Published in Am J Pathol on June 26, 2008
The lymphatic system in health and disease. Lymphat Res Biol (2008) 1.78
Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin. Blood (2010) 1.67
Lymphangiogenesis and lymphatic metastasis in breast cancer. Pathophysiology (2009) 1.48
Lymphangiogenesis and cancer metastasis. J Cell Mol Med (2009) 1.47
Broad targeting of angiogenesis for cancer prevention and therapy. Semin Cancer Biol (2015) 1.24
An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells. Blood (2010) 1.14
Developmental and pathological lymphangiogenesis: from models to human disease. Histochem Cell Biol (2008) 1.07
Macrophage-mediated lymphangiogenesis: the emerging role of macrophages as lymphatic endothelial progenitors. Cancers (Basel) (2012) 1.06
Tumor lymphangiogenesis as a potential therapeutic target. J Oncol (2012) 0.97
Interleukin-8 reduces post-surgical lymphedema formation by promoting lymphatic vessel regeneration. Angiogenesis (2012) 0.90
A role for all-trans-retinoic acid in the early steps of lymphatic vasculature development. J Vasc Res (2010) 0.88
Microanatomy of the intestinal lymphatic system. Ann N Y Acad Sci (2010) 0.86
Lysophosphatidic acid induces lymphangiogenesis and IL-8 production in vitro in human lymphatic endothelial cells. Am J Pathol (2012) 0.85
Interaction between the extracellular matrix and lymphatics: consequences for lymphangiogenesis and lymphatic function. Matrix Biol (2010) 0.84
Growth hormone receptor inhibition decreases the growth and metastasis of pancreatic ductal adenocarcinoma. Exp Mol Med (2014) 0.79
An in vivo method to quantify lymphangiogenesis in zebrafish. PLoS One (2012) 0.75
Regulation of wound healing by growth factors and cytokines. Physiol Rev (2003) 9.82
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol (2003) 7.42
Lymphangiogenesis in development and human disease. Nature (2005) 5.93
Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J (2001) 4.70
Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med (1992) 4.39
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. Cancer Cell (2004) 4.12
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J (2002) 3.99
VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med (2005) 3.98
Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet (2004) 3.38
Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells. Am J Pathol (2003) 3.35
Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis. J Exp Med (2002) 3.16
The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature. Genes Dev (2002) 2.99
VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood (2006) 2.66
Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants. Nat Med (2006) 2.56
Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nat Genet (2004) 2.47
Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis. Am J Pathol (2007) 2.40
Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1. Mol Cell Biol (2000) 2.36
Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea. Proc Natl Acad Sci U S A (2002) 2.30
VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins. FASEB J (2004) 2.27
Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am J Pathol (2007) 2.27
Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer. Cancer Res (2002) 2.13
Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes. Mod Pathol (2005) 2.12
Dose-dependent response of FGF-2 for lymphangiogenesis. Proc Natl Acad Sci U S A (2004) 1.98
[Correlation of growth hormone and aetiology of psoriasis]. Arch Dermatol Res (1981) 1.97
Hepatocyte growth factor promotes lymphatic vessel formation and function. EMBO J (2005) 1.89
Vascular growth factors and lymphangiogenesis. Physiol Rev (2002) 1.85
The role of tumor lymphangiogenesis in metastatic spread. FASEB J (2002) 1.84
VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors. Int J Cancer (2002) 1.80
New insights into the molecular control of the lymphatic vascular system and its role in disease. J Invest Dermatol (2006) 1.76
Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Blood (2005) 1.75
Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo. Proc Natl Acad Sci U S A (2005) 1.72
Tumor and lymph node lymphangiogenesis--impact on cancer metastasis. J Leukoc Biol (2006) 1.72
Lymphangiogenesis and tumor metastasis. Cell Tissue Res (2003) 1.50
Immunoelectron microscopic characterization of human dermal lymphatic microvascular endothelial cells. Differential expression of CD31, CD34, and type IV collagen with lymphatic endothelial cells vs blood capillary endothelial cells in normal human skin, lymphangioma, and hemangioma in situ. J Histochem Cytochem (1998) 1.47
Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly. Endocr Rev (2002) 1.41
Opposing actions of intact and N-terminal fragments of the human prolactin/growth hormone family members on angiogenesis: an efficient mechanism for the regulation of angiogenesis. Proc Natl Acad Sci U S A (1999) 1.35
Treatment of psoriasis with somatostatin. Arch Dermatol Res (1982) 1.31
Cytokine regulation of proliferation and ICAM-1 expression of human dermal microvascular endothelial cells in vitro. J Invest Dermatol (1992) 1.25
Increased sentinel lymph node lymphangiogenesis is associated with nonsentinel axillary lymph node involvement in breast cancer patients with a positive sentinel node. Clin Cancer Res (2007) 1.22
Epidermal homeostasis: the role of the growth hormone and insulin-like growth factor systems. Endocr Rev (2003) 1.22
Lymphatic endothelial regulation, lymphoedema, and lymph node metastasis. Semin Cell Dev Biol (2002) 0.98
Antitumor activity of the growth hormone receptor antagonist pegvisomant against human meningiomas in nude mice. J Neurosurg (2001) 0.98
Growth hormone (GH) receptors in prostate cancer: gene expression in human tissues and cell lines and characterization, GH signaling and androgen receptor regulation in LNCaP cells. Mol Cell Endocrinol (2004) 0.97
The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth. Breast Cancer Res Treat (2006) 0.94
Lymphangiogenic growth factors as markers of tumor metastasis. APMIS (2004) 0.94
Transgenic mice reveal novel activities of growth hormone in wound repair, angiogenesis, and myofibroblast differentiation. J Biol Chem (2004) 0.93
Human growth hormone stimulates proliferation of human retinal microvascular endothelial cells in vitro. Proc Natl Acad Sci U S A (1991) 0.93
Growth hormone receptor is expressed in human breast cancer. Am J Pathol (2001) 0.93
Lymphatic versus blood vascular endothelial growth factors and receptors in humans. Microsc Res Tech (2001) 0.92
Angiogenic activity of anterior pituitary tissue and growth hormone on the chick embryo chorio-allantoic membrane: a novel action of GH. Life Sci (1995) 0.88
Localization of growth hormone messenger ribonucleic acid in the human immune system--a Clinical Research Center study. J Clin Endocrinol Metab (1996) 0.86
Autocrine human growth hormone inhibits placental transforming growth factor-beta gene transcription to prevent apoptosis and allow cell cycle progression of human mammary carcinoma cells. J Biol Chem (2002) 0.85
Expression of growth hormone receptor in benign and malignant cutaneous proliferative entities. J Cutan Pathol (2000) 0.85
Signaling mechanism for the insulin-like effects of growth hormone--another example of a classical hormonal negative feedback loop. Curr Drug Targets Immune Endocr Metabol Disord (2005) 0.85
Splicing variants of the human growth hormone mRNA: detection in pituitary, mononuclear cells and dermal fibroblasts. Mol Cell Endocrinol (1995) 0.85
Growth hormone receptor antagonist administration inhibits growth of human colorectal carcinoma in nude mice. Anticancer Res (2005) 0.85
Growth hormone restores glucocorticoid-induced T cell suppression. FASEB J (2001) 0.84
Immunoreactive growth hormone (GH) secretion by human lymphocytes: augmented release by exogenous GH. Biochem Biophys Res Commun (1990) 0.84
Breast cancer: further metabolic-endocrine risk markers? Br J Cancer (1997) 0.83
Growth hormone receptor expression in human colorectal cancer. Dig Dis Sci (2004) 0.83
Growth hormone expression in the perinatal and postnatal rat lung. Dev Dyn (2005) 0.79
Growth hormone (GH) and prolactin (PRL) regulate IGFBP-3 gene expression in rat beta-cells. Mol Cell Endocrinol (1995) 0.78
Influence of growth hormone on maintenance of capillary-like structures in an in vitro model of stromal vascular tissue--results from morphometric analysis. Artif Organs (2005) 0.77
Recurrent acromegaly resulting from ectopic growth hormone gene expression by a metastatic pancreatic tumor. Cancer (1993) 0.77
Relapsing eruptive psoriasis and immunological changes triggered by growth hormone therapy in a growth hormone-deficient girl. Dermatologica (1990) 0.76
Growth hormone producing hyperplasia of pituitary gland in psoriasis. Arch Dermatol Res (1985) 0.76
Growth hormone expression in murine bone marrow cells is independent of the pituitary transcription factor Pit-1. Endocrinology (1997) 0.76
A promoter-level mammalian expression atlas. Nature (2014) 6.25
An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J (2002) 5.07
