J Am Coll Cardiol on April 01, 2008
Thin-walled microvessels in human coronary atherosclerotic plaques show incomplete endothelial junctions relevance of compromised structural integrity for intraplaque microvascular leakage. J Am Coll Cardiol (2009) 2.26
Chemokines as mediators of neovascularization. Arterioscler Thromb Vasc Biol (2008) 1.71
Temporal characterization of the functional density of the vasa vasorum by contrast-enhanced ultrasonography maximum intensity projection imaging. JACC Cardiovasc Imaging (2010) 1.28
Hypoxia is present in murine atherosclerotic plaques and has multiple adverse effects on macrophage lipid metabolism. Circ Res (2011) 1.22
Heme on innate immunity and inflammation. Front Pharmacol (2014) 1.15
Inflammation and immunity in diseases of the arterial tree: players and layers. Circ Res (2015) 1.14
Autophagy in cardiovascular biology. J Clin Invest (2015) 1.14
Hypoxia induces netrin-1 and Unc5b in atherosclerotic plaques: mechanism for macrophage retention and survival. Arterioscler Thromb Vasc Biol (2013) 1.05
Metabolic memory: a vascular perspective. Cardiovasc Diabetol (2010) 1.03
Vascular ultrasound for atherosclerosis imaging. Interface Focus (2011) 1.00
¹⁸F-FDG PET and biomarkers for tumour angiogenesis in early breast cancer. Eur J Nucl Med Mol Imaging (2010) 1.00
Role of hyaluronan in angiogenesis and its utility to angiogenic tissue engineering. Organogenesis (2008) 1.00
Macrophage autophagy in atherosclerosis. Mediators Inflamm (2013) 1.00
Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease. Nitric Oxide (2011) 0.99
(18)F-FDG PET imaging of murine atherosclerosis: association with gene expression of key molecular markers. PLoS One (2012) 0.93
Molecular imaging of inflammation and intraplaque vasa vasorum: a step forward to identification of vulnerable plaques? J Nucl Cardiol (2010) 0.93
Involvement of COX-2/PGE2 signalling in hypoxia-induced angiogenic response in endothelial cells. J Cell Mol Med (2012) 0.92
The paradox of hypoxic and oxidative stress in atherosclerosis. J Am Coll Cardiol (2008) 0.92
Adipocytokines in atherothrombosis: focus on platelets and vascular smooth muscle cells. Mediators Inflamm (2010) 0.90
Moderate hypoxia potentiates interleukin-1β production in activated human macrophages. Circ Res (2014) 0.88
Hypoxia stimulates the expression of macrophage migration inhibitory factor in human vascular smooth muscle cells via HIF-1alpha dependent pathway. BMC Cell Biol (2010) 0.87
Macrophages transmit potent proangiogenic effects of oxLDL in vitro and in vivo involving HIF-1α activation: a novel aspect of angiogenesis in atherosclerosis. J Cardiovasc Transl Res (2013) 0.87
Noninvasive assessment of hypoxia in rabbit advanced atherosclerosis using ¹⁸F-fluoromisonidazole positron emission tomographic imaging. Circ Cardiovasc Imaging (2014) 0.87
Age-related macular degeneration and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Ophthalmology (2011) 0.87
Red blood cell, hemoglobin and heme in the progression of atherosclerosis. Front Physiol (2014) 0.85
Kruppel-like factors and vascular inflammation: implications for atherosclerosis. Curr Atheroscler Rep (2012) 0.84
Coronary plaque neovascularization and hemorrhage: a potential target for plaque stabilization? JACC Cardiovasc Imaging (2010) 0.84
HIF-1α and VEGF expression correlates with thrombus remodeling in cases of intravascular papillary endothelial hyperplasia. Int J Clin Exp Pathol (2013) 0.83
Autophagy: an emerging therapeutic target in vascular diseases. Br J Pharmacol (2015) 0.82
Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. Cell Death Dis (2015) 0.82
Acidification of the intimal fluid: the perfect storm for atherogenesis. J Lipid Res (2014) 0.81
Vasa vasorum in atherosclerosis and clinical significance. Int J Mol Sci (2015) 0.81
Metabolism, energetics, and lipid biology in the podocyte - cellular cholesterol-mediated glomerular injury. Front Endocrinol (Lausanne) (2014) 0.81
Atherosclerotic plaque biomarkers: beyond the horizon of the vulnerable plaque. Curr Cardiol Rev (2011) 0.80
Positron emission tomography of the vulnerable atherosclerotic plaque in man--a contemporary review. Clin Physiol Funct Imaging (2013) 0.80
(18)F-FDG imaging of human atherosclerotic carotid plaques reflects gene expression of the key hypoxia marker HIF-1α. Am J Nucl Med Mol Imaging (2013) 0.79
The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases. J Cell Physiol (2015) 0.79
Deficiency of HIF1α in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice. Arterioscler Thromb Vasc Biol (2015) 0.78
