Published in Nat Protoc on January 01, 2008
The circadian molecular clock creates epidermal stem cell heterogeneity. Nature (2011) 2.34
MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling. Dev Cell (2010) 2.11
Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches. Nat Commun (2012) 1.77
Review of hair follicle dermal cells. J Dermatol Sci (2010) 1.72
Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J Clin Invest (2010) 1.64
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY) (2012) 1.57
12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor. J Exp Med (2014) 1.54
IL-1R-MyD88 signaling in keratinocyte transformation and carcinogenesis. J Exp Med (2012) 1.48
Whole animal knockout of smooth muscle alpha-actin does not alter excisional wound healing or the fibroblast-to-myofibroblast transition. Wound Repair Regen (2012) 1.47
PDGFRβ signaling regulates mural cell plasticity and inhibits fat development. Dev Cell (2011) 1.45
Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin. Development (2011) 1.43
Elevating CLIC4 in Multiple Cell Types Reveals a TGF- Dependent Induction of a Dominant Negative Smad7 Splice Variant. PLoS One (2016) 1.39
Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop. Genes Dev (2012) 1.33
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15. Genes Dev (2013) 1.30
Toll-like receptor 7-induced immune response to cutaneous West Nile virus infection. J Gen Virol (2009) 1.22
Micro-RNA-31 controls hair cycle-associated changes in gene expression programs of the skin and hair follicle. FASEB J (2010) 1.21
Inducible cutaneous inflammation reveals a protumorigenic role for keratinocyte CXCR2 in skin carcinogenesis. Cancer Res (2009) 1.17
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J Clin Invest (2012) 1.16
TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3. Nat Cell Biol (2009) 1.15
Jarid2 regulates mouse epidermal stem cell activation and differentiation. EMBO J (2011) 1.14
Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice. J Invest Dermatol (2011) 1.11
MacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells. Mol Cell Biol (2012) 1.11
Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency. J Allergy Clin Immunol (2012) 1.07
Neuropilins are positive regulators of Hedgehog signal transduction. Genes Dev (2011) 1.07
EMILIN1-α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation. J Cell Biol (2011) 1.05
MicroRNA-21 is an important downstream component of BMP signalling in epidermal keratinocytes. J Cell Sci (2011) 1.01
Epithelial stem cell mutations that promote squamous cell carcinoma metastasis. J Clin Invest (2013) 1.01
Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling. J Biol Chem (2011) 1.01
A simplified procedure to reconstitute hair-producing skin. Tissue Eng Part C Methods (2011) 1.01
Module-based complexity formation: periodic patterning in feathers and hairs. Wiley Interdiscip Rev Dev Biol (2013) 1.00
PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity. Genes Dev (2015) 0.99
Inhibition of mTOR suppresses UVB-induced keratinocyte proliferation and survival. Cancer Prev Res (Phila) (2012) 0.96
Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase. Proc Natl Acad Sci U S A (2011) 0.95
Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering. Expert Opin Biol Ther (2013) 0.95
KLF5 activates microRNA 200 transcription to maintain epithelial characteristics and prevent induced epithelial-mesenchymal transition in epithelial cells. Mol Cell Biol (2013) 0.94
The role of TRADD in TRAIL-induced apoptosis and signaling. FASEB J (2010) 0.94
Autoantibodies in scurfy mice and IPEX patients recognize keratin 14. J Invest Dermatol (2010) 0.94
Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-Ogna. PLoS Genet (2011) 0.93
CLIC4 regulates TGF-β-dependent myofibroblast differentiation to produce a cancer stroma. Oncogene (2013) 0.93
IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms. Proc Natl Acad Sci U S A (2014) 0.92
Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells. Nat Commun (2014) 0.92
Loss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesis. Oncogene (2010) 0.92
SHARPIN regulates mitochondria-dependent apoptosis in keratinocytes. J Dermatol Sci (2011) 0.91
Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth. Neoplasia (2012) 0.91
Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero. Dev Cell (2012) 0.91
