Published in J Biol Chem on August 24, 2010
Progress and Trends in Complement Therapeutics. Adv Exp Med Biol (2013) 1.20
The role of the immune response in age-related macular degeneration. Int J Inflam (2013) 1.16
The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning. Am J Pathol (2014) 1.12
A non membrane-targeted human soluble CD59 attenuates choroidal neovascularization in a model of age related macular degeneration. PLoS One (2011) 1.09
The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization. Mol Immunol (2011) 0.98
Systemic human CR2-targeted complement alternative pathway inhibitor ameliorates mouse laser-induced choroidal neovascularization. J Ocul Pharmacol Ther (2012) 0.96
Relationship between complement membrane attack complex, chemokine (C-C motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularization. J Biol Chem (2011) 0.96
Matrix metalloproteinase activity creates pro-angiogenic environment in primary human retinal pigment epithelial cells exposed to complement. Invest Ophthalmol Vis Sci (2012) 0.92
Longitudinally extensive NMO spinal cord pathology produced by passive transfer of NMO-IgG in mice lacking complement inhibitor CD59. J Autoimmun (2014) 0.91
Complement factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice. Invest Ophthalmol Vis Sci (2012) 0.85
Polyethylene glycol (PEG)-induced mouse model of choroidal neovascularization. J Biol Chem (2011) 0.85
Complement regulatory protein CD46 protects against choroidal neovascularization in mice. Am J Pathol (2014) 0.83
Soluble CD59 expressed from an adenovirus in vivo is a potent inhibitor of complement deposition on murine liver vascular endothelium. PLoS One (2011) 0.83
The role of glial cells and the complement system in retinal diseases and Alzheimer's disease: common neural degeneration mechanisms. Exp Brain Res (2014) 0.81
Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation? J Clin Med (2014) 0.78
Targeting the complement system for the management of retinal inflammatory and degenerative diseases. Eur J Pharmacol (2016) 0.78
The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration-Like Phenotype. Am J Pathol (2016) 0.76
Nitrite Modification of Extracellular Matrix Alters CD46 Expression and VEGF Release in Human Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci (2015) 0.76
A Revised Hemodynamic Theory of Age-Related Macular Degeneration. Trends Mol Med (2016) 0.75
Preliminary in vitro and in vivo assessment of a new targeted inhibitor for choroidal neovascularization in age-related macular degeneration. Drug Des Devel Ther (2016) 0.75
New Insights on Complement Inhibitor CD59 in Mouse Laser-Induced Choroidal Neovascularization: Mislocalization After Injury and Targeted Delivery for Protein Replacement. J Ocul Pharmacol Ther (2017) 0.75
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Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization. J Immunol (2005) 1.89
CD59a is the primary regulator of membrane attack complex assembly in the mouse. J Immunol (2004) 1.45
Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H. J Immunol (2006) 1.42
The role of complement system in ocular diseases including uveitis and macular degeneration. Mol Immunol (2007) 1.37
Molecular basis for a link between complement and the vascular complications of diabetes. Proc Natl Acad Sci U S A (2000) 1.32
CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration. J Immunol (2007) 1.31
Beyond lysis: how complement influences cell fate. Clin Sci (Lond) (2003) 1.30
Terminal complement complex C5b-9 stimulates mitogenesis in 3T3 cells. J Clin Invest (1993) 1.29
The development of an experimental model of subretinal neovascularization in disciform macular degeneration. Trans Am Ophthalmol Soc (1979) 1.27
The membrane attack complex of complement induces caspase activation and apoptosis. Eur J Immunol (2002) 1.20
Complement regulatory activity of normal human intraocular fluid is mediated by MCP, DAF, and CD59. Invest Ophthalmol Vis Sci (2000) 1.07
Generation of a recombinant, membrane-targeted form of the complement regulator CD59: activity in vitro and in vivo. J Biol Chem (2003) 1.07
Characterization of the mouse analogues of CD59 using novel monoclonal antibodies: tissue distribution and functional comparison. Immunology (2003) 1.04
Membrane-targeted complement inhibitors. Mol Immunol (2001) 1.03
The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout mice. Mol Immunol (2009) 0.98
C5b-9 membrane attack complex mediates endothelial cell apoptosis in experimental glomerulonephritis. Am J Physiol Renal Physiol (2000) 0.95
The terminal sequence of complement plays an essential role in antibody-mediated renal cell apoptosis. J Am Soc Nephrol (1999) 0.93
Mechanisms of age-related macular degeneration. Ophthalmol Clin North Am (2002) 0.90
Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization. FEBS J (2006) 0.87
Bacterial expression and membrane targeting of the rat complement regulator Crry: a new model anticomplement therapeutic. Protein Sci (2002) 0.86
Influence of triamcinolone intravitreal injection on retinochoroidal healing processes. Exp Eye Res (2007) 0.85
Influence of age on retinochoroidal healing processes after argon photocoagulation in C57bl/6j mice. Mol Vis (2009) 0.84
