Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus.

PubWeight™: 3.65‹?› | Rank: Top 1%

🔗 View Article (PMID 16444274)

Published in Nat Genet on January 29, 2006

Authors

Limin Zhu1, Roger Vranckx, Philippe Khau Van Kien, Alain Lalande, Nicolas Boisset, Flavie Mathieu, Mark Wegman, Luke Glancy, Jean-Marie Gasc, François Brunotte, Patrick Bruneval, Jean-Eric Wolf, Jean-Baptiste Michel, Xavier Jeunemaitre

Author Affiliations

1: Assistance Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Département de Génétique, 75015 Paris, France.

Articles citing this

(truncated to the top 100)

Lessons on the pathogenesis of aneurysm from heritable conditions. Nature (2011) 2.97

Mutations in myosin light chain kinase cause familial aortic dissections. Am J Hum Genet (2010) 2.67

Phenotypic variability and genetic susceptibility to genomic disorders. Hum Mol Genet (2010) 2.57

MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II. Hum Mol Genet (2007) 2.17

Genetic testing in aortic aneurysm disease: PRO. Cardiol Clin (2010) 2.12

Rare copy number variants disrupt genes regulating vascular smooth muscle cell adhesion and contractility in sporadic thoracic aortic aneurysms and dissections. Am J Hum Genet (2010) 2.07

Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling. Curr Opin Cell Biol (2009) 1.96

Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility. Nat Biotechnol (2012) 1.94

Exome sequencing identifies SMAD3 mutations as a cause of familial thoracic aortic aneurysm and dissection with intracranial and other arterial aneurysms. Circ Res (2011) 1.93

Genetics of congenital heart disease: the glass half empty. Circ Res (2013) 1.90

Epidemiology of thoracic aortic dissection. Nat Rev Cardiol (2010) 1.74

Cellular and molecular mechanisms of thoracic aortic aneurysms. Nat Rev Cardiol (2009) 1.65

Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. J Clin Invest (2008) 1.63

Aortic aneurysms: an immune disease with a strong genetic component. Circulation (2008) 1.48

Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1. Nat Genet (2011) 1.48

Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression. Circ Res (2009) 1.46

Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis. J Vasc Res (2008) 1.42

Novel MYH11 and ACTA2 mutations reveal a role for enhanced TGFβ signaling in FTAAD. Int J Cardiol (2011) 1.41

Canadian Cardiovascular Society 2009 Consensus Conference on the management of adults with congenital heart disease: outflow tract obstruction, coarctation of the aorta, tetralogy of Fallot, Ebstein anomaly and Marfan's syndrome. Can J Cardiol (2010) 1.40

Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. Am J Hum Genet (2013) 1.40

Recurrent chromosome 16p13.1 duplications are a risk factor for aortic dissections. PLoS Genet (2011) 1.35

Matrix-dependent perturbation of TGFβ signaling and disease. FEBS Lett (2012) 1.31

TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections. Cardiovasc Res (2010) 1.30

Aortic disease in the young: genetic aneurysm syndromes, connective tissue disorders, and familial aortic aneurysms and dissections. Int J Vasc Med (2013) 1.29

Rationale and design of the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC). Am Heart J (2008) 1.28

Male-biased autosomal effect of 16p13.11 copy number variation in neurodevelopmental disorders. PLoS One (2013) 1.23

Unregulated smooth-muscle myosin in human intestinal neoplasia. Proc Natl Acad Sci U S A (2008) 1.20

Report of the National Heart, Lung, and Blood Institute and National Marfan Foundation Working Group on research in Marfan syndrome and related disorders. Circulation (2008) 1.18

Marfan syndrome. Part 1: pathophysiology and diagnosis. Nat Rev Cardiol (2010) 1.15

Noncompaction of the ventricular myocardium is associated with a de novo mutation in the beta-myosin heavy chain gene. PLoS One (2007) 1.15

Effect of copy number variants on outcomes for infants with single ventricle heart defects. Circ Cardiovasc Genet (2013) 1.11

