Published in PPAR Res on January 01, 2008
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Candesartan, an angiotensin II AT₁-receptor blocker and PPAR-γ agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice. Neuropsychopharmacology (2012) 0.88
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Pilot study of oral administration of a curcumin-phospholipid formulation for treatment of central serous chorioretinopathy. Clin Ophthalmol (2012) 0.83
Pioglitazone normalizes insulin signaling in the diabetic rat retina through reduction in tumor necrosis factor α and suppressor of cytokine signaling 3. J Biol Chem (2014) 0.82
Peroxisome proliferator activating receptor (PPAR) in cerebral malaria (CM): a novel target for an additional therapy. Eur J Clin Microbiol Infect Dis (2010) 0.81
Management of chronic anterior uveitis relapses: efficacy of oral phospholipidic curcumin treatment. Long-term follow-up. Clin Ophthalmol (2010) 0.81
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Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma. J Neurosci (2006) 2.37
Evidence for a potent antiinflammatory effect of rosiglitazone. J Clin Endocrinol Metab (2004) 2.36
Glial reactivity, an early feature of diabetic retinopathy. Invest Ophthalmol Vis Sci (2000) 2.34
PPARgamma ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis. J Clin Invest (2002) 2.31
Microglia activation in retinal degeneration. J Leukoc Biol (2007) 2.31
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The relationship of dietary lipid intake and age-related macular degeneration in a case-control study: AREDS Report No. 20. Arch Ophthalmol (2007) 2.12
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PPARs and molecular mechanisms of transrepression. Biochim Biophys Acta (2007) 2.10
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The potential angiogenic role of macrophages in the formation of choroidal neovascular membranes. Invest Ophthalmol Vis Sci (1999) 2.07
The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration. FASEB J (2004) 2.04
Increased levels of vascular endothelial growth factor and interleukin-6 in the aqueous humor of diabetics with macular edema. Am J Ophthalmol (2002) 2.01
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Tumor necrosis factor-alpha: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head. Glia (2000) 1.87
Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis. Ann Neurol (2002) 1.86
Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis. J Immunol (2002) 1.83
Macrophage differentiation to foam cells. Curr Pharm Des (2005) 1.77
Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis. Arterioscler Thromb Vasc Biol (2006) 1.74
Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model. Invest Ophthalmol Vis Sci (2007) 1.73
AGEs mediated expression and secretion of TNF alpha in rat retinal microglia. Exp Eye Res (2007) 1.65
Peroxisome proliferator-activated receptor alpha agonists as therapy for autoimmune disease. J Immunol (2004) 1.62
Blood-neural barrier: intercellular communication at glio-vascular interface. J Biochem Mol Biol (2006) 1.59
Nitric oxide: ocular blood flow, glaucoma, and diabetic retinopathy. Prog Retin Eye Res (2007) 1.58
Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation. J Leukoc Biol (2003) 1.57
Detection of early neuron degeneration and accompanying microglial responses in the retina of a rat model of glaucoma. Invest Ophthalmol Vis Sci (2002) 1.57
Neuronal and microglial response in the retina of streptozotocin-induced diabetic rats. Vis Neurosci (2000) 1.53
Ambulatory blood pressure reduction after rosiglitazone treatment in patients with type 2 diabetes and hypertension correlates with insulin sensitivity increase. J Hypertens (2004) 1.52
Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization. Exp Eye Res (2005) 1.50
Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-gamma. J Neuroimmunol (2001) 1.50
Inflammatory cytokines in vitreous fluid and serum of patients with diabetic vitreoretinopathy. J Diabetes Complications (2001) 1.49
Identification of sequential events and factors associated with microglial activation, migration, and cytotoxicity in retinal degeneration in rd mice. Invest Ophthalmol Vis Sci (2005) 1.48
Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation. Genes Immun (2002) 1.44
Role of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and its natural ligand 15-deoxy-Delta12, 14-prostaglandin J2 in the regulation of microglial functions. Eur J Neurosci (2000) 1.44
Distribution, markers, and functions of retinal microglia. Ocul Immunol Inflamm (2002) 1.42
Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors. Nat Clin Pract Endocrinol Metab (2007) 1.41
Monocyte chemotactic protein gene expression by cytokine-treated human retinal pigment epithelial cells. Lab Invest (1991) 1.39
Neuromyelitis optica: changing concepts. J Neuroimmunol (2007) 1.39