Regeneration of multilineage skin epithelia by differentiated keratinocytes. J Invest Dermatol (2009) 0.91
S-nitrosylation regulates nuclear translocation of chloride intracellular channel protein CLIC4. J Biol Chem (2010) 0.89
The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stress. Carcinogenesis (2012) 0.89
Erbb2 suppresses DNA damage-induced checkpoint activation and UV-induced mouse skin tumorigenesis. Am J Pathol (2009) 0.89
Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function. J Invest Dermatol (2014) 0.89
Pharmacologic inhibition of JAK-STAT signaling promotes hair growth. Sci Adv (2015) 0.89
Bone morphogenetic protein signaling suppresses wound-induced skin repair by inhibiting keratinocyte proliferation and migration. J Invest Dermatol (2013) 0.89
Delayed cutaneous wound healing and aberrant expression of hair follicle stem cell markers in mice selectively lacking Ctip2 in epidermis. PLoS One (2012) 0.88
Selenoproteins are essential for proper keratinocyte function and skin development. PLoS One (2010) 0.88
Epidermal p65/NF-κB signalling is essential for skin carcinogenesis. EMBO Mol Med (2014) 0.87
CIKS/Act1-mediated signaling by IL-17 cytokines in context: implications for how a CIKS gene variant may predispose to psoriasis. J Immunol (2012) 0.87
Targeted disruption of glutathione peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2. J Invest Dermatol (2013) 0.87
BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny. Genes Dev (2012) 0.86
CLIC4 is a tumor suppressor for cutaneous squamous cell cancer. Carcinogenesis (2012) 0.86
Suppression of the C/EBP family of transcription factors in adipose tissue causes lipodystrophy. J Mol Endocrinol (2011) 0.86
ADAM17 transactivates EGFR signaling during embryonic eyelid closure. Invest Ophthalmol Vis Sci (2013) 0.85
Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice. Am J Pathol (2012) 0.85
Aberrant connexin26 hemichannels underlying keratitis-ichthyosis-deafness syndrome are potently inhibited by mefloquine. J Invest Dermatol (2014) 0.84
Polyclonal origin and hair induction ability of dermal papillae in neonatal and adult mouse back skin. Dev Biol (2012) 0.84
Hair organ regeneration via the bioengineered hair follicular unit transplantation. Sci Rep (2012) 0.83
Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis. J Biol Chem (2013) 0.83
E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis. Cancer Res (2014) 0.83
MYC degradation under low O2 tension promotes survival by evading hypoxia-induced cell death. Mol Cell Biol (2013) 0.83
Ctip2 is a dynamic regulator of epidermal proliferation and differentiation by integrating EGFR and Notch signaling. J Cell Sci (2012) 0.83
Epidermal or dermal specific knockout of PHD-2 enhances wound healing and minimizes ischemic injury. PLoS One (2014) 0.83
Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: role of Cav1 in Shh heterotypic signaling and transendothelial migration. Cancer Res (2012) 0.83
Enhanced UV-induced skin carcinogenesis in transgenic mice overexpressing proprotein convertases. Neoplasia (2013) 0.83
CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels. Cancer Prev Res (Phila) (2011) 0.83
Regulation of the dynamic chromatin architecture of the epidermal differentiation complex is mediated by a c-Jun/AP-1-modulated enhancer. J Invest Dermatol (2014) 0.83
Survivin Modulates Squamous Cell Carcinoma-Derived Stem-Like Cell Proliferation, Viability and Tumor Formation in Vivo. Int J Mol Sci (2016) 0.82
Muramyl dipeptide induces Th17 polarization through activation of endothelial cells. J Immunol (2011) 0.82
Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia. Cell Death Differ (2012) 0.81
An absence of nuclear lamins in keratinocytes leads to ichthyosis, defective epidermal barrier function, and intrusion of nuclear membranes and endoplasmic reticulum into the nuclear chromatin. Mol Cell Biol (2014) 0.81
Engraftment potential of dermal fibroblasts following in vivo myogenic conversion in immunocompetent dystrophic skeletal muscle. Mol Ther Methods Clin Dev (2014) 0.81
Integrating animal models and in vitro tissue models to elucidate the role of desmosomal proteins in diseases. Cell Commun Adhes (2014) 0.81
Loss of syndecan-1 is associated with malignant conversion in skin carcinogenesis. Mol Carcinog (2010) 0.81