Heterozygous de novo and inherited mutations in the smooth muscle actin (ACTG2) gene underlie megacystis-microcolon-intestinal hypoperistalsis syndrome. PLoS Genet (2014) 1.10

Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion. Development (2010) 1.10

Rare, nonsynonymous variant in the smooth muscle-specific isoform of myosin heavy chain, MYH11, R247C, alters force generation in the aorta and phenotype of smooth muscle cells. Circ Res (2012) 1.10

Of mice and men: molecular genetics of congenital heart disease. Cell Mol Life Sci (2013) 1.10

The genetics and genomics of thoracic aortic disease. Ann Cardiothorac Surg (2013) 1.08

Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms. Cardiovasc Res (2010) 1.07

Surgical treatment of patients enrolled in the national registry of genetically triggered thoracic aortic conditions. Ann Thorac Surg (2009) 1.06

A direct comparison of next generation sequencing enrichment methods using an aortopathy gene panel- clinical diagnostics perspective. BMC Med Genomics (2012) 1.05

Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections. Circ Res (2015) 1.04

Genetic basis of congenital cardiovascular malformations. Eur J Med Genet (2014) 1.00

The clinical spectrum of complete FBN1 allele deletions. Eur J Hum Genet (2010) 1.00

Determination of genetic predisposition to patent ductus arteriosus in preterm infants. Pediatrics (2009) 0.99

MicroRNAs, fibrotic remodeling, and aortic aneurysms. J Clin Invest (2012) 0.99

Autosomal dominant inheritance of a predisposition to thoracic aortic aneurysms and dissections and intracranial saccular aneurysms. Am J Med Genet A (2011) 0.98

MFAP5 loss-of-function mutations underscore the involvement of matrix alteration in the pathogenesis of familial thoracic aortic aneurysms and dissections. Am J Hum Genet (2014) 0.97

Molecular mechanisms of thoracic aortic dissection. J Surg Res (2013) 0.96

MAT2A mutations predispose individuals to thoracic aortic aneurysms. Am J Hum Genet (2014) 0.96

Endothelial and smooth muscle cells from abdominal aortic aneurysm have increased oxidative stress and telomere attrition. PLoS One (2012) 0.96

A roadmap to investigate the genetic basis of bicuspid aortic valve and its complications: insights from the International BAVCon (Bicuspid Aortic Valve Consortium). J Am Coll Cardiol (2014) 0.96

Myh11(R247C/R247C) mutations increase thoracic aorta vulnerability to intramural damage despite a general biomechanical adaptivity. J Biomech (2014) 0.95

Incomplete segregation of MYH11 variants with thoracic aortic aneurysms and dissections and patent ductus arteriosus. Eur J Hum Genet (2012) 0.95

Skeletogenic phenotype of human Marfan embryonic stem cells faithfully phenocopied by patient-specific induced-pluripotent stem cells. Proc Natl Acad Sci U S A (2011) 0.94

Three novel mutations in the ACTA2 gene in German patients with thoracic aortic aneurysms and dissections. Eur J Hum Genet (2011) 0.94

Transforming growth factor-β and smooth muscle differentiation. World J Biol Chem (2012) 0.94

Pathophysiology of thoracic aortic aneurysm (TAA): is it not one uniform aorta? Role of embryologic origin. Prog Cardiovasc Dis (2013) 0.93

Combined mutation screening of NKX2-5, GATA4, and TBX5 in congenital heart disease: multiple heterozygosity and novel mutations. Congenit Heart Dis (2011) 0.92

FBN1 mutations in patients with descending thoracic aortic dissections. Am J Med Genet A (2010) 0.90

Genetic dissection of marfan syndrome and related connective tissue disorders: an update 2012. Mol Syndromol (2012) 0.90

Linkage of monogenic infantile hypertrophic pyloric stenosis to chromosome 16p12-p13 and evidence for genetic heterogeneity. Am J Hum Genet (2006) 0.89