Standard classification of rosacea: Report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea. J Am Acad Dermatol (2002) 4.52
Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum (2008) 4.08
VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med (2005) 3.98
T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J (2003) 3.82
Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells. Am J Pathol (2003) 3.35
TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays. Biotechniques (2009) 3.35
Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol (2005) 3.21
Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. Dev Dyn (2002) 3.10
The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature. Genes Dev (2002) 2.99
Standard grading system for rosacea: report of the National Rosacea Society Expert Committee on the classification and staging of rosacea. J Am Acad Dermatol (2004) 2.81
Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival. Am J Pathol (2003) 2.81
VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood (2006) 2.66
Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nat Genet (2004) 2.47
VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins. FASEB J (2004) 2.27
Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease. Cell (2010) 2.26
Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes. Mod Pathol (2005) 2.12
Global lymphoid tissue remodeling during a viral infection is orchestrated by a B cell-lymphotoxin-dependent pathway. Blood (2010) 2.03
Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis. Blood (2003) 2.03
Endothelialized networks with a vascular geometry in microfabricated poly(dimethyl siloxane). Biomed Microdevices (2004) 1.97
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science (2015) 1.91
Hepatocyte growth factor promotes lymphatic vessel formation and function. EMBO J (2005) 1.89
Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse. J Clin Invest (2011) 1.88
VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood (2007) 1.78
The lymphatic system in health and disease. Lymphat Res Biol (2008) 1.78
Tumor progression: the effects of thrombospondin-1 and -2. Int J Biochem Cell Biol (2004) 1.77
New insights into the molecular control of the lymphatic vascular system and its role in disease. J Invest Dermatol (2006) 1.76
The alpha(1)beta(1) and alpha(2)beta(1) integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis. Am J Pathol (2002) 1.75
Tumor and lymph node lymphangiogenesis--impact on cancer metastasis. J Leukoc Biol (2006) 1.72
Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation. J Exp Med (2010) 1.69
Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin. Blood (2010) 1.67
Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation. J Biol Chem (2003) 1.66
Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. Nat Immunol (2005) 1.65
Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell (2005) 1.62
An important role of lymphatic vessel activation in limiting acute inflammation. Blood (2011) 1.62
Pathways targeting tumor lymphangiogenesis. Clin Cancer Res (2006) 1.56
Angiogenesis, lymphangiogenesis, and melanoma metastasis. Oncogene (2003) 1.48
Lymphangiogenesis and cancer metastasis. J Cell Mol Med (2009) 1.47
Mechanisms of lymphatic metastasis. J Clin Invest (2014) 1.46
Quantitative imaging of lymphatic function with liposomal indocyanine green. Cancer Res (2010) 1.43
A critical role of placental growth factor in the induction of inflammation and edema formation. Blood (2002) 1.38
Tissue inflammation modulates gene expression of lymphatic endothelial cells and dendritic cell migration in a stimulus-dependent manner. Blood (2011) 1.35
Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth. Am J Pathol (2002) 1.35
Tumor lymphangiogenesis and melanoma metastasis. J Cell Physiol (2008) 1.32
Vascular endothelial growth factor-A mediates ultraviolet B-induced impairment of lymphatic vessel function. Am J Pathol (2006) 1.31
Stable expression of angiopoietin-1 and other markers by cultured pericytes: phenotypic similarities to a subpopulation of cells in maturing vessels during later stages of angiogenesis in vivo. Lab Invest (2002) 1.30
Prox1, master regulator of the lymphatic vasculature phenotype. Cell Tissue Res (2003) 1.28
Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice. Oncogene (2002) 1.27
Lymphatic endothelium in health and disease. Cell Tissue Res (2008) 1.25
IL-7-producing stromal cells are critical for lymph node remodeling. Blood (2012) 1.22
Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis. Biomaterials (2013) 1.22
