Published in Crit Care on May 20, 2008
Sedation and Psychopharmacology in Critical Care | NCT00205517
Reducing iatrogenic risks: ICU-acquired delirium and weakness--crossing the quality chasm. Chest (2010) 2.28
Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study. Intensive Care Med (2013) 1.56
Sedation practice in the intensive care unit: a UK national survey. Crit Care (2008) 1.14
Alcohol-use disorders in the critically ill patient. Chest (2010) 1.07
Intensive Care Unit-acquired infection as a side effect of sedation. Crit Care (2010) 1.03
Intensive care sedation: the past, present and the future. Crit Care (2013) 0.84
Remifentanil discontinuation and subsequent intensive care unit-acquired infection: a cohort study. Crit Care (2009) 0.83
Daily sedative interruption versus intermittent sedation in mechanically ventilated critically ill patients: a randomized trial. Ann Intensive Care (2014) 0.83
Current practices and barriers impairing physicians' and nurses' adherence to analgo-sedation recommendations in the intensive care unit--a national survey. Crit Care (2014) 0.80
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Management and outcome of mechanically ventilated patients after cardiac arrest. Crit Care (2015) 0.78
Nurse and patient interaction behaviors' effects on nursing care quality for mechanically ventilated older adults in the ICU. Res Gerontol Nurs (2014) 0.75
Defining sedation-related adverse events in the pediatric intensive care unit. Heart Lung (2013) 0.75
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Statistical evaluation of ventilator-free days as an efficacy measure in clinical trials of treatments for acute respiratory distress syndrome. Crit Care Med (2002) 3.87
A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients. Crit Care Med (2006) 3.49
Daily interruption of sedative infusions and complications of critical illness in mechanically ventilated patients. Crit Care Med (2004) 2.46
A randomized, controlled trial of the role of weaning predictors in clinical decision making. Crit Care Med (2006) 2.38
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Sedation algorithm in critically ill patients without acute brain injury. Crit Care Med (2005) 1.30
Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes. Anesthesiology (2001) 1.29
UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver. J Pharmacol Exp Ther (2004) 1.21
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A prospective evaluation of empiric versus protocol-based sedation and analgesia. Pharmacotherapy (2000) 1.05
Alcohol use disorders increase the risk for mechanical ventilation in medical patients. Alcohol Clin Exp Res (2007) 1.02
Intervention at the level of the neuroendocrine-immune axis and postoperative pneumonia rate in long-term alcoholics. Am J Respir Crit Care Med (2006) 0.98
Prevalence and impact of alcohol and other drug use disorders on sedation and mechanical ventilation: a retrospective study. BMC Anesthesiol (2007) 0.91
Protocol-driven ventilator management in a trauma intensive care unit population. Arch Surg (2002) 0.82
Noninvasive positive-pressure ventilation for respiratory failure after extubation. N Engl J Med (2004) 7.03
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Post-ICU mechanical ventilation at 23 long-term care hospitals: a multicenter outcomes study. Chest (2007) 2.38
A randomized, controlled trial of the role of weaning predictors in clinical decision making. Crit Care Med (2006) 2.38
Characteristics and outcomes of ventilated patients according to time to liberation from mechanical ventilation. Am J Respir Crit Care Med (2011) 2.15
Ventilator-dependent survivors of catastrophic illness transferred to 23 long-term care hospitals for weaning from prolonged mechanical ventilation. Chest (2007) 2.03
Bloodstream infections due to Candida species in the intensive care unit: identifying especially high-risk patients to determine prevention strategies. Clin Infect Dis (2005) 1.87
Ineffective triggering predicts increased duration of mechanical ventilation. Crit Care Med (2009) 1.78
Short course of omeprazole: a better first diagnostic approach to noncardiac chest pain than endoscopy, manometry, or 24-hour esophageal pH monitoring. J Clin Gastroenterol (2002) 1.58
Intensive care unit sedation: waking up clinicians to the gap between research and practice. Crit Care Med (2006) 1.45
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Lessons learned from the introduction of personalized genotyping into a medical school curriculum. Genet Med (2011) 1.41
Aerobic exercise alters postprandial lipemia in African American versus White women. Int J Sport Nutr Exerc Metab (2008) 1.39
Thyroid-hormone-disrupting chemicals: evidence for dose-dependent additivity or synergism. Environ Health Perspect (2005) 1.35
Effect of educational interventions and medical school policies on medical students' attitudes toward pharmaceutical marketing practices: a multi-institutional study. Acad Med (2011) 1.28
Perceived barriers to the use of sedation protocols and daily sedation interruption: a multidisciplinary survey. J Crit Care (2008) 1.27
