Published in Br J Pharmacol on May 12, 2008
Targeting CB2 receptors and the endocannabinoid system for the treatment of pain. Brain Res Rev (2008) 1.28
Cannabinoid-opioid interactions during neuropathic pain and analgesia. Curr Opin Pharmacol (2009) 1.02
Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain. Nat Rev Drug Discov (2012) 0.99
Central antinociception induced by mu-opioid receptor agonist morphine, but not delta- or kappa-, is mediated by cannabinoid CB1 receptor. Br J Pharmacol (2009) 0.92
AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies. Neuropharmacology (2012) 0.89
Morphine modulation of pain processing in medial and lateral pain pathways. Mol Pain (2009) 0.88
Cannabinoid receptor-mediated antinociception with acetaminophen drug combinations in rats with neuropathic spinal cord injury pain. Neuropharmacology (2009) 0.88
Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice. J Pharmacol Exp Ther (2012) 0.86
Cannabinoid CB(2) receptor attenuates morphine-induced inflammatory responses in activated microglial cells. Br J Pharmacol (2012) 0.86
Effects of morphine on pain-elicited and pain-suppressed behavior in CB1 knockout and wildtype mice. Psychopharmacology (Berl) (2011) 0.85
Peripheral interactions between cannabinoid and opioid systems contribute to the antinociceptive effect of crotalphine. Br J Pharmacol (2014) 0.82
PnPP-19, a spider toxin peptide, induces peripheral antinociception through opioid and cannabinoid receptors and inhibition of neutral endopeptidase. Br J Pharmacol (2016) 0.80
The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain. Neuropsychopharmacology (2017) 0.78
The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice. Neuropharmacology (2016) 0.77
The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model. J Pharmacol Exp Ther (2016) 0.76
Opioid-Sparing Effect of Cannabinoids: A Systematic Review and Meta-Analysis. Neuropsychopharmacology (2017) 0.75
A spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems. J Venom Anim Toxins Incl Trop Dis (2016) 0.75
Microinjection of WIN55,212-2 as A Cannabinoid Agonist into The Basolateral Amygdala Induces Sensitization to Morphine in Rats. Basic Clin Neurosci (2014) 0.75
Peripheral Antinociception Induced by Aripiprazole Is Mediated by the Opioid System. Biomed Res Int (2017) 0.75
Guide to Receptors and Channels (GRAC), 3rd edition. Br J Pharmacol (2008) 13.18
International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev (2002) 8.50
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc Natl Acad Sci U S A (2001) 7.15
Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature (1994) 5.70
Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science (2005) 5.12
Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem (1995) 4.53
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci (2007) 2.78
Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists. J Med Chem (1999) 2.73
Cannabinoid CB2 receptors: immunohistochemical localization in rat brain. Brain Res (2006) 2.62
Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. Br J Pharmacol (1999) 2.56
Cannabinoid receptors and pain. Prog Neurobiol (2001) 2.48
CB2 cannabinoid receptor-mediated peripheral antinociception. Pain (2001) 2.38
CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proc Natl Acad Sci U S A (2005) 2.36
Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain. Ann N Y Acad Sci (2006) 2.07
Analgesic effects of fatty acid amide hydrolase inhibition in a rat model of neuropathic pain. J Neurosci (2006) 2.02
A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation. Chem Phys Lipids (2002) 1.98
mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis. Br J Pharmacol (2006) 1.93
The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. Proc Natl Acad Sci U S A (1996) 1.84
Differential roles of CB1 and CB2 cannabinoid receptors in mast cells. J Immunol (2003) 1.75
Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase. Biochem Pharmacol (1997) 1.74
Cannabinoid pharmacology: the first 66 years. Br J Pharmacol (2006) 1.73
Regulation of human epidermal melanocyte biology by beta-endorphin. J Invest Dermatol (2003) 1.66
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest (2003) 1.61
