Published in J Exp Med on April 14, 2008
The role of TNF superfamily members in T-cell function and diseases. Nat Rev Immunol (2009) 3.72
The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity (2008) 2.04
The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation. Mucosal Immunol (2010) 1.65
Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia. Mucosal Immunol (2010) 1.61
Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. J Clin Invest (2010) 1.50
The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis. J Exp Med (2008) 1.45
TNF superfamily in inflammatory disease: translating basic insights. Trends Immunol (2011) 1.29
Recent advances in IBD pathogenesis: genetics and immunobiology. Curr Gastroenterol Rep (2008) 1.23
IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells. J Immunol (2012) 1.21
TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation. Immunol Rev (2011) 1.19
Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. J Immunol (2009) 1.18
Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells. Eur J Immunol (2009) 1.18
The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro. J Immunol (2010) 1.16
IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein. PLoS One (2009) 1.15
SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine. Immunogenetics (2010) 1.15
Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis. PLoS One (2011) 1.08
Insights into IBD Pathogenesis. Curr Gastroenterol Rep (2009) 1.05
TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers. Mucosal Immunol (2013) 1.02
The role of TRADD in death receptor signaling. Cell Cycle (2012) 1.00
MicroRNA regulation of human protease genes essential for influenza virus replication. PLoS One (2012) 0.96
The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4⁺ and CD8⁺ T-cell immunity. FASEB J (2012) 0.95
Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient mice. J Immunol (2008) 0.95
The adaptor protein TRADD is essential for TNF-like ligand 1A/death receptor 3 signaling. J Immunol (2011) 0.94
The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells. J Immunol (2015) 0.93
A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity. J Immunol (2010) 0.93
Tumor antigen specific iTreg accumulate in the tumor microenvironment and suppress therapeutic vaccination. Oncoimmunology (2012) 0.92
Tumour necrosis factor superfamily members in the pathogenesis of inflammatory bowel disease. Mediators Inflamm (2014) 0.92
Progranulin-derived Atsttrin directly binds to TNFRSF25 (DR3) and inhibits TNF-like ligand 1A (TL1A) activity. PLoS One (2014) 0.90
Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis. Am J Pathol (2011) 0.90
The TNF-family cytokine TL1A inhibits proliferation of human activated B cells. PLoS One (2013) 0.89
The role of TL1A and DR3 in autoimmune and inflammatory diseases. Mediators Inflamm (2013) 0.88
Age-dependent maintenance of motor control and corticostriatal innervation by death receptor 3. J Neurosci (2010) 0.88
TL1A selectively enhances IL-12/IL-18-induced NK cell cytotoxicity against NK-resistant tumor targets. J Clin Immunol (2010) 0.88
TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3. Dis Model Mech (2012) 0.88
TNFRSF25 agonistic antibody and galectin-9 combination therapy controls herpes simplex virus-induced immunoinflammatory lesions. J Virol (2012) 0.87
Two functionally distinct isoforms of TL1A (TNFSF15) generated by differential ectodomain shedding. J Gerontol A Biol Sci Med Sci (2010) 0.87
Signals for the execution of Th2 effector function. Cytokine (2009) 0.86
TLR8-mediated activation of human monocytes inhibits TL1A expression. Eur J Immunol (2009) 0.85
Regulation of early cartilage destruction in inflammatory arthritis by death receptor 3. Arthritis Rheumatol (2014) 0.85
T cell costimulation by TNFR superfamily (TNFRSF)4 and TNFRSF25 in the context of vaccination. J Immunol (2012) 0.84
c-Myc is essential to prevent endothelial pro-inflammatory senescent phenotype. PLoS One (2013) 0.82