Peroxisome proliferator-activated receptor-gamma ligands inhibit choroidal neovascularization. Invest Ophthalmol Vis Sci (2000) 1.37
Microglia and macrophages are increased in response to ischemia-induced retinopathy in the mouse retina. Mol Vis (2006) 1.37
Cytokines in the vitreous of patients with proliferative diabetic retinopathy. Am J Ophthalmol (1992) 1.36
Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma. Glia (2007) 1.36
Gemfibrozil ameliorates relapsing-remitting experimental autoimmune encephalomyelitis independent of peroxisome proliferator-activated receptor-alpha. Mol Pharmacol (2007) 1.35
Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation. J Biol Chem (2005) 1.34
PPAR-gamma agonists as regulators of microglial activation and brain inflammation. Curr Pharm Des (2006) 1.33
PPARalpha activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation. Circ Res (2003) 1.33
Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia. J Neurosci Res (2005) 1.32
Bone marrow-derived progenitor cells contribute to experimental choroidal neovascularization. Invest Ophthalmol Vis Sci (2003) 1.32
Turnover of resident retinal microglia in the normal adult mouse. Glia (2007) 1.31
Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis. J Neuroimmunol (2005) 1.30
Protective effects of a peroxisome proliferator-activated receptor-beta/delta agonist in experimental autoimmune encephalomyelitis. J Neuroimmunol (2005) 1.29
Neuromyelitis optica is a variant of multiple sclerosis. Arch Neurol (2007) 1.24
Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization. Am J Pathol (2007) 1.23
Inflammation in diabetes mellitus: role of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma agonists. Am J Cardiol (2006) 1.23
Peroxisome proliferator-activated receptor-gamma agonists increase vascular endothelial growth factor expression in human vascular smooth muscle cells. Biochem Biophys Res Commun (2000) 1.22
Early response of neurons and glial cells to hypoxia in the retina. Invest Ophthalmol Vis Sci (2006) 1.19
Increased levels of acute-phase inflammatory proteins in plasma of patients with sporadic CJD. Neurology (2012) 1.49
Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures. J Neuroinflammation (2005) 1.36
PPAR-gamma agonists as regulators of microglial activation and brain inflammation. Curr Pharm Des (2006) 1.33
Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration. J Neuropathol Exp Neurol (2004) 1.20
Cyclo-oxygenase-1 and -2 differently contribute to prostaglandin E2 synthesis and lipid peroxidation after in vivo activation of N-methyl-D-aspartate receptors in rat hippocampus. J Neurochem (2005) 1.15
Muscarinic receptor subtypes as potential targets to modulate oligodendrocyte progenitor survival, proliferation, and differentiation. Dev Neurobiol (2012) 1.10
Nuclear receptor peroxisome proliferator-activated receptor-gamma is activated in rat microglial cells by the anti-inflammatory drug HCT1026, a derivative of flurbiprofen. J Neurochem (2005) 1.02
TGF-β and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression. J Neurochem (2010) 0.99
Role of neuroinflammation in hypertension-induced brain amyloid pathology. Neurobiol Aging (2010) 0.99
Apoptotic PC12 cells exposing phosphatidylserine promote the production of anti-inflammatory and neuroprotective molecules by microglial cells. J Neuropathol Exp Neurol (2003) 0.99
Microglial polarization and plasticity: evidence from organotypic hippocampal slice cultures. Glia (2013) 0.99
Minocycline in phenotypic models of Huntington's disease. Neurobiol Dis (2005) 0.98
Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice. Exp Gerontol (2006) 0.98
Taking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity. PLoS One (2011) 0.97
Paracetamol effectively reduces prostaglandin E2 synthesis in brain macrophages by inhibiting enzymatic activity of cyclooxygenase but not phospholipase and prostaglandin E synthase. J Neurosci Res (2003) 0.97
Expression of phosphatidylserine receptor and down-regulation of pro-inflammatory molecule production by its natural ligand in rat microglial cultures. J Neuropathol Exp Neurol (2002) 0.92
Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells. J Neurosci Res (2011) 0.92
Atypical antiinflammatory activation of microglia induced by apoptotic neurons: possible role of phosphatidylserine-phosphatidylserine receptor interaction. Mol Neurobiol (2004) 0.92
TNFalpha downregulates PPARdelta expression in oligodendrocyte progenitor cells: implications for demyelinating diseases. Glia (2003) 0.90
Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1. Aging Cell (2013) 0.90
Isoprostanes in clinically isolated syndrome and early multiple sclerosis as biomarkers of tissue damage and predictors of clinical course. Mult Scler (2012) 0.90
Lipid raft disruption protects mature neurons against amyloid oligomer toxicity. Biochim Biophys Acta (2010) 0.90
15-deoxy-delta12,14-prostaglandin J2 regulates the functional state and the survival of microglial cells through multiple molecular mechanisms. J Neurochem (2003) 0.87
Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists. PPAR Res (2008) 0.87
Amyloid oligomer neurotoxicity, calcium dysregulation, and lipid rafts. Int J Alzheimers Dis (2011) 0.87
Differential lipid peroxidation, Mn superoxide, and bcl-2 expression contribute to the maturation-dependent vulnerability of oligodendrocytes to oxidative stress. J Neuropathol Exp Neurol (2003) 0.86
Cognitive and neurological deficits induced by early and prolonged basal forebrain cholinergic hypofunction in rats. Exp Neurol (2004) 0.85
Neuroprotective effects of the mGlu5R antagonist MPEP towards quinolinic acid-induced striatal toxicity: involvement of pre- and post-synaptic mechanisms and lack of direct NMDA blocking activity. J Neurochem (2004) 0.85
Isoprostanes as biomarkers and mediators of oxidative injury in infant and adult central nervous system diseases. Curr Neurovasc Res (2004) 0.85
Modulation of PGE(2) and TNFalpha by nitric oxide and LPS-activated RAW 264.7 cells. Cytokine (2002) 0.84
Dynamic regulation of microglial functions by the non-steroidal anti-inflammatory drug NCX 2216: implications for chronic treatments of neurodegenerative diseases. Neurobiol Dis (2005) 0.84
Pro-gliogenic effect of IL-1alpha in the differentiation of embryonic neural precursor cells in vitro. J Neurochem (2010) 0.84
Branched-chain amino acids influence the immune properties of microglial cells and their responsiveness to pro-inflammatory signals. Biochim Biophys Acta (2013) 0.82
Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells. J Neuropathol Exp Neurol (2009) 0.82
Modulatory effects following subchronic stimulation of brain 5-HT7-R system in mice and rats. Rev Neurosci (2014) 0.81
Striatal 6-OHDA lesion in mice: Investigating early neurochemical changes underlying Parkinson's disease. Behav Brain Res (2009) 0.81
Early effects of high glucose in retinal tissue cultures Renin-Angiotensin system-dependent and -independent signaling. Neurobiol Dis (2009) 0.81
Microglia in development and disease. Clin Dev Immunol (2013) 0.80
Branched-chain amino acids induce neurotoxicity in rat cortical cultures. Neurotox Res (2009) 0.80
Cerebrospinal fluid isoprostanes are not related to inflammatory activity in relapsing-remitting multiple sclerosis. J Neurol Sci (2004) 0.80
The matrix metalloproteinase inhibitor marimastat promotes neural progenitor cell differentiation into neurons by gelatinase-independent TIMP-2-dependent mechanisms. Stem Cells Dev (2012) 0.80
Plasma levels of 15-F(2t)-isoprostane in newborn infants are affected by mode of delivery. Clin Biochem (2007) 0.80
Transplacental exposure to AZT induces adverse neurochemical and behavioral effects in a mouse model: protection by L-acetylcarnitine. PLoS One (2013) 0.80
Cytogenetic analysis of human cells reveals specific patterns of DNA damage in replicative and oncogene-induced senescence. Aging Cell (2012) 0.80
Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: no impact on survival of seizure-generated neurons. Neurobiol Dis (2006) 0.79
Altered expression of cyclooxygenase-2, presenilins and oxygen radical scavenging enzymes in a rat model of global perinatal asphyxia. Exp Neurol (2007) 0.78
Blockade of chloride intracellular ion channel 1 stimulates Abeta phagocytosis. J Neurosci Res (2008) 0.78
The nuclear receptor peroxisome proliferator-activated receptor-γ promotes oligodendrocyte differentiation through mechanisms involving mitochondria and oscillatory Ca2+ waves. Biol Chem (2013) 0.78
Increased brain levels of F2-isoprostane are an early marker of behavioral sequels in a rat model of global perinatal asphyxia. Pediatr Res (2003) 0.78
Modulation of the bystander effects induced by soluble factors in HaCaT cells by different exposure strategies. Radiat Res (2010) 0.78
Adenosine A2A receptor antagonism and neuroprotection: mechanisms, lights, and shadows. Crit Rev Neurobiol (2004) 0.78
Phosphorylation on threonine 11 of β-dystrobrevin alters its interaction with kinesin heavy chain. FEBS J (2012) 0.78
Peroxisome proliferator-activated receptor γ agonists accelerate oligodendrocyte maturation and influence mitochondrial functions and oscillatory Ca(2+) waves. J Neuropathol Exp Neurol (2011) 0.77
Greater resistance to inflammation at adulthood could contribute to extended life span of p66(Shc-/-) mice. Exp Gerontol (2010) 0.77
Peroxisomes and PPARs in cultured neural cells. Adv Exp Med Biol (2003) 0.77
Induction of apoptosis in rat retinal cell cultures by partially fluorinated alkanes. Am J Ophthalmol (2005) 0.76
Non steroidal anti-inflammatory drugs and neurogenesis in the adult mammalian brain. Curr Pharm Des (2008) 0.76
The stimulation of adenosine A2A receptors ameliorates the pathological phenotype of fibroblasts from Niemann-Pick type C patients. J Neurosci (2013) 0.75
Cyclooxygenases and cyclooxygenase inhibitors in neurological and psychiatric diseases. Curr Pharm Des (2008) 0.75