Published in Biochemistry on May 07, 2008
Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR. Cell (2013) 1.83
Lifting the lid on GPCRs: the role of extracellular loops. Br J Pharmacol (2012) 1.50
Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping. FASEB J (2012) 1.13
Spatial approximations between residues 6 and 12 in the amino-terminal region of glucagon-like peptide 1 and its receptor: a region critical for biological activity. J Biol Chem (2010) 1.02
Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs? Br J Pharmacol (2012) 0.97
Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function. Biochim Biophys Acta (2011) 0.93
Structural and functional insights into the juxtamembranous amino-terminal tail and extracellular loop regions of class B GPCRs. Br J Pharmacol (2014) 0.88
PTH and PTH antagonist induce different conformational changes in the PTHR1 receptor. J Bone Miner Res (2009) 0.84
The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling. Biosci Rep (2015) 0.84
International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors. Pharmacol Rev (2015) 0.83
Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraints. Bioorg Med Chem Lett (2010) 0.81
The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach. J R Soc Interface (2013) 0.80
Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties. J Biol Chem (2016) 0.80
Experiment-Guided Molecular Modeling of Protein-Protein Complexes Involving GPCRs. Methods Mol Biol (2015) 0.77
Disulfide Trapping for Modeling and Structure Determination of Receptor: Chemokine Complexes. Methods Enzymol (2016) 0.77
Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells. Elife (2017) 0.76
High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5. Biochem Pharmacol (2016) 0.75
G protein coupled receptor structure and activation. Biochim Biophys Acta (2006) 2.48
Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors. Drug Discov Today (2005) 2.29
Family-B G-protein-coupled receptors. Genome Biol (2001) 1.75
Methionine acts as a "magnet" in photoaffinity crosslinking experiments. FEBS Lett (2006) 1.45
Parathyroid hormone-receptor interactions identified directly by photocross-linking and molecular modeling studies. J Biol Chem (1998) 1.27
Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor. Proc Natl Acad Sci U S A (2005) 1.23
Photoaffinity cross-linking identifies differences in the interactions of an agonist and an antagonist with the parathyroid hormone/parathyroid hormone-related protein receptor. J Biol Chem (2000) 1.21
The mid-region of parathyroid hormone (1-34) serves as a functional docking domain in receptor activation. Biochemistry (2006) 1.17
Multiple sites of contact between the carboxyl-terminal binding domain of PTHrP-(1--36) analogs and the amino-terminal extracellular domain of the PTH/PTHrP receptor identified by photoaffinity cross-linking. J Biol Chem (2001) 1.07
Determining the environment of the ligand binding pocket of the human angiotensin II type I (hAT1) receptor using the methionine proximity assay. J Biol Chem (2005) 1.04
Identification of a contact site for residue 19 of parathyroid hormone (PTH) and PTH-related protein analogs in transmembrane domain two of the type 1 PTH receptor. Mol Endocrinol (2003) 1.04
Mapping ligand-receptor interfaces: approaching the resolution limit of benzophenone-based photoaffinity scanning. Chem Biol Drug Des (2008) 1.01
Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor. J Biol Chem (2004) 0.96
Photoaffinity scanning in the mapping of the peptide receptor interface of class II G protein-coupled receptors. J Pept Sci (2004) 0.92
Structure of the complement factor 5a receptor-ligand complex studied by disulfide trapping and molecular modeling. J Biol Chem (2008) 0.91
Direct mapping of an agonist-binding domain within the parathyroid hormone/parathyroid hormone-related protein receptor by photoaffinity crosslinking. Proc Natl Acad Sci U S A (1997) 0.91
Methionine proximity assay, a novel method for exploring peptide ligand-receptor interaction. J Recept Signal Transduct Res (2002) 0.91
Evidence for a ligand interaction site at the amino-terminus of the parathyroid hormone (PTH)/PTH-related protein receptor from cross-linking and mutational studies. J Biol Chem (1998) 0.90
Arginine 186 in the extracellular N-terminal region of the human parathyroid hormone 1 receptor is essential for contact with position 13 of the hormone. Mol Endocrinol (1998) 0.87
Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe. Proc Natl Acad Sci U S A (2007) 0.83
Photo-oxidation of methionine-containing peptides by the 4-carboxybenzophenone triplet state in aqueous solution. Competition between intramolecular two-centered three-electron bonded (S...S)+ and (S...N)+ formation. Photochem Photobiol (2000) 0.79
Parathyroid hormone: chemistry and structure-activity relations. Pathobiol Annu (1981) 0.78
Photolabeling study of the ligand binding domain of natriuretic peptide receptor A: development of a model. Biochemistry (2005) 0.77
A mouse model of human breast cancer metastasis to human bone. Cancer Res (2005) 2.24
Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone. Cancer Res (2009) 1.74
Successful nonoperative management of the most severe blunt liver injuries: a multicenter study of the research consortium of new England centers for trauma. Arch Surg (2012) 1.63
Human bone marrow-derived MSCs can home to orthotopic breast cancer tumors and promote bone metastasis. Cancer Res (2010) 1.61
Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem Biol (2004) 1.49
Tissue-engineered bone serves as a target for metastasis of human breast cancer in a mouse model. Cancer Res (2007) 1.46
Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy. J Clin Invest (2008) 1.46
Methionine acts as a "magnet" in photoaffinity crosslinking experiments. FEBS Lett (2006) 1.45
Morphologic and body composition changes are different in men and women on generic combination antiretroviral therapy--an observational study. J Assoc Physicians India (2010) 1.43
Lessons learned from the introduction of personalized genotyping into a medical school curriculum. Genet Med (2011) 1.41
Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking. J Neurosci (2008) 1.41
Perceptions of gender and tuberculosis in a south Indian urban community. Indian J Tuberc (2008) 1.33
An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1. J Biol Chem (2010) 1.32
Depressive symptoms and human immunodeficiency virus risk behavior among men who have sex with men in Chennai, India. Psychol Health Med (2009) 1.30
Dual role of the second extracellular loop of the cannabinoid receptor 1: ligand binding and receptor localization. Mol Pharmacol (2009) 1.23
Selective ligand-induced stabilization of active and desensitized parathyroid hormone type 1 receptor conformations. J Biol Chem (2002) 1.21
The mid-region of parathyroid hormone (1-34) serves as a functional docking domain in receptor activation. Biochemistry (2006) 1.17
Targeting CAL as a negative regulator of DeltaF508-CFTR cell-surface expression: an RNA interference and structure-based mutagenetic approach. J Biol Chem (2006) 1.15
Mechanisms regulating the expression, self-maintenance, and signaling-function of the bradykinin B2 and B1 receptors. J Cell Physiol (2002) 1.15
Quantitative phosphoproteomic analysis of the STAT3/IL-6/HIF1alpha signaling network: an initial study in GSC11 glioblastoma stem cells. J Proteome Res (2010) 1.09
Architecture of the 99 bp DNA-six-protein regulatory complex of the lambda att site. Mol Cell (2006) 1.09
The PDZ1 domain of SAP90. Characterization of structure and binding. J Biol Chem (2001) 1.09
Alcohol use disorders (AUD) among tuberculosis patients: a study from Chennai, South India. PLoS One (2011) 1.05
Identification of amino acid residues in BK virus VP1 that are critical for viability and growth. J Virol (2007) 1.04
Modeling a sialic acid binding pocket in the external loops of JC virus VP1. J Biol Chem (2004) 1.03
Sharing of clinical trial data: benefits, risks, and uniform principles. Ann Intern Med (2015) 1.03
A steroid modulatory domain on NR2B controls N-methyl-D-aspartate receptor proton sensitivity. Proc Natl Acad Sci U S A (2004) 1.03
Mapping ligand-receptor interfaces: approaching the resolution limit of benzophenone-based photoaffinity scanning. Chem Biol Drug Des (2008) 1.01
Hydrophobic residues in helix 8 of cannabinoid receptor 1 are critical for structural and functional properties. Biochemistry (2010) 0.93
Blunt pancreatoduodenal injury: a multicenter study of the Research Consortium of New England Centers for Trauma (ReCONECT). Arch Surg (2009) 0.92
The conformation of cyclo(-D-Pro-Ala4-) as a model for cyclic pentapeptides of the DL4 type. J Am Chem Soc (2006) 0.92
Association of the cystic fibrosis transmembrane regulator with CAL: structural features and molecular dynamics. Biochemistry (2005) 0.91
Cannabinoid receptor-G protein interactions: G(alphai1)-bound structures of IC3 and a mutant with altered G protein specificity. Protein Sci (2002) 0.90
Structural analysis of the human cannabinoid receptor one carboxyl-terminus identifies two amphipathic helices. Biopolymers (2009) 0.89
Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents. J Med Chem (2012) 0.89
Commentary: a call for culture change in academic medicine. Acad Med (2010) 0.89
Of mice and (wo)men: mouse models of breast cancer metastasis to bone. J Bone Miner Res (2010) 0.89
Structural characterization of the intermolecular interactions of synapse-associated protein-97 with the NR2B subunit of N-methyl-D-aspartate receptors. J Biol Chem (2005) 0.89
Spider silk-based gene carriers for tumor cell-specific delivery. Bioconjug Chem (2011) 0.88
Defining the retinoid binding site in the rod cyclic nucleotide-gated channel. J Gen Physiol (2005) 0.88
Large-scale purification and characterization of human parathyroid hormone-1 receptor stably expressed in HEK293S GnTI- cells. Protein Expr Purif (2005) 0.87
The delta e13 isoform of the calcitonin receptor forms a six-transmembrane domain receptor with dominant-negative effects on receptor surface expression and signaling. Mol Endocrinol (2005) 0.87