The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses. Immunity (2016) 0.81
TNFSF15 Modulates Neovascularization and Inflammation. Cancer Microenviron (2012) 0.81
Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis. Mucosal Immunol (2014) 0.81
An essential role for death receptor 3 in experimental autoimmune uveoretinitis. Ocul Immunol Inflamm (2012) 0.80
SUSTAINED TL1A (TNFSF15) EXPRESSION ON BOTH LYMPHOID AND MYELOID CELLS LEADS TO MILD SPONTANEOUS INTESTINAL INFLAMMATION AND FIBROSIS. Eur J Microbiol Immunol (Bp) (2013) 0.80
The role of tumor necrosis factor receptor superfamily members in mammalian brain development, function and homeostasis. Rev Neurosci (2011) 0.79
A Novel Role for TL1A/DR3 in Protection against Intestinal Injury and Infection. J Immunol (2016) 0.79
Human group3 innate lymphoid cells express DR3 and respond to TL1A with enhanced IL-22 production and IL-2-dependent proliferation. Eur J Immunol (2015) 0.78
Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases. Nat Rev Rheumatol (2017) 0.77
The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator. J Leukoc Biol (2015) 0.77
Alternative spliced CD1d transcripts in human bronchial epithelial cells. PLoS One (2011) 0.77
TL1A induces TCR independent IL-6 and TNF-α production and growth of PLZF⁺ leukocytes. PLoS One (2014) 0.77
On death receptor 3 and its ligands…. Immunology (2012) 0.76
TNF superfamily member 13, APRIL, inhibits allergic lung inflammation. Eur J Immunol (2010) 0.76
Upregulation of DR3 expression in CD4⁺ T cells promotes secretion of IL-17 in experimental autoimmune uveitis. Mol Vis (2011) 0.76
Directed evolution of a soluble human DR3 receptor for the inhibition of TL1A induced cytokine secretion. PLoS One (2017) 0.75
Characterization of death receptor 3-dependent aortic changes during inflammatory arthritis. Pharmacol Res Perspect (2016) 0.75
Death Receptor 3 Promotes Chemokine-Directed Leukocyte Recruitment in Acute Resolving Inflammation and Is Essential for Pathological Development of Mesothelial Fibrosis in Chronic Disease. Am J Pathol (2016) 0.75
Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis. Inflamm Bowel Dis (2016) 0.75
Effect of infusion of mAbs to TNFRSF25 on graft rejection in allo-immune mice receiving autologous marrow transplantation. Immunology (2016) 0.75
CCL3 and MMP-9 are induced by TL1A during death receptor 3 (TNFRSF25)-dependent osteoclast function and systemic bone loss. Bone (2017) 0.75
Multiple activating and repressive cis-promoter regions regulate TNFSF15 expression in human primary mononuclear cells. Cytokine (2013) 0.75
DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft versus host disease. Blood (2016) 0.75
The role of death receptor 3 in the biological behavior of hepatocellular carcinoma cells. Mol Med Rep (2014) 0.75
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell (2003) 11.07
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell (1995) 9.81
Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors. Science (1997) 8.95
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell (1996) 8.89
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest (1999) 8.38
Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med (2003) 6.42
A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J Biol Chem (1995) 5.34
Going both ways: immune regulation via CD1d-dependent NKT cells. J Clin Invest (2004) 5.16
TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity (2002) 3.46
Cutting edge: invariant V alpha 14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model. J Immunol (2003) 2.95
Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science (1996) 2.87
Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells. Proc Natl Acad Sci U S A (2006) 2.34
OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. J Exp Med (2003) 2.26
Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease. J Immunol (2003) 2.21
Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells. Immunity (1999) 2.09
