Published in J Cell Physiol on August 01, 2008
The metastatic niche: adapting the foreign soil. Nat Rev Cancer (2009) 5.28
The lymphatic system in health and disease. Lymphat Res Biol (2008) 1.78
Paracrine induction of endothelium by tumor exosomes. Lab Invest (2009) 1.63
Lymphangiogenesis and cancer metastasis. J Cell Mol Med (2009) 1.47
In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis. Proc Natl Acad Sci U S A (2012) 1.19
Lymphangiogenesis and cancer. Genes Cancer (2011) 1.16
Macrophage-mediated lymphangiogenesis: the emerging role of macrophages as lymphatic endothelial progenitors. Cancers (Basel) (2012) 1.06
Preclinical lymphatic imaging. Mol Imaging Biol (2011) 1.06
Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer. Mol Cancer (2011) 1.00
New approaches to lymphatic imaging. Lymphat Res Biol (2009) 0.99
Identification of genes regulating migration and invasion using a new model of metastatic prostate cancer. BMC Cancer (2014) 0.98
Acidic pH via NF-κB favours VEGF-C expression in human melanoma cells. Clin Exp Metastasis (2013) 0.96
Bevacizumab and breast cancer: what does the future hold? Future Oncol (2012) 0.92
Relationship between expression and prognostic ability of PTEN, STAT3 and VEGF-C in colorectal cancer. Exp Ther Med (2012) 0.92
High lymphatic vessel density and lymphatic invasion underlie the adverse prognostic effect of radial growth phase regression in melanoma. Am J Surg Pathol (2011) 0.92
Direct visualization of changes of lymphatic function and drainage pathways in lymph node metastasis of B16F10 melanoma using near-infrared fluorescence imaging. Biomed Opt Express (2013) 0.90
Constitutive expression of the alpha4 integrin correlates with tumorigenicity and lymph node metastasis of the B16 murine melanoma. Neoplasia (2010) 0.90
Nodal lymphangiogenesis and metastasis: Role of tumor-induced lymphatic vessel activation in extramammary Paget's disease. Am J Pathol (2009) 0.90
Molecular regulation of tumor angiogenesis and perfusion via redox signaling. Chem Rev (2009) 0.89
A role for all-trans-retinoic acid in the early steps of lymphatic vasculature development. J Vasc Res (2010) 0.88
Stromal expression of vascular endothelial growth factor C is relevant to predict sentinel lymph node status in melanomas. Virchows Arch (2011) 0.87
OCT-based label-free in vivo lymphangiography within human skin and areola. Sci Rep (2016) 0.84
The role of EMT and MET in cancer dissemination. Connect Tissue Res (2015) 0.84
Phage-derived fully human monoclonal antibody fragments to human vascular endothelial growth factor-C block its interaction with VEGF receptor-2 and 3. PLoS One (2010) 0.84
The role of lymphatics in cancer as assessed by near-infrared fluorescence imaging. Ann Biomed Eng (2011) 0.84
Recent advances in lymphatic targeted drug delivery system for tumor metastasis. Cancer Biol Med (2014) 0.84
Clinical utilities and biological characteristics of melanoma sentinel lymph nodes. World J Clin Oncol (2016) 0.82
Tumor-induced lymphangiogenesis in cervical lymph nodes in oral melanoma-bearing mice. J Exp Clin Cancer Res (2012) 0.82
Chemokines, chemokine receptors and the gastrointestinal system. World J Gastroenterol (2013) 0.82
Lymphatics, lymph nodes and the immune system: barriers and gateways for cancer spread. Clin Exp Metastasis (2012) 0.82
Molecular regulation of lymphangiogenesis in development and tumor microenvironment. Cancer Microenviron (2012) 0.81
Inducible nitric oxide synthase expression in gastric adenocarcinoma: impact on lymphangiogenesis and lymphatic metastasis. Diagn Pathol (2013) 0.78
Melanoma exosomes enable tumor tolerance in lymph nodes. Med Hypotheses (2016) 0.77
Development of individualized anti-metastasis strategies by engineering nanomedicines. Chem Soc Rev (2015) 0.77
The non-canonical role of vascular endothelial growth factor-C axis in cancer progression. Exp Biol Med (Maywood) (2015) 0.77
Biomarkers of cancer metastasis through the lymphovascular system: future perspectives. Clin Exp Metastasis (2012) 0.77
Melanoma exosome induction of endothelial cell GM-CSF in pre-metastatic lymph nodes may result in different M1 and M2 macrophage mediated angiogenic processes. Med Hypotheses (2016) 0.76
Therapeutic implications of cellular and molecular biology of cancer stem cells in melanoma. Mol Cancer (2017) 0.75
Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors. Neoplasia (2016) 0.75
Are Mast Cells MASTers in Cancer? Front Immunol (2017) 0.75
Significantly high lymphatic vessel density in cutaneous metastasizing melanoma. Hippokratia (2016) 0.75
Lymphatic invasion as a prognostic biomarker in primary cutaneous melanoma. Methods Mol Biol (2014) 0.75
Extracellular vesicles: how they interact with endothelium, potentially contributing to metastatic cancer cell implants. Clin Transl Med (2017) 0.75
Metastatic pathway and the microvascular and physicochemical microenvironments of human melanoma xenografts. J Transl Med (2017) 0.75
A promoter-level mammalian expression atlas. Nature (2014) 6.25
