Published in Science on September 14, 1984
Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease. Neurology (1997) 8.50
Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron (2009) 7.02
Propagation of tau pathology in a model of early Alzheimer's disease. Neuron (2012) 6.23
The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals. Cereb Cortex (2008) 5.36
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease. Proc Natl Acad Sci U S A (1985) 4.97
Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia. Ann Neurol (2008) 3.99
Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease. Neurology (1998) 3.90
Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD. Eur J Nucl Med Mol Imaging (2005) 3.32
Neuropathological alterations in Alzheimer disease. Cold Spring Harb Perspect Med (2011) 3.28
Detection of prodromal Alzheimer's disease via pattern classification of magnetic resonance imaging. Neurobiol Aging (2006) 3.26
Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Med (2010) 2.77
Modes and models of forebrain cholinergic neuromodulation of cognition. Neuropsychopharmacology (2010) 2.74
High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment. Neuroimage (2010) 2.62
Putting names to faces: successful encoding of associative memories activates the anterior hippocampal formation. Neuroimage (2003) 2.55
Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy. Am J Pathol (2006) 2.47
Genetic variability in the regulation of gene expression in ten regions of the human brain. Nat Neurosci (2014) 2.23
Regional white matter volume differences in nondemented aging and Alzheimer's disease. Neuroimage (2008) 2.23
Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease. EMBO J (1987) 2.16
Relationships between hippocampal atrophy, white matter disruption, and gray matter hypometabolism in Alzheimer's disease. J Neurosci (2008) 2.15
Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set. Physiol Genomics (2008) 2.11
Differential effects of aging and Alzheimer's disease on medial temporal lobe cortical thickness and surface area. Neurobiol Aging (2007) 2.09
Neurofibrillary changes confined to the entorhinal region and an abundance of cortical amyloid in cases of presenile and senile dementia. Acta Neuropathol (1990) 2.05
Detection of entorhinal layer II using 7Tesla [corrected] magnetic resonance imaging. Ann Neurol (2005) 2.02
White matter pathology isolates the hippocampal formation in Alzheimer's disease. Neurobiol Aging (2010) 2.01
Cognitive and neurobiologic markers of early Alzheimer disease. Proc Natl Acad Sci U S A (1996) 2.01
Selective neuronal vulnerability to oxidative stress in the brain. Front Aging Neurosci (2010) 1.96
Multidimensional classification of hippocampal shape features discriminates Alzheimer's disease and mild cognitive impairment from normal aging. Neuroimage (2009) 1.95
Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease. Neuroimage (2009) 1.92
Neuropsychological and neuroimaging changes in preclinical Alzheimer's disease. J Int Neuropsychol Soc (2006) 1.90
Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. Physiol Genomics (2006) 1.88
Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis. Proc Natl Acad Sci U S A (2003) 1.86
Familial risk for Alzheimer's disease alters fMRI activation patterns. Brain (2006) 1.86
Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease. Ann Neurol (1998) 1.86
Neural correlates of Alzheimer's disease and mild cognitive impairment: a systematic and quantitative meta-analysis involving 1351 patients. Neuroimage (2009) 1.85
Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriers. Neuroimage (2008) 1.83
Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: insights from functional MRI studies. Neuropsychologia (2007) 1.81
Profile of executive and memory function associated with amphetamine and opiate dependence. Neuropsychopharmacology (2006) 1.81
Neuropsychological assessment of dementia. Annu Rev Psychol (2009) 1.76
Proteome-based plasma markers of brain amyloid-β deposition in non-demented older individuals. J Alzheimers Dis (2010) 1.73
Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease. Lancet Neurol (2010) 1.71
Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model. Am J Pathol (2007) 1.69
Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment. Arch Neurol (2011) 1.68
Cognitive and neuroimaging predictors of instrumental activities of daily living. J Int Neuropsychol Soc (2007) 1.66
Selective disruption of the cerebral neocortex in Alzheimer's disease. PLoS One (2010) 1.65
Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease. Ann N Y Acad Sci (2008) 1.64
Alzheimer disease. Dis Mon (2010) 1.64
Hippocampal disconnection contributes to memory dysfunction in individuals at risk for Alzheimer's disease. Proc Natl Acad Sci U S A (2006) 1.63
