Structure and expression of a rat agrin.

PubWeight™: 1.49‹?› | Rank: Top 4%

🔗 View Article (PMID 1851019)

Published in Neuron on May 01, 1991

Authors

F Rupp1, D G Payan, C Magill-Solc, D M Cowan, R H Scheller

Author Affiliations

1: Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Beckman Center, Stanford University, California 94305.

Articles citing this

Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions. EMBO J (1997) 3.11

Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site. J Cell Biol (1995) 1.90

The biology of perlecan: the multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices. Biochem J (1994) 1.87

A single EGF-like motif of laminin is responsible for high affinity nidogen binding. EMBO J (1993) 1.62

Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms. Proc Natl Acad Sci U S A (1993) 1.62

Agrin isoforms with distinct amino termini: differential expression, localization, and function. J Cell Biol (2000) 1.50

The role of laminins in basement membrane function. J Anat (1998) 1.45

Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40. EMBO J (1997) 1.44

An amino-terminal extension is required for the secretion of chick agrin and its binding to extracellular matrix. J Cell Biol (1995) 1.31

Essential roles of the acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning. Development (2008) 1.22

The SEA module: a new extracellular domain associated with O-glycosylation. Protein Sci (1995) 1.20

Agrin binds to the nerve-muscle basal lamina via laminin. J Cell Biol (1997) 1.16

Laminin-induced acetylcholine receptor clustering: an alternative pathway. J Cell Biol (1997) 1.15

Laminin A chain: expression during Drosophila development and genomic sequence. EMBO J (1992) 1.13

Expression of agrin, dystroglycan, and utrophin in normal renal tissue and in experimental glomerulopathies. Am J Pathol (2000) 1.12

Role of extracellular matrix proteins and their receptors in the development of the vertebrate neuromuscular junction. Dev Neurobiol (2011) 1.10

The extracellular matrix protein Agrin promotes heart regeneration in mice. Nature (2017) 1.09

Kinase domain of the muscle-specific receptor tyrosine kinase (MuSK) is sufficient for phosphorylation but not clustering of acetylcholine receptors: required role for the MuSK ectodomain? Proc Natl Acad Sci U S A (1997) 1.07

Effects of purified recombinant neural and muscle agrin on skeletal muscle fibers in vivo. J Cell Biol (2001) 1.06

Neural regulation of muscle acetylcholine receptor epsilon- and alpha-subunit gene promoters in transgenic mice. J Cell Biol (1993) 1.05

Structural domains of agrin required for clustering of nicotinic acetylcholine receptors. EMBO J (1994) 1.00

A targeted glycan-related gene screen reveals heparan sulfate proteoglycan sulfation regulates WNT and BMP trans-synaptic signaling. PLoS Genet (2012) 1.00

Electron microscopic structure of agrin and mapping of its binding site in laminin-1. EMBO J (1998) 0.96

Neural agrin controls acetylcholine receptor stability in skeletal muscle fibers. Proc Natl Acad Sci U S A (2001) 0.95

Glycosylated synaptomatrix regulation of trans-synaptic signaling. Dev Neurobiol (2012) 0.95

O-fucosylation of muscle agrin determines its ability to cluster acetylcholine receptors. Mol Cell Neurosci (2008) 0.94

The Caenorhabditis elegans homologue of the extracellular calcium binding protein SPARC/osteonectin affects nematode body morphology and mobility. Mol Biol Cell (1993) 0.94

Polydom: a secreted protein with pentraxin, complement control protein, epidermal growth factor and von Willebrand factor A domains. Biochem J (2000) 0.94

Agrin is a major heparan sulfate proteoglycan accumulating in Alzheimer's disease brain. Am J Pathol (1999) 0.91

AChR phosphorylation and aggregation induced by an agrin fragment that lacks the binding domain for alpha-dystroglycan. EMBO J (1996) 0.87

Agrin mediates a rapid switch from electrical coupling to chemical neurotransmission during synaptogenesis. J Cell Biol (2005) 0.87

C. elegans agrin is expressed in pharynx, IL1 neurons and distal tip cells and does not genetically interact with genes involved in synaptogenesis or muscle function. PLoS One (2007) 0.87

Induction of filopodia-like protrusions by transmembrane agrin: role of agrin glycosaminoglycan chains and Rho-family GTPases. Exp Cell Res (2010) 0.85

Agrin-induced clustering of acetylcholine receptors: a cytoskeletal link. J Cell Biol (1994) 0.84

The role of agrin in synaptic development, plasticity and signaling in the central nervous system. Neurochem Int (2012) 0.84

Agrin expression during synaptogenesis induced by traumatic brain injury. J Neurotrauma (2008) 0.83

Expression of the KAL gene in multiple neuronal sites during chicken development. Proc Natl Acad Sci U S A (1993) 0.83

