Impaired capsaicin-induced relaxation of coronary arteries in a porcine model of the metabolic syndrome.

PubWeight™: 1.32‹?› | Rank: Top 10%

🔗 View Article (PMID 18390821)

Published in Am J Physiol Heart Circ Physiol on April 04, 2008

Authors

Ian N Bratz1, Gregory M Dick, Johnathan D Tune, Jason M Edwards, Zachary P Neeb, U Deniz Dincer, Michael Sturek

Author Affiliations

1: Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202-5120, USA. ibratz@iupui.edu

Articles citing this

Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension. Cell Metab (2010) 2.11

Impaired function of coronary BK(Ca) channels in metabolic syndrome. Am J Physiol Heart Circ Physiol (2009) 1.89

TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. Am J Physiol Heart Circ Physiol (2009) 1.76

Metabolic syndrome and coronary artery disease in Ossabaw compared with Yucatan swine. Comp Med (2010) 1.61

Exercise training decreases store-operated Ca2+entry associated with metabolic syndrome and coronary atherosclerosis. Cardiovasc Res (2009) 1.43

Epicardial perivascular adipose-derived leptin exacerbates coronary endothelial dysfunction in metabolic syndrome via a protein kinase C-beta pathway. Arterioscler Thromb Vasc Biol (2010) 1.35

TRPV channels and vascular function. Acta Physiol (Oxf) (2010) 1.16

Ca2+ regulatory mechanisms of exercise protection against coronary artery disease in metabolic syndrome and diabetes. J Appl Physiol (1985) (2011) 1.14

Transient receptor potential channels in the vasculature. Physiol Rev (2015) 1.14

Morbid obesity and metabolic syndrome in Ossabaw miniature swine are associated with increased platelet reactivity. Diabetes Metab Syndr Obes (2011) 1.09

Metabolic syndrome reduces the contribution of K+ channels to ischemic coronary vasodilation. Am J Physiol Heart Circ Physiol (2010) 1.04

Periadventitial adipose tissue impairs coronary endothelial function via PKC-beta-dependent phosphorylation of nitric oxide synthase. Am J Physiol Heart Circ Physiol (2009) 1.04

Contribution of BK(Ca) channels to local metabolic coronary vasodilation: Effects of metabolic syndrome. Am J Physiol Heart Circ Physiol (2009) 1.02

Dynamic micro- and macrovascular remodeling in coronary circulation of obese Ossabaw pigs with metabolic syndrome. J Appl Physiol (1985) (2012) 1.02

Transient receptor potential channel activation and endothelium-dependent dilation in the systemic circulation. J Cardiovasc Pharmacol (2011) 1.01

TRP channels and their implications in metabolic diseases. Pflugers Arch (2010) 1.00

Heart of the matter: coronary dysfunction in metabolic syndrome. J Mol Cell Cardiol (2011) 0.99

Contribution of voltage-dependent K⁺ channels to metabolic control of coronary blood flow. J Mol Cell Cardiol (2011) 0.99

Canonical transient receptor potential channels expression is elevated in a porcine model of metabolic syndrome. Mol Endocrinol (2009) 0.94

Mice lacking functional TRPV1 are protected from pressure overload cardiac hypertrophy. Channels (Austin) (2011) 0.94

Propofol restores transient receptor potential vanilloid receptor subtype-1 sensitivity via activation of transient receptor potential ankyrin receptor subtype-1 in sensory neurons. Anesthesiology (2011) 0.92

Update on vascular endothelial Ca(2+) signalling: A tale of ion channels, pumps and transporters. World J Biol Chem (2012) 0.91

Regional variation in arterial stiffening and dysfunction in Western diet-induced obesity. Am J Physiol Heart Circ Physiol (2015) 0.89

Influence of obesity and metabolic dysfunction on the endothelial control in the coronary circulation. J Mol Cell Cardiol (2011) 0.87

Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swine. Physiol Genomics (2013) 0.87

Unique transcriptomic signature of omental adipose tissue in Ossabaw swine: a model of childhood obesity. Physiol Genomics (2014) 0.85

Contribution of electromechanical coupling between Kv and Ca v1.2 channels to coronary dysfunction in obesity. Basic Res Cardiol (2013) 0.84

Metabolic syndrome impairs notch signaling and promotes apoptosis in chronically ischemic myocardium. J Thorac Cardiovasc Surg (2014) 0.79

Mechanisms underlying capsaicin effects in canine coronary artery: implications for coronary spasm. Cardiovasc Res (2014) 0.78

Capsaicin may have important potential for promoting vascular and metabolic health. Open Heart (2015) 0.78

Propofol causes vasodilation in vivo via TRPA1 ion channels: role of nitric oxide and BKCa channels. PLoS One (2015) 0.76