An assessment of the vulnerability of carotid plaques: a comparative study between intraplaque neovascularization and plaque echogenicity. BMC Med Imaging (2013) 0.78
Dynamic Contrast-Enhanced MRI to Study Atherosclerotic Plaque Microvasculature. Curr Atheroscler Rep (2016) 0.78
Regulation of foam cells by adenosine. Arterioscler Thromb Vasc Biol (2012) 0.78
Conformational changes of apoB-100 in SMase-modified LDL mediate formation of large aggregates at acidic pH. J Lipid Res (2012) 0.78
Increased Vascularization in the Vulnerable Upstream Regions of Both Early and Advanced Human Carotid Atherosclerosis. PLoS One (2016) 0.77
Systemic and renal lipids in kidney disease development and progression. Am J Physiol Renal Physiol (2015) 0.77
Future imaging of atherosclerosis: molecular imaging of coronary atherosclerosis with (18)F positron emission tomography. Cardiovasc Diagn Ther (2016) 0.76
Profiling of genes associated with the murine model of oxygen-induced retinopathy. Mol Vis (2013) 0.76
Emerging diagnostic and therapeutic molecular imaging applications in vascular disease. Vasc Med (2011) 0.76
Specific matrix metalloproteinases play different roles in intraplaque angiogenesis and plaque instability in rabbits. PLoS One (2014) 0.76
Vascular Imaging With (18)F-Fluorodeoxyglucose Positron Emission Tomography Is Influenced by Hypoxia. J Am Coll Cardiol (2017) 0.75
Anti-angiogenic activity of rPAI-1(23) and vasa vasorum regression. Trends Cardiovasc Med (2013) 0.75
Vasa vasorum anti-angiogenesis through H₂O₂, HIF-1α, NF-κB, and iNOS inhibition by mangosteen pericarp ethanolic extract (Garcinia mangostana Linn) in hypercholesterol-diet-given Rattus norvegicus Wistar strain. Vasc Health Risk Manag (2014) 0.75
Identification of neovascularization by contrast-enhanced ultrasound to detect unstable carotid stenosis. PLoS One (2017) 0.75
Effects of simulated heat waves on cardiovascular functions in senile mice. Int J Environ Res Public Health (2014) 0.75
Feasibility of in vivo (18)F-florbetaben PET/MR imaging of human carotid amyloid-β. Eur J Nucl Med Mol Imaging (2017) 0.75
Correlation between vascular endothelial growth factor and long-term prognosis in patients with acute myocardial infarction. Exp Ther Med (2016) 0.75
PET/MRI of Hypoxic Atherosclerosis Using 64Cu-ATSM in a Rabbit Model. J Nucl Med (2016) 0.75
RNA interference therapy: a new solution for intracranial atherosclerosis? Ann Transl Med (2014) 0.75
Effects of copper sulfate-oxidized or myeloperoxidase-modified LDL on lipid loading and programmed cell death in macrophages under hypoxia. Hypoxia (Auckl) (2014) 0.75
Hypoxia in plaque macrophages: a new danger signal for interleukin-1β activation? Circ Res (2014) 0.75
Hypoxia stimulates the proliferation of neonatal rat vascular smooth muscle cells through activation of hypoxia-inducible factor-1α. Int J Clin Exp Med (2015) 0.75
Imaging of hypoxia in mouse atherosclerotic plaques with (64)Cu-ATSM. Nucl Med Biol (2016) 0.75
Arterial microvessels: an early or late sign of atherosclerosis? J Am Coll Cardiol (2008) 0.75
PET imaging of the neurovascular interface in cerebrovascular disease. Nat Rev Neurol (2017) 0.75
Comparison of diagnostic values of ultrasound micro-flow imaging and contrast-enhanced ultrasound for neovascularization in carotid plaques. Exp Ther Med (2017) 0.75
Depletion of ATP and glucose in advanced human atherosclerotic plaques. PLoS One (2017) 0.75
Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites. Arterioscler Thromb Vasc Biol (2017) 0.75
Beyond Impressions: How Altered Shear Stress Connects Hypoxic Signaling to Endothelial Inflammation. Arterioscler Thromb Vasc Biol (2017) 0.75
Effect of Coenzyme Q10 on Biomarkers of Oxidative Stress and Cardiac Function in Hemodialysis Patients: The CoQ10 Biomarker Trial. Am J Kidney Dis (2016) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. Mol Cell Biol (2002) 4.11
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J (2005) 3.79
Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. Nat Genet (2006) 3.65
Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. J Pathol (2014) 3.21
Additive value of semiautomated quantification of coronary artery disease using cardiac computed tomographic angiography to predict future acute coronary syndrome. J Am Coll Cardiol (2013) 3.12
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J Clin Invest (2009) 3.01
Cancer classification using the Immunoscore: a worldwide task force. J Transl Med (2012) 2.88