Heavy and light roles: myosin in the morphogenesis of the heart. Cell Mol Life Sci (2012) 0.89

Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth Through Disturbed Downstream TGF-β Signaling. EBioMedicine (2016) 0.89

Micromanaging abdominal aortic aneurysms. Int J Mol Sci (2013) 0.89

Successes and challenges of using whole exome sequencing to identify novel genes underlying an inherited predisposition for thoracic aortic aneurysms and acute aortic dissections. Trends Cardiovasc Med (2013) 0.88

Characterization of large genomic deletions in the FBN1 gene using multiplex ligation-dependent probe amplification. BMC Med Genet (2011) 0.88

A homozygous loss-of-function variant in MYH11 in a case with megacystis-microcolon-intestinal hypoperistalsis syndrome. Eur J Hum Genet (2014) 0.88

Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development. Proc Natl Acad Sci U S A (2015) 0.87

An essential requirement for β1 integrin in the assembly of extracellular matrix proteins within the vascular wall. Dev Biol (2012) 0.87

LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections. Circ Res (2016) 0.86

TGFβRIIb mutations trigger aortic aneurysm pathogenesis by altering transforming growth factor β2 signal transduction. Circ Cardiovasc Genet (2012) 0.86

Aortic Disease Presentation and Outcome Associated With ACTA2 Mutations. Circ Cardiovasc Genet (2015) 0.85

Genetic variants in FBN-1 and risk for thoracic aortic aneurysm and dissection. PLoS One (2014) 0.84

Ebstein's anomaly may be caused by mutations in the sarcomere protein gene MYH7. Neth Heart J (2013) 0.84

A deleterious MYH11 mutation causing familial thoracic aortic dissection. Hum Genome Var (2015) 0.83

Rare copy number variants and congenital heart defects in the 22q11.2 deletion syndrome. Hum Genet (2016) 0.83

Connective tissue disorders and cardiovascular complications: the indomitable role of transforming growth factor-beta signaling. Adv Exp Med Biol (2014) 0.83

Phenotypic expansion of visceral myopathy associated with ACTG2 tandem base substitution. Eur J Hum Genet (2015) 0.83

The genetic basis of aortic aneurysm. Cold Spring Harb Perspect Med (2014) 0.82

Educational paper. Connective tissue disorders with vascular involvement: from gene to therapy. Eur J Pediatr (2012) 0.82

Compound heterozygous or homozygous truncating MYBPC3 mutations cause lethal cardiomyopathy with features of noncompaction and septal defects. Eur J Hum Genet (2014) 0.82

Overexpression of smooth muscle myosin heavy chain leads to activation of the unfolded protein response and autophagic turnover of thick filament-associated proteins in vascular smooth muscle cells. J Biol Chem (2014) 0.82

Use of genetics for personalized management of heritable thoracic aortic disease: how do we get there? J Thorac Cardiovasc Surg (2014) 0.82

Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application. Cell Mol Life Sci (2014) 0.82

Pharmacologically Improved Contractility Protects Against Aortic Dissection in Mice With Disrupted Transforming Growth Factor-β Signaling Despite Compromised Extracellular Matrix Properties. Arterioscler Thromb Vasc Biol (2016) 0.82

Acute aortic dissections with pregnancy in women with ACTA2 mutations. Am J Med Genet A (2013) 0.81

PGE2 through the EP4 receptor controls smooth muscle gene expression patterns in the ductus arteriosus critical for remodeling at birth. Prostaglandins Other Lipid Mediat (2012) 0.81

The non-syndromic familial thoracic aortic aneurysms and dissections maps to 15q21 locus. BMC Med Genet (2010) 0.81

A balanced translocation truncates Neurotrimin in a family with intracranial and thoracic aortic aneurysm. J Med Genet (2012) 0.81

Novel SMAD3 Mutation in a Patient with Hypoplastic Left Heart Syndrome with Significant Aortic Aneurysm. Case Rep Genet (2014) 0.81

