Published in J Biol Chem on May 15, 1991
Comparative anatomy of the aldo-keto reductase superfamily. Biochem J (1997) 3.39
Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc Natl Acad Sci U S A (2006) 2.01
Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily. Proc Natl Acad Sci U S A (1994) 1.39
Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder. Biochem J (1994) 1.32
The kinetic mechanism catalysed by homogeneous rat liver 3 alpha-hydroxysteroid dehydrogenase. Evidence for binary and ternary dead-end complexes containing non-steroidal anti-inflammatory drugs. Biochem J (1991) 1.15
Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2. Biochem J (1996) 1.13
Tissue distribution of human AKR1C3 and rat homolog in the adult genitourinary system. J Histochem Cytochem (2008) 1.04
An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases. Proc Natl Acad Sci U S A (1993) 1.00
Bacterial morphine dehydrogenase further defines a distinct superfamily of oxidoreductases with diverse functional activities. Biochem J (1994) 0.98
Purification of NADPH-dependent dehydroascorbate reductase from rat liver and its identification with 3 alpha-hydroxysteroid dehydrogenase. Biochem J (1994) 0.97
The role of cysteine in the alteration of bovine liver dihydrodiol dehydrogenase 3 activity. Biochem J (1995) 0.94
Molecular cloning of cDNA for rat ovarian 20 alpha-hydroxysteroid dehydrogenase (HSD1). Biochem J (1994) 0.93
Substrate specificity of an aflatoxin-metabolizing aldehyde reductase. Biochem J (1995) 0.90
Aldo-keto reductases and formation of polycyclic aromatic hydrocarbon o-quinones. Methods Enzymol (2004) 0.88
Activation of human liver 3 alpha-hydroxysteroid dehydrogenase by sulphobromophthalein. Biochem J (1996) 0.82
Purification from rat liver of a novel constitutively expressed member of the aldo-keto reductase 7 family that is widely distributed in extrahepatic tissues. Biochem J (2000) 0.80
Neurosteroid biosynthesis in the brain of amphibians. Front Endocrinol (Lausanne) (2011) 0.76
Purification and characterization of a novel dimeric 20 alpha-hydroxysteroid dehydrogenase from Tetrahymena pyriformis. Biochem J (1994) 0.75
Role of quinones in toxicology. Chem Res Toxicol (2000) 4.55
Comparative anatomy of the aldo-keto reductase superfamily. Biochem J (1997) 3.39
A new nomenclature for the aldo-keto reductase superfamily. Biochem Pharmacol (1997) 1.99
Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. Structure (1997) 1.63
Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution. Mol Endocrinol (1997) 1.59
Purification and properties of a 3 alpha-hydroxysteroid dehydrogenase of rat liver cytosol and its inhibition by anti-inflammatory drugs. Biochem J (1984) 1.54
The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome. J Clin Endocrinol Metab (2001) 1.54
The aldo-keto reductase (AKR) superfamily: an update. Chem Biol Interact (2001) 1.52
Mutagenesis of 3 alpha-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases. Biochemistry (1998) 1.49
Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma. Endocr Relat Cancer (2006) 1.48
Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+. Biochemistry (1996) 1.39
Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily. Proc Natl Acad Sci U S A (1994) 1.39
Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione. Biochemistry (1998) 1.32
The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation. Biochemistry (2001) 1.31
Inhibition of a major NAD(P)-linked oxidoreductase from rat liver cytosol by steroidal and nonsteroidal anti-inflammatory agents and by prostaglandins. Proc Natl Acad Sci U S A (1983) 1.29
Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate. Biochemistry (2001) 1.24
