A comparative metabolomic study of NHR-49 in Caenorhabditis elegans and PPAR-alpha in the mouse.

PubWeight™: 1.08‹?› | Rank: Top 10%

🔗 View Article (PMID 18435929)

Published in FEBS Lett on April 22, 2008

Authors

Helen J Atherton1, Oliver A H Jones, Shahid Malik, Eric A Miska, Julian L Griffin

Author Affiliations

1: The Department of Biochemistry, Tennis Court Road, University of Cambridge, Cambridge CB2 1QW, UK.

Articles citing this

Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids. Cell (2015) 2.27

Fat synthesis and adiposity regulation in Caenorhabditis elegans. Trends Endocrinol Metab (2009) 1.91

Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. FASEB J (2008) 1.45

NMR-spectroscopic analysis of mixtures: from structure to function. Curr Opin Chem Biol (2010) 1.37

A metabolic signature of long life in Caenorhabditis elegans. BMC Biol (2010) 1.36

Hierarchical alignment and full resolution pattern recognition of 2D NMR spectra: application to nematode chemical ecology. Anal Chem (2011) 1.12

PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. PLoS Genet (2013) 1.00

The adiponectin receptor homologs in C. elegans promote energy utilization and homeostasis. PLoS One (2011) 0.96

Profiling the anaerobic response of C. elegans using GC-MS. PLoS One (2012) 0.87

Dietary restriction during development enlarges intestinal and hypodermal lipid droplets in Caenorhabditis elegans. PLoS One (2012) 0.86

A metabolomic strategy defines the regulation of lipid content and global metabolism by Δ9 desaturases in Caenorhabditis elegans. BMC Genomics (2012) 0.83

The cellular geometry of growth drives the amino acid economy of Caenorhabditis elegans. Proc Biol Sci (2009) 0.81

PDHK-2 deficiency is associated with attenuation of lipase-mediated fat consumption for the increased survival of Caenorhabditis elegans dauers. PLoS One (2012) 0.80

A metabolomics based test of independent action and concentration addition using the earthworm Lumbricus rubellus. Ecotoxicology (2012) 0.79

Cranberry Product Decreases Fat Accumulation in Caenorhabditis elegans. J Med Food (2016) 0.78

Oat consumption reduced intestinal fat deposition and improved health span in Caenorhabditis elegans model. Nutr Res (2015) 0.76

Prowashonupana barley dietary fibre reduces body fat and increases insulin sensitivity in Caenorhabditis elegans model. J Funct Foods (2015) 0.76

1H NMR-Based Metabolomic Analysis of Sub-Lethal Perfluorooctane Sulfonate Exposure to the Earthworm, Eisenia fetida, in Soil. Metabolites (2013) 0.76

Mutation of the lbp-5 gene alters metabolic output in Caenorhabditis elegans. BMB Rep (2014) 0.75

AMP-Activated Protein Kinase Regulates Oxidative Metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 Transcriptional Regulators. PLoS One (2016) 0.75

Articles by these authors

(truncated to the top 100)

MicroRNA expression profiles classify human cancers. Nature (2005) 69.12

Requirement of bic/microRNA-155 for normal immune function. Science (2007) 16.24

MicroRNA functions in animal development and human disease. Development (2005) 8.41

Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI). Metabolomics (2007) 6.93

microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity (2007) 6.72

MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype. Genome Biol (2007) 6.41

The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev Cell (2005) 5.90

Toward interoperable bioscience data. Nat Genet (2012) 4.72

A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes Dev (2007) 4.69

Natural and experimental infection of Caenorhabditis nematodes by novel viruses related to nodaviruses. PLoS Biol (2011) 3.58

piRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans. Cell (2012) 3.49

Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline. Mol Cell (2008) 3.37

MetaboLights--an open-access general-purpose repository for metabolomics studies and associated meta-data. Nucleic Acids Res (2012) 3.32

MicroRNA: implications for cancer. Virchows Arch (2007) 3.17

Mapping the Arabidopsis organelle proteome. Proc Natl Acad Sci U S A (2006) 3.03

MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis. PLoS One (2008) 2.82

LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans. Nat Struct Mol Biol (2009) 2.79

The metabolomics standards initiative. Nat Biotechnol (2007) 2.54

Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy. Chem Soc Rev (2010) 2.50

The shaping and functional consequences of the microRNA landscape in breast cancer. Nature (2013) 2.22

Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med (2012) 2.13

Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression. Cancer Res (2011) 2.07

Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron (2008) 2.07

Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy. FASEB J (2009) 2.05

A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans. Nat Methods (2010) 1.82

miRNAs in cancer: approaches, aetiology, diagnostics and therapy. Hum Mol Genet (2007) 1.73

The prevalence of non-alcoholic fatty liver disease and metabolic syndrome in obese children. J Pediatr Endocrinol Metab (2011) 1.60

MetaboLights: towards a new COSMOS of metabolomics data management. Metabolomics (2012) 1.53

Metabolic fingerprinting as a diagnostic tool. Pharmacogenomics (2007) 1.51

Proton NMR analysis of plasma is a weak predictor of coronary artery disease. Nat Med (2006) 1.49

Acetylation of beta-catenin by CREB-binding protein (CBP). J Biol Chem (2002) 1.47

Long-term effects of balloon angioplasty on left ventricular hypertrophy in adolescent and adult patients with native coarctation of the aorta. Up to 18 years follow-up results. Catheter Cardiovasc Interv (2007) 1.42

Deletion of btn1, an orthologue of CLN3, increases glycolysis and perturbs amino acid metabolism in the fission yeast model of Batten disease. Mol Biosyst (2010) 1.42

A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-alpha null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome. Physiol Genomics (2006) 1.34

High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease. J Biol Chem (2005) 1.27

Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study. Circulation (2011) 1.26

The contrasting roles of PPARδ and PPARγ in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue. Genome Biol (2011) 1.22

The microRNA miR-124 controls gene expression in the sensory nervous system of Caenorhabditis elegans. Nucleic Acids Res (2010) 1.22

Characterisation of microRNA expression in post-natal mouse mammary gland development. BMC Genomics (2009) 1.21

Differential impact of the HEN1 homolog HENN-1 on 21U and 26G RNAs in the germline of Caenorhabditis elegans. PLoS Genet (2012) 1.20

Application of partial least squares discriminant analysis to two-dimensional difference gel studies in expression proteomics. Proteomics (2005) 1.20

An integrated functional genomic study of acute phenobarbital exposure in the rat. BMC Genomics (2010) 1.19

Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse. Mol Syst Biol (2009) 1.18

Pitfalls in diagnosis and clinical, echocardiographic, and hemodynamic findings in endomyocardial fibrosis: a 25-year experience. Chest (2005) 1.18

Environmental pollution and diabetes: a neglected association. Lancet (2008) 1.15

The organelle proteome of the DT40 lymphocyte cell line. Mol Cell Proteomics (2009) 1.14

miR-124 acts through CoREST to control onset of Sema3A sensitivity in navigating retinal growth cones. Nat Neurosci (2011) 1.14

A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy. PLoS Genet (2010) 1.13

Abundant and dynamically expressed miRNAs, piRNAs, and other small RNAs in the vertebrate Xenopus tropicalis. Genome Res (2009) 1.12

Quantitative proteomic approach to study subcellular localization of membrane proteins. Nat Protoc (2006) 1.11

A matter of fat: an introduction to lipidomic profiling methods. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 1.11

The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice. Free Radic Biol Med (2011) 1.10

Metabolic phenotyping of a model of adipocyte differentiation. Physiol Genomics (2009) 1.10

Remodeling of central metabolism in invasive breast cancer compared to normal breast tissue - a GC-TOFMS based metabolomics study. BMC Genomics (2012) 1.10

A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease. Neurochem Int (2010) 1.10

A LIN28-dependent structural change in pre-let-7g directly inhibits dicer processing. Biochemistry (2011) 1.08

A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity. Elife (2013) 1.08

Metabolic characterization of the R6/2 transgenic mouse model of Huntington's disease by high-resolution MAS 1H NMR spectroscopy. J Proteome Res (2006) 1.08

Metabolic profiling detects biomarkers of protein degradation in COPD patients. Eur Respir J (2011) 1.06

The conserved miR-51 microRNA family is redundantly required for embryonic development and pharynx attachment in Caenorhabditis elegans. Genetics (2010) 1.06

Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis. FASEB J (2005) 1.06

Two Piwi proteins, Xiwi and Xili, are expressed in the Xenopus female germline. RNA (2009) 1.05