Structure of the third intracellular loop of the human cannabinoid 1 receptor. Biochemistry (2002) 0.87
The role of sialic acid in human polyomavirus infections. Glycoconj J (2006) 0.86
A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation. Brain Res (2006) 0.86
Residue 17 of sauvagine cross-links to the first transmembrane domain of corticotropin-releasing factor receptor 1 (CRFR1). J Biol Chem (2008) 0.85
PTH and PTH antagonist induce different conformational changes in the PTHR1 receptor. J Bone Miner Res (2009) 0.84
Identification of the principal binding site for RGD-containing ligands in the alpha(V)beta(3) integrin: a photoaffinity cross-linking study. Biochemistry (2002) 0.83
Access to patient-level trial data. N Engl J Med (2014) 0.83
Conformational preference and potential templates of N-methylated cyclic pentaalanine peptides. Chemistry (2008) 0.82
Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor. Biochemistry (2002) 0.82
Molecular characterization of a ligand-tethered parathyroid hormone receptor. Biophys Chem (2002) 0.81
Cysteine at position 217 in the intracellular loop 1 plays a critical role in human PTH receptor type 1 membrane translocation and function. J Bone Miner Res (2007) 0.80
Small-molecule inhibitors of JC polyomavirus infection. J Pept Sci (2014) 0.80
Bradykinin B2 receptor signaling: structural and functional characterization of the C-terminus. Biopolymers (2005) 0.80
Recombinant production of TEV cleaved human parathyroid hormone. J Pept Sci (2013) 0.80
Conformational changes in the parathyroid hormone receptor associated with activation by agonist. Mol Endocrinol (2008) 0.80
Chimeric exchanges within the bradykinin B2 receptor intracellular face with the prostaglandin EP2 receptor as the donor: importance of the second intracellular loop for cAMP synthesis. Arch Biochem Biophys (2003) 0.79
Recombinant expression and purification of the N-terminal extracellular domain of the parathyroid hormone receptor. Protein Expr Purif (2007) 0.79
C-terminus of ETA/ETB receptors regulate endothelin-1 signal transmission. J Pept Sci (2013) 0.79
Structural insight into the role of the second intracellular loop of the bradykinin 2 receptor in signaling and internalization. Biopolymers (2002) 0.79
When two keys fit one lock, surprises follow. Nat Chem Biol (2009) 0.79
Toward parathyroid hormone minimization: conformational studies of cyclic PTH(1-14) analogues. Biochemistry (2004) 0.79
A pilot RCT of an intervention to reduce HIV sexual risk and increase self-acceptance among MSM in Chennai, India. AIDS Behav (2014) 0.78
Backbone dynamics of human parathyroid hormone (1-34): flexibility of the central region under different environmental conditions. Biopolymers (2006) 0.78
Peptides modeled on the RGG domain of AUF1/hnRNP-D regulate 3' UTR-dependent gene expression. Int Immunopharmacol (2013) 0.78
Global chimeric exchanges within the intracellular face of the bradykinin B2 receptor with corresponding angiotensin II type Ia receptor regions: generation of fully functional hybrids showing characteristic signaling of the AT1a receptor. J Cell Biochem (2002) 0.78
Targeting the PDZ domains of molecular scaffolds of transmembrane ion channels. AAPS J (2006) 0.78
Determination of ligand-receptor interactions of cholecystokinin by nuclear magnetic resonance. Life Sci (2003) 0.78
A pan-inhibitor of DASH family enzymes induces immune-mediated regression of murine sarcoma and is a potent adjuvant to dendritic cell vaccination and adoptive T-cell therapy. J Immunother (2013) 0.77
Residue 19 of the parathyroid hormone: structural consequences. Biochemistry (2002) 0.77
Extracellular domains of the neurokinin-1 receptor: structural characterization and interactions with substance P. Biopolymers (2002) 0.77
4-Substituted boro-proline dipeptides: synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities. Bioorg Med Chem Lett (2012) 0.77
Protein engineering of the N-terminus of NEMO: structure stabilization and rescue of IKKβ binding. Biochemistry (2014) 0.77
Immune reconstitution syndrome following initiation of antiretroviral therapy in a patient with HIV infection and multidrug-resistant tuberculosis. Indian J Chest Dis Allied Sci (2005) 0.77
Small molecule inhibition of the Na(+)/H(+) exchange regulatory factor 1 and parathyroid hormone 1 receptor interaction. Biochemistry (2014) 0.77
NMR studies of CCK-8/CCK1 complex support membrane-associated pathway for ligand-receptor interaction. Can J Physiol Pharmacol (2002) 0.77
Side chain cyclization based on serine residues: synthesis, structure, and activity of a novel cyclic analogue of the parathyroid hormone fragment 1-11. J Med Chem (2010) 0.77
Monitoring ATP hydrolysis and ATPase inhibitor screening using (1)H NMR. Chem Commun (Camb) (2014) 0.76
Evidence for a C-terminal structural motif in gastrin and its bioactive fragments in membrane mimetic media. Peptides (2007) 0.76
Studies of osteotropism on both sides of the breast cancer-bone interaction. Ann N Y Acad Sci (2007) 0.76
AUF1-RGG peptides up-regulate the VEGF antagonist, soluble VEGF receptor-1 (sFlt-1). Cytokine (2013) 0.76