The arginine 276 anchor for NADP(H) dictates fluorescence kinetic transients in 3 alpha-hydroxysteroid dehydrogenase, a representative aldo-keto reductase. Biochemistry (1999) 1.21
Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor. Cancer Res (2000) 1.20
The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene. J Biol Chem (2000) 1.18
Reactivity of benzo[a]pyrene-7,8-dione with DNA. Evidence for the formation of deoxyguanosine adducts. Carcinogenesis (1993) 1.18
The kinetic mechanism catalysed by homogeneous rat liver 3 alpha-hydroxysteroid dehydrogenase. Evidence for binary and ternary dead-end complexes containing non-steroidal anti-inflammatory drugs. Biochem J (1991) 1.15
Overexpression and mutagenesis of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. Role of cysteines and tyrosines in catalysis. J Biol Chem (1994) 1.15
Members of the nuclear factor 1 transcription factor family regulate rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD AKR1C9) gene expression: a member of the aldo-keto reductase superfamily. Mol Endocrinol (1999) 1.14
Regio- and stereospecificity of homogeneous 3 alpha-hydroxysteroid-dihydrodiol dehydrogenase for trans-dihydrodiol metabolites of polycyclic aromatic hydrocarbons. J Biol Chem (1986) 1.12
Synthesis and characterization of polycyclic aromatic hydrocarbon o-quinone depurinating N7-guanine adducts. Chem Res Toxicol (1999) 1.11
Engineering steroid 5 beta-reductase activity into rat liver 3 alpha-hydroxysteroid dehydrogenase. Biochemistry (1998) 1.09
Purification and properties of 3 alpha-hydroxysteroid dehydrogenase from rat brain cytosol. Inhibition by nonsteroidal anti-inflammatory drugs and progestins. J Biol Chem (1985) 1.09
Characterization of the substrate binding site in rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase. The roles of tryptophans in ligand binding and protein fluorescence. J Biol Chem (1996) 1.03
Spectroscopic identification of ortho-quinones as the products of polycyclic aromatic trans-dihydrodiol oxidation catalyzed by dihydrodiol dehydrogenase. A potential route of proximate carcinogen metabolism. J Biol Chem (1988) 1.02
DNA strand scission by polycyclic aromatic hydrocarbon o-quinones: role of reactive oxygen species, Cu(II)/Cu(I) redox cycling, and o-semiquinone anion radicals,. Biochemistry (1997) 1.02
Rat liver 3 alpha-hydroxysteroid dehydrogenase. Steroids (1987) 1.00
Disposition and biological activity of benzo[a]pyrene-7,8-dione. A genotoxic metabolite generated by dihydrodiol dehydrogenase. Biochemistry (1996) 0.99
Cytotoxicity and mutagenicity of polycyclic aromatic hydrocarbon ortho-quinones produced by dihydrodiol dehydrogenase. Chem Biol Interact (1996) 0.99
Steroid 5alpha-reductases and 3alpha-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism. Best Pract Res Clin Endocrinol Metab (2001) 0.98
The role in CaCO3 crystallization of an acid Ca2+-binding polysaccharide associated with coccoliths of Emiliania huxleyi. Eur J Biochem (1982) 0.98
Conversion of mammalian 3alpha-hydroxysteroid dehydrogenase to 20alpha-hydroxysteroid dehydrogenase using loop chimeras: changing specificity from androgens to progestins. Proc Natl Acad Sci U S A (1999) 0.97
Retention of NADPH-linked quinone reductase activity in an aldo-keto reductase following mutation of the catalytic tyrosine. Biochemistry (1998) 0.94
Profiling Fragile X Syndrome in males: strengths and weaknesses in cognitive abilities. Res Dev Disabil (2009) 0.93
Mutation of nicotinamide pocket residues in rat liver 3 alpha-hydroxysteroid dehydrogenase reveals different modes of cofactor binding. Biochemistry (2000) 0.92
Indomethacin-sensitive 3 alpha-hydroxysteroid dehydrogenase in rat tissues. Biochem Pharmacol (1985) 0.89
