Published in Mol Cell Endocrinol on November 25, 2011
Number of CpG islands and genes in human and mouse. Proc Natl Acad Sci U S A (1993) 6.79
Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science (1996) 3.39
Rap1 signalling: adhering to new models. Nat Rev Mol Cell Biol (2001) 3.36
Epac: defining a new mechanism for cAMP action. Annu Rev Pharmacol Toxicol (2010) 3.01
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc Natl Acad Sci U S A (2007) 2.59
Rap1b is required for normal platelet function and hemostasis in mice. J Clin Invest (2005) 2.46
Gonadotropin-releasing hormone receptor-coupled gene network organization. J Biol Chem (2001) 2.01
Minireview: Nuclear hormone receptor 4A signaling: implications for metabolic disease. Mol Endocrinol (2010) 1.92
Does Rap1 deserve a bad Rap? Trends Biochem Sci (2003) 1.82
Focused microarray analysis. Methods (2003) 1.73
Dynamics of single-cell gene expression. Mol Syst Biol (2006) 1.69
Specificity in Ras and Rap signaling. J Biol Chem (2008) 1.62
GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells. Mol Endocrinol (2002) 1.53
PR localization and anterior pituitary cell populations in vitro in ovariectomized wild-type and PR-knockout mice. Endocrinology (2001) 1.48
Steroid and pulsatile gonadotropin-releasing hormone (GnRH) regulation of luteinizing hormone and GnRH receptor in a novel gonadotrope cell line. Mol Endocrinol (1996) 1.44
Activation of luteinizing hormone beta gene by gonadotropin-releasing hormone requires the synergy of early growth response-1 and steroidogenic factor-1. J Biol Chem (1999) 1.38
Amplification of RNA transcripts using terminal continuation. Lab Invest (2004) 1.30
Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2. Mol Endocrinol (2007) 1.30
Absence of gonadotropin surges and gonadotropin-releasing hormone self-priming in ovariectomized (OVX), estrogen (E2)-treated, progesterone receptor knockout (PRKO) mice. Endocrinology (1999) 1.28
Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form. Oncogene (2003) 1.22
Sp1, steroidogenic factor 1 (SF-1), and early growth response protein 1 (egr-1) binding sites form a tripartite gonadotropin-releasing hormone response element in the rat luteinizing hormone-beta gene promoter: an integral role for SF-1. Mol Endocrinol (2000) 1.13
Two cAMP-dependent pathways differentially regulate exocytosis of large dense-core and small vesicles in mouse beta-cells. J Physiol (2007) 1.12
Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways. Mol Endocrinol (2006) 1.10
Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice. J Physiol (2010) 1.07
Characterization of a monoclonal antibody which detects luteinizing hormone from diverse mammalian species. Domest Anim Endocrinol (1987) 1.05
The calcium component of gonadotropin-releasing hormone-stimulated luteinizing hormone subunit gene transcription is mediated by calcium/calmodulin-dependent protein kinase type II. Endocrinology (2003) 1.02
On the mitogenic properties of Rap1b: cAMP-induced G(1)/S entry requires activated and phosphorylated Rap1b. Proc Natl Acad Sci U S A (2002) 1.01
Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells. Eur J Biochem (1992) 0.97
p300 regulates the synergy of steroidogenic factor-1 and early growth response-1 in activating luteinizing hormone-beta subunit gene. J Biol Chem (2003) 0.96
Coupling of GnRH concentration and the GnRH receptor-activated gene program. Mol Endocrinol (2002) 0.95
cAMP-dependent oncogenic action of Rap1b in the thyroid gland. J Biol Chem (2004) 0.94
Beta-adrenergic-induced cytosolic redistribution of Rap1 in rat parotid acini: role in secretion. Am J Physiol (1998) 0.92
Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1. Vitam Horm (2010) 0.91
Rap1 activation plays a regulatory role in pancreatic amylase secretion. J Biol Chem (2008) 0.90
Effects of pituitary adenylate cyclase-activating polypeptide on gonadotropin secretion and subunit messenger ribonucleic acids in perifused rat pituitary cells. Endocrinology (1994) 0.90
Rapid augmentation by progesterone of agonist-stimulated luteinizing hormone secretion by cultured pituitary cells. Endocrinology (1990) 0.89