VILIP-1 expression in vivo results in decreased mouse skin keratinocyte proliferation and tumor development. PLoS One (2010) 0.81
Altered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout mice. PLoS One (2013) 0.80
Perivascular hair follicle stem cells associate with a venule annulus. J Invest Dermatol (2013) 0.80
Hair follicle regeneration in skin grafts: current concepts and future perspectives. Tissue Eng Part B Rev (2011) 0.80
Keratin 76 is required for tight junction function and maintenance of the skin barrier. PLoS Genet (2014) 0.80
Premature graying as a consequence of compromised antioxidant activity in hair bulb melanocytes and their precursors. PLoS One (2014) 0.80
The epidermal growth factor receptor increases cytokine production and cutaneous inflammation in response to ultraviolet irradiation. ISRN Dermatol (2013) 0.80
Modeling AEC-New approaches to study rare genetic disorders. Am J Med Genet A (2014) 0.80
Cav1 inhibits benign skin tumor development in a two-stage carcinogenesis model by suppressing epidermal proliferation. Am J Transl Res (2013) 0.79
Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection. Int J Parasitol (2015) 0.79
3D Printing in the Laboratory: Maximize Time and Funds with Customized and Open-Source Labware. J Lab Autom (2016) 0.79
p53 requires the stress sensor USF1 to direct appropriate cell fate decision. PLoS Genet (2014) 0.79
Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA. Oncogene (2014) 0.78
Skin Keratins. Methods Enzymol (2015) 0.78
Detection of active matriptase using a biotinylated chloromethyl ketone peptide. PLoS One (2013) 0.78
Highly upregulated Lhx2 in the Foxn1-/- nude mouse phenotype reflects a dysregulated and expanded epidermal stem cell niche. PLoS One (2013) 0.78
Microfluidic Isolation of CD34-Positive Skin Cells Enables Regeneration of Hair and Sebaceous Glands In Vivo. Stem Cells Transl Med (2014) 0.78
uPARAP function in cutaneous wound repair. PLoS One (2014) 0.78
The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation. J Invest Dermatol (2006) 1.53
Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy. Sci Transl Med (2013) 1.44
CXCR2 ligands and G-CSF mediate PKCalpha-induced intraepidermal inflammation. J Clin Invest (2006) 1.36
EGFR enhances early healing after cutaneous incisional wounding. J Invest Dermatol (2004) 1.35
The organellular chloride channel protein CLIC4/mtCLIC translocates to the nucleus in response to cellular stress and accelerates apoptosis. J Biol Chem (2003) 1.33
HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling. Blood (2008) 1.33
Identification and characterization of tumor-initiating cells in human primary cutaneous squamous cell carcinoma. J Invest Dermatol (2011) 1.31
Strain-dependent differences in malignant conversion of mouse skin tumors is an inherent property of the epidermal keratinocyte. Carcinogenesis (2004) 1.31
Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15. J Immunol (2008) 1.30
mtCLIC/CLIC4, an organellular chloride channel protein, is increased by DNA damage and participates in the apoptotic response to p53. Mol Cell Biol (2002) 1.28
S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways. Cancer Res (2011) 1.25
A humanized stromal bed is required for engraftment of isolated human primary squamous cell carcinoma cells in immunocompromised mice. J Invest Dermatol (2011) 1.23
Activator protein-1 activity regulates epithelial tumor cell identity. Cancer Res (2006) 1.21
Quantitative proteomic analysis of myc-induced apoptosis: a direct role for Myc induction of the mitochondrial chloride ion channel, mtCLIC/CLIC4. J Biol Chem (2005) 1.18
Inducible cutaneous inflammation reveals a protumorigenic role for keratinocyte CXCR2 in skin carcinogenesis. Cancer Res (2009) 1.17
Reduced migration, altered matrix and enhanced TGFbeta1 signaling are signatures of mouse keratinocytes lacking Sdc1. J Cell Sci (2007) 1.17
Protein kinase C alpha-mediated chemotaxis of neutrophils requires NF-kappa B activity but is independent of TNF alpha signaling in mouse skin in vivo. J Immunol (2005) 1.16
Progress in cutaneous cancer research. J Investig Dermatol Symp Proc (2002) 1.16
TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3. Nat Cell Biol (2009) 1.15
Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes. J Biol Chem (2005) 1.14
Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways. J Immunol (2003) 1.13
EGFR regulates the expression of keratinocyte-derived granulocyte/macrophage colony-stimulating factor in vitro and in vivo. J Invest Dermatol (2009) 1.09
Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers. Clin Cancer Res (2007) 1.05
Gene from a psoriasis susceptibility locus primes the skin for inflammation. Sci Transl Med (2010) 1.04
Antisense suppression of the chloride intracellular channel family induces apoptosis, enhances tumor necrosis factor {alpha}-induced apoptosis, and inhibits tumor growth. Cancer Res (2005) 1.04
The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. Cancer Res (2010) 1.04
RasGRP3 contributes to formation and maintenance of the prostate cancer phenotype. Cancer Res (2010) 1.04
CLIC4, an intracellular chloride channel protein, is a novel molecular target for cancer therapy. J Investig Dermatol Symp Proc (2005) 1.03
CLIC4 mediates and is required for Ca2+-induced keratinocyte differentiation. J Cell Sci (2007) 1.02
CLIC4, skin homeostasis and cutaneous cancer: surprising connections. Mol Carcinog (2007) 0.99
Src family kinases phosphorylate protein kinase C delta on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes. J Biol Chem (2002) 0.97
Novel S100A7 (psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function. Amino Acids (2010) 0.96
Tissue homeostasis and the control of the neoplastic phenotype in epithelial cancers. Semin Cancer Biol (2005) 0.95
Genomic structure and promoter analysis of PKC-delta. Genomics (2003) 0.93
The contribution of epidermal stem cells to skin cancer. Stem Cell Rev (2005) 0.92
Intracellular chloride channels: critical mediators of cell viability and potential targets for cancer therapy. Curr Pharm Des (2005) 0.91
Characterization of a novel cyclin-dependent kinase 1 inhibitor, BMI-1026. Cancer Res (2003) 0.90
Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assay. Proc Natl Acad Sci U S A (2009) 0.90
S-nitrosylation regulates nuclear translocation of chloride intracellular channel protein CLIC4. J Biol Chem (2010) 0.89
Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer. Cancer Lett (2009) 0.89
Isolation of a mesenchymal cell population from murine dermis that contains progenitors of multiple cell lineages. FASEB J (2007) 0.89
MyD88 and its divergent toll in carcinogenesis. Trends Immunol (2013) 0.88
Selenoproteins are essential for proper keratinocyte function and skin development. PLoS One (2010) 0.88
The black box illuminated: signals and signaling. J Invest Dermatol (2011) 0.88
Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference. PLoS One (2013) 0.88
Targeted disruption of glutathione peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2. J Invest Dermatol (2013) 0.87
Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development. J Cell Sci (2012) 0.87
CLIC4 and Schnurri-2: a dynamic duo in TGF-beta signaling with broader implications in cellular homeostasis and disease. Nucleus (2011) 0.87
A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis. Cancer Res (2003) 0.87
CLIC4 is a tumor suppressor for cutaneous squamous cell cancer. Carcinogenesis (2012) 0.86
Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation. Proc Natl Acad Sci U S A (2012) 0.86
Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice. Am J Pathol (2012) 0.85
Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension. Circulation (2014) 0.84
Opposing functions of psoriasin (S100A7) and koebnerisin (S100A15) in epithelial carcinogenesis. Curr Opin Pharmacol (2013) 0.82
Loss of syndecan-1 is associated with malignant conversion in skin carcinogenesis. Mol Carcinog (2010) 0.81
Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation. Carcinogenesis (2012) 0.81
Purification, crystallization and preliminary X-ray diffraction of human S100A15. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.81
Transforming growth factor beta1 enhances tumor promotion in mouse skin carcinogenesis. Carcinogenesis (2010) 0.81
Cutaneous retinoic acid levels determine hair follicle development and downgrowth. J Biol Chem (2012) 0.80
The human promyelocytic leukemia protein is a tumor suppressor for murine skin carcinogenesis. Mol Carcinog (2009) 0.79
Modeling the transcriptional consequences of epidermal growth factor receptor ablation in Ras-initiated squamous cancer. Clin Cancer Res (2011) 0.76