Inhibition of new vessel growth in mouse model of laser-induced choroidal neovascularization by adiponectin peptide II. Cell Biol Int (2009) 0.83
Characterisation of the complement susceptibility of the rat aortic smooth muscle cell line A7r5. Mol Immunol (2006) 0.80
Modulation of choroidal neovascularization by subretinal injection of retinal pigment epithelium and polystyrene microbeads. Mol Vis (2009) 0.79
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome. Proc Natl Acad Sci U S A (2006) 3.80
Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis. Nat Genet (2012) 3.34
IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis. Brain (2008) 2.91
National trends in rates of death and hospital admissions related to acute myocardial infarction, heart failure and stroke, 1994-2004. CMAJ (2009) 2.89
HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell (2008) 2.46
Predicting value of serum soluble ST2 and interleukin-33 for risk stratification and prognosis in patients with acute myocardial infarction. Chin Med J (Engl) (2013) 2.24
Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation. J Clin Invest (2010) 2.18
Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization. J Immunol (2005) 1.89
Complement-mediated lysis by anti-CD20 mAb correlates with segregation into lipid rafts. Blood (2002) 1.87
High-fat diet induced neuropathy of pre-diabetes and obesity: effects of "healthy" diet and aldose reductase inhibition. Diabetes (2007) 1.85
The leptin-deficient (ob/ob) mouse: a new animal model of peripheral neuropathy of type 2 diabetes and obesity. Diabetes (2006) 1.84
C3-dependent mechanism of microglial priming relevant to multiple sclerosis. Proc Natl Acad Sci U S A (2012) 1.73
A novel computational framework for simultaneous integration of multiple types of genomic data to identify microRNA-gene regulatory modules. Bioinformatics (2011) 1.68
Presence and pathogenic relevance of antibodies to clustered acetylcholine receptor in ocular and generalized myasthenia gravis. Arch Neurol (2012) 1.67
Dimerization of complement factor H-related proteins modulates complement activation in vivo. Proc Natl Acad Sci U S A (2013) 1.63
Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivo. ACS Nano (2012) 1.62
Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions. Mol Immunol (2006) 1.61
Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk. J Immunol (2003) 1.61
Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk. Proc Natl Acad Sci U S A (2011) 1.60
Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration. Atherosclerosis (2011) 1.58
Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells. J Immunol (2012) 1.57
CD59a deficiency exacerbates accelerated nephrotoxic nephritis in mice. J Am Soc Nephrol (2003) 1.54
Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNgamma-dependent iNOS expression in the vasculature of healthy mice. Blood (2008) 1.53
The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity. Hum Mol Genet (2009) 1.52
Retracted Modulation of CD59 expression by restrictive silencer factor-derived peptides in cancer immunotherapy for neuroblastoma. Cancer Res (2008) 1.49
CD59a is the primary regulator of membrane attack complex assembly in the mouse. J Immunol (2004) 1.45
A targeted complement-dependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer. Blood (2012) 1.45
The human complement fragment receptor, C5L2, is a recycling decoy receptor. Mol Immunol (2008) 1.45
Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H. J Immunol (2006) 1.42
Increased 1,5-anhydroglucitol predicts glycemic remission in patients with newly diagnosed type 2 diabetes treated with short-term intensive insulin therapy. Diabetes Technol Ther (2012) 1.40
Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59. Eur J Immunol (2003) 1.40
HIV-1 DNA vaccine with adjuvant cytokines induces specific immune responses against HIV-1 infection in mice. Chin Med J (Engl) (2006) 1.38
Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells. Nat Med (2003) 1.38
The role of complement system in ocular diseases including uveitis and macular degeneration. Mol Immunol (2007) 1.37
Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B. Proc Natl Acad Sci U S A (2009) 1.36
Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina. J Biol Chem (2010) 1.36
A dramatic increase of C1q protein in the CNS during normal aging. J Neurosci (2013) 1.35
Molecular dissection of interactions between components of the alternative pathway of complement and decay accelerating factor (CD55). J Biol Chem (2004) 1.35
The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation. J Cell Sci (2013) 1.33
Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy. Diabetes (2006) 1.32
Measurement of factor H variants in plasma using variant-specific monoclonal antibodies: application to assessing risk of age-related macular degeneration. Invest Ophthalmol Vis Sci (2008) 1.32
CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration. J Immunol (2007) 1.31
Holding T cells in check--a new role for complement regulators? Trends Immunol (2006) 1.30
Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages. J Immunol (2009) 1.30
Beyond lysis: how complement influences cell fate. Clin Sci (Lond) (2003) 1.30