Evidence that PACAP and GnRH down-regulate follicle-stimulating hormone-beta mRNA levels by stimulating follistatin gene expression: effects on folliculostellate cells, gonadotrophs and LbetaT2 gonadotroph cells. Mol Cell Endocrinol (2002) 0.87
PACAP, an autocrine/paracrine regulator of gonadotrophs. Biol Reprod (2010) 0.86
Activation of the progesterone receptor by the gonadotropin-releasing hormone self-priming signaling pathway. Mol Endocrinol (1994) 0.86
Pulse frequency-dependent gonadotropin gene expression by adenylate cyclase-activating polypeptide 1 in perifused mouse pituitary gonadotroph LbetaT2 cells. Biol Reprod (2009) 0.86
Gonadotropin subunit transcriptional responses to calcium signals in the rat: evidence for regulation by pulse frequency. Biol Reprod (2001) 0.86
The self-priming effect of LHRH: a unique servomechanism and possible cellular model for memory. Front Neuroendocrinol (1995) 0.85
A pathway for luteinizing hormone releasing-hormone self-potentiation: cross-talk with the progesterone receptor. Endocrinology (1992) 0.84
The functional relationship between priming and releasing actions of luteinizing hormone-releasing hormone. J Clin Endocrinol Metab (1979) 0.83
Differential expression and regulation of progesterone receptor isoforms in rat and mouse pituitary cells and LbetaT2 gonadotropes. J Endocrinol (2006) 0.83
Modulation of stimulus-secretion coupling in single rat gonadotrophs. J Physiol (1997) 0.82
Luteinizing hormone secretion from wild-type and progesterone receptor knockout mouse anterior pituitary cells. Endocrinology (2001) 0.82
cAMP augmentation of secretagogue-induced luteinizing hormone secretion. Am J Physiol (1986) 0.81
The timing of progesterone-induced ribonucleic acid and protein synthesis for augmentation of luteinizing hormone secretion. Endocrinology (1991) 0.81
Nature of gonadotropin-releasing hormone self-priming of luteinizing hormone secretion during the normal menstrual cycle. Am J Obstet Gynecol (1990) 0.79
Ca2+-activated K+ channels in gonadotropin-releasing hormone-stimulated mouse gonadotrophs. Endocrinology (2008) 0.78
Functional cross-talk between receptors for peptide and steroid hormones. Trends Endocrinol Metab (1992) 0.78
LHRH self priming of gonadotrophin secretion: time course of development. Am J Physiol (1983) 0.77
Accuracy and calibration of commercial oligonucleotide and custom cDNA microarrays. Nucleic Acids Res (2002) 6.70
Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature (2008) 4.09
Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. Neuron (2007) 2.98
Influenza virus evades innate and adaptive immunity via the NS1 protein. J Virol (2006) 2.94
CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer. Clin Cancer Res (2008) 2.65
Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell (2011) 2.55
Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science (2006) 2.49
Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation. J Neurosci (2005) 2.00
Focused microarray analysis. Methods (2003) 1.73
Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer. Proc Natl Acad Sci U S A (2009) 1.72
Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex. J Neurosci (2003) 1.64
flowPeaks: a fast unsupervised clustering for flow cytometry data via K-means and density peak finding. Bioinformatics (2012) 1.53
Differential gene expression in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler (2011) 1.48
Monitoring G-protein-coupled receptor signaling with DNA microarrays and real-time polymerase chain reaction. Methods Enzymol (2002) 1.41
Chromosome-specific and noisy IFNB1 transcription in individual virus-infected human primary dendritic cells. Nucleic Acids Res (2007) 1.40
Interferon-beta pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus. PLoS Pathog (2008) 1.32
Psychedelics and schizophrenia. Trends Neurosci (2009) 1.32
CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis. Brain (2005) 1.30
Early single cell bifurcation of pro- and antiapoptotic states during oxidative stress. J Biol Chem (2004) 1.24
Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists. Neurosci Lett (2011) 1.21
Agonist-specific transactivation of phosphoinositide 3-kinase signaling pathway mediated by the dopamine D2 receptor. J Biol Chem (2003) 1.18
Improved compensation in flow cytometry by multivariable optimization. Cytometry A (2011) 1.15
Getting started in biological pathway construction and analysis. PLoS Comput Biol (2008) 1.14
Chronic exposure to TNF-alpha increases airway mucus gene expression in vivo. J Allergy Clin Immunol (2005) 1.13
Misty Mountain clustering: application to fast unsupervised flow cytometry gating. BMC Bioinformatics (2010) 1.13
Method for multiplex cellular detection of mRNAs using quantum dot fluorescent in situ hybridization. Nucleic Acids Res (2005) 1.12
Biphasic effects of postnatal exposure to diethylhexylphthalate on the timing of puberty in male rats. J Androl (2007) 1.11
Antiviral response dictated by choreographed cascade of transcription factors. J Immunol (2010) 1.10
Multiple testing and its applications to microarrays. Stat Methods Med Res (2009) 1.10
Research resource: Gonadotropin-releasing hormone receptor-mediated signaling network in LbetaT2 cells: a pathway-based web-accessible knowledgebase. Mol Endocrinol (2010) 1.09
Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations. J Biol Chem (2002) 1.05
Bone morphogenetic protein 2 and activin A synergistically stimulate follicle-stimulating hormone beta subunit transcription. J Mol Endocrinol (2007) 1.04
Mixed analog/digital gonadotrope biosynthetic response to gonadotropin-releasing hormone. J Biol Chem (2006) 1.04
Group II metabotropic glutamate receptors and schizophrenia. Cell Mol Life Sci (2009) 1.04
Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation. J Biol Chem (2012) 1.03
Transcript profiling of immediate early genes reveals a unique role for activating transcription factor 3 in mediating activation of the glycoprotein hormone alpha-subunit promoter by gonadotropin-releasing hormone. Mol Endocrinol (2005) 1.02
Time and length scales of autocrine signals in three dimensions. Biophys J (2007) 1.01
Role of cell-to-cell variability in activating a positive feedback antiviral response in human dendritic cells. PLoS One (2011) 1.00
The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells. J Clin Invest (2006) 1.00
Agonist-trafficking and hallucinogens. Curr Med Chem (2009) 1.00
Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem (2012) 1.00
Acute induction of gene expression in brain and liver by insulin-induced hypoglycemia. Diabetes (2005) 1.00
Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors. Neuropharmacology (2011) 0.99
p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition. J Biol Chem (2006) 0.99
Structure of the GnRH receptor-stimulated signaling network: insights from genomics. Front Neuroendocrinol (2003) 0.98
BioPP: a tool for web-publication of biological networks. BMC Bioinformatics (2007) 0.98
Activation of phosphoinositide 3-kinase by D2 receptor prevents apoptosis in dopaminergic cell lines. Biochem J (2003) 0.97
Coupling of GnRH concentration and the GnRH receptor-activated gene program. Mol Endocrinol (2002) 0.95
Involvement of histone demethylase LSD1 in short-time-scale gene expression changes during cell cycle progression in embryonic stem cells. Mol Cell Biol (2012) 0.94
Immune response modeling of interferon beta-pretreated influenza virus-infected human dendritic cells. Biophys J (2010) 0.93
Genomics view of gonadotrope signaling circuits. Trends Endocrinol Metab (2004) 0.93
Signaling network of dendritic cells in response to pathogens: a community-input supported knowledgebase. BMC Syst Biol (2010) 0.92
Validated genomic approach to study differentially expressed genes in complex tissues. Neurochem Res (2002) 0.91
MDM2 gene amplification is correlated to tumor progression but not to the presence of SNP309 or TP53 mutational status in primary colorectal cancers. Mol Cancer Res (2008) 0.91
Epsilon-sarcoglycan immunoreactivity and mRNA expression in mouse brain. J Comp Neurol (2005) 0.90
Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression. Neurochem Res (2004) 0.89
Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy. Mol Pharmacol (2003) 0.89
SOME STEP-DOWN PROCEDURES CONTROLLING THE FALSE DISCOVERY RATE UNDER DEPENDENCE. Stat Sin (2008) 0.89
Noise propagation and scaling in regulation of gonadotrope biosynthesis. Biophys J (2007) 0.87
Microtranscriptome regulation by gonadotropin-releasing hormone. Mol Cell Endocrinol (2009) 0.86
Heteromerization of G protein-coupled receptors: relevance to neurological disorders and neurotherapeutics. CNS Neurol Disord Drug Targets (2010) 0.84
Novel Nipah virus immune-antagonism strategy revealed by experimental and computational study. J Virol (2010) 0.84
Plato's cave algorithm: inferring functional signaling networks from early gene expression shadows. PLoS Comput Biol (2010) 0.84
Differential expression and regulation of progesterone receptor isoforms in rat and mouse pituitary cells and LbetaT2 gonadotropes. J Endocrinol (2006) 0.83
Validation of efficient high-throughput plasmid and siRNA transfection of human monocyte-derived dendritic cells without cell maturation. J Immunol Methods (2010) 0.82
Optimized protocol for efficient transfection of dendritic cells without cell maturation. J Vis Exp (2011) 0.82
Reconstruction of regulatory networks through temporal enrichment profiling and its application to H1N1 influenza viral infection. BMC Bioinformatics (2013) 0.82
Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancer. J Surg Oncol (2008) 0.82
Characterization of a MAPK scaffolding protein logic gate in gonadotropes. Mol Endocrinol (2011) 0.82
Mouse dendritic cell (DC) influenza virus infectivity is much lower than that for human DCs and is hemagglutinin subtype dependent. J Virol (2012) 0.81
G proteins and autocrine signaling differentially regulate gonadotropin subunit expression in pituitary gonadotrope. J Biol Chem (2012) 0.81
Effects of triclocarban on intact immature male rat: augmentation of androgen action. Reprod Sci (2010) 0.81
Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl) (2012) 0.81
Estradiol inhibition of voltage-activated and gonadotropin-releasing hormone-induced currents in mouse gonadotrophs. Endocrinology (2006) 0.80
β-catenin regulates GnRH-induced FSHβ gene expression. Mol Endocrinol (2012) 0.80
Chronic treatment with LY341495 decreases 5-HT(2A) receptor binding and hallucinogenic effects of LSD in mice. Neurosci Lett (2013) 0.79
High incidence of LRAT promoter hypermethylation in colorectal cancer correlates with tumor stage. Med Oncol (2014) 0.79
Receptor pair for schizophrenia. Pediatr Res (2008) 0.78
Strategies for mapping the binding site of the serotonin 5-HT2A receptor. Methods Enzymol (2002) 0.78
Ca2+-activated K+ channels in gonadotropin-releasing hormone-stimulated mouse gonadotrophs. Endocrinology (2008) 0.78
Multi-scale stochastic simulation of diffusion-coupled agents and its application to cell culture simulation. PLoS One (2011) 0.77
Homer1 alternative splicing is regulated by gonadotropin-releasing hormone and modulates gonadotropin gene expression. Mol Cell Biol (2014) 0.76
Authors response to correspondence about an improved compensation method. Cytometry A (2011) 0.75
Noise propagation through extracellular signaling leads to fluctuations in gene expression. BMC Syst Biol (2013) 0.75
Computational approaches to understanding dendritic cell responses to influenza virus infection. Immunol Res (2012) 0.75
Mutational analysis of the serotonin receptor 5HT2c in severe early-onset human obesity. Can J Physiol Pharmacol (2004) 0.75
Cell-to-cell communication: time and length scales of ligand internalization in cultures of suspended cells. J Chem Phys (2008) 0.75
[An ambiguous role of steroidogenic factor 1 in the rat GnRH receptor gene expression. Lessons from transgenic mice]. J Soc Biol (2004) 0.75
A comprehensive evaluation of human plasmacytoid dendritic cells using small volumes of human blood. J Interferon Cytokine Res (2008) 0.75
Model of autocrine/paracrine signaling in epithelial layer: geometrical regulation of intercellular communication. J Phys Chem B (2009) 0.75