Stent-induced coronary artery stenosis characterized by multimodal nonlinear optical microscopy. J Biomed Opt (2011) 0.76

Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction. Basic Res Cardiol (2016) 0.75

Capsaicinoids Modulating Cardiometabolic Syndrome Risk Factors: Current Perspectives. J Nutr Metab (2016) 0.75

Vascular Expression of Transient Receptor Potential Vanilloid 1 (TRPV1). J Histochem Cytochem (2015) 0.75

Articles by these authors

Smooth muscle cell plasticity: fact or fiction? Circ Res (2012) 2.18

Fatality involving complications of bupivacaine toxicity and hypersensitivity reaction. J Forensic Sci (2011) 2.16

Components of metabolic syndrome and coronary artery disease in female Ossabaw swine fed excess atherogenic diet. Comp Med (2006) 2.04

Label-free bond-selective imaging by listening to vibrationally excited molecules. Phys Rev Lett (2011) 2.01

Increased lymphatic flow in the thoracic duct during manipulative intervention. J Am Osteopath Assoc (2005) 1.98

Impaired function of coronary BK(Ca) channels in metabolic syndrome. Am J Physiol Heart Circ Physiol (2009) 1.89

Flipped classroom model improves graduate student performance in cardiovascular, respiratory, and renal physiology. Adv Physiol Educ (2013) 1.88

Nutritional model of steatohepatitis and metabolic syndrome in the Ossabaw miniature swine. Hepatology (2009) 1.78

Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells. J Gen Physiol (2010) 1.71

Aging and muscle fiber type alter K+ channel contributions to the myogenic response in skeletal muscle arterioles. J Appl Physiol (1985) (2009) 1.61

Metabolic syndrome and coronary artery disease in Ossabaw compared with Yucatan swine. Comp Med (2010) 1.61

Restoration of coronary endothelial function in obese Zucker rats by a low-carbohydrate diet. Am J Physiol Heart Circ Physiol (2007) 1.54

Label-free molecular imaging of atherosclerotic lesions using multimodal nonlinear optical microscopy. J Biomed Opt (2007) 1.53

Hydrogen peroxide: a feed-forward dilator that couples myocardial metabolism to coronary blood flow. Arterioscler Thromb Vasc Biol (2006) 1.52

Leptin receptors are expressed in coronary arteries, and hyperleptinemia causes significant coronary endothelial dysfunction. Am J Physiol Heart Circ Physiol (2005) 1.50

Nitric oxide contributes to oxygen demand-supply balance in hypoperfused right ventricle. Cardiovasc Res (2004) 1.43

Exercise training decreases store-operated Ca2+entry associated with metabolic syndrome and coronary atherosclerosis. Cardiovasc Res (2009) 1.43

Imaging and quantitative analysis of atherosclerotic lesions by CARS-based multimodal nonlinear optical microscopy. Arterioscler Thromb Vasc Biol (2009) 1.40

Epicardial perivascular adipose-derived leptin exacerbates coronary endothelial dysfunction in metabolic syndrome via a protein kinase C-beta pathway. Arterioscler Thromb Vasc Biol (2010) 1.35

TMEM16A channels generate Ca²⁺-activated Cl⁻ currents in cerebral artery smooth muscle cells. Am J Physiol Heart Circ Physiol (2011) 1.29

Functional P2Y2 nucleotide receptors mediate uridine 5'-triphosphate-induced intimal hyperplasia in collared rabbit carotid arteries. Circulation (2002) 1.27

Overfed Ossabaw swine with early stage metabolic syndrome have normal coronary collateral development in response to chronic ischemia. Basic Res Cardiol (2012) 1.26

H2O2 activates redox- and 4-aminopyridine-sensitive Kv channels in coronary vascular smooth muscle. Am J Physiol Heart Circ Physiol (2006) 1.24

TMEM16A/ANO1 channels contribute to the myogenic response in cerebral arteries. Circ Res (2012) 1.23

Perivascular adipose tissue potentiates contraction of coronary vascular smooth muscle: influence of obesity. Circulation (2013) 1.22

Bond-selective imaging of deep tissue through the optical window between 1600 and 1850 nm. J Biophotonics (2011) 1.20

Diabetes increases formation of advanced glycation end products on Sarco(endo)plasmic reticulum Ca2+-ATPase. Diabetes (2004) 1.18

Marvels, mysteries, and misconceptions of vascular compensation to peripheral artery occlusion. Microcirculation (2010) 1.18

Mechanisms of coronary dysfunction in obesity and insulin resistance. Microcirculation (2007) 1.16

H2O2-induced redox-sensitive coronary vasodilation is mediated by 4-aminopyridine-sensitive K+ channels. Am J Physiol Heart Circ Physiol (2006) 1.16

Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+). Am J Physiol Endocrinol Metab (2002) 1.14

