Published in PPAR Res on January 01, 2008
Induction of necrotic cell death by oxidative stress in retinal pigment epithelial cells. Cell Death Dis (2013) 0.98
Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration. Mol Endocrinol (2011) 0.91
Triamcinolone acetonide prevents oxidative stress-induced tight junction disruption of retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol (2009) 0.80
Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration. Cell Mol Life Sci (2014) 0.80
Reversal of the Caspase-Dependent Apoptotic Cytotoxicity Pathway by Taurine from Lycium barbarum (Goji Berry) in Human Retinal Pigment Epithelial Cells: Potential Benefit in Diabetic Retinopathy. Evid Based Complement Alternat Med (2012) 0.77
Lycium barbarum polysaccharides protected human retinal pigment epithelial cells against oxidative stress-induced apoptosis. Int J Ophthalmol (2015) 0.76
Expression of peroxisome proliferator-activated receptor γ in rat retina during development. Int J Ophthalmol (2015) 0.75
Cell death: critical control points. Cell (2004) 22.56
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature (2006) 15.69
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature (1998) 13.58
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature (1998) 10.09
Inducible cyclooxygenase may have anti-inflammatory properties. Nat Med (1999) 6.91
The role of apoptosis in age-related macular degeneration. Arch Ophthalmol (2002) 3.10
Oxidative damage and age-related macular degeneration. Mol Vis (1999) 2.97
The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci (2000) 2.92
Oxidative damage and protection of the RPE. Prog Retin Eye Res (2000) 2.65
Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2). Mol Cell Biol (2004) 2.25
Cyclopentenone prostaglandins: new insights on biological activities and cellular targets. Med Res Rev (2001) 2.09
Age-related macular degeneration. The lipofusion component N-retinyl-N-retinylidene ethanolamine detaches proapoptotic proteins from mitochondria and induces apoptosis in mammalian retinal pigment epithelial cells. J Biol Chem (2000) 1.84
Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2. Proc Natl Acad Sci U S A (1999) 1.74
Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage. Proc Natl Acad Sci U S A (2004) 1.64
Cyclopentenone prostaglandins as potential inducers of intracellular oxidative stress. J Biol Chem (2001) 1.63
Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death. Invest Ophthalmol Vis Sci (2006) 1.56
Age-related changes in human RPE cell density and apoptosis proportion in situ. Invest Ophthalmol Vis Sci (2002) 1.50
Role of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and its natural ligand 15-deoxy-Delta12, 14-prostaglandin J2 in the regulation of microglial functions. Eur J Neurosci (2000) 1.44
Inhibition of IkappaB kinase and IkappaB phosphorylation by 15-deoxy-Delta(12,14)-prostaglandin J(2) in activated murine macrophages. Mol Cell Biol (2000) 1.39
Evaluation of oxidative processes in human pigment epithelial cells associated with retinal outer segment phagocytosis. Exp Cell Res (1994) 1.34
Retinal pigment epithelium is protected against apoptosis by alphaB-crystallin. Invest Ophthalmol Vis Sci (2002) 1.30
15-deoxy-Delta 12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors. J Biol Chem (2001) 1.25
Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci (2007) 1.24
SOD2 protects against oxidation-induced apoptosis in mouse retinal pigment epithelium: implications for age-related macular degeneration. Invest Ophthalmol Vis Sci (2005) 1.22
Antioxidant enzymes in the aging human retinal pigment epithelium. Arch Ophthalmol (1991) 1.22
Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. BMC Ophthalmol (2003) 1.21
Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-Delta(12,14)(12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells. J Immunol (2000) 1.21
Phagocytosis and H2O2 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci (1995) 1.19
Biphasic effects of 15-deoxy-delta(12,14)-prostaglandin J(2) on glutathione induction and apoptosis in human endothelial cells. Arterioscler Thromb Vasc Biol (2001) 1.17
Role of heme oxygenase-1 protein in the neuroprotective effects of cyclopentenone prostaglandin derivatives under oxidative stress. Eur J Neurosci (2003) 1.12
Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands as bifunctional regulators of cell proliferation. Biochem Pharmacol (2003) 1.10