Cholinergic system during the progression of Alzheimer's disease: therapeutic implications. Expert Rev Neurother (2008) 1.63
Diffusion tensor imaging in Alzheimer's disease and mild cognitive impairment. Behav Neurol (2009) 1.63
The intersection of amyloid beta and tau at synapses in Alzheimer's disease. Neuron (2014) 1.59
Partial volume effect-corrected FDG PET and grey matter volume loss in patients with mild Alzheimer's disease. Eur J Nucl Med Mol Imaging (2007) 1.58
Effects of injected Alzheimer beta-amyloid cores in rat brain. Proc Natl Acad Sci U S A (1991) 1.58
Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2012) 1.58
Vulnerable neural systems and the borderland of brain aging and neurodegeneration. Neuron (2013) 1.54
Memory performance is related to amyloid and tau pathology in the hippocampus. J Neurol Neurosurg Psychiatry (2009) 1.52
Mechanisms of protein seeding in neurodegenerative diseases. JAMA Neurol (2013) 1.51
Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression. Biol Psychiatry (2010) 1.49
Olfactory impairment in presymptomatic Alzheimer's disease. Ann N Y Acad Sci (2009) 1.49
Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease. Proc Natl Acad Sci U S A (1988) 1.43
Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories. Cell (2017) 1.40
Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. J Neuropathol Exp Neurol (2009) 1.39
Memory disorders in probable Alzheimer's disease: the role of hippocampal atrophy as shown with MRI. J Neurol Neurosurg Psychiatry (1995) 1.38
Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis of a transgenic mouse model. Proc Natl Acad Sci U S A (2003) 1.37
Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys. Proc Natl Acad Sci U S A (1996) 1.37
Loss of perforated synapses in the dentate gyrus: morphological substrate of memory deficit in aged rats. Proc Natl Acad Sci U S A (1986) 1.35
Predicting the location of entorhinal cortex from MRI. Neuroimage (2009) 1.35
Serotonin 1A receptors in the living brain of Alzheimer's disease patients. Proc Natl Acad Sci U S A (2006) 1.34
Automated hippocampal shape analysis predicts the onset of dementia in mild cognitive impairment. Neuroimage (2011) 1.34
Target identification for CNS diseases by transcriptional profiling. Neuropsychopharmacology (2008) 1.32
Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease. Neurobiol Dis (2011) 1.31
Imaging the progression of Alzheimer pathology through the brain. Proc Natl Acad Sci U S A (2002) 1.30
Laminar distribution of neocortical senile plaques in senile dementia of the Alzheimer type. Acta Neuropathol (1986) 1.29
Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imaging. J Alzheimers Dis (2010) 1.28
GABA(B) receptor activation inhibits neuronal excitability and spatial learning in the entorhinal cortex by activating TREK-2 K+ channels. Neuron (2009) 1.27
Clinically concordant variations of Alzheimer pathology in aphasic versus amnestic dementia. Brain (2012) 1.26
Impaired medial temporal repetition suppression is related to failure of parietal deactivation in Alzheimer disease. Am J Geriatr Psychiatry (2008) 1.24
The ageing brain: normal and abnormal memory. Philos Trans R Soc Lond B Biol Sci (1997) 1.24
Selective frontoinsular von Economo neuron and fork cell loss in early behavioral variant frontotemporal dementia. Cereb Cortex (2011) 1.24
Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid. Am J Pathol (1992) 1.23
Cell loss in the hippocampus of schizophrenics. Eur Arch Psychiatry Neurol Sci (1986) 1.23
Rate of entorhinal and hippocampal atrophy in incipient and mild AD: relation to memory function. Neurobiol Aging (2008) 1.23
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. Nat Commun (2015) 1.23
Effects of age and caloric intake on glutathione redox state in different brain regions of C57BL/6 and DBA/2 mice. Brain Res (2006) 1.22
Single cell gene expression profiling in Alzheimer's disease. NeuroRx (2006) 1.22
A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model. Am J Pathol (2010) 1.22
Decline in verbal memory during preclinical Alzheimer's disease: examination of the effect of APOE genotype. J Int Neuropsychol Soc (2002) 1.21
Transgenic models of Alzheimer's disease: learning from animals. NeuroRx (2005) 1.21
Alterations in multiple measures of white matter integrity in normal women at high risk for Alzheimer's disease. Neuroimage (2010) 1.20
APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis. Brain Struct Funct (2009) 1.20
Mild cognitive impairment: pathology and mechanisms. Acta Neuropathol (2011) 1.20
Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles. Brain (2013) 1.20