Opioid receptor-coupled second messenger systems. Life Sci (1991) 1.58
Purification and characterization of an acid amidase selective for N-palmitoylethanolamine, a putative endogenous anti-inflammatory substance. J Biol Chem (2001) 1.57
Pharmacological and biochemical interactions between opioids and cannabinoids. Trends Pharmacol Sci (1999) 1.49
Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors. Life Sci (1997) 1.42
Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain. Eur J Neurosci (2004) 1.40
Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism. Mol Pharmacol (2004) 1.40
Endocannabinoids and pain: spinal and peripheral analgesia in inflammation and neuropathy. Prostaglandins Leukot Essent Fatty Acids (2002) 1.29
Endocannabinoid mechanisms of pain modulation. AAPS J (2006) 1.28
Cannabinoid receptors and modulation of cyclic AMP accumulation in the rat brain. J Neurochem (1990) 1.27
Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. Br J Pharmacol (2007) 1.25
The enzymatic inactivation of the fatty acid amide class of signaling lipids. Chem Phys Lipids (2002) 1.23
A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation. Neuroscience (2003) 1.23
Spinal phospholipase A2 in inflammatory hyperalgesia: role of group IVA cPLA2. Br J Pharmacol (2005) 1.13
Diversity of agents that modify opioid tolerance, physical dependence, abstinence syndrome, and self-administrative behavior. Pharmacol Rev (1994) 1.08
The enhancement of morphine antinociception in mice by delta9-tetrahydrocannabinol. Pharmacol Biochem Behav (1998) 1.04
Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurones via activation of CB2 receptors in anaesthetised rats. Neuropharmacology (2003) 1.04
Expression of CB2 cannabinoid receptor mRNA in adult rat retina. Vis Neurosci (2000) 1.02
Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2. Biochemistry (1996) 1.02
Enhancement mu opioid antinociception by oral delta9-tetrahydrocannabinol: dose-response analysis and receptor identification. J Pharmacol Exp Ther (1999) 0.96
Intrathecally applied flurbiprofen produces an endocannabinoid-dependent antinociception in the rat formalin test. Eur J Neurosci (2003) 0.96
Synergistic interactions of endogenous opioids and cannabinoid systems. Brain Res (1999) 0.93
Potentiation of delta 9-tetrahydrocannabinol-induced analgesia by morphine in mice: involvement of mu- and kappa-opioid receptors. Eur J Pharmacol (1996) 0.92
The role of endogenous opioids in enhancing the antinociception produced by the combination of delta 9-tetrahydrocannabinol and morphine in the spinal cord. J Pharmacol Exp Ther (1996) 0.88
Activation of peripheral cannabinoid CB1 receptors inhibits mechanically evoked responses of spinal neurons in noninflamed rats and rats with hindpaw inflammation. Eur J Neurosci (2003) 0.87
Blockade of cannabinoid-induced antinociception by norbinaltorphimine, but not N,N-diallyl-tyrosine-Aib-phenylalanine-leucine, ICI 174,864 or naloxone in mice. J Pharmacol Exp Ther (1993) 0.86
Molecular biology of opioid receptors: recent advances. Neuroimmunomodulation (1998) 0.85
Recent advances in GABAB receptors: from pharmacology to molecular biology. Acta Pharmacol Sin (2000) 0.83
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat. Eur J Pharmacol (2004) 0.81
Cannabis-induced potentiation of morphine analgesia in rat--role of brain monoamines. Indian J Med Res (1979) 0.77
Capsule endoscopy in acute upper gastrointestinal hemorrhage: a prospective cohort study. Endoscopy (2012) 3.28
Construction of an integration vector for use in the archaebacterium Methanococcus voltae and expression of a eubacterial resistance gene. Mol Gen Genet (1990) 2.78
The value of whole potato in human nutrition. Biochem J (1928) 2.38
Isolation and characterization of thermosensitive Escherichia coli mutants defective in deoxyribonucleic acid replication. J Bacteriol (1973) 2.38
Laparoscopic live donor nephrectomy: the recipient. Transplantation (2000) 2.11
Cytokeratin 20: a new marker for early detection of bladder cell carcinoma? J Urol (1998) 1.84
Relatedness of archaebacterial RNA polymerase core subunits to their eubacterial and eukaryotic equivalents. Nucleic Acids Res (1988) 1.77