Myocardin: dominant driver of the smooth muscle cell contractile phenotype. Arterioscler Thromb Vasc Biol (2008) 0.80

Wide mutation spectrum and frequent variant Ala27Thr of FBN1 identified in a large cohort of Chinese patients with sporadic TAAD. Sci Rep (2015) 0.80

Further delineation of Loeys-Dietz syndrome type 4 in a family with mild vascular involvement and a TGFB2 splicing mutation. BMC Med Genet (2014) 0.80

Impact of Mendelian inheritance in cardiovascular disease. Ann N Y Acad Sci (2010) 0.80

Rapid detection of gene mutations responsible for non-syndromic aortic aneurysm and dissection using two different methods: resequencing microarray technology and next-generation sequencing. Hum Genet (2011) 0.80

Structure of the Elastin-Contractile Units in the Thoracic Aorta and How Genes That Cause Thoracic Aortic Aneurysms and Dissections Disrupt This Structure. Can J Cardiol (2015) 0.79

Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background. J Cardiovasc Dev Dis (2015) 0.79

Cyclooxygenase-2 inhibition attenuates abdominal aortic aneurysm progression in hyperlipidemic mice. PLoS One (2012) 0.79

The role of mechanotransduction on vascular smooth muscle myocytes' [corrected] cytoskeleton and contractile function. Anat Rec (Hoboken) (2014) 0.79

Effects of prenatal tobacco exposure on gene expression profiling in umbilical cord tissue. Pediatr Res (2008) 0.78

Genomic research to identify novel pathways in the development of abdominal aortic aneurysm. Cardiol Res Pract (2012) 0.78

Articles by these authors

Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science (2006) 24.54

Effector memory T cells, early metastasis, and survival in colorectal cancer. N Engl J Med (2005) 12.64

Quantifying the evolutionary dynamics of language. Nature (2007) 6.12

Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J Clin Oncol (2011) 5.63

Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer. Cancer Res (2011) 5.30

Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. J Am Coll Cardiol (2003) 4.91

Antibody-mediated vascular rejection of kidney allografts: a population-based study. Lancet (2012) 4.85

Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes. Nat Genet (2011) 4.81

SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs. Nat Protoc (2008) 4.60

Clinical presentation and penetrance of pheochromocytoma/paraganglioma syndromes. J Clin Endocrinol Metab (2005) 4.07

In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer. J Clin Oncol (2009) 3.97

Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity (2013) 3.50

Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseases. Physiol Rev (2005) 3.46

Effect of celiprolol on prevention of cardiovascular events in vascular Ehlers-Danlos syndrome: a prospective randomised, open, blinded-endpoints trial. Lancet (2010) 3.36

Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis. J Am Coll Cardiol (2008) 3.24

Genetic testing in pheochromocytoma or functional paraganglioma. J Clin Oncol (2005) 3.20

SDHA is a tumor suppressor gene causing paraganglioma. Hum Mol Genet (2010) 3.07

Genotype-phenotype analysis in 2,405 patients with a dystrophinopathy using the UMD-DMD database: a model of nationwide knowledgebase. Hum Mutat (2009) 2.93

Evolutionary paths to antibiotic resistance under dynamically sustained drug selection. Nat Genet (2011) 2.86

Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension. Nat Genet (2013) 2.83

In newly diagnosed diffuse large B-cell lymphoma, determination of bone marrow involvement with 18F-FDG PET/CT provides better diagnostic performance and prognostic stratification than does biopsy. J Nucl Med (2013) 2.65

PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor. J Clin Invest (2012) 2.61

Prognostic value of tumor-infiltrating CD4+ T-cell subpopulations in head and neck cancers. Clin Cancer Res (2006) 2.56

Bone morphogenetic protein-9 is a circulating vascular quiescence factor. Circ Res (2008) 2.43

PD-1-expressing tumor-infiltrating T cells are a favorable prognostic biomarker in HPV-associated head and neck cancer. Cancer Res (2012) 2.43