Structure-function analysis of endogenous lectin mind-the-gap in synaptogenesis. Dev Neurobiol (2012) 0.83

Agrin induced morphological and structural changes in growth cones of cultured hippocampal neurons. Neuroscience (2007) 0.81

Articles by these authors

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion. Cell (1993) 10.66

Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. Nature (2000) 6.96

Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. Science (1992) 6.50

SNARE-mediated membrane fusion. Nat Rev Mol Cell Biol (2001) 5.58

Chemical synthesis of restriction enzyme recognition sites useful for cloning. Science (1977) 4.81

Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells. Cell (1998) 4.80

A genomic perspective on membrane compartment organization. Nature (2001) 4.80

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci (1988) 4.36

The molecular machinery for secretion is conserved from yeast to neurons. Proc Natl Acad Sci U S A (1993) 4.22

The syntaxin family of vesicular transport receptors. Cell (1993) 4.14

Specificity and regulation of a synaptic vesicle docking complex. Neuron (1994) 4.02

Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell (1996) 3.88

VAMP-1: a synaptic vesicle-associated integral membrane protein. Proc Natl Acad Sci U S A (1988) 3.76

Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking. Science (1994) 3.08

SNARE complex formation is triggered by Ca2+ and drives membrane fusion. Cell (1999) 3.04

n-Sec1: a neural-specific syntaxin-binding protein. Proc Natl Acad Sci U S A (1994) 2.95

Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. Neuron (1998) 2.70

Syntaxin 6 functions in trans-Golgi network vesicle trafficking. Mol Biol Cell (1997) 2.70

SNAREs and NSF in targeted membrane fusion. Curr Opin Cell Biol (1997) 2.66

Mechanisms of synaptic vesicle exocytosis. Annu Rev Cell Dev Biol (2000) 2.66

Structural organization of the synaptic exocytosis core complex. Neuron (1997) 2.64

SNARE interactions are not selective. Implications for membrane fusion specificity. J Biol Chem (1999) 2.60

Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes. J Cell Biol (1998) 2.59

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem J (1996) 2.55

Functional impact of syntaxin on gating of N-type and Q-type calcium channels. Nature (1995) 2.46

nSec1 binds a closed conformation of syntaxin1A. J Cell Biol (2000) 2.44

The mammalian brain rsec6/8 complex. Neuron (1996) 2.44

Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process. Neuron (1998) 2.36

Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Cell (1997) 2.26

Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A). Proc Natl Acad Sci U S A (1999) 2.25

Seven novel mammalian SNARE proteins localize to distinct membrane compartments. J Biol Chem (1998) 2.25

Two vesicle-associated membrane protein genes are differentially expressed in the rat central nervous system. J Biol Chem (1989) 2.23

Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit. Proc Natl Acad Sci U S A (1999) 2.23

A role for synaptotagmin (p65) in regulated exocytosis. Cell (1993) 2.22

A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes. Mol Cell (2000) 2.21

A molecular description of synaptic vesicle membrane trafficking. Annu Rev Biochem (1994) 2.13

Botulinum neurotoxin type C cleaves a single Lys-Ala bond within the carboxyl-terminal region of syntaxins. J Biol Chem (1995) 2.06

Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. J Clin Invest (1997) 2.04

VAMP-7 mediates vesicular transport from endosomes to lysosomes. J Cell Biol (1999) 2.01

Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2. Proc Natl Acad Sci U S A (1997) 1.99

Mechanisms of desensitization and resensitization of proteinase-activated receptor-2. J Biol Chem (1996) 1.99

Distinct domains of syntaxin are required for synaptic vesicle fusion complex formation and dissociation. Neuron (1995) 1.94

The ability of agrin to cluster AChRs depends on alternative splicing and on cell surface proteoglycans. Neuron (1993) 1.91

Three SNARE complexes cooperate to mediate membrane fusion. Proc Natl Acad Sci U S A (2001) 1.91

Neutrophil rolling altered by inhibition of L-selectin shedding in vitro. Nature (1996) 1.90

SNAREs contribute to the specificity of membrane fusion. Neuron (2000) 1.88

Subunit structure of the mammalian exocyst complex. Proc Natl Acad Sci U S A (1997) 1.87

Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB. Curr Biol (1999) 1.85

Differential expression of synaptic vesicle protein 2 (SV2) isoforms. J Neurosci (1994) 1.84

SV2, a brain synaptic vesicle protein homologous to bacterial transporters. Science (1992) 1.83

A role for dystrophin-associated glycoproteins and utrophin in agrin-induced AChR clustering. Cell (1994) 1.80

The sec6/8 complex is located at neurite outgrowth and axonal synapse-assembly domains. J Neurosci (1999) 1.78

