Published in PLoS Comput Biol on February 01, 2008
Comparisons of seven algorithms for pathway analysis using the WTCCC Crohn's Disease dataset. BMC Res Notes (2011) 1.24
Analysis of bacterial biofilms using NMR-based metabolomics. Future Med Chem (2012) 1.11
Comprehensive analysis of human microRNA target networks. BioData Min (2011) 1.04
Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev Biol (2009) 0.99
Ontology-based instance data validation for high-quality curated biological pathways. BMC Bioinformatics (2011) 0.98
A quick guide to large-scale genomic data mining. PLoS Comput Biol (2010) 0.93
Boolean modeling and fault diagnosis in oxidative stress response. BMC Genomics (2012) 0.90
siRNA Genome Screening Approaches to Therapeutic Drug Repositioning. Pharmaceuticals (Basel) (2013) 0.89
Cell cycle gene networks are associated with melanoma prognosis. PLoS One (2012) 0.88
Pandora, a pathway and network discovery approach based on common biological evidence. Bioinformatics (2009) 0.83
PINT: Pathways INtegration Tool. Nucleic Acids Res (2010) 0.80
An integrated mathematical model of thrombin-, histamine-and VEGF-mediated signalling in endothelial permeability. BMC Syst Biol (2011) 0.80
A network-based kernel machine test for the identification of risk pathways in genome-wide association studies. Hum Hered (2014) 0.80
Transcriptome alterations of mitochondrial and coagulation function in schizophrenia by cortical sequencing analysis. BMC Genomics (2014) 0.79
A primer for disease gene prioritization using next-generation sequencing data. Genomics Inform (2013) 0.79
MiRNome and transcriptome aided pathway analysis in human regulatory T cells. Genes Immun (2014) 0.78
A nutrigenomic framework to identify time-resolving responses of hepatic genes in diet-induced obese mice. Mol Cells (2013) 0.77
Modeling of the hypothalamic-pituitary-adrenal axis-mediated interaction between the serotonin regulation pathway and the stress response using a Boolean approximation: a novel study of depression. Theor Biol Med Model (2013) 0.76
Systematic synergy modeling: understanding drug synergy from a systems biology perspective. BMC Syst Biol (2015) 0.76
Coregulation mapping based on individual phenotypic variation in response to virus infection. Immunome Res (2010) 0.76
Systems toxicology identifies mechanistic impacts of 2-amino-4,6-dinitrotoluene (2A-DNT) exposure in Northern Bobwhite. BMC Genomics (2015) 0.75
Encoding the states of interacting proteins to facilitate biological pathways reconstruction. Biol Direct (2010) 0.75
Reactome: a knowledgebase of biological pathways. Nucleic Acids Res (2005) 20.05
Efficient sampling algorithm for estimating subgraph concentrations and detecting network motifs. Bioinformatics (2004) 3.25
A comprehensive map of the toll-like receptor signaling network. Mol Syst Biol (2006) 2.89
Tools for kinetic modeling of biochemical networks. Nat Biotechnol (2006) 2.29
Standards for systems biology. Nat Rev Genet (2006) 1.77
Representing, storing and accessing molecular interaction data: a review of models and tools. Brief Bioinform (2006) 1.39
Accuracy and calibration of commercial oligonucleotide and custom cDNA microarrays. Nucleic Acids Res (2002) 6.70
Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature (2008) 4.09
Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. Neuron (2007) 2.98
Influenza virus evades innate and adaptive immunity via the NS1 protein. J Virol (2006) 2.94
Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell (2011) 2.55
Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science (2006) 2.49
Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation. J Neurosci (2005) 2.00
Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. J Clin Invest (2012) 1.90
Focused microarray analysis. Methods (2003) 1.73
Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex. J Neurosci (2003) 1.64
Platelet PECAM-1 inhibits thrombus formation in vivo. Blood (2005) 1.53
flowPeaks: a fast unsupervised clustering for flow cytometry data via K-means and density peak finding. Bioinformatics (2012) 1.53