The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins. J Cell Biol (1996) 1.77
An eclectic approach to quality control in fee-for-service health care: The New York City Medicaid Experience. Am J Public Health (1976) 1.71
Targeted disruption of the mouse sphingolipid activator protein gene: a complex phenotype, including severe leukodystrophy and wide-spread storage of multiple sphingolipids. Hum Mol Genet (1996) 1.70
Electrocardiogram of the athlete. Alterations simulating those of organic heart disease. Arch Intern Med (1973) 1.70
Isolation of a complex between the P protein of phage lambda and the dnaB protein of Escherichia coli. Eur J Biochem (1980) 1.61
Noninvasive evaluation of ventricular hypertrophy in professional athletes. Circulation (1976) 1.56
Impact of malnutrition-inflammation on the association between homocysteine and mortality. Kidney Int (2006) 1.53
Metabolism of cyclic carotenoids: a model for the alteration of this biosynthetic pathway in Capsicum annuum chromoplasts. Plant J (1995) 1.47
Increased signals seen in globus pallidus in T1-weighted magnetic resonance imaging in cirrhotics are not suggestive of chronic hepatic encephalopathy. Hepatology (1995) 1.46
Modulation of pulmonary vascular resistance and edema formation by short-term infusion of a 10% fish oil emulsion. Infusionsther Transfusionsmed (1993) 1.43
Cloning and characterization of the methyl coenzyme M reductase genes from Methanobacterium thermoautotrophicum. J Bacteriol (1988) 1.43
The mouse ribosomal protein L7 gene. Its primary structure and functional analysis of the promoter region. J Biol Chem (1990) 1.42
Human airway mucin glycosylation: a combinatory of carbohydrate determinants which vary in cystic fibrosis. Glycoconj J (2001) 1.40
Bayesian analysis of pentaquark signals from CLAS data. Phys Rev Lett (2008) 1.39
Predictive value of ASA classification for the assessment of the perioperative risk. Int Surg (1994) 1.38
Genome complexity of methanogenic bacteria. J Bacteriol (1984) 1.38
Measurement of two- and three-nucleon short-range correlation probabilities in nuclei. Phys Rev Lett (2006) 1.37
DNA replication. Annu Rev Biochem (1972) 1.36
Termination of a transcription unit comprising highly expressed genes in the archaebacterium Methanococcus voltae. Nucleic Acids Res (1985) 1.36
Initiation of lambda DNA replication in vitro. Nat New Biol (1972) 1.34
Non-repetitive AT-rich sequences are found in intergenic regions of Methanococcus voltae DNA. EMBO J (1985) 1.31
New bacteriophages of Staphylococcus epidermidis. J Infect Dis (1975) 1.30
Simultaneous deficiency of sphingolipid activator proteins 1 and 2 is caused by a mutation in the initiation codon of their common gene. J Biol Chem (1992) 1.28
Nature of the band gap of In2O3 revealed by first-principles calculations and x-ray spectroscopy. Phys Rev Lett (2008) 1.28
Complete nucleotide sequence of plasmid pME2001 of Methanobacterium thermoautotrophicum (Marburg). Nucleic Acids Res (1990) 1.27
Methanococcus voltae harbors four gene clusters potentially encoding two [NiFe] and two [NiFeSe] hydrogenases, each of the cofactor F420-reducing or F420-non-reducing types. Mol Gen Genet (1992) 1.26
H2-forming methylenetetrahydromethanopterin dehydrogenase, a novel type of hydrogenase without iron-sulfur clusters in methanogenic archaea. Eur J Biochem (1992) 1.24
Replication of lambda dv DNA in vitro. Nucleic Acids Res (1982) 1.23
Natural ligands of the B cell adhesion molecule CD22 beta can be masked by 9-O-acetylation of sialic acids. J Cell Biol (1994) 1.22
Molecular cloning and functional expression in E. coli of a novel plant enzyme mediating zeta-carotene desaturation. FEBS Lett (1995) 1.22
Congenital myopathies--clinical features and frequency of individual subtypes diagnosed over a 5-year period in the United Kingdom. Neuromuscul Disord (2013) 1.17
Nucleotide sequence of the methyl coenzyme M reductase gene cluster from Methanosarcina barkeri. Nucleic Acids Res (1987) 1.15
Structural measures as predictors of injury basketball players. Med Sci Sports Exerc (1991) 1.14
Cloning of the replication gene O of E. coli bacteriophage lambda and its expression under the control of the lac promoter. Gene (1980) 1.14