An important role of lymphatic vessels in the control of UVB-induced edema formation and inflammation. J Invest Dermatol (2006) 1.20
Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis. Proc Natl Acad Sci U S A (2009) 1.19
SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. Ann Rheum Dis (2011) 1.19
Lymphatic invasion in cutaneous melanoma is associated with sentinel lymph node metastasis. J Cutan Pathol (2008) 1.18
Lymphangiogenesis and cancer. Genes Cancer (2011) 1.16
Vascular endothelial growth factor promotes sensitivity to ultraviolet B-induced cutaneous photodamage. Blood (2004) 1.15
miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo. Mol Cell Biol (2010) 1.15
An unexpected role of semaphorin3a-neuropilin-1 signaling in lymphatic vessel maturation and valve formation. Circ Res (2012) 1.15
Endocan is upregulated on tumor vessels in invasive bladder cancer where it mediates VEGF-A-induced angiogenesis. Cancer Res (2012) 1.14
Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2--deficient mice. Blood (2002) 1.14
An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells. Blood (2010) 1.14
Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin. Am J Pathol (2010) 1.13
Down-regulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance. Arthritis Rheum (2011) 1.13
Activation of the VEGFR-3 pathway by VEGF-C attenuates UVB-induced edema formation and skin inflammation by promoting lymphangiogenesis. J Invest Dermatol (2008) 1.12
Infantile hemangiomas are arrested in an early developmental vascular differentiation state. Mod Pathol (2004) 1.10
In vivo imaging of inflammation- and tumor-induced lymph node lymphangiogenesis by immuno-positron emission tomography. Cancer Res (2010) 1.10
Chapter 1. Inflammation, angiogenesis, and lymphangiogenesis. Methods Enzymol (2008) 1.09
Soluble neuropilin targeted to the skin inhibits vascular permeability. Angiogenesis (2005) 1.08
VEGF-C and VEGF-D blockade inhibits inflammatory skin carcinogenesis. Cancer Res (2013) 1.07
The cutaneous vascular system in chronic skin inflammation. J Investig Dermatol Symp Proc (2011) 1.06
Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium. Exp Cell Res (2010) 1.05
Blockade of VEGF receptor-3 aggravates inflammatory bowel disease and lymphatic vessel enlargement. Inflamm Bowel Dis (2013) 1.05
Targeted overexpression of the angiogenesis inhibitor thrombospondin-1 in the epidermis of transgenic mice prevents ultraviolet-B-induced angiogenesis and cutaneous photo-damage. J Invest Dermatol (2002) 1.05
Induction of lymphatic endothelial cell differentiation in embryoid bodies. Blood (2005) 1.05
Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor. Am J Pathol (2008) 1.05
Lymphatic vessels: new targets for the treatment of inflammatory diseases. Angiogenesis (2013) 1.05
An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis. Blood (2009) 1.04
Differential requirement for ROCK in dendritic cell migration within lymphatic capillaries in steady-state and inflammation. Blood (2012) 1.04
The expression levels of microRNA-361-5p and its target VEGFA are inversely correlated in human cutaneous squamous cell carcinoma. PLoS One (2012) 1.04
Apelin inhibits diet-induced obesity by enhancing lymphatic and blood vessel integrity. Diabetes (2013) 1.03
Expression of the type-1 repeats of thrombospondin-1 inhibits tumor growth through activation of transforming growth factor-beta. Am J Pathol (2004) 1.02
Thrombospondin 2 functions as an endogenous regulator of angiogenesis and inflammation in rheumatoid arthritis. Am J Pathol (2004) 1.01
Dynamics of lymphatic regeneration and flow patterns after lymph node dissection. Breast Cancer Res Treat (2013) 1.01
Ultraviolet B-induced skin angiogenesis is associated with a switch in the balance of vascular endothelial growth factor and thrombospondin-1 expression. J Invest Dermatol (2004) 1.01
Prox-1 promotes invasion of kaposiform hemangioendotheliomas. J Invest Dermatol (2008) 1.01
Development of the lymphatic vascular system: a mystery unravels. Dev Dyn (2004) 1.01
Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions. Exp Cell Res (2009) 1.00
Molecular imaging of atherosclerotic plaques using a human antibody against the extra-domain B of fibronectin. Circ Res (2004) 0.99
Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis. Proc Natl Acad Sci U S A (2012) 0.99
Nitric oxide mediates lymphatic vessel activation via soluble guanylate cyclase alpha1beta1-impact on inflammation. FASEB J (2007) 0.97
Systemic inhibition of tumor growth and angiogenesis by thrombospondin-2 using cell-based antiangiogenic gene therapy. Cancer Res (2002) 0.95