Differential gene expression in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler (2011) 1.48
Monitoring G-protein-coupled receptor signaling with DNA microarrays and real-time polymerase chain reaction. Methods Enzymol (2002) 1.41
Chromosome-specific and noisy IFNB1 transcription in individual virus-infected human primary dendritic cells. Nucleic Acids Res (2007) 1.40
Psychedelics and schizophrenia. Trends Neurosci (2009) 1.32
Interferon-beta pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus. PLoS Pathog (2008) 1.32
CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis. Brain (2005) 1.30
Early single cell bifurcation of pro- and antiapoptotic states during oxidative stress. J Biol Chem (2004) 1.24
Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists. Neurosci Lett (2011) 1.21
Agonist-specific transactivation of phosphoinositide 3-kinase signaling pathway mediated by the dopamine D2 receptor. J Biol Chem (2003) 1.18
Super-resolution imaging reveals the internal architecture of nano-sized syntaxin clusters. J Biol Chem (2012) 1.15
Improved compensation in flow cytometry by multivariable optimization. Cytometry A (2011) 1.15
Chronic exposure to TNF-alpha increases airway mucus gene expression in vivo. J Allergy Clin Immunol (2005) 1.13
Misty Mountain clustering: application to fast unsupervised flow cytometry gating. BMC Bioinformatics (2010) 1.13
Method for multiplex cellular detection of mRNAs using quantum dot fluorescent in situ hybridization. Nucleic Acids Res (2005) 1.12
Biphasic effects of postnatal exposure to diethylhexylphthalate on the timing of puberty in male rats. J Androl (2007) 1.11
Antiviral response dictated by choreographed cascade of transcription factors. J Immunol (2010) 1.10
Multiple testing and its applications to microarrays. Stat Methods Med Res (2009) 1.10
Research resource: Gonadotropin-releasing hormone receptor-mediated signaling network in LbetaT2 cells: a pathway-based web-accessible knowledgebase. Mol Endocrinol (2010) 1.09
Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations. J Biol Chem (2002) 1.05
Bone morphogenetic protein 2 and activin A synergistically stimulate follicle-stimulating hormone beta subunit transcription. J Mol Endocrinol (2007) 1.04
Mixed analog/digital gonadotrope biosynthetic response to gonadotropin-releasing hormone. J Biol Chem (2006) 1.04
Group II metabotropic glutamate receptors and schizophrenia. Cell Mol Life Sci (2009) 1.04
Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation. J Biol Chem (2012) 1.03
Transcript profiling of immediate early genes reveals a unique role for activating transcription factor 3 in mediating activation of the glycoprotein hormone alpha-subunit promoter by gonadotropin-releasing hormone. Mol Endocrinol (2005) 1.02
Time and length scales of autocrine signals in three dimensions. Biophys J (2007) 1.01
Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem (2012) 1.00
Agonist-trafficking and hallucinogens. Curr Med Chem (2009) 1.00
Role of cell-to-cell variability in activating a positive feedback antiviral response in human dendritic cells. PLoS One (2011) 1.00
The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells. J Clin Invest (2006) 1.00
Acute induction of gene expression in brain and liver by insulin-induced hypoglycemia. Diabetes (2005) 1.00
p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition. J Biol Chem (2006) 0.99
Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors. Neuropharmacology (2011) 0.99
Structure of the GnRH receptor-stimulated signaling network: insights from genomics. Front Neuroendocrinol (2003) 0.98
BioPP: a tool for web-publication of biological networks. BMC Bioinformatics (2007) 0.98
Activation of phosphoinositide 3-kinase by D2 receptor prevents apoptosis in dopaminergic cell lines. Biochem J (2003) 0.97
Coupling of GnRH concentration and the GnRH receptor-activated gene program. Mol Endocrinol (2002) 0.95
Involvement of histone demethylase LSD1 in short-time-scale gene expression changes during cell cycle progression in embryonic stem cells. Mol Cell Biol (2012) 0.94
Genomics view of gonadotrope signaling circuits. Trends Endocrinol Metab (2004) 0.93