Polycyclic aromatic hydrocarbon (PAH) ortho-quinone conjugate chemistry: kinetics of thiol addition to PAH ortho-quinones and structures of thioether adducts of naphthalene-1,2-dione. Chem Biol Interact (1992) 0.89
Characterization of mercapturic acid and glutathionyl conjugates of benzo[a]pyrene-7,8-dione by two-dimensional NMR. Bioconjug Chem (1992) 0.87
Inactivation of delta 5-3-oxo steroid isomerase with active-site-directed acetylenic steroids. Biochem J (1981) 0.87
Characterization of homogeneous recombinant rat ovarian 20alpha-hydroxysteroid dehydrogenase: fluorescent properties and inhibition profile. Biochem J (1999) 0.86
Active-site directed inactivation of rat ovarian 20 alpha-hydroxysteroid dehydrogenase. Biochem J (1986) 0.85
Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase. Endocrinology (2000) 0.84
Evidence that enzyme-generated aromatic Michael acceptors covalently modify the nucleotide-binding site of 3 alpha-hydroxysteroid dehydrogenase. Biochem J (1990) 0.84
Synthesis and evaluation of non-steroidal mechanism-based inactivators of 3 alpha-hydroxysteroid dehydrogenase. Biochem J (1989) 0.84
Hormonal control of Leydig cell differentiation. Ann N Y Acad Sci (1991) 0.83
Irreversible inhibition of delta 5-3-oxosteroid isomerase by 2-substituted progesterones. Biochem J (1985) 0.83
Inhibition of trans-dihydrodiol oxidation by the non-steroidal anti-inflammatory drugs. Carcinogenesis (1986) 0.82
Linkage of an acetylenic secosteroid suicide substrate to the active site of delta 5-3-ketosteroid isomerase. Isolation and characterization of a tetrapeptide. J Biol Chem (1981) 0.82
Mass spectrometric studies of a modified active-site tetrapeptide from delta 5-3-ketosteroid isomerase of Pseudomonas testosteroni. J Biol Chem (1982) 0.81
Isolation and partial characterization of a full-length cDNA clone for 3 alpha-hydroxysteroid dehydrogenase: a potential target enzyme for nonsteroidal anti-inflammatory drugs. Agents Actions (1991) 0.81
Development of affinity labeling agents based on nonsteroidal anti-inflammatory drugs: labeling of the nonsteroidal anti-inflammatory drug binding site of 3 alpha-hydroxysteroid dehydrogenase. Biochemistry (1991) 0.81
Stable expression of rat dihydrodiol dehydrogenase (AKR1C9) in human breast MCF-7 cells results in the formation of PAH-o-quinones and enzyme mediated cell death. Chem Res Toxicol (2001) 0.80
A nomenclature system for the aldo-keto reductase superfamily. Adv Exp Med Biol (1997) 0.80
Examination of diols and diol epoxides of polycyclic aromatic hydrocarbons as substrates for rat liver dihydrodiol dehydrogenase. Chem Res Toxicol (1992) 0.80
Cytotoxicity of polycyclic aromatic hydrocarbon o-quinones in rat and human hepatoma cells. Chem Res Toxicol (1993) 0.80
Inhibition of 5 beta-dihydrocortisone reduction in rat liver cytosol: a rapid spectrophotometric screen for nonsteroidal anti-inflammatory drug potency. J Pharm Sci (1985) 0.80
Cloning, sequencing, and functional analysis of the 5'-flanking region of the rat 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase gene. Cancer Res (1995) 0.79
"Mammalian 3 alpha-hydroxysteroid dehydrogenases". Steroids (1997) 0.79
Inactivation of delta 5-3-ketosteroid isomerase(s) from beef adrenal cortex by acetylenic ketosteroids. J Steroid Biochem (1982) 0.79
Identification of benzo[a]pyrene-7,8-dione as an authentic metabolite of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in isolated rat hepatocytes. Carcinogenesis (1995) 0.79
On the number of steroid-binding sites of delta 5-3-oxosteroid isomerase. Eur J Biochem (1980) 0.78
Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1). Chem Biol Interact (2001) 0.78
