Published in Cell on April 16, 1999
Membrane fusion machines of paramyxoviruses: capture of intermediates of fusion. EMBO J (2001) 3.76
Rapid and efficient fusion of phospholipid vesicles by the alpha-helical core of a SNARE complex in the absence of an N-terminal regulatory domain. Proc Natl Acad Sci U S A (1999) 3.16
Accessory proteins stabilize the acceptor complex for synaptobrevin, the 1:1 syntaxin/SNAP-25 complex. Structure (2008) 3.01
Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors. J Cell Biol (2000) 2.91
Single molecule observation of liposome-bilayer fusion thermally induced by soluble N-ethyl maleimide sensitive-factor attachment protein receptors (SNAREs). Biophys J (2004) 2.75
Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115. J Cell Biol (2002) 2.50
The role of intraorganellar Ca(2+) in late endosome-lysosome heterotypic fusion and in the reformation of lysosomes from hybrid organelles. J Cell Biol (2000) 2.46
nSec1 binds a closed conformation of syntaxin1A. J Cell Biol (2000) 2.44
Endophilin B1 is required for the maintenance of mitochondrial morphology. J Cell Biol (2004) 2.28
Sequential N- to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles. EMBO J (2006) 2.19
Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins. J Cell Biol (2002) 2.13
Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+. Nat Struct Mol Biol (2008) 2.11
Ordering the final events in yeast exocytosis. J Cell Biol (2000) 2.03
Content mixing and membrane integrity during membrane fusion driven by pairing of isolated v-SNAREs and t-SNAREs. Proc Natl Acad Sci U S A (1999) 1.95
Single-molecule studies of SNARE complex assembly reveal parallel and antiparallel configurations. Proc Natl Acad Sci U S A (2003) 1.94
Three SNARE complexes cooperate to mediate membrane fusion. Proc Natl Acad Sci U S A (2001) 1.91
Open syntaxin docks synaptic vesicles. PLoS Biol (2007) 1.90
Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells. EMBO J (2001) 1.67
Synaptotagmin isoforms couple distinct ranges of Ca2+, Ba2+, and Sr2+ concentration to SNARE-mediated membrane fusion. Mol Biol Cell (2005) 1.67
Geranylgeranylated SNAREs are dominant inhibitors of membrane fusion. J Cell Biol (2000) 1.66
A cycle of Vam7p release from and PtdIns 3-P-dependent rebinding to the yeast vacuole is required for homotypic vacuole fusion. J Cell Biol (2002) 1.62
Electrochemical imaging of fusion pore openings by electrochemical detector arrays. Proc Natl Acad Sci U S A (2005) 1.62
ER to Golgi transport: Requirement for p115 at a pre-Golgi VTC stage. J Cell Biol (1999) 1.57
Formation, stabilisation and fusion of the readily releasable pool of secretory vesicles. Pflugers Arch (2004) 1.55
SNAREpins are functionally resistant to disruption by NSF and alphaSNAP. J Cell Biol (2000) 1.53
Phosphoinositide signaling plays a key role in cytokinesis. J Cell Biol (2006) 1.51
Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells. J Cell Biol (2003) 1.51
The SNARE protein SNAP-25 is linked to fast calcium triggering of exocytosis. Proc Natl Acad Sci U S A (2002) 1.46
The C2B domain of synaptotagmin is a Ca(2+)-sensing module essential for exocytosis. J Cell Biol (2000) 1.45
Trans-SNARE interactions elicit Ca2+ efflux from the yeast vacuole lumen. J Cell Biol (2004) 1.40
The Vtc proteins in vacuole fusion: coupling NSF activity to V(0) trans-complex formation. EMBO J (2002) 1.40
Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity. J Neurosci (2012) 1.36
Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size. Proc Natl Acad Sci U S A (2006) 1.35
Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex. J Cell Biol (2003) 1.35
CAPS drives trans-SNARE complex formation and membrane fusion through syntaxin interactions. Proc Natl Acad Sci U S A (2009) 1.26
Exocytotic mechanism studied by truncated and zero layer mutants of the C-terminus of SNAP-25. EMBO J (2000) 1.26
Compromised cytoarchitecture and polarized trafficking in autosomal dominant polycystic kidney disease cells. J Cell Biol (2000) 1.22
Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion. J Cell Biol (2002) 1.20
Conserved prefusion protein assembly in regulated exocytosis. Mol Biol Cell (2005) 1.20
Mechanism and function of synaptotagmin-mediated membrane apposition. Nat Struct Mol Biol (2011) 1.19
SNARE-complex disassembly by NSF follows synaptic-vesicle fusion. Proc Natl Acad Sci U S A (2001) 1.19
Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis. EMBO J (2002) 1.18
Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release. J Cell Biol (2008) 1.16
Acute stress increases depolarization-evoked glutamate release in the rat prefrontal/frontal cortex: the dampening action of antidepressants. PLoS One (2010) 1.16