Analysis of the interaction of phytoestrogens and synthetic chemicals: an in vitro/in vivo comparison. Toxicol Appl Pharmacol (2006) 1.16
Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine. Eur J Pharmacol (2005) 1.13
Extubation failure: magnitude of the problem, impact on outcomes, and prevention. Curr Opin Crit Care (2003) 1.09
Why do we pay? A national survey of investigators and IRB chairpersons. J Empir Res Hum Res Ethics (2010) 1.07
Changing trends in phthalate exposures. Environ Health Perspect (2014) 1.06
Alcohol use disorders increase the risk for mechanical ventilation in medical patients. Alcohol Clin Exp Res (2007) 1.02
Analysis of Environmental Chemical Mixtures and Non-Hodgkin Lymphoma Risk in the NCI-SEER NHL Study. Environ Health Perspect (2015) 1.00
Observational study of patient-ventilator asynchrony and relationship to sedation level. J Crit Care (2009) 0.96
Support of science-based decisions concerning the evaluation of the toxicology of mixtures: a new beginning. Regul Toxicol Pharmacol (2002) 0.96
Corticosteroids to prevent postextubation upper airway obstruction: the evidence mounts. Crit Care (2007) 0.93
Clinical and pathologic features of cynomolgus macaques (Macaca fascicularis) infected with aerosolized Yersinia pestis. Comp Med (2008) 0.92
Prevalence and impact of alcohol and other drug use disorders on sedation and mechanical ventilation: a retrospective study. BMC Anesthesiol (2007) 0.91
Physiological effects of enteral and parenteral feeding on pancreaticobiliary secretion in humans. Am J Physiol Gastrointest Liver Physiol (2003) 0.91
Predictors for daily interruption of sedation therapy by nurses: a prospective, multicenter study. J Crit Care (2010) 0.91
What Can Epidemiological Studies Tell Us about the Impact of Chemical Mixtures on Human Health? Environ Health Perspect (2016) 0.89
Neurotoxicological interactions of a five-pesticide mixture in preweanling rats. Toxicol Sci (2006) 0.88
Characterizing the learning curve of the VBLaST-PT(©) (Virtual Basic Laparoscopic Skill Trainer). Surg Endosc (2013) 0.88
Insulin therapy and acute kidney injury in critically ill patients a systematic review. Nephrol Dial Transplant (2007) 0.88
Influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to chemotherapy in breast tumor cells. Breast Cancer Res Treat (2010) 0.88
Administration of sedatives and level of sedation: comparative evaluation via the Sedation-Agitation Scale and the Bispectral Index. Am J Crit Care (2003) 0.87
Multiple classes of environmental chemicals are associated with liver disease: NHANES 2003-2004. Int J Hyg Environ Health (2013) 0.87
Response-surface modeling of the effect of 5alpha-dihydrotestosterone and androgen receptor levels on the response to the androgen antagonist vinclozolin. Toxicol Sci (2002) 0.86
Evidence for dose-additive effects of pyrethroids on motor activity in rats. Environ Health Perspect (2009) 0.84
The moderating role of sensory Overresponsivity in HPA activity: a pilot study with children diagnosed with ADHD. J Atten Disord (2009) 0.84
Resistance exercise and postprandial lipemia: The dose effect of differing volumes of acute resistance exercise bouts. Metabolism (2005) 0.84
How we launched a developmental student-as-teacher (SAT) program for all medical students. Med Teach (2014) 0.83
Preventing postextubation respiratory failure. Crit Care Med (2006) 0.83
Who's doing the math? Are we really compensating research participants? J Empir Res Hum Res Ethics (2010) 0.83
Creation of virtual patients from CT images of cadavers to enhance integration of clinical and basic science student learning in anatomy. Med Teach (2009) 0.83
Should patients be able to follow commands prior to extubation? Respir Care (2010) 0.82
Component-based and whole-mixture techniques for addressing the toxicity of drinking-water disinfection by-product mixtures. J Toxicol Environ Health A (2004) 0.82
Managing acute respiratory failure during exacerbation of chronic obstructive pulmonary disease. Respir Care (2004) 0.81
R = 20: bias in the reporting of respiratory rates. Am J Emerg Med (2008) 0.81
Potentiation of cell killing by fractionated radiation and suppression of proliferative recovery in MCF-7 breast tumor cells by the Vitamin D3 analog EB 1089. J Steroid Biochem Mol Biol (2004) 0.81
Can we identify patients at high risk for unplanned extubation? A large-scale multidisciplinary survey. Respir Care (2010) 0.80
The utility of microvascular perfusion assessment in heart failure: a pilot study. J Card Fail (2005) 0.80
Pharmacological synergy: the next frontier on therapeutic advancement for migraine. Headache (2012) 0.80
Bioenergetic markers in skin fibroblasts of sporadic amyotrophic lateral sclerosis and progressive lateral sclerosis patients. Ann Neurol (2014) 0.79
Titrating and evaluating multi-drug regimens within subjects. Stat Med (2003) 0.79
Integrated disinfection by-products research: assessing reproductive and developmental risks posed by complex disinfection by-product mixtures. J Toxicol Environ Health A (2008) 0.79
