Published in J Neuropathol Exp Neurol on April 01, 2008
Alzheimer's disease as homeostatic responses to age-related myelin breakdown. Neurobiol Aging (2009) 2.14
Atrophy of the cholinergic Basal forebrain over the adult age range and in early stages of Alzheimer's disease. Biol Psychiatry (2011) 1.29
Cholinergic treatments with emphasis on m1 muscarinic agonists as potential disease-modifying agents for Alzheimer's disease. Neurotherapeutics (2008) 1.19
Parenchymal and vascular Abeta-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease. J Cell Mol Med (2008) 1.16
Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis. Acta Neuropathol (2009) 1.09
Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. Am J Pathol (2011) 1.07
Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders. CNS Neurol Disord Drug Targets (2010) 1.06
Age-related loss of calcium buffering and selective neuronal vulnerability in Alzheimer's disease. Acta Neuropathol (2011) 1.01
Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease. Brain (2015) 1.00
Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease. Neurobiol Aging (2012) 0.99
Cholinergic circuitry of the human nucleus basalis and its fate in Alzheimer's disease. J Comp Neurol (2013) 0.92
Where attention falls: Increased risk of falls from the converging impact of cortical cholinergic and midbrain dopamine loss on striatal function. Exp Neurol (2014) 0.91
Subregional basal forebrain atrophy in Alzheimer's disease: a multicenter study. J Alzheimers Dis (2014) 0.90
Brainstem: neglected locus in neurodegenerative diseases. Front Neurol (2011) 0.90
MRI-based volumetric measurement of the substantia innominata in amnestic MCI and mild AD. Neurobiol Aging (2009) 0.90
Synaptic ultrastructural alterations anticipate the development of neuroaxonal dystrophy in sympathetic ganglia of aged and diabetic mice. J Neuropathol Exp Neurol (2008) 0.89
The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimers Res Ther (2013) 0.88
Neuronal and axonal loss are selectively linked to fibrillar amyloid-{beta} within plaques of the aged primate cerebral cortex. Am J Pathol (2010) 0.87
Levels of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variants. Exp Gerontol (2011) 0.87
Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer's Disease? Trends Neurosci (2016) 0.87
Cholinergic basal forebrain atrophy predicts amyloid burden in Alzheimer's disease. Neurobiol Aging (2013) 0.86
Early endosomal abnormalities and cholinergic neuron degeneration in amyloid-β protein precursor transgenic mice. J Alzheimers Dis (2013) 0.82
A novel approach for integrative studies on neurodegenerative diseases in human brains. J Neurosci Methods (2014) 0.81
Cognitive Correlates of Basal Forebrain Atrophy and Associated Cortical Hypometabolism in Mild Cognitive Impairment. Cereb Cortex (2015) 0.80
Neural restrictive silencer factor and choline acetyltransferase expression in cerebral tissue of Alzheimer's Disease patients: A pilot study. Genet Mol Biol (2013) 0.79
Turning on the Light Within: Subcortical Nuclei of the Isodentritic Core and their Role in Alzheimer's Disease Pathogenesis. J Alzheimers Dis (2015) 0.79
Biochemical differentiation of cholinesterases from normal and Alzheimer's disease cortex. Curr Alzheimer Res (2012) 0.78
Alterations of Ca²⁺-responsive proteins within cholinergic neurons in aging and Alzheimer's disease. Neurobiol Aging (2013) 0.78
Lynx1 supports neuronal health in the mouse dorsal striatum during aging: an ultrastructural investigation. J Mol Neurosci (2014) 0.76
Loss of calbindin-D28K is associated with the full range of tangle pathology within basal forebrain cholinergic neurons in Alzheimer's disease. Neurobiol Aging (2015) 0.76
S100b counteracts neurodegeneration of rat cholinergic neurons in brain slices after oxygen-glucose deprivation. Cardiovasc Psychiatry Neurol (2010) 0.76
Polymorphisms of CHAT but not TFAM or VR22 are Associated with Alzheimer Disease Risk. Med Sci Monit (2016) 0.75
Targeting β-secretase with RNAi in neural stem cells for Alzheimer's disease therapy. Neural Regen Res (2013) 0.75