Activating transcription factor 4 is translationally regulated by hypoxic stress. Mol Cell Biol (2004) 2.68
Bone morphogenetic protein-9 is a circulating vascular quiescence factor. Circ Res (2008) 2.43
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J (2006) 2.41
Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation. Circulation (2011) 2.41
Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma. Am J Pathol (2003) 2.30
Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas. Cancer Res (2003) 2.29
Disparity between in vivo EGFR expression and 89Zr-labeled cetuximab uptake assessed with PET. J Nucl Med (2008) 2.08
Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice. Circulation (2007) 2.00
Implication of Ref-1 in the repression of renin gene transcription by intracellular calcium. J Hypertens (2003) 1.83
"Translating" tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathways. Mol Cancer Res (2006) 1.80
Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness. Proc Natl Acad Sci U S A (2006) 1.79
Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform. Mol Cell Biol (2003) 1.76
Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans. Hum Mol Genet (2005) 1.74
Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton. Circ Res (2006) 1.73
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. J Clin Invest (2003) 1.73
Angiotensinogen and its cleaved derivatives inhibit angiogenesis. Hypertension (2002) 1.72
Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis. Circulation (2012) 1.71
Lessons from constitutively active mutants of G protein-coupled receptors. Trends Endocrinol Metab (2002) 1.70
Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile. J Exp Med (2010) 1.68
The biological effectiveness of antiproton irradiation. Radiother Oncol (2006) 1.66
Functionality of two new polymorphisms in the human renin gene enhancer region. J Hypertens (2002) 1.65
Autosomal dominant pseudohypoaldosteronism type 1: mechanisms, evidence for neonatal lethality, and phenotypic expression in adults. J Am Soc Nephrol (2006) 1.63
Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction. J Exp Med (2008) 1.62
Identification of residual metabolic-active areas within individual NSCLC tumours using a pre-radiotherapy (18)Fluorodeoxyglucose-PET-CT scan. Radiother Oncol (2009) 1.59
Translational control of gene expression during hypoxia. Cancer Biol Ther (2006) 1.57
Elevated blood pressure and heart rate in human renin receptor transgenic rats. Hypertension (2006) 1.51
Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations. PLoS Genet (2006) 1.50
Soluble form of the (pro)renin receptor generated by intracellular cleavage by furin is secreted in plasma. Hypertension (2009) 1.48
NanoStringNorm: an extensible R package for the pre-processing of NanoString mRNA and miRNA data. Bioinformatics (2012) 1.45
Expression of endothelins in human cardiogenesis. J Mol Med (Berl) (2002) 1.41
Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response. Breast Cancer Res (2013) 1.33
Regulation of autophagy through multiple independent hypoxic signaling pathways. Curr Mol Med (2009) 1.32
Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer. FEBS Lett (2006) 1.30
Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B. Dev Cell (2011) 1.29
Angiogenic activity of human chorionic gonadotropin through LH receptor activation on endothelial and epithelial cells of the endometrium. FASEB J (2006) 1.29
Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis. J Pathol (2009) 1.27
Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3. Radiother Oncol (2009) 1.27
Akt is a major downstream target of PI3-kinase involved in angiotensin II-induced proliferation. Hypertension (2003) 1.26
Citrulline: a physiologic marker enabling quantitation and monitoring of epithelial radiation-induced small bowel damage. Int J Radiat Oncol Biol Phys (2003) 1.24
Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response. Clin Cancer Res (2013) 1.24
Angiogenesis and vascular architecture in pheochromocytomas: distinctive traits in malignant tumors. Am J Pathol (2002) 1.24
Atherosclerotic plaque destabilization: mechanisms, models, and therapeutic strategies. Circ Res (2014) 1.24
Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice. J Clin Invest (2007) 1.23
The hypoxic proteome is influenced by gene-specific changes in mRNA translation. Radiother Oncol (2005) 1.22
Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure. Am J Hum Genet (2009) 1.21
Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in thrombospondin-1-deficient mice. PLoS One (2008) 1.21