A death-domain-containing receptor that mediates apoptosis. Nature (1996) 1.92
Role of TL1A and its receptor DR3 in two models of chronic murine ileitis. Proc Natl Acad Sci U S A (2006) 1.87
TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells. J Immunol (2004) 1.85
Endogenous interleukin-10 suppresses allergen-induced airway inflammation and nonspecific airway responsiveness. Clin Exp Allergy (2000) 1.82
Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a sphingosine-truncated analog of alpha-galactosylceramide. Arthritis Rheum (2004) 1.74
TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). Immunity (1997) 1.74
Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B. Curr Biol (1996) 1.72
LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing. Proc Natl Acad Sci U S A (1997) 1.58
Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils. Blood (1991) 1.51
Role of IL-13 in regulation of anti-tumor immunity and tumor growth. Cancer Immunol Immunother (2003) 1.51
DR3 regulates negative selection during thymocyte development. Mol Cell Biol (2001) 1.44
TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells. J Biol Chem (2003) 1.40
Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function. J Immunol (2006) 1.39
Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma. Eur J Immunol (2003) 1.37
Interleukin-13 in asthma pathogenesis. Curr Allergy Asthma Rep (2004) 1.15
Soluble decoy receptor 3 induces angiogenesis by neutralization of TL1A, a cytokine belonging to tumor necrosis factor superfamily and exhibiting angiostatic action. Cancer Res (2004) 1.14
iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity. J Immunol (2007) 1.13
Retracted V alpha 24-invariant NKT cells from patients with allergic asthma express CCR9 at high frequency and induce Th2 bias of CD3+ T cells upon CD226 engagement. J Immunol (2005) 1.10
Regulation of immune responses by CD1d-restricted natural killer T cells. Immunol Res (2004) 1.07
Genomic structure, expression, and chromosome mapping of the mouse homologue for the WSL-1 (DR3, Apo3, TRAMP, LARD, TR3, TNFRSF12) gene. Immunogenetics (2001) 1.04
Kinetics and quantitation of eosinophil and neutrophil recruitment to allergic lung inflammation in a brown Norway rat model. Am J Respir Cell Mol Biol (1997) 1.02
Efficacy of a traditional Korean medicine, Chung-Sang-Bo-Ha-Tang, in a murine model of chronic asthma. Int Immunopharmacol (2005) 0.98
Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway. Virology (2005) 0.95
A new death receptor 3 isoform: expression in human lymphoid cell lines and non-Hodgkin's lymphomas. Biochem Biophys Res Commun (1998) 0.94
Human eosinophils in culture undergo a striking and rapid shrinkage during apoptosis. Role of K+ channels. J Leukoc Biol (1995) 0.92
Challenges in infant immunity: implications for responses to infection and vaccines. Nat Immunol (2011) 2.17
Deterministic regulation of hematopoietic stem cell self-renewal and differentiation. Blood (2002) 2.04
Murine neonatal recent thymic emigrants are phenotypically and functionally distinct from adult recent thymic emigrants. Blood (2009) 1.95
Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells. Trends Immunol (2009) 1.88
Immunotherapy as a strategy for the treatment of non-small-cell lung cancer. Therapy (2011) 1.74
Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. J Clin Invest (2010) 1.50
Murine neonatal CD4+ cells are poised for rapid Th2 effector-like function. J Immunol (2007) 1.41
IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells. J Immunol (2012) 1.21
Polynucleotide phosphorylase independently controls virulence factor expression levels and export in Yersinia spp. FEMS Microbiol Lett (2007) 1.07
Surmounting tumor-induced immune suppression by frequent vaccination or immunization in the absence of B cells. J Immunother (2008) 1.06
Molecular and cellular requirements for enhanced antigen cross-presentation to CD8 cytotoxic T lymphocytes. J Immunol (2007) 1.06