Coordination of intratumoral immune reaction and human colorectal cancer recurrence. Cancer Res (2009) 2.37

Transplantation of cardiac-committed mouse embryonic stem cells to infarcted sheep myocardium: a preclinical study. Lancet (2005) 2.36

Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism. Hypertension (2012) 2.31

Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma. Am J Pathol (2003) 2.30

Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas. Cancer Res (2003) 2.29

European consensus on the diagnosis and management of fibromuscular dysplasia. J Hypertens (2014) 2.28

Intimal sarcoma is the most frequent primary cardiac sarcoma: clinicopathologic and molecular retrospective analysis of 100 primary cardiac sarcomas. Am J Surg Pathol (2014) 2.23

The succinate dehydrogenase genetic testing in a large prospective series of patients with paragangliomas. J Clin Endocrinol Metab (2009) 2.22

Focal segmental glomerulosclerosis plays a major role in the progression of IgA nephropathy. II. Light microscopic and clinical studies. Kidney Int (2010) 2.22

Fasting plasma glucose and serum lipids in patients with primary aldosteronism: a controlled cross-sectional study. Hypertension (2009) 2.20

Cardiac stem cells in the real world. J Thorac Cardiovasc Surg (2008) 2.19

Fibromuscular dysplasia. Orphanet J Rare Dis (2007) 2.18

Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration. Intensive Care Med (2010) 2.15

The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles. Cardiovasc Res (2012) 2.08

Tracheal regeneration: evidence of bone marrow mesenchymal stem cell involvement. J Thorac Cardiovasc Surg (2012) 2.07

Can erythropoietin improve skeletal myoblast engraftment in infarcted myocardium? Interact Cardiovasc Thorac Surg (2007) 2.07

A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. J Clin Invest (2010) 2.06

Succinate dehydrogenase B gene mutations predict survival in patients with malignant pheochromocytomas or paragangliomas. J Clin Endocrinol Metab (2007) 2.06

Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer. Gastroenterology (2009) 2.01

Change in salt intake affects blood pressure of chimpanzees: implications for human populations. Circulation (2007) 1.99

Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice. Mol Med (2003) 1.95

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron. Nat Genet (2012) 1.93

High sirolimus levels may induce focal segmental glomerulosclerosis de novo. Clin J Am Soc Nephrol (2007) 1.90

Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase. Hypertension (2011) 1.89

Functional consequences of a SDHB gene mutation in an apparently sporadic pheochromocytoma. J Clin Endocrinol Metab (2002) 1.84

High prevalence of anal human papillomavirus infection and anal cancer precursors among HIV-infected persons in the absence of anal intercourse. Ann Intern Med (2003) 1.80

Parietal podocytes in normal human glomeruli. J Am Soc Nephrol (2006) 1.79

Comparison of human skeletal myoblasts and bone marrow-derived CD133+ progenitors for the repair of infarcted myocardium. J Am Coll Cardiol (2004) 1.79

Thrombotic microangiopathy secondary to VEGF pathway inhibition by sunitinib. Nephrol Dial Transplant (2008) 1.76

Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform. Mol Cell Biol (2003) 1.76

The Warburg effect is genetically determined in inherited pheochromocytomas. PLoS One (2009) 1.75

Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway. J Pathol (2009) 1.74

Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans. Hum Mol Genet (2005) 1.74

Angiotensinogen and its cleaved derivatives inhibit angiogenesis. Hypertension (2002) 1.72

Inflammation and hypertension: the interplay of interleukin-6, dietary sodium, and the renin-angiotensin system in humans. Am J Hypertens (2011) 1.72

Beta-2 adrenergic receptor diplotype defines a subset of salt-sensitive hypertension. Hypertension (2006) 1.72

Pathology of pulmonary antibody-mediated rejection: 2012 update from the Pathology Council of the ISHLT. J Heart Lung Transplant (2013) 1.71