Mice lacking endothelial angiotensin-converting enzyme have a normal blood pressure. Circ Res (2002) 1.19
Irradiation induced modest changes in murine cardiac function despite progressive structural damage to the myocardium and microvasculature. Radiother Oncol (2011) 1.19
Ovarian brain-derived neurotrophic factor (BDNF) promotes the development of oocytes into preimplantation embryos. Proc Natl Acad Sci U S A (2005) 1.19
Fn14-Fc fusion protein regulates atherosclerosis in ApoE-/- mice and inhibits macrophage lipid uptake in vitro. Arterioscler Thromb Vasc Biol (2009) 1.18
Effect of reduced angiotensin-converting enzyme gene expression and angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptide levels in mice. Hypertension (2004) 1.17
Neutrophils, neutrophil extracellular traps and interleukin-17 associate with the organisation of thrombi in acute myocardial infarction. Thromb Haemost (2012) 1.16
A role of the (pro)renin receptor in neuronal cell differentiation. Am J Physiol Regul Integr Comp Physiol (2009) 1.16
Angiogenesis associated with visceral and subcutaneous adipose tissue in severe human obesity. Diabetes (2008) 1.16
Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas. Cell Oncol (2007) 1.16
Role of the N-terminal catalytic domain of angiotensin-converting enzyme investigated by targeted inactivation in mice. J Biol Chem (2004) 1.13
Hyperglycemia-induced defects in angiogenesis in the chicken chorioallantoic membrane model. Diabetes (2004) 1.12
Self-measurement and self-titration in hypertension: a pilot telemedicine study. Am J Hypertens (2007) 1.11
Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure. Nat Cell Biol (2013) 1.11
Deficiency of angiotensin type 2 receptor rescues obesity but not hypertension induced by overexpression of angiotensinogen in adipose tissue. Endocrinology (2008) 1.11
Angiotensin-converting enzyme 2 (ACE2) and ACE activities display tissue-specific sensitivity to undernutrition-programmed hypertension in the adult rat. Hypertension (2005) 1.08
Novel insights into pathological changes in muscular arteries of radiotherapy patients. Radiother Oncol (2009) 1.08
Autophagy is required during cycling hypoxia to lower production of reactive oxygen species. Radiother Oncol (2009) 1.08
Angiotensin-converting enzyme C-terminal catalytic domain is the main site of angiotensin I cleavage in vivo. Hypertension (2007) 1.08
The dynamic extracellular matrix: intervention strategies during heart failure and atherosclerosis. J Pathol (2003) 1.07
Radiation dose prescription for non-small-cell lung cancer according to normal tissue dose constraints: an in silico clinical trial. Int J Radiat Oncol Biol Phys (2008) 1.07
Renal tubular dysgenesis, a not uncommon autosomal recessive disorder leading to oligohydramnios: Role of the Renin-Angiotensin system. J Am Soc Nephrol (2006) 1.06
Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis. Hum Mutat (2011) 1.06
Genetic determinants of nonmodulating hypertension. Hypertension (2003) 1.06
A simple but highly effective approach to evaluate the prognostic performance of gene expression signatures. PLoS One (2011) 1.05
Mice lacking endothelial ACE: normal blood pressure with elevated angiotensin II. Hypertension (2003) 1.05
Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia. Radiother Oncol (2007) 1.05
A deep sequencing approach to uncover the miRNOME in the human heart. PLoS One (2013) 1.04
Familial hyperkalemic hypertension: phenotypic analysis in a large family with the WNK1 deletion mutation. Am J Med (2003) 1.04
Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response. J Biol Chem (2009) 1.03
Development of a flexible and potent hypoxia-inducible promoter for tumor-targeted gene expression in attenuated Salmonella. Cancer Biol Ther (2006) 1.03
Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis. Am J Pathol (2007) 1.03
Local atherosclerotic plaques are a source of prognostic biomarkers for adverse cardiovascular events. Arterioscler Thromb Vasc Biol (2009) 1.02
Critical overexpression of thrombospondin 1 in chronic leg ischaemia. J Pathol (2005) 1.02
Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model. Radiother Oncol (2009) 1.02
In patients with pseudoxanthoma elasticum a thicker and more elastic carotid artery is associated with elastin fragmentation and proteoglycans accumulation. Ultrasound Med Biol (2004) 1.01
Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease. J Biol Chem (2002) 1.01
Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors. Radiother Oncol (2007) 1.00