Vesicle-associated membrane protein and synaptophysin are associated on the synaptic vesicle. J Biol Chem (1994) 1.77

Generation and maintenance of neuronal polarity: mechanisms of transport and targeting. Neuron (1999) 1.77

Targeting vesicles to specific sites on the plasma membrane: the role of the sec6/8 complex. Trends Cell Biol (1999) 1.76

A single gene encodes multiple neuropeptides mediating a stereotyped behavior. Cell (1983) 1.75

Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs. J Cell Biol (1998) 1.74

Isolation and characterization of a Drosophila neuropeptide gene. Neuron (1988) 1.74

The intranuclear localization of [6,7-3H]-oestradiol-17-beta in dimethylbenzanthracene-induced rat mammary adenocarcinoma and other tissues. J Endocrinol (1966) 1.73

Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins. J Biol Chem (2001) 1.70

Dominant effector genetics in mammalian cells. Nat Genet (2001) 1.68

Three novel proteins of the syntaxin/SNAP-25 family. J Biol Chem (1998) 1.67

Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking. Mol Biol Cell (1999) 1.67

Cellular and molecular biology of neuropeptide processing and packaging. Neuron (1989) 1.66

A new syntaxin family member implicated in targeting of intracellular transport vesicles. J Biol Chem (1996) 1.66

Detection of programmed cell death using fluorescence energy transfer. Nucleic Acids Res (1998) 1.65

Synaptic vesicle biogenesis, docking, and fusion: a molecular description. Physiol Rev (1996) 1.65

Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin. J Biol Chem (1996) 1.65

Specific stimulation of human T lymphocytes by substance P. J Immunol (1983) 1.65

Synaptic vesicle membrane proteins interact to form a multimeric complex. J Cell Biol (1992) 1.64

Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking. Mol Biol Cell (1999) 1.64

Characterization of antisera specific to NK1, NK2, and NK3 neurokinin receptors and their utilization to localize receptors in the rat gastrointestinal tract. J Neurosci (1996) 1.58

The Di-leucine motif of vesicle-associated membrane protein 4 is required for its localization and AP-1 binding. J Biol Chem (2001) 1.57

Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell (1995) 1.52

Mammalian vesicle trafficking proteins of the endoplasmic reticulum and Golgi apparatus. J Biol Chem (1996) 1.51

TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton. J Biol Chem (1999) 1.50

Dynamics of tubulovesicular recycling endosomes in hippocampal neurons. J Neurosci (1999) 1.49

Two rat homologs of clathrin-associated adaptor proteins. Gene (1994) 1.47

The rat brain synucleins; family of proteins transiently associated with neuronal membrane. Brain Res Mol Brain Res (1991) 1.46

Regulation of membrane trafficking: structural insights from a Rab/effector complex. Cell (1999) 1.46

Localization of synaptotagmin-binding domains on syntaxin. J Neurosci (1996) 1.44

Syntaxin 18, a SNAP receptor that functions in the endoplasmic reticulum, intermediate compartment, and cis-Golgi vesicle trafficking. J Biol Chem (2000) 1.44

RNA splicing regulates agrin-mediated acetylcholine receptor clustering activity on cultured myotubes. Neuron (1992) 1.44

Binding of viridans group streptococci to human platelets: a quantitative analysis. Infect Immun (1990) 1.41

Sequential SNARE assembly underlies priming and triggering of exocytosis. Neuron (2001) 1.41

p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues. Oncogene (2001) 1.41

Identification and characterization of Drosophila genes for synaptic vesicle proteins. J Neurosci (1993) 1.40

Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells. J Neurosci (1994) 1.40

The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells. Proc Natl Acad Sci U S A (2001) 1.38

Cellular and molecular biology of the presynaptic nerve terminal. Annu Rev Neurosci (1991) 1.38

Developmental regulation of highly active alternatively spliced forms of agrin. Neuron (1993) 1.38

The biochemistry of neurotransmitter secretion. J Biol Chem (1995) 1.37

Neuroimmunology. Adv Immunol (1986) 1.37

Brain contains two forms of synaptic vesicle protein 2. Proc Natl Acad Sci U S A (1993) 1.36

Identification of synaptic proteins and their isoform mRNAs in compartments of pancreatic endocrine cells. Proc Natl Acad Sci U S A (1994) 1.35

Multiple neuropeptides derived from a common precursor are differentially packaged and transported. Cell (1988) 1.35

The cysteine string secretory vesicle protein activates Hsc70 ATPase. J Biol Chem (1996) 1.34

Phosphorylation of synaptic vesicle proteins: modulation of the alpha SNAP interaction with the core complex. Proc Natl Acad Sci U S A (1996) 1.33

Tomosyn binds t-SNARE proteins via a VAMP-like coiled coil. Neuron (1998) 1.33