The absence of B lymphocytes reduces the number and function of T-regulatory cells and enhances the anti-tumor response in a murine tumor model. Cancer Immunol Immunother (2011) 1.06
CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease. J Immunol (2004) 1.05
CD30: an important new target in hematologic malignancies. Leuk Lymphoma (2011) 1.05
Lung cancer immunotherapy. Clin Med Res (2005) 1.04
Host innate recognition of an intestinal bacterial pathogen induces TRIF-dependent protective immunity. J Exp Med (2011) 1.02
Perforin is required for innate and adaptive immunity induced by heat shock protein gp96. Immunity (2003) 0.98
B lymphocyte inhibition of anti-tumor response depends on expansion of Treg but is independent of B-cell IL-10 secretion. Cancer Immunol Immunother (2012) 0.98
Murine neonates develop vigorous in vivo cytotoxic and Th1/Th2 responses upon exposure to low doses of NIMA-like alloantigens. Blood (2008) 0.96
Immunomodulatory effects of sensory nerves during respiratory syncytial virus infection in rats. Am J Physiol Lung Cell Mol Physiol (2003) 0.96
Allogeneic vaccination with a B7.1 HLA-A gene-modified adenocarcinoma cell line in patients with advanced non-small-cell lung cancer. J Clin Oncol (2004) 0.96
Tumor-induced suppression of CTL expansion and subjugation by gp96-Ig vaccination. Cancer Res (2009) 0.95
Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection. J Mol Med (Berl) (2014) 0.94
Effector cells derived from host CD8 memory T cells mediate rapid resistance against minor histocompatibility antigen-mismatched allogeneic marrow grafts without participation of perforin, Fas ligand, and the simultaneous inhibition of 3 tumor necrosis factor family effector pathways. Biol Blood Marrow Transplant (2005) 0.93
B cell regulation of anti-tumor immune response. Immunol Res (2013) 0.91
Cutting edge: novel vaccination modality provides significant protection against mucosal infection by highly pathogenic simian immunodeficiency virus. J Immunol (2013) 0.91
APRIL (TNFSF13) regulates collagen-induced arthritis, IL-17 production and Th2 response. Eur J Immunol (2008) 0.90
A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Gastroenterology (2007) 0.90
CD30: from basic research to cancer therapy. Immunol Res (2013) 0.90
Murine neonates are highly resistant to Yersinia enterocolitica following orogastric exposure. Infect Immun (2007) 0.89
Tregs expanded in vivo by TNFRSF25 agonists promote cardiac allograft survival. Transplantation (2012) 0.89
A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells. J Immunol (2005) 0.88
Inhibition of intracellular bacterial replication in fibroblasts is dependent on the perforin-like protein (perforin-2) encoded by macrophage-expressed gene 1. J Innate Immun (2012) 0.88
CD30 ligand is a target for a novel biological therapy against colitis associated with Th17 responses. J Immunol (2010) 0.88
Secreted heat shock protein gp96-Ig: an innovative vaccine approach. Am J Reprod Immunol (2008) 0.88
Systemic and local expression of perforin in lymphocyte subsets in acute and chronic rheumatoid arthritis. J Rheumatol (2003) 0.88
Immunobiology of TNFSF15 and TNFRSF25. Immunol Res (2013) 0.88
The role of TNFRSF25:TNFSF15 in disease… and health? Adv Exp Med Biol (2011) 0.87
Tumor immunogenicity and responsiveness to cancer vaccine therapy: the state of the art. Semin Immunol (2010) 0.87
TNFRSF25 agonistic antibody and galectin-9 combination therapy controls herpes simplex virus-induced immunoinflammatory lesions. J Virol (2012) 0.87
A novel role of CD30L/CD30 signaling by T-T cell interaction in Th1 response against mycobacterial infection. J Immunol (2008) 0.86
Heat shock protein-based cancer vaccines. Hematol Oncol Clin North Am (2006) 0.86
Cloning, expression, and functional characterization of TL1A-Ig. J Immunol (2013) 0.85
Gp96 SIV Ig immunization induces potent polyepitope specific, multifunctional memory responses in rectal and vaginal mucosa. Vaccine (2011) 0.84