Pigment epithelium-derived factor inhibits oxidative stress-induced cell death by activation of extracellular signal-regulated kinases in cultured retinal pigment epithelial cells. Life Sci (2006) 1.10
Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells. Invest Ophthalmol Vis Sci (2003) 1.09
Photoreceptor phagocytosis selectively activates PPARgamma expression in retinal pigment epithelial cells. J Neurosci Res (2000) 1.09
Prostaglandin J2 alters pro-survival and pro-death gene expression patterns and 26 S proteasome assembly in human neuroblastoma cells. J Biol Chem (2006) 1.08
Cyclopentenone prostaglandins as potential inducers of phase II detoxification enzymes. 15-deoxy-delta(12,14)-prostaglandin j2-induced expression of glutathione S-transferases. J Biol Chem (2000) 1.08
Prostaglandin D(2), its metabolite 15-d-PGJ(2), and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells. Immunology (2002) 1.06
(R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage. Invest Ophthalmol Vis Sci (2005) 1.06
Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma. J Neurochem (2002) 1.06
Fluid shear stress induces lipocalin-type prostaglandin D(2) synthase expression in vascular endothelial cells. Circ Res (2000) 1.03
Cytoprotective effects of geranylgeranylacetone against retinal photooxidative damage. J Neurosci (2005) 1.03
Melatonin protects human retinal pigment epithelial (RPE) cells against oxidative stress. Exp Eye Res (2004) 1.02
Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU). J Immunol (2006) 1.00
Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells. Curr Eye Res (2007) 1.00
The complement system plays a critical role in the development of experimental autoimmune anterior uveitis. Invest Ophthalmol Vis Sci (2006) 1.00
Protection from oxidative stress by methionine sulfoxide reductases in RPE cells. Biochem Biophys Res Commun (2005) 1.00
15-deoxy-delta 12, 14-Prostaglandin J2 prevents reactive oxygen species generation and mitochondrial membrane depolarization induced by oxidative stress. BMC Pharmacol (2004) 0.99
Effects of photodegradation on the physical and antioxidant properties of melanosomes isolated from retinal pigment epithelium. Photochem Photobiol (2007) 0.96
Lens epithelium-derived growth factor: increased survival and decreased DNA breakage of human RPE cells induced by oxidative stress. Invest Ophthalmol Vis Sci (2001) 0.95
Protection of RPE cells from oxidative injury by 15-deoxy-delta12,14-prostaglandin J2 by augmenting GSH and activating MAPK. Invest Ophthalmol Vis Sci (2006) 0.94
Oxysterol-induced toxicity in R28 and ARPE-19 cells. Neurochem Res (2003) 0.93
Adenovirus-mediated delivery of catalase to retinal pigment epithelial cells protects neighboring photoreceptors from photo-oxidative stress. Hum Gene Ther (2004) 0.92
Microsomal glutathione S-transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging. Biochemistry (2005) 0.92
Enhanced expression of glutathione-S-transferase A1-1 protects against oxidative stress in human retinal pigment epithelial cells. Exp Eye Res (2005) 0.90
Metallothionein shows an age-related decrease in human macular retinal pigment epithelium. Invest Ophthalmol Vis Sci (1993) 0.90
Cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) acts as a general inhibitor of inflammatory responses in activated BV-2 microglial cells. Brain Res (2000) 0.89
Poly(ADP-ribose) polymerase offers protection against oxidative and alkylation damage to the nuclear and mitochondrial genomes of the retinal pigment epithelium. Ophthalmic Res (2007) 0.88
Protection against hydrogen peroxide-induced cell death in cultured human retinal pigment epithelial cells by 17beta-estradiol: a differential gene expression profile. Mech Ageing Dev (2005) 0.87
Induction of glutathione S-transferase hGST 5.8 is an early response to oxidative stress in RPE cells. Invest Ophthalmol Vis Sci (1999) 0.87
15-Deoxy-Delta12,14-prostaglandin J(2) protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis. J Biol Chem (2004) 0.87
Peroxisome proliferator-activated receptor agonists prevent 25-OH-cholesterol induced c-jun activation and cell death. BMC Pharmacol (2001) 0.85
KGF prevents oxygen-mediated damage in ARPE-19 cells. Invest Ophthalmol Vis Sci (2005) 0.85
Bcl-2 overexpression increases survival in human retinal pigment epithelial cells exposed to H(2)O(2). Exp Eye Res (2002) 0.84
N-tert-butyl hydroxylamine, a mitochondrial antioxidant, protects human retinal pigment epithelial cells from iron overload: relevance to macular degeneration. FASEB J (2007) 0.83