An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J (2002) 5.07
Standard classification of rosacea: Report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea. J Am Acad Dermatol (2002) 4.52
Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum (2008) 4.08
VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med (2005) 3.98
T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J (2003) 3.82
Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells. Am J Pathol (2003) 3.35
TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays. Biotechniques (2009) 3.35
Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol (2005) 3.21
Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. Dev Dyn (2002) 3.10
The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature. Genes Dev (2002) 2.99
Standard grading system for rosacea: report of the National Rosacea Society Expert Committee on the classification and staging of rosacea. J Am Acad Dermatol (2004) 2.81
Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival. Am J Pathol (2003) 2.81
VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood (2006) 2.66
Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nat Genet (2004) 2.47
VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins. FASEB J (2004) 2.27
Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease. Cell (2010) 2.26
Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes. Mod Pathol (2005) 2.12
Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis. Blood (2003) 2.03
Endothelialized networks with a vascular geometry in microfabricated poly(dimethyl siloxane). Biomed Microdevices (2004) 1.97
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science (2015) 1.91
Hepatocyte growth factor promotes lymphatic vessel formation and function. EMBO J (2005) 1.89
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse. J Clin Invest (2011) 1.88
VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood (2007) 1.78
The lymphatic system in health and disease. Lymphat Res Biol (2008) 1.78
Tumor progression: the effects of thrombospondin-1 and -2. Int J Biochem Cell Biol (2004) 1.77
New insights into the molecular control of the lymphatic vascular system and its role in disease. J Invest Dermatol (2006) 1.76
The alpha(1)beta(1) and alpha(2)beta(1) integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis. Am J Pathol (2002) 1.75
Tumor and lymph node lymphangiogenesis--impact on cancer metastasis. J Leukoc Biol (2006) 1.72
Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation. J Exp Med (2010) 1.69
Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin. Blood (2010) 1.67
Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation. J Biol Chem (2003) 1.66
Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell (2005) 1.62
An important role of lymphatic vessel activation in limiting acute inflammation. Blood (2011) 1.62
Pathways targeting tumor lymphangiogenesis. Clin Cancer Res (2006) 1.56
Angiogenesis, lymphangiogenesis, and melanoma metastasis. Oncogene (2003) 1.48
Lymphangiogenesis and cancer metastasis. J Cell Mol Med (2009) 1.47
Mechanisms of lymphatic metastasis. J Clin Invest (2014) 1.46
Quantitative imaging of lymphatic function with liposomal indocyanine green. Cancer Res (2010) 1.43
A critical role of placental growth factor in the induction of inflammation and edema formation. Blood (2002) 1.38
Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth. Am J Pathol (2002) 1.35
Vascular endothelial growth factor-A mediates ultraviolet B-induced impairment of lymphatic vessel function. Am J Pathol (2006) 1.31
Stable expression of angiopoietin-1 and other markers by cultured pericytes: phenotypic similarities to a subpopulation of cells in maturing vessels during later stages of angiogenesis in vivo. Lab Invest (2002) 1.30
Prox1, master regulator of the lymphatic vasculature phenotype. Cell Tissue Res (2003) 1.28
Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice. Oncogene (2002) 1.27
Lymphatic endothelium in health and disease. Cell Tissue Res (2008) 1.25
Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis. Biomaterials (2013) 1.22
An important role of lymphatic vessels in the control of UVB-induced edema formation and inflammation. J Invest Dermatol (2006) 1.20
Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis. Proc Natl Acad Sci U S A (2009) 1.19
SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. Ann Rheum Dis (2011) 1.19
Lymphatic invasion in cutaneous melanoma is associated with sentinel lymph node metastasis. J Cutan Pathol (2008) 1.18
Lymphangiogenesis and cancer. Genes Cancer (2011) 1.16
Vascular endothelial growth factor promotes sensitivity to ultraviolet B-induced cutaneous photodamage. Blood (2004) 1.15
miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo. Mol Cell Biol (2010) 1.15
An unexpected role of semaphorin3a-neuropilin-1 signaling in lymphatic vessel maturation and valve formation. Circ Res (2012) 1.15