Cholinergic neuronal and axonal abnormalities are present early in aging and in Alzheimer disease. J Neuropathol Exp Neurol (2008) 1.18
Medial temporal structures relate to memory impairment in Alzheimer's disease: an MRI volumetric study. J Neurol Neurosurg Psychiatry (1997) 1.17
Objective metamemory testing captures awareness of deficit in Alzheimer's disease. Cortex (2007) 1.17
Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive impairment that predict subsequent diagnosis of Alzheimer disease. AJNR Am J Neuroradiol (2008) 1.15
Synaptic characteristics of dentate gyrus axonal boutons and their relationships with aging, menopause, and memory in female rhesus monkeys. J Neurosci (2011) 1.15
SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon 4 allele. J Neurol Neurosurg Psychiatry (1996) 1.15
Tau in physiology and pathology. Nat Rev Neurosci (2015) 1.15
Prefrontal-hippocampal-fusiform activity during encoding predicts intraindividual differences in free recall ability: an event-related functional-anatomic MRI study. Hippocampus (2007) 1.14
Association of atrophy of the medial temporal lobe with reduced blood flow in the posterior parietotemporal cortex in patients with a clinical and pathological diagnosis of Alzheimer's disease. J Neurol Neurosurg Psychiatry (1992) 1.13
Insensitivity to future consequences following damage to human prefrontal cortex. Cognition (1994) 14.92
Deciding advantageously before knowing the advantageous strategy. Science (1997) 9.82
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology (1992) 9.30
Emotion, decision making and the orbitofrontal cortex. Cereb Cortex (2000) 8.25
Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nat Genet (1998) 7.26
Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J Neurosci (1996) 7.19
Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease. Ann Neurol (2000) 6.40
Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease. J Neuropathol Exp Neurol (1997) 6.12
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol (1997) 6.02
Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making. J Neurosci (1999) 5.78
The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. Cereb Cortex (1992) 5.57
The human amygdala in social judgment. Nature (1998) 5.03
A neural basis for lexical retrieval. Nature (1996) 4.69
MRI measures of entorhinal cortex vs hippocampus in preclinical AD. Neurology (2002) 4.67
Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease. Neurology (1992) 4.52
APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1. J Neuropathol Exp Neurol (1997) 4.29
Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology (2004) 4.00
Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron (1993) 3.92
Time-locked multiregional retroactivation: a systems-level proposal for the neural substrates of recall and recognition. Cognition (1989) 3.88
Severe disturbance of higher cognition after bilateral frontal lobe ablation: patient EVR. Neurology (1985) 3.88
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat Neurosci (1999) 3.85
Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science (1995) 3.82
Impairment of social and moral behavior related to early damage in human prefrontal cortex. Nat Neurosci (1999) 3.81
Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex. Cereb Cortex (1996) 3.73
Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy. Ann Neurol (1995) 3.60
Fear and the human amygdala. J Neurosci (1995) 3.46
The return of Phineas Gage: clues about the brain from the skull of a famous patient. Science (1994) 3.40
Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease. N Engl J Med (1998) 3.23
Imaging amyloid deposition in Lewy body diseases. Neurology (2008) 3.09
Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J Neurosci (1997) 2.91
Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol (2000) 2.78
A role for somatosensory cortices in the visual recognition of emotion as revealed by three-dimensional lesion mapping. J Neurosci (2000) 2.75
Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med (2001) 2.75
Prefrontal cortex in humans and apes: a comparative study of area 10. Am J Phys Anthropol (2001) 2.71
Structure of ferric pseudobactin, a siderophore from a plant growth promoting Pseudomonas. Biochemistry (1981) 2.70
BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc Natl Acad Sci U S A (1997) 2.53
A neural basis for the retrieval of conceptual knowledge. Neuropsychologia (1997) 2.44
Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat Med (1996) 2.43
Recognition of facial emotion in nine individuals with bilateral amygdala damage. Neuropsychologia (1999) 2.42
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell (1995) 2.37
Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer's disease. Proc Natl Acad Sci U S A (1999) 2.36