L-carnitine protects human retinal pigment epithelial cells from oxidative damage. Curr Eye Res (2007) 0.82
Toxicity of cholesterol oxides on cultured neuroretinal cells. Curr Eye Res (1998) 0.80
Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization. J Immunol (2005) 1.89
Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H. J Immunol (2006) 1.42
Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells. Nat Med (2003) 1.38
The role of complement system in ocular diseases including uveitis and macular degeneration. Mol Immunol (2007) 1.37
CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration. J Immunol (2007) 1.31
Immunotherapy for choroidal neovascularization in a laser-induced mouse model simulating exudative (wet) macular degeneration. Proc Natl Acad Sci U S A (2003) 1.17
The role of complement in ocular pathology. Semin Immunopathol (2008) 1.07
Recombinant membrane-targeted form of CD59 inhibits the growth of choroidal neovascular complex in mice. J Biol Chem (2010) 1.02
Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU). J Immunol (2006) 1.00
The complement system plays a critical role in the development of experimental autoimmune anterior uveitis. Invest Ophthalmol Vis Sci (2006) 1.00
Novel role for a complement regulatory protein (CD46) in retinal pigment epithelial adhesion. Invest Ophthalmol Vis Sci (2003) 0.99
Expression of adiponectin in choroidal tissue and inhibition of laser induced choroidal neovascularization by adiponectin. FEBS Lett (2007) 0.97
Relationship between complement membrane attack complex, chemokine (C-C motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularization. J Biol Chem (2011) 0.96
Role of ocular complement factor H in a murine model of choroidal neovascularization. Am J Pathol (2010) 0.95
Type I collagen is the autoantigen in experimental autoimmune anterior uveitis. J Immunol (2004) 0.93
Pathogenesis of age-related macular degeneration. Trends Mol Med (2004) 0.93
Tolerance to melanin-associated antigen in autoimmune uveitis is mediated by CD4+CD25+ T-regulatory cells. Am J Pathol (2008) 0.90
Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization. FEBS J (2006) 0.87
Polyethylene glycol (PEG)-induced mouse model of choroidal neovascularization. J Biol Chem (2011) 0.85
Alcohol and nicotine consumption exacerbates choroidal neovascularization by modulating the regulation of complement system. FEBS Lett (2008) 0.84
PAX6 increases glioma cell susceptibility to detachment and oxidative stress. J Neurooncol (2007) 0.84
Inhibition of new vessel growth in mouse model of laser-induced choroidal neovascularization by adiponectin peptide II. Cell Biol Int (2009) 0.83
Inhibitory role of adiponectin peptide I on rat choroidal neovascularization. Biochim Biophys Acta (2012) 0.83
Inhibition of complement alternative pathway suppresses experimental autoimmune anterior uveitis by modulating T cell responses. J Biol Chem (2011) 0.81
Crucial role of apoptosis in the resolution of experimental autoimmune anterior uveitis. Invest Ophthalmol Vis Sci (2007) 0.81
Suppression of complement activation by recombinant Crry inhibits experimental autoimmune anterior uveitis (EAAU). Mol Immunol (2010) 0.81
Complement system and the eye. Adv Exp Med Biol (2006) 0.81
Proteolytic cleavage of type I collagen generates an autoantigen in autoimmune uveitis. J Biol Chem (2009) 0.80
Antigen-specific tolerance inhibits autoimmune uveitis in pre-sensitized animals by deletion and CD4+CD25+ T-regulatory cells. Immunol Cell Biol (2009) 0.80
The ethanol metabolite, linolenic acid ethyl ester, stimulates mitogen-activated protein kinase and cyclin signaling in hepatic stellate cells. Life Sci (2003) 0.79
Complement, innate immunity and ocular disease. Chem Immunol Allergy (2007) 0.78
The use of topical honey in the treatment of corneal abrasions and endotoxin-induced keratitis in an animal model. Curr Eye Res (2011) 0.77
Anti-inflammatory effects of specific cyclooxygenase 2,5-lipoxygenase, and inducible nitric oxide synthase inhibitors on experimental autoimmune anterior uveitis (EAAU). Ocul Immunol Inflamm (2005) 0.75
The effect of nicotine on anti-vascular endothelial growth factor therapy in a mouse model of neovascular age-related macular degeneration. Retina (2012) 0.75
Molecular characterization of human eye and heart fatty acid ethyl ester synthase/carboxylesterase by site-directed mutagenesis. Biochem Biophys Res Commun (2003) 0.75