Contribution of dihydrodiol dehydrogenase to the metabolism of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in fortified rat liver subcellular fractions. Carcinogenesis (1992) 0.78
Radiochemical detection of dihydrodiol dehydrogenase: distribution of the enzyme in male Sprague-Dawley rat tissues and its sensitivity to inhibition by indomethacin and 6-medroxyprogesterone acetate. Cancer Res (1987) 0.78
Studies on the biosynthesis, assembly and secretion of vitellogenin, an oestrogen-induced multicomponent protein. Biochem J (1977) 0.78
Electrophoretic and immunochemical characterization of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenases of rat tissues. Biochem J (1988) 0.78
Detection of an Fe2+-protoporphyrin-IX intermediate during aspirin-treated prostaglandin H2 synthase II catalysis of arachidonic acid to 15-HETE. Biochemistry (1997) 0.78
Genomic structure of rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD, AKR1C9). J Steroid Biochem Mol Biol (1999) 0.78
Oestrogen-stimulated cholesterol and lipid synthesis in Xenopus laevis liver. Biochem Soc Trans (1973) 0.78
Irreversible inactivation of delta 5-3-ketosteroid isomerase of Pseudomonas testosteroni by acetylenic suicide substrates. Mechanism of formation and properties of the steroid-enzyme adduct. J Biol Chem (1981) 0.78
Oestrogen-induced cholesterol and fatty acid biosynthesis in Xenopus laevis liver during vitellogenic response. Biochem J (1978) 0.77
Rat dihydrodiol dehydrogenase: complexity of gene structure and tissue-specific and sexually dimorphic gene expression. Cancer Res (1994) 0.77
Secosteroid mechanism-based inactivators and site-directed mutagenesis as probes for steroid hormone recognition by 3 alpha-hydroxysteroid dehydrogenase. Biochemistry (1994) 0.77
Dexamethasone regulation of the rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase gene. Mol Pharmacol (1998) 0.77
Characterization of dihydrodiol dehydrogenase in rat H-4IIe hepatoma cells. Cancer Res (1989) 0.77
The development and preliminary validation of the Tower of Hanoi-revised. Assessment (2001) 0.76
Sex differences in indomethacin-sensitive 3 alpha-hydroxysteroid dehydrogenase of rat liver cytosol. Cancer Res (1985) 0.76
Potent inhibition of mammalian progesterone synthesis by 2 alpha-cyanoprogesterone. Biochem J (1985) 0.75
Application of laboratory data to nighttime driving situations. Appl Opt (1973) 0.75
Indomethacin and glucocorticoid metabolism in rat liver cytosol. Biochem Pharmacol (1986) 0.75
RAST with animal dander, urine, saliva and serum. Ann Allergy (1983) 0.75
Inactivation of delta5-3-ketosteroid isomerase(s) from beef adrenal cortex by beta, gamma-acetylenic ketosteroids. Steroids (1982) 0.75
Inhibition of progesterone synthesis in normal and transformed human placental cells by tight binding inhibitors of 3 beta-hydroxysteroid dehydrogenase. Steroids (1989) 0.75
Detection of precipitating and complement consuming antibodies by enzyme linked immune sorbent assay in pigeon breeders' disease. Immunobiology (1984) 0.75
Prediction of nighttime driving visibility from laboratory data. Appl Opt (1974) 0.75
Bromoacetamido-analogs of indomethacin and mefenamic acid affinity-label prostaglandin H2 synthase at two sites. Adv Exp Med Biol (1997) 0.75
Detection of class-specific antibodies against Aspergillus fumigatus antigens in various pulmonary diseases. Ann Inst Pasteur Immunol (1985) 0.75
Bromoacetamido analogs of indomethacin and mefenamic acid as affinity-labeling agents and mechanistic probes for prostaglandin H2 synthase. Biochemistry (1995) 0.75
Detection of class-specific antibodies against Micropolyspora faeni antigens in farmers' lung. Clin Allergy (1985) 0.75