BACE1 activity impairs neuronal glucose oxidation: rescue by beta-hydroxybutyrate and lipoic acid. Front Cell Neurosci (2015) 0.75
Regulatory role of microRNA-30b and plasminogen activator inhibitor-1 in the pathogenesis of cognitive impairment. Exp Ther Med (2016) 0.75
The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep (2017) 0.75
Cerebrospinal fluid levels of Aβ42 relationship with cholinergic cortical activity in Alzheimer's disease patients. J Neural Transm (Vienna) (2012) 0.75
Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (1991) 49.03
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology (1991) 23.01
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A (1998) 16.04
Diagnosis of Alzheimer's disease. Arch Neurol (1985) 12.77
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science (1984) 6.86
The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. Cereb Cortex (1992) 5.57
Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease. Neurology (1992) 4.52
Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J Neurosci (1999) 3.92
Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann Neurol (2002) 3.84
Cholinergic markers in elderly patients with early signs of Alzheimer disease. JAMA (1999) 3.22
Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons. J Cell Biol (2002) 2.39
Neurotransmitter-related enzymes in senile dementia of the Alzheimer type. Brain Res (1979) 2.04
Basal forebrain lesions in monkeys disrupt attention but not learning and memory. J Neurosci (1994) 2.00
Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue. J Neurol Sci (1977) 1.83
Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum. Ann Neurol (2004) 1.81
A post-mortem study of the cholinergic and GABA systems in senile dementia. Brain (1982) 1.62
Neuronal loss in different parts of the nucleus basalis is related to neuritic plaque formation in cortical target areas in Alzheimer's disease. Neuroscience (1985) 1.59
Visualization of detailed acetylcholinesterase fiber and neuron staining in rat brain by a sensitive histochemical procedure. J Histochem Cytochem (1986) 1.58
Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: observations based on the distribution of acetylcholinesterase and choline acetyltransferase. J Comp Neurol (1988) 1.54
Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits. J Neurochem (1995) 1.41
Biochemical assessment of serotonergic and cholinergic dysfunction and cerebral atrophy in Alzheimer's disease. J Neurochem (1983) 1.28
Rivastigmine and donepezil treatment in moderate to moderately-severe Alzheimer's disease over a 2-year period. Curr Med Res Opin (2005) 1.26
Loss of calbindin-D28k from aging human cholinergic basal forebrain: relation to neuronal loss. J Comp Neurol (2003) 1.25
Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease. J Comp Neurol (1999) 1.25
Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease. J Comp Neurol (2000) 1.24
Systematic regional variations in the loss of cortical cholinergic fibers in Alzheimer's disease. Cereb Cortex (1996) 1.22
Choline acetyltransferase activity and histopathology of frontal neocortex from biopsies of demented patients. J Neurol Sci (1982) 1.21
Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease. J Comp Neurol (2002) 1.19
Heterogeneity and selectivity of the degeneration of cholinergic neurons in the basal forebrain of patients with Alzheimer's disease. J Comp Neurol (1993) 1.18
Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration. J Neurosci (1990) 1.17
Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert. Acta Neuropathol (2000) 1.14
Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: a quantitative analysis across subregions of the basal forebrain. Exp Neurol (1989) 1.13
Attentional functions of the forebrain cholinergic systems: effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task. Exp Brain Res (1992) 1.10
Cortical cholinergic fibers in aging and Alzheimer's disease: a morphometric study. Neuroscience (1989) 1.10
Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: correlation with Alzheimer's neuropathology. J Alzheimers Dis (2003) 1.07
Learning impairments following injection of a selective cholinergic immunotoxin, ME20.4 IgG-saporin, into the basal nucleus of Meynert in monkeys. Neuroscience (1997) 1.04
A clinical overview of cholinesterase inhibitors in Alzheimer's disease. Int Psychogeriatr (2002) 1.04
Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group. Ann Neurol (1992) 1.00
Differential cholinergic innervation within functional subdivisions of the human cerebral cortex: a choline acetyltransferase study. J Comp Neurol (1992) 0.99
Selective age-related loss of calbindin-D28k from basal forebrain cholinergic neurons in the common marmoset (Callithrix jacchus). Neuroscience (2003) 0.96
Selective immunolesioning of the basal forebrain cholinergic system disrupts short-term memory in rats. Eur J Neurosci (1996) 0.94
The demonstration of cholinesterases by the formation of osmium blacks at the sites of Hatchett's brown. Histochemie (1973) 0.93
Comparative distribution of tau phosphorylated at Ser262 in pre-tangles and tangles. Neurobiol Aging (2003) 0.91
Neurochemical activities in human temporal lobe related to aging and Alzheimer-type changes. Neurobiol Aging (1981) 0.89
Age-related loss of calbindin from human basal forebrain cholinergic neurons. Neuroreport (1997) 0.88
Overlap between acetylcholinesterase-rich and choline acetyltransferase-positive (cholinergic) axons in human cerebral cortex. Brain Res (1992) 0.88
Highly selective effects of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 on intact and injured basal forebrain magnocellular neurons. J Comp Neurol (1994) 0.86
Relationship between plaques, tangles, and loss of cortical cholinergic fibers in Alzheimer disease. J Neuropathol Exp Neurol (1998) 0.85
Loss of calbindin-D28K from aging human cholinergic basal forebrain: relation to plaques and tangles. J Neuropathol Exp Neurol (2003) 0.85
Long-term neuropathological and neurochemical effects of nucleus basalis lesions in the rat. Science (1987) 0.80
Memantine in patients with frontotemporal lobar degeneration: a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol (2013) 1.84
Loss of calbindin-D28k from aging human cholinergic basal forebrain: relation to neuronal loss. J Comp Neurol (2003) 1.25
Clinician assessment of the driving competence of patients with dementia. J Am Geriatr Soc (2005) 1.09
Age-related changes in calbindin-D28k, calretinin, and parvalbumin-immunoreactive neurons in the human cerebral cortex. Exp Neurol (2003) 1.07
Quantitative analysis of somatic mitochondrial DNA mutations by single-cell single-molecule PCR. Methods Mol Biol (2009) 1.07
Age-related loss of calcium buffering and selective neuronal vulnerability in Alzheimer's disease. Acta Neuropathol (2011) 1.01
Amyloid-beta deposits in the cerebral cortex of the aged common marmoset (Callithrix jacchus): incidence and chemical composition. Acta Neuropathol (2002) 1.00
Distribution, progression and chemical composition of cortical amyloid-beta deposits in aged rhesus monkeys: similarities to the human. Acta Neuropathol (2002) 0.96
Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A (2012) 0.95
Presence of Chapman reflex points in hospitalized patients with pneumonia. J Am Osteopath Assoc (2003) 0.92
Butyrylcholinesterase activity in the rat forebrain and upper brainstem: postnatal development and adult distribution. Exp Neurol (2006) 0.87
Loss of calbindin-D28K from aging human cholinergic basal forebrain: relation to plaques and tangles. J Neuropathol Exp Neurol (2003) 0.85
Mitochondrial DNA deletions in mice in men: substantia nigra is much less affected in the mouse. Biochim Biophys Acta (2010) 0.81
Collection of isolated cells for studying mitochondrial DNA mutations within individual cells. Methods Mol Biol (2009) 0.79
Are somatic mitochondrial DNA mutations relevant to our health? A challenge for mutation analysis techniques. Expert Opin Med Diagn (2007) 0.79
Pharmacotherapy of dementia with Lewy bodies. Expert Opin Pharmacother (2003) 0.76