Chronic hemodynamic overload of the atria is an important factor for gap junction remodeling in human and rat hearts. Cardiovasc Res (2006) 1.71

Functionality of two new polymorphisms in the human renin gene enhancer region. J Hypertens (2002) 1.65

A CD31-derived peptide prevents angiotensin II-induced atherosclerosis progression and aneurysm formation. Cardiovasc Res (2012) 1.63

Involvement of the mural thrombus as a site of protease release and activation in human aortic aneurysms. Am J Pathol (2002) 1.63

Association between 2 angiographic subtypes of renal artery fibromuscular dysplasia and clinical characteristics. Circulation (2012) 1.61

Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels. Nat Commun (2013) 1.60

Evidence for carotid and radial artery wall subclinical lesions in renal fibromuscular dysplasia. J Hypertens (2003) 1.59

Cloacal exstrophy in an infant with 9q34.1-qter deletion resulting from a de novo unbalanced translocation between chromosome 9q and Yq. Am J Med Genet A (2004) 1.59

Baseline metabolic tumour volume is an independent prognostic factor in Hodgkin lymphoma. Eur J Nucl Med Mol Imaging (2014) 1.58

Radiolabeled fucoidan as a p-selectin targeting agent for in vivo imaging of platelet-rich thrombus and endothelial activation. J Nucl Med (2011) 1.58

Spectrum of mutations in Gitelman syndrome. J Am Soc Nephrol (2011) 1.57

Atrial dyssynchrony syndrome: an overlooked phenomenon and a potential cause of 'diastolic' heart failure. Eur J Heart Fail (2012) 1.55

Tracheal replacement with cryopreserved, decellularized, or glutaraldehyde-treated aortic allografts. Ann Thorac Surg (2009) 1.55

Focal segmental glomerulosclerosis plays a major role in the progression of IgA nephropathy. I. Immunohistochemical studies. Kidney Int (2010) 1.54

M1 macrophages act as LTβR-independent lymphoid tissue inducer cells during atherosclerosis-related lymphoid neogenesis. Cardiovasc Res (2013) 1.54

Evidence of leaflet injury during percutaneous aortic valve deployment. Eur J Cardiothorac Surg (2010) 1.52

(99m)Tc-annexin V and (111)In-antimyosin antibody uptake in experimental myocardial infarction in rats. Eur J Nucl Med Mol Imaging (2005) 1.52

KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronism. Hypertension (2011) 1.51

Elevated blood pressure and heart rate in human renin receptor transgenic rats. Hypertension (2006) 1.51

A clinicopathologic study of thrombotic microangiopathy in IgA nephropathy. J Am Soc Nephrol (2011) 1.51

Mapping myocardial fiber orientation using echocardiography-based shear wave imaging. IEEE Trans Med Imaging (2011) 1.49

Quantitative assessment of arterial wall biomechanical properties using shear wave imaging. Ultrasound Med Biol (2010) 1.49

Gene polymorphisms and cytokine plasma levels as predictive factors of complications after cardiopulmonary bypass. J Thorac Cardiovasc Surg (2012) 1.47

Inhibition of maturation and function of dendritic cells by intravenous immunoglobulin. Blood (2002) 1.46

Carinal replacement with an aortic allograft. Ann Thorac Surg (2006) 1.46

Blood pressure loci identified with a gene-centric array. Am J Hum Genet (2011) 1.44

Prorenin contributes to angiotensin peptide formation in transgenic rats with rat prorenin expression targeted to the liver. Hypertension (2009) 1.44

B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction. Nat Med (2013) 1.43

Angiotensin II promotes thoracic aortic dissections and ruptures in Col3a1 haploinsufficient mice. Hypertension (2013) 1.43

Evaluation of matrix metalloproteinases in atherosclerosis using a novel noninvasive imaging approach. Arterioscler Thromb Vasc Biol (2008) 1.41

Expression of endothelins in human cardiogenesis. J Mol Med (Berl) (2002) 1.41