Endocan is upregulated on tumor vessels in invasive bladder cancer where it mediates VEGF-A-induced angiogenesis. Cancer Res (2012) 1.14
Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2--deficient mice. Blood (2002) 1.14
An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells. Blood (2010) 1.14
Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin. Am J Pathol (2010) 1.13
Down-regulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance. Arthritis Rheum (2011) 1.13
Activation of the VEGFR-3 pathway by VEGF-C attenuates UVB-induced edema formation and skin inflammation by promoting lymphangiogenesis. J Invest Dermatol (2008) 1.12
Infantile hemangiomas are arrested in an early developmental vascular differentiation state. Mod Pathol (2004) 1.10
In vivo imaging of inflammation- and tumor-induced lymph node lymphangiogenesis by immuno-positron emission tomography. Cancer Res (2010) 1.10
Chapter 1. Inflammation, angiogenesis, and lymphangiogenesis. Methods Enzymol (2008) 1.09
Soluble neuropilin targeted to the skin inhibits vascular permeability. Angiogenesis (2005) 1.08
VEGF-C and VEGF-D blockade inhibits inflammatory skin carcinogenesis. Cancer Res (2013) 1.07
The cutaneous vascular system in chronic skin inflammation. J Investig Dermatol Symp Proc (2011) 1.06
Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium. Exp Cell Res (2010) 1.05
Blockade of VEGF receptor-3 aggravates inflammatory bowel disease and lymphatic vessel enlargement. Inflamm Bowel Dis (2013) 1.05
Targeted overexpression of the angiogenesis inhibitor thrombospondin-1 in the epidermis of transgenic mice prevents ultraviolet-B-induced angiogenesis and cutaneous photo-damage. J Invest Dermatol (2002) 1.05
Induction of lymphatic endothelial cell differentiation in embryoid bodies. Blood (2005) 1.05
Lymphatic vessels: new targets for the treatment of inflammatory diseases. Angiogenesis (2013) 1.05
Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor. Am J Pathol (2008) 1.05
An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis. Blood (2009) 1.04
The expression levels of microRNA-361-5p and its target VEGFA are inversely correlated in human cutaneous squamous cell carcinoma. PLoS One (2012) 1.04
Expression of the type-1 repeats of thrombospondin-1 inhibits tumor growth through activation of transforming growth factor-beta. Am J Pathol (2004) 1.02
Thrombospondin 2 functions as an endogenous regulator of angiogenesis and inflammation in rheumatoid arthritis. Am J Pathol (2004) 1.01
Dynamics of lymphatic regeneration and flow patterns after lymph node dissection. Breast Cancer Res Treat (2013) 1.01
Ultraviolet B-induced skin angiogenesis is associated with a switch in the balance of vascular endothelial growth factor and thrombospondin-1 expression. J Invest Dermatol (2004) 1.01
Prox-1 promotes invasion of kaposiform hemangioendotheliomas. J Invest Dermatol (2008) 1.01
Development of the lymphatic vascular system: a mystery unravels. Dev Dyn (2004) 1.01
Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions. Exp Cell Res (2009) 1.00
Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis. Proc Natl Acad Sci U S A (2012) 0.99
Nitric oxide mediates lymphatic vessel activation via soluble guanylate cyclase alpha1beta1-impact on inflammation. FASEB J (2007) 0.97
Systemic inhibition of tumor growth and angiogenesis by thrombospondin-2 using cell-based antiangiogenic gene therapy. Cancer Res (2002) 0.95
An N-terminal 80 kDa recombinant fragment of human thrombospondin-2 inhibits vascular endothelial growth factor induced endothelial cell migration in vitro and tumor growth and angiogenesis in vivo. J Invest Dermatol (2003) 0.95
An unexpected connection: lymph node lymphangiogenesis and dendritic cell migration. Immunity (2006) 0.94
An important role of blood and lymphatic vessels in inflammation and allergy. J Allergy (Cairo) (2013) 0.94
Reduction of lymphatic vessels in photodamaged human skin. J Dermatol Sci (2007) 0.93
Coxsackie- and adenovirus receptor (CAR) is expressed in lymphatic vessels in human skin and affects lymphatic endothelial cell function in vitro. Exp Cell Res (2008) 0.93
Growth hormone promotes lymphangiogenesis. Am J Pathol (2008) 0.92
Identification of the surface-accessible, lineage-specific vascular proteome by two-dimensional peptide mapping. FASEB J (2008) 0.92
Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice. J Invest Dermatol (2003) 0.92
The angiogenesis inhibitor thrombospondin-1 inhibits acute cutaneous hypersensitivity reactions. J Invest Dermatol (2009) 0.90
Nodal lymphangiogenesis and metastasis: Role of tumor-induced lymphatic vessel activation in extramammary Paget's disease. Am J Pathol (2009) 0.90
Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice. Cancer Res (2012) 0.90
Thrombospondin-1 plays a critical role in the induction of hair follicle involution and vascular regression during the catagen phase. J Invest Dermatol (2003) 0.89
Angiogenesis and lymphangiogenesis of skin cancers. Hematol Oncol Clin North Am (2004) 0.89