Prosopagnosia: anatomic basis and behavioral mechanisms. Neurology (1982) 2.35
Perforant pathway changes and the memory impairment of Alzheimer's disease. Ann Neurol (1986) 2.33
Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J Neurosci (1993) 2.27
Hippocampal formation: anatomy and the patterns of pathology in Alzheimer's disease. Prog Brain Res (1990) 2.26
Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model. Ann Neurol (2000) 2.21
Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain. Neuroscience (2006) 2.19
The anatomic basis of pure alexia. Neurology (1983) 2.15
Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy. J Neurosci (2001) 2.12
Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends Neurosci (1993) 2.09
Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J Neurochem (2007) 2.09
Efferent connections of the cingulate gyrus in the rhesus monkey. Exp Brain Res (1981) 2.04
Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. J Biol Chem (2000) 2.00
Autosomal dominant dementia with widespread neurofibrillary tangles. Ann Neurol (1997) 1.98
A role for left temporal pole in the retrieval of words for unique entities. Hum Brain Mapp (2001) 1.96
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol (2001) 1.96
A neurological model for childhood autism. Arch Neurol (1978) 1.93
Treatment of congenital lactic acidosis with dichloroacetate. Arch Dis Child (1997) 1.92
Cortical systems for the recognition of emotion in facial expressions. J Neurosci (1996) 1.92
The Iowa Gambling Task and the somatic marker hypothesis: some questions and answers. Trends Cogn Sci (2005) 1.91
Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease. Neurology (1996) 1.89
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease. Proc Natl Acad Sci U S A (2002) 1.87
Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults. Neurology (2011) 1.83
Application of the National Institute on Aging (NIA)-Reagan Institute criteria for the neuropathological diagnosis of Alzheimer disease. J Neuropathol Exp Neurol (1999) 1.81
Hippocampal efferents reach widespread areas of cerebral cortex and amygdala in the rhesus monkey. Science (1977) 1.81
Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons. Neuroscience (2001) 1.80
The anatomical basis of conduction aphasia. Brain (1980) 1.78
Pathological laughter and crying: a link to the cerebellum. Brain (2001) 1.72
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nat Genet (1993) 1.72
Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations. J Biol Chem (2000) 1.72
H. M.'s medial temporal lobe lesion: findings from magnetic resonance imaging. J Neurosci (1997) 1.71
Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family. J Cereb Blood Flow Metab (1998) 1.71
Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity. J Neuropathol Exp Neurol (1998) 1.67
Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. Am J Pathol (2000) 1.66
Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease. Ann Neurol (1996) 1.66
Single-neuron responses to emotional visual stimuli recorded in human ventral prefrontal cortex. Nat Neurosci (2001) 1.65
The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A (2000) 1.65
Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. Arch Gen Psychiatry (1991) 1.64
Neural correlates of naming actions and of naming spatial relations. Neuroimage (2001) 1.62
Amyloid beta-peptide is transported on lipoproteins and albumin in human plasma. J Biol Chem (1996) 1.61
Gait disturbances in patients with autistic behavior: a preliminary study. Arch Neurol (1981) 1.61
Apolipoprotein E epsilon 4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy. Stroke (1996) 1.60
Memory-related neural systems in Alzheimer's disease: an anatomic study. Neurology (1990) 1.58
Preserved access and processing of social knowledge in a patient with acquired sociopathy due to ventromedial frontal damage. Neuropsychologia (1991) 1.57
Apolipoprotein E epsilon4 does not modulate amyloid-β-associated neurodegeneration in preclinical Alzheimer disease. AJNR Am J Neuroradiol (2012) 1.57
Association of apolipoprotein E epsilon2 and vasculopathy in cerebral amyloid angiopathy. Neurology (1998) 1.56
Nonhemorrhagic infarction of the thalamus: behavioral, anatomic, and physiologic correlates. Neurology (1984) 1.56
Behavioural manifestations of third ventricular colloid cysts. J Neurol Neurosurg Psychiatry (1984) 1.54
Notch1 inhibits neurite outgrowth in postmitotic primary neurons. Neuroscience (1999) 1.54
Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption. J Neuropathol Exp Neurol (2001) 1.53
Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. III. Efferent connections. Brain Res (1975) 1.53