Selenium is involved in the negative regulation of the expression of selenium-free [NiFe] hydrogenases in Methanococcus voltae. Mol Gen Genet (1994) 1.14
Use of the Escherichia coli uidA gene as a reporter in Methanococcus voltae for the analysis of the regulatory function of the intergenic region between the operons encoding selenium-free hydrogenases. Mol Gen Genet (1995) 1.14
Transcriptional regulation of genes encoding the selenium-free [NiFe]-hydrogenases in the archaeon Methanococcus voltae involves positive and negative control elements. Genetics (1999) 1.12
Lack of known hepatitis virus in hepatitis-associated aplastic anemia and outcome after bone marrow transplantation. Bone Marrow Transplant (2001) 1.11
Telomerase activity in ductal carcinoma in situ of the breast. Breast Cancer Res Treat (1999) 1.11
The [NiFe] hydrogenases of Methanococcus voltae: genes, enzymes and regulation. Arch Microbiol (1997) 1.11
Isolation and characterization of insertional mutations in flagellin genes in the archaeon Methanococcus voltae. Mol Microbiol (1996) 1.11
Peptide chain elongation: discrimination against the initiator transfer RNA by microbial amino-acid polymerization factors. Nature (1968) 1.11
The complexity of mucins. Biochimie (1988) 1.10
A new immunomodulating compound (AS-101) with potential therapeutic application. Nature (1987) 1.10
Model-based study of the human cupular time constant. J Vestib Res (1999) 1.09
Studies on the functions of DNA helicase I and DNA helicase II of Escherichia coli. J Biol Chem (1980) 1.08
A multigene family of intron lacking and containing genes, encoding for mouse ribosomal protein L7. Nucleic Acids Res (1984) 1.08
Hepatitis B virus precore mutants are identical in carriers from various ethnic origins and are associated with a range of liver disease severity. Hepatology (1992) 1.08
Occult hepatitis B viral DNA in liver carcinomas from a region with a low prevalence of chronic hepatitis B infection. J Viral Hepat (2004) 1.07
Relation between urinary hydration biomarkers and total fluid intake in healthy adults. Eur J Clin Nutr (2013) 1.06
Expression of cytokeratin 20 in the blood of patients with disseminated carcinoma of the pancreas, colon, stomach, and lung. Cancer (1999) 1.06
Selective recognition of fluoride salts by vasarenes: a key role of a self-assembled in situ dimeric entity via an exceptionally short [O-H-O](-) H-bond. Dalton Trans (2016) 1.06
Intrauterine infection with Ureaplasma urealyticum as a cause of fatal neonatal pneumonia. Pediatr Infect Dis (1985) 1.06
Analysis of drug resistance in the archaebacterium Methanococcus voltae with respect to potential use in genetic engineering. Appl Environ Microbiol (1988) 1.05
Altered carbohydrate composition of salivary mucins from patients with cystic fibrosis and the adhesion of Pseudomonas aeruginosa. Am J Respir Cell Mol Biol (1993) 1.05
Physical and genetic map of the Methanococcus voltae chromosome. Mol Microbiol (1991) 1.05
[Mechanisms of the host-controlled modification of phage T1]. Z Vererbungsl (1965) 1.05
Regional diastolic function by pulsed Doppler myocardial mapping for the detection of left ventricular ischemia during pharmacologic stress testing: a comparison with stress echocardiography and perfusion scintigraphy. J Am Coll Cardiol (2000) 1.04
Over-expression of a functionally active human GM2-activator protein in Escherichia coli. Biochem J (1993) 1.04
A new percutaneous technique for establishing venous bypass access in orthotopic liver transplantation. J Cardiothorac Vasc Anesth (1994) 1.04
Insertional Mutations in the Hydrogenase vhc and frc Operons Encoding Selenium-Free Hydrogenases in Methanococcus voltae. Appl Environ Microbiol (1995) 1.03
Purification and characterization of an 8-hydroxy-5-deazaflavin-reducing hydrogenase from the archaebacterium Methanococcus voltae. Eur J Biochem (1987) 1.03
Gene dosage as a possible major determinant for equal expression levels of genes encoding RNA polymerase subunits in the hypotrichous ciliate Euplotes octocarinatus. Nucleic Acids Res (1992) 1.02
T lymphocytes and plasma inhibitory factor in ACTH-dependent Cushing's patients. Clin Immunol Immunopathol (1979) 1.02