Cysteine residues of SNAP-25 are required for SNARE disassembly and exocytosis, but not for membrane targeting. Biochem J (2001) 1.15
Ca2+-dependent regulation of synaptic SNARE complex assembly via a calmodulin- and phospholipid-binding domain of synaptobrevin. Proc Natl Acad Sci U S A (2000) 1.13
Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain. J Biol Chem (2008) 1.13
The V-ATPase proteolipid cylinder promotes the lipid-mixing stage of SNARE-dependent fusion of yeast vacuoles. EMBO J (2011) 1.12
Dynamics of SNARE assembly and disassembly during sperm acrosomal exocytosis. PLoS Biol (2005) 1.12
The role of synaptobrevin1/VAMP1 in Ca2+-triggered neurotransmitter release at the mouse neuromuscular junction. J Physiol (2011) 1.10
Supramolecular SNARE assembly precedes hemifusion in SNARE-mediated membrane fusion. Nat Struct Mol Biol (2008) 1.08
SNAP-29: a general SNARE protein that inhibits SNARE disassembly and is implicated in synaptic transmission. Proc Natl Acad Sci U S A (2001) 1.08
EBAG9 adds a new layer of control on large dense-core vesicle exocytosis via interaction with Snapin. Mol Biol Cell (2005) 1.08
A null mutation in VAMP1/synaptobrevin is associated with neurological defects and prewean mortality in the lethal-wasting mouse mutant. Neurogenetics (2006) 1.07
SNARE proteins contribute to calcium cooperativity of synaptic transmission. Proc Natl Acad Sci U S A (2000) 1.07
Accessory alpha-helix of complexin I can displace VAMP2 locally in the complexin-SNARE quaternary complex. J Mol Biol (2009) 1.05
The N-terminal domain of the t-SNARE Vam3p coordinates priming and docking in yeast vacuole fusion. Mol Biol Cell (2001) 1.03
Low pH is required for avian sarcoma and leukosis virus Env-dependent viral penetration into the cytosol and not for viral uncoating. J Virol (2004) 1.03
Mechanisms of degranulation in neutrophils. Allergy Asthma Clin Immunol (2006) 1.02
SNARE proteins mediate lipid bilayer fusion. Proc Natl Acad Sci U S A (1999) 1.02
A molecular basis underlying differences in the toxicity of botulinum serotypes A and E. EMBO Rep (2004) 1.01
Constitutive versus regulated SNARE assembly: a structural basis. EMBO J (2004) 1.01
Two distinct effects on neurotransmission in a temperature-sensitive SNAP-25 mutant. EMBO J (2001) 1.01
Genetic modifiers of the Drosophila NSF mutant, comatose, include a temperature-sensitive paralytic allele of the calcium channel alpha1-subunit gene, cacophony. Genetics (2000) 0.99
Exocytosis requires asymmetry in the central layer of the SNARE complex. EMBO J (2000) 0.98
Structural transitions in the synaptic SNARE complex during Ca2+-triggered exocytosis. J Cell Biol (2006) 0.98
Ca2+/calmodulin transfers the membrane-proximal lipid-binding domain of the v-SNARE synaptobrevin from cis to trans bilayers. Proc Natl Acad Sci U S A (2004) 0.97
Calcium-dependent interactions of the human norepinephrine transporter with syntaxin 1A. Mol Cell Neurosci (2006) 0.96
Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis. Elife (2015) 0.96
APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice. Proc Natl Acad Sci U S A (2012) 0.95
Role of secretory carrier membrane protein SCAMP2 in granule exocytosis. Mol Biol Cell (2002) 0.93
A second SNARE role for exocytic SNAP25 in endosome fusion. Mol Biol Cell (2006) 0.92
Temperature-dependent differences between readily releasable and reserve pool vesicles in chromaffin cells. Biochim Biophys Acta (2007) 0.92
The ionic layer is required for efficient dissociation of the SNARE complex by alpha-SNAP and NSF. Proc Natl Acad Sci U S A (2001) 0.91
The structural and functional implications of linked SNARE motifs in SNAP25. Mol Biol Cell (2008) 0.90
The voltage-gated Ca2+ channel is the Ca2+ sensor of fast neurotransmitter release. Cell Mol Neurobiol (2001) 0.89
Identification of genes regulated by chronic social stress in the rat dorsal raphe nucleus. Cell Mol Neurobiol (2006) 0.89
Transmission, Development, and Plasticity of Synapses. Genetics (2015) 0.89
SNAP-23 functions in docking/fusion of granules at low Ca2+. Mol Biol Cell (2004) 0.88
Differential interaction of tomosyn with syntaxin and SNAP25 depends on domains in the WD40 β-propeller core and determines its inhibitory activity. J Biol Chem (2014) 0.86
Sea urchin egg preparations as systems for the study of calcium-triggered exocytosis. J Physiol (1999) 0.85
Ca2+-dependent release of Munc18-1 from presynaptic mGluRs in short-term facilitation. Proc Natl Acad Sci U S A (2009) 0.85
The C2H2 zinc-finger protein SYD-9 is a putative posttranscriptional regulator for synaptic transmission. Proc Natl Acad Sci U S A (2006) 0.85
Allelic variants of SNAP25 in a family-based sample of ADHD. J Neural Transm (Vienna) (2008) 0.84
Physiological role of Kv1.3 channel in T lymphocyte cell investigated quantitatively by kinetic modeling. PLoS One (2014