Voltage-dependent K+ channels regulate the duration of reactive hyperemia in the canine coronary circulation. Am J Physiol Heart Circ Physiol (2008) 1.12

Role of potassium channels in coronary vasodilation. Exp Biol Med (Maywood) (2010) 1.12

Exercise training prevents Ca2+ dysregulation in coronary smooth muscle from diabetic dyslipidemic yucatan swine. J Appl Physiol (1985) (2006) 1.11

Diversifying Biomedical Training: A Synergistic Intervention. J Women Minor Sci Eng (2010) 1.10

Redox-dependent coronary metabolic dilation. Am J Physiol Heart Circ Physiol (2007) 1.10

Resistin impairs endothelium-dependent dilation to bradykinin, but not acetylcholine, in the coronary circulation. Am J Physiol Heart Circ Physiol (2006) 1.10

Morbid obesity and metabolic syndrome in Ossabaw miniature swine are associated with increased platelet reactivity. Diabetes Metab Syndr Obes (2011) 1.09

Chronic diabetes increases advanced glycation end products on cardiac ryanodine receptors/calcium-release channels. Diabetes (2003) 1.08

Hyperglycemia-induced insulin resistance in diabetic dyslipidemic Yucatan swine. Comp Med (2003) 1.07

Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficiencies. J Clin Endocrinol Metab (2007) 1.07

Epicardial perivascular adipose tissue as a therapeutic target in obesity-related coronary artery disease. Br J Pharmacol (2012) 1.05

Altered mechanism of adenosine-induced coronary arteriolar dilation in early-stage metabolic syndrome. Exp Biol Med (Maywood) (2009) 1.05

Characterisation of gut microbiota in Ossabaw and Göttingen minipigs as models of obesity and metabolic syndrome. PLoS One (2013) 1.04

Metabolic syndrome reduces the contribution of K+ channels to ischemic coronary vasodilation. Am J Physiol Heart Circ Physiol (2010) 1.04

Periadventitial adipose tissue impairs coronary endothelial function via PKC-beta-dependent phosphorylation of nitric oxide synthase. Am J Physiol Heart Circ Physiol (2009) 1.04

Fetuin-A uptake in bovine vascular smooth muscle cells is calcium dependent and mediated by annexins. Am J Physiol Renal Physiol (2006) 1.04

Endogenous adipose-derived factors diminish coronary endothelial function via inhibition of nitric oxide synthase. Microcirculation (2008) 1.04

Mechanisms of oxygen demand/supply balance in the right ventricle. Exp Biol Med (Maywood) (2005) 1.02

Sensitization of coronary alpha-adrenoceptor vasoconstriction in the prediabetic metabolic syndrome. Microcirculation (2006) 1.02

Contribution of BK(Ca) channels to local metabolic coronary vasodilation: Effects of metabolic syndrome. Am J Physiol Heart Circ Physiol (2009) 1.02

Dynamic micro- and macrovascular remodeling in coronary circulation of obese Ossabaw pigs with metabolic syndrome. J Appl Physiol (1985) (2012) 1.02

Coronary arteriolar vasoconstriction to angiotensin II is augmented in prediabetic metabolic syndrome via activation of AT1 receptors. Am J Physiol Heart Circ Physiol (2005) 1.01

Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels. Microcirculation (2010) 1.01

Leptin and mechanisms of endothelial dysfunction and cardiovascular disease. Curr Hypertens Rep (2008) 1.01

Interactions between A(2A) adenosine receptors, hydrogen peroxide, and KATP channels in coronary reactive hyperemia. Am J Physiol Heart Circ Physiol (2013) 1.00

Increased atherosclerosis in diabetic dyslipidemic swine: protection by atorvastatin involves decreased VLDL triglycerides but minimal effects on the lipoprotein profile. J Lipid Res (2002) 1.00

Coronary blood flow regulation in the prediabetic metabolic syndrome. Basic Res Cardiol (2003) 1.00

Contribution of voltage-dependent K⁺ channels to metabolic control of coronary blood flow. J Mol Cell Cardiol (2011) 0.99

Heart of the matter: coronary dysfunction in metabolic syndrome. J Mol Cell Cardiol (2011) 0.99

Impaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitus. Basic Res Cardiol (2013) 0.99

SWI/SNF complexes containing Brahma or Brahma-related gene 1 play distinct roles in smooth muscle development. Mol Cell Biol (2011) 0.98

Bisphenol A activates Maxi-K (K(Ca)1.1) channels in coronary smooth muscle. Br J Pharmacol (2010) 0.98

Effects of stent sizing on endothelial and vessel wall stress: potential mechanisms for in-stent restenosis. J Appl Physiol (1985) (2009) 0.96

Adenosine A1 receptors in neointimal hyperplasia and in-stent stenosis in Ossabaw miniature swine. Coron Artery Dis (2008) 0.96