Injectable collagen: a clinical overview. Cutis (1983) 1.01
Leukotriene B(4) induces nitric oxide synthesis in Trypanosoma cruzi-infected murine macrophages and mediates resistance to infection. Infect Immun (2002) 1.01
Direct monitoring of microvascular anastomoses with the 20-MHz ultrasonic Doppler probe: an experimental and clinical study. Plast Reconstr Surg (1988) 1.00
Host cell reactivation in strains of E. coli lacking DNA polymerase activity in vitro. Nat New Biol (1971) 0.99
Immunocytochemical localization of component C of the methylreductase system in Methanococcus voltae and Methanobacterium thermoautotrophicum. Proc Natl Acad Sci U S A (1986) 0.99
Methyl-coenzyme-M reductase from Methanobacterium thermoautotrophicum (strain Marburg). Purity, activity and novel inhibitors. Eur J Biochem (1989) 0.99
Satellite cell dysfunction contributes to the progressive muscle atrophy in myotonic dystrophy type 1. Neuropathol Appl Neurobiol (2009) 0.99
The vhuU gene encoding a small subunit of a selenium-containing [NiFe]-hydrogenase in Methanococcus voltae appears to be essential for the cell. Arch Microbiol (1998) 0.98
The carbohydrate diversity of human respiratory mucins: a protection of the underlying mucosa? Am Rev Respir Dis (1991) 0.97
Adenylylsulphate reductase from the sulphate-reducing archaeon Archaeoglobus fulgidus: cloning and characterization of the genes and comparison of the enzyme with other iron-sulphur flavoproteins. Microbiology (1994) 0.97
Prolonged hemiplegic episodes in children due to mutations in ATP1A2. J Neurol Neurosurg Psychiatry (2007) 0.95
Glycoprotein lysosomal storage disorders: alpha- and beta-mannosidosis, fucosidosis and alpha-N-acetylgalactosaminidase deficiency. Biochim Biophys Acta (1999) 0.95
Cloning of the replication gene P of bacteriophage lambda: effects of increased P-protein synthesis on cellular and phage DNA replication. Mol Gen Genet (1979) 0.95
Inhibition of peptide-chain initiation in Escherichia coli by hydroxylamine and effects on ribonucleic acid synthesis. Biochemistry (1970) 0.95
Flagellin genes of Methanococcus vannielii: amplification by the polymerase chain reaction, demonstration of signal peptides and identification of major components of the flagellar filament. Mol Gen Genet (1998) 0.95
Serotonin binding protein:enhancement of binding by Fe2+ and inhibition of binding by drugs. J Neurochem (1976) 0.95
Carriage of methicillin-resistant Staphylococcus aureus on admission to European rehabilitation centres--a prospective study. Clin Microbiol Infect (2012) 0.95
Intracellular trafficking of glycosphingolipids: role of sphingolipid activator proteins in the topology of endocytosis and lysosomal digestion. FEBS Lett (1994) 0.95
Competitive bulk liquid membrane transport of some metal ions using RC(S)NHP(S)(OiPr)(2) as ionophores. Unusual supramolecular "honeycomb" aggregate of the polynuclear copper(I) complex of H(2)NC(S)NHP(S)(OiPr)(2). Dalton Trans (2009) 0.95
Prospective study of extracorporeal photopheresis in steroid-refractory or steroid-resistant extensive chronic graft-versus-host disease: analysis of response and survival incorporating prognostic factors. Bone Marrow Transplant (2005) 0.95
Chemotherapy resistance of mouse WAP-SVT/t breast cancer cells is mediated by osteopontin, inhibiting apoptosis downstream of caspase-3. Oncogene (2006) 0.95
Analysis of a splice-site mutation in the sap-precursor gene of a patient with metachromatic leukodystrophy. Am J Hum Genet (1996) 0.94
The Second Canadian Consensus Conference on the Management of Patients with Gastroesophageal Reflux Disease. Can J Gastroenterol (1997) 0.94
Structure and expression of two plant genes encoding chromoplast-specific proteins: occurrence of partially spliced transcripts. Biochem Biophys Res Commun (1994) 0.93
Carbohydrate chains from human bronchial mucus glycoproteins: a wide spectrum of oligosaccharide structures. Biochem Soc Trans (1984) 0.93
Conversion of stable liver transplant recipients from a twice-daily Prograf-based regimen to a once-daily modified release tacrolimus-based regimen. Transplant Proc (2005) 0.93
Intrauterine diagnosis and control of fetal ventricular arrhythmia during labor. Am J Obstet Gynecol (1975) 0.93