T cell costimulation by TNFR superfamily (TNFRSF)4 and TNFRSF25 in the context of vaccination. J Immunol (2012) 0.84
CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice. J Immunol (2010) 0.84
Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo. Cancer Res (2007) 0.84
Killing machines: three pore-forming proteins of the immune system. Immunol Res (2013) 0.84
Present and future of lung cancer vaccines. Expert Opin Emerg Drugs (2006) 0.83
Statistical Considerations in Clinical Trial Design of Immunotherapeutic Cancer Agents. J Immunother (2015) 0.83
Induction of CD8 T-cell-Ifn-gamma response and positive clinical outcome after immunization with gene-modified allogeneic tumor cells in advanced non-small-cell lung carcinoma. Cancer Gene Ther (2003) 0.83
The allure and peril of hematopoietic stem cell transplantation: overcoming immune challenges to improve success. Immunol Res (2013) 0.82
Progesterone induced blocking factor (PIBF) mediates progesterone induced suppression of decidual lymphocyte cytotoxicity. Am J Reprod Immunol (2002) 0.82
Donor T cells lacking Fas ligand and perforin retain the capacity to induce severe GvHD in minor histocompatibility antigen mismatched bone-marrow transplantation recipients. Transplantation (2004) 0.82
IL-18 is present at the maternal-fetal interface and enhances cytotoxic activity of decidual lymphocytes. Am J Reprod Immunol (2002) 0.82
Humanized mice: novel model for studying mechanisms of human immune-based therapies. Immunol Res (2013) 0.82
Pore formers of the immune system. Adv Exp Med Biol (2007) 0.81
Loss of the perforin cytotoxic pathway predisposes mice to experimental cytomegalovirus retinitis. J Virol (2003) 0.81
Murine neonates infected with Yersinia enterocolitica develop rapid and robust proinflammatory responses in intestinal lymphoid tissues. Infect Immun (2013) 0.81
Secreted heat shock protein gp96-Ig: next-generation vaccines for cancer and infectious diseases. Immunol Res (2013) 0.80
CD30 is required for activation of a unique subset of interleukin-17A-producing γδ T cells in innate immunity against Mycobacterium bovis Bacillus Calmette-Guerin infection. Infect Immun (2013) 0.80
Yersinia enterocolitica promotes robust mucosal inflammatory T-cell immunity in murine neonates. Infect Immun (2010) 0.80
The pendulum swings: Tolerance versus priming to NIMA. Chimerism (2016) 0.79
The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice. Eur J Immunol (2011) 0.79
The key regulators of adult T helper cell responses, STAT6 and T-bet, are established in early life in mice. Eur J Immunol (2006) 0.79
Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice. Blood (2014) 0.78
Heat shock fusion protein gp96-Ig mediates strong CD8 CTL expansion in vivo. Am J Reprod Immunol (2002) 0.78
CD30 supports lung inflammation. Int Immunol (2007) 0.78
A new unexpected twist in newborn immunity. Nat Med (2014) 0.77
Murine cytomegalovirus retinitis during retrovirus-induced immunodeficiency (MAIDS) in mice: interleukin-2 immunotherapy correlates with increased intraocular levels of perforin mRNA. Antiviral Res (2003) 0.77
Influence of breast cancer on thymic function in mice. J Mammary Gland Biol Neoplasia (2002) 0.77
CD30 ligand/CD30 interaction is involved in pathogenesis of inflammatory bowel disease. Dig Dis Sci (2012) 0.76
Short-term cytolytic mediators' expression in decidual lymphocytes is enhanced by interleukin-15. Am J Reprod Immunol (2006) 0.76
Regulation of lymphocyte clustering by CD30-mediated ICAM-1 up-regulation. Cell Immunol (2002) 0.76
TNF superfamily member 13, APRIL, inhibits allergic lung inflammation. Eur J Immunol (2010) 0.76
The murine Th2 locus undergoes epigenetic modification in the thymus during fetal and postnatal ontogeny. PLoS One (2013) 0.75
MPEG1/perforin-2 mutations in human pulmonary nontuberculous mycobacterial infections. JCI Insight (2017) 0.75
Clinical trials targeting lung cancer with active immunotherapy: the scope of vaccines. Expert Rev Anticancer Ther (2005) 0.75