Immune response modeling of interferon beta-pretreated influenza virus-infected human dendritic cells. Biophys J (2010) 0.93
Signaling network of dendritic cells in response to pathogens: a community-input supported knowledgebase. BMC Syst Biol (2010) 0.92
Validated genomic approach to study differentially expressed genes in complex tissues. Neurochem Res (2002) 0.91
Epsilon-sarcoglycan immunoreactivity and mRNA expression in mouse brain. J Comp Neurol (2005) 0.90
Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression. Neurochem Res (2004) 0.89
Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy. Mol Pharmacol (2003) 0.89
SOME STEP-DOWN PROCEDURES CONTROLLING THE FALSE DISCOVERY RATE UNDER DEPENDENCE. Stat Sin (2008) 0.89
Noise propagation and scaling in regulation of gonadotrope biosynthesis. Biophys J (2007) 0.87
Jerky, a protein deficient in a mouse epilepsy model, is associated with translationally inactive mRNA in neurons. J Neurosci (2002) 0.87
Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11. J Immunol (2011) 0.86
Microtranscriptome regulation by gonadotropin-releasing hormone. Mol Cell Endocrinol (2009) 0.86
Heteromerization of G protein-coupled receptors: relevance to neurological disorders and neurotherapeutics. CNS Neurol Disord Drug Targets (2010) 0.84
Plato's cave algorithm: inferring functional signaling networks from early gene expression shadows. PLoS Comput Biol (2010) 0.84
Novel Nipah virus immune-antagonism strategy revealed by experimental and computational study. J Virol (2010) 0.84
The RNA binding domain of Jerky consists of tandemly arranged helix-turn-helix/homeodomain-like motifs and binds specific sets of mRNAs. Mol Cell Biol (2003) 0.83
Validation of efficient high-throughput plasmid and siRNA transfection of human monocyte-derived dendritic cells without cell maturation. J Immunol Methods (2010) 0.82
Characterization of a MAPK scaffolding protein logic gate in gonadotropes. Mol Endocrinol (2011) 0.82
Reconstruction of regulatory networks through temporal enrichment profiling and its application to H1N1 influenza viral infection. BMC Bioinformatics (2013) 0.82
Optimized protocol for efficient transfection of dendritic cells without cell maturation. J Vis Exp (2011) 0.82
Mouse dendritic cell (DC) influenza virus infectivity is much lower than that for human DCs and is hemagglutinin subtype dependent. J Virol (2012) 0.81
G proteins and autocrine signaling differentially regulate gonadotropin subunit expression in pituitary gonadotrope. J Biol Chem (2012) 0.81
Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl) (2012) 0.81
β-catenin regulates GnRH-induced FSHβ gene expression. Mol Endocrinol (2012) 0.80
Chronic treatment with LY341495 decreases 5-HT(2A) receptor binding and hallucinogenic effects of LSD in mice. Neurosci Lett (2013) 0.79
Receptor pair for schizophrenia. Pediatr Res (2008) 0.78
Strategies for mapping the binding site of the serotonin 5-HT2A receptor. Methods Enzymol (2002) 0.78
Multi-scale stochastic simulation of diffusion-coupled agents and its application to cell culture simulation. PLoS One (2011) 0.77
Optimized amplification and single-cell analysis identify GnRH-mediated activation of Rap1b in primary rat gonadotropes. Mol Cell Endocrinol (2011) 0.76
Homer1 alternative splicing is regulated by gonadotropin-releasing hormone and modulates gonadotropin gene expression. Mol Cell Biol (2014) 0.76
Computational approaches to understanding dendritic cell responses to influenza virus infection. Immunol Res (2012) 0.75
Authors response to correspondence about an improved compensation method. Cytometry A (2011) 0.75
Mutational analysis of the serotonin receptor 5HT2c in severe early-onset human obesity. Can J Physiol Pharmacol (2004) 0.75
Cell-to-cell communication: time and length scales of ligand internalization in cultures of suspended cells. J Chem Phys (2008) 0.75
Noise propagation through extracellular signaling leads to fluctuations in gene expression. BMC Syst Biol (2013) 0.75
A comprehensive evaluation of human plasmacytoid dendritic cells using small volumes of human blood. J Interferon Cytokine Res (2008) 0.75