A functional analysis of mouse models of cardiac disease through metabolic profiling. J Biol Chem (2004) 1.04

Systems toxicology approaches for understanding the joint effects of environmental chemical mixtures. Sci Total Environ (2010) 1.04

Genome-wide identification of targets and function of individual MicroRNAs in mouse embryonic stem cells. PLoS Genet (2010) 1.03

Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD. Mol Biosyst (2012) 1.02

Leptin regulates peripheral lipid metabolism primarily through central effects on food intake. Endocrinology (2008) 1.01

Comparative metabolomics of estrogen receptor positive and estrogen receptor negative breast cancer: alterations in glutamine and beta-alanine metabolism. J Proteomics (2013) 1.01

Metabolites from cerebrospinal fluid in aneurysmal subarachnoid haemorrhage correlate with vasospasm and clinical outcome: a pattern-recognition 1H NMR study. NMR Biomed (2005) 1.00

Polynucleotide phosphorylase activity may be modulated by metabolites in Escherichia coli. J Biol Chem (2011) 1.00

Sixty-five years since the New York heat wave: advances in sweat testing for cystic fibrosis. Pediatr Pulmonol (2013) 0.99

A practical guide to metabolomic profiling as a discovery tool for human heart disease. J Mol Cell Cardiol (2012) 0.98

Molecular biology. Is there social RNA? Science (2013) 0.98

Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts. Phytochemistry (2004) 0.98

Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice. Physiol Genomics (2010) 0.97

A metabolomics investigation of non-genotoxic carcinogenicity in the rat. J Proteome Res (2013) 0.96

Developmental characterization of the microRNA-specific C. elegans Argonautes alg-1 and alg-2. PLoS One (2012) 0.96

A metabolomics based approach to assessing the toxicity of the polyaromatic hydrocarbon pyrene to the earthworm Lumbricus rubellus. Chemosphere (2007) 0.96

High-resolution magic-angle-spinning 1H NMR spectroscopy reveals different responses in choline-containing metabolites upon gene therapy-induced programmed cell death in rat brain glioma. NMR Biomed (2005) 0.96

Mutation of nfxB causes global changes in the physiology and metabolism of Pseudomonas aeruginosa. J Proteome Res (2010) 0.96

Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro. J Biol Chem (2003) 0.95

Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation. Hepatology (2010) 0.95

Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor delta from Peroxisome proliferator-activated receptor gamma in the ob/ob mouse. Genome Med (2009) 0.94

Metabolomics: a new tool for the neonatologist. J Matern Fetal Neonatal Med (2009) 0.94

Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer. Genome Med (2012) 0.93

Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancer-link to patient survival, hormone receptor status, and metabolic profiling. J Proteome Res (2011) 0.93

Cryogenic probe 13C NMR spectroscopy of urine for metabonomic studies. Anal Chem (2002) 0.93

Omega-3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers. Mol Nutr Food Res (2013) 0.92

PRDE-1 is a nuclear factor essential for the biogenesis of Ruby motif-dependent piRNAs in C. elegans. Genes Dev (2014) 0.91

Formation and abundance of 5-hydroxymethylcytosine in RNA. Chembiochem (2015) 0.91

Metabolomic strategies to study lipotoxicity in cardiovascular disease. Biochim Biophys Acta (2009) 0.91

1H magnetic resonance spectroscopy metabolites as biomarkers for cell cycle arrest and cell death in rat glioma cells. Int J Biochem Cell Biol (2010) 0.90

Regulation of pre-miRNA processing. Adv Exp Med Biol (2010) 0.90

A gender-specific discriminator in Sprague-Dawley rat urine: the deployment of a metabolic profiling strategy for biomarker discovery and identification. Anal Biochem (2006) 0.90

The microRNAs of Caenorhabditis elegans. Semin Cell Dev Biol (2010) 0.89

An introduction to biological nuclear magnetic resonance spectroscopy. Biol Rev Camb Philos Soc (2010) 0.89

Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Diabetes (2013) 0.89

MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes. Neurobiol Dis (2007) 0.89

Competition between virus-derived and endogenous small RNAs regulates gene expression in Caenorhabditis elegans. Genome Res (2013) 0.88

omega-3 oil intake during weight loss in obese women results in remodelling of plasma triglyceride and fatty acids. Metabolomics (2009) 0.88