Superior penetration and retention behavior of 50 nm gold nanoparticles in tumors. Cancer Res (2012) 1.29
The membrane attack complex of complement causes severe demyelination associated with acute axonal injury. J Immunol (2002) 1.28
Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis. J Clin Invest (2011) 1.24
In vivo characterization and therapeutic efficacy of a C5-specific inhibitor from the soft tick Ornithodoros moubata. J Biol Chem (2007) 1.22
PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy. Free Radic Biol Med (2007) 1.22
Nitrosative stress and peripheral diabetic neuropathy in leptin-deficient (ob/ob) mice. Exp Neurol (2007) 1.21
Regulatory T cells ameliorate cardiac remodeling after myocardial infarction. Basic Res Cardiol (2011) 1.21
Prediction of conformational B-cell epitopes from 3D structures by random forests with a distance-based feature. BMC Bioinformatics (2011) 1.20
Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1β release. J Immunol (2013) 1.20
Identification of a novel genetic locus on chromosome 8p21.1-q11.23 for idiopathic basal ganglia calcification. Am J Med Genet B Neuropsychiatr Genet (2010) 1.20
Complement dysregulation and disease: from genes and proteins to diagnostics and drugs. Immunobiology (2012) 1.19
Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9. Cell Rep (2012) 1.16
Complement factor H binds to denatured rather than to native pentameric C-reactive protein. J Biol Chem (2008) 1.15
Inhibition of coxsackie B virus infection by soluble forms of its receptors: binding affinities, altered particle formation, and competition with cellular receptors. J Virol (2005) 1.15
Complement regulation by Kaposi's sarcoma-associated herpesvirus ORF4 protein. J Virol (2003) 1.15
CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells. J Biol Chem (2005) 1.15
Histone methyltransferase Ash1l suppresses interleukin-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20. Immunity (2013) 1.15
Identifying protein complexes and functional modules--from static PPI networks to dynamic PPI networks. Brief Bioinform (2013) 1.14
A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice. Eur J Pharmacol (2007) 1.14
Roles of the complement system in human neurodegenerative disorders: pro-inflammatory and tissue remodeling activities. Mol Neurobiol (2002) 1.14
Gold nanoparticles functionalized with therapeutic and targeted peptides for cancer treatment. Biomaterials (2011) 1.14
Complement component c1q mediates mitochondria-driven oxidative stress in neonatal hypoxic-ischemic brain injury. J Neurosci (2010) 1.13
{N'-[(E)-1-(5-Bromo-2-oxidophen-yl)ethyl-idene]-4-hy-droxy-benzohydrazidato}pyridine-copper(II). Acta Crystallogr Sect E Struct Rep Online (2011) 1.12
Structural basis for complement factor I control and its disease-associated sequence polymorphisms. Proc Natl Acad Sci U S A (2011) 1.12
CYP2E1 mediated isoniazid-induced hepatotoxicity in rats. Acta Pharmacol Sin (2004) 1.11
Complement abnormalities in acquired lipodystrophy revisited. J Clin Endocrinol Metab (2008) 1.10
Sequence-indexed mutations in maize using the UniformMu transposon-tagging population. BMC Genomics (2007) 1.10
Sensitive and specific assays for C3 nephritic factors clarify mechanisms underlying complement dysregulation. Kidney Int (2012) 1.09
Hereditary angioedema--therapies old and new. N Engl J Med (2010) 1.08
Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. J Immunol (2002) 1.08
Complement regulator loss on apoptotic neuronal cells causes increased complement activation and promotes both phagocytosis and cell lysis. Mol Immunol (2006) 1.07
Generation of a recombinant, membrane-targeted form of the complement regulator CD59: activity in vitro and in vivo. J Biol Chem (2003) 1.07
The role of complement in ocular pathology. Semin Immunopathol (2008) 1.07
Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions. J Immunol (2013) 1.06
Experimental investigation on the competition between wideband stimulated Brillouin scattering and forward stimulated Raman scattering in water. Opt Lett (2012) 1.06
Glycosylation and the complement system. Chem Rev (2002) 1.06
A new cytotoxic sesquiterpene quinone produced by Penicillium sp. F00120 isolated from a deep sea sediment sample. Mar Drugs (2012) 1.06
Evaluation of the peroxynitrite decomposition catalyst Fe(III) tetra-mesitylporphyrin octasulfonate on peripheral neuropathy in a mouse model of type 1 diabetes. Int J Mol Med (2007) 1.05
CD59a deficiency exacerbates influenza-induced lung inflammation through complement-dependent and -independent mechanisms. Eur J Immunol (2007) 1.05
Myasthenia gravis thymus: complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status. Am J Pathol (2007) 1.05
Himalayan fossils of the oldest known pantherine establish ancient origin of big cats. Proc Biol Sci (2013) 1.05
Characterization of the mouse analogues of CD59 using novel monoclonal antibodies: tissue distribution and functional comparison. Immunology (2003) 1.04
Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study. Retrovirology (2008) 1.03
The complotype: dictating risk for inflammation and infection. Trends Immunol (2012) 1.03
Immune complex/Ig negatively regulate TLR4-triggered inflammatory response in macrophages through Fc gamma RIIb-dependent PGE2 production. J Immunol (2009) 1.03