An empirical approach to sufficient similarity: combining exposure data and mixtures toxicology data. Risk Anal (2013) 0.79
Drug withdrawal, cocaine and sedative use disorders increase the need for mechanical ventilation in medical patients. Addiction (2008) 0.79
Are we ready to monitor for delirium in the intensive care unit? Crit Care Med (2004) 0.78
Experimental designs for mixtures of chemicals along fixed ratio rays. Environ Health Perspect (2002) 0.78
Optimizing patient-ventilator interaction: how we sync about it? Crit Care Med (2008) 0.78
Severe respiratory muscle weakness related to long-term colchicine therapy. Respir Care (2004) 0.77
Efficiency is not enough; you have to prove that you care: role modelling of compassionate care in an innovative resident-as-teacher initiative. Educ Health (Abingdon) (2013) 0.77
Statistical Approaches for Assessing Health Effects of Environmental Chemical Mixtures in Epidemiology: Lessons from an Innovative Workshop. Environ Health Perspect (2016) 0.77
Weaning the "unweanable": liberating patients from prolonged mechanical ventilation. Crit Care Med (2007) 0.77
Testing for departures from additivity in mixtures of perfluoroalkyl acids (PFAAs). Toxicology (2013) 0.77
The interaction effects of binary mixtures of benzene and toluene on the developing heart of medaka (Oryzias latipes). Chemosphere (2005) 0.77
Detecting Departure From Additivity Along a Fixed-Ratio Mixture Ray With a Piecewise Model for Dose and Interaction Thresholds. J Agric Biol Environ Stat (2010) 0.76
Testing for additivity at select mixture groups of interest based on statistical equivalence testing methods. Risk Anal (2006) 0.76
Effect of the vitamin D3 analog ILX 23-7553 on apoptosis and sensitivity to fractionated radiation in breast tumor cells and normal human fibroblasts. Cancer Chemother Pharmacol (2003) 0.76
Quality of life in refractory ascites: transjugular intrahepatic portal-systemic shunting versus medical therapy. Hepatology (2005) 0.76
Thermoregulatory response to an organophosphate and carbamate insecticide mixture: testing the assumption of dose-additivity. Toxicology (2005) 0.76
TGIF: tracheal gas insufflation: for whom? Chest (2002) 0.75
Putting it all together to predict extubation outcome. Intensive Care Med (2004) 0.75
Effects of bone-conducted music on swimming performance. J Strength Cond Res (2012) 0.75
Optimal design for the precise estimation of an interaction threshold: the impact of exposure to a mixture of 18 polyhalogenated aromatic hydrocarbons. Risk Anal (2012) 0.75
Severe acute exacerbation of chronic obstructive pulmonary disease: when are multiple-drug-resistant bacteria the culprits? Crit Care Med (2006) 0.75
Spontaneous breathing trials: should we use automatic tube compensation? Respir Care (2010) 0.75
Residual attributable mortality, a new concept for understanding the value of antibiotics in treating life-threatening acute infections. Antimicrob Agents Chemother (2010) 0.75
"Narrow" thinking about difficult weaning: don't forget the endotracheal tube. Respir Care (2012) 0.75
Using decentralized medical education to address the workforce needs of a rural state: a partnership between Maine Medical Center and Tufts University school of medicine. Rural Remote Health (2010) 0.75
D-optimal experimental designs to test for departure from additivity in a fixed-ratio mixture ray. Toxicol Sci (2005) 0.75
Further considerations on the evaluation of potential reduced-risk tobacco products. Part II: Re-assessment of a heuristic using the CPS-II database. Regul Toxicol Pharmacol (2009) 0.75
The simultaneous analysis of discrete and continuous outcomes in a dose-response study: using desirability functions. Regul Toxicol Pharmacol (2007) 0.75
Big and disparate data: considerations for pediatric consortia. Curr Opin Pediatr (2017) 0.75
Hypotheses and fundamental study design characteristics for evaluating potential reduced-risk tobacco products. Part I: Heuristic. Regul Toxicol Pharmacol (2009) 0.75
Official Executive Summary of an American Thoracic Society/American College of Chest Physicians Clinical Practice Guideline: Liberation from Mechanical Ventilation in Critically Ill Adults. Am J Respir Crit Care Med (2016) 0.75
An Official American Thoracic Society/American College of Chest Physicians Clinical Practice Guideline: Liberation from Mechanical Ventilation in Critically Ill Adults. Rehabilitation Protocols, Ventilator Liberation Protocols, and Cuff Leak Tests. Am J Respir Crit Care Med (2016) 0.75
Maternal lifetime stress and prenatal psychological functioning are associated with decreased placental mitochondrial DNA copy number in the PRISM study. Am J Epidemiol (2017) 0.75
Effects of different macronutrient consumption following a resistance-training session on fat and carbohydrate metabolism. J Strength Cond Res (2004) 0.75
Prenatal stress, methylation in inflammation-related genes, and adiposity measures in early childhood: the PROGRESS cohort study. Psychosom Med (2017) 0.75
Analysis of an interaction threshold in a mixture of drugs and/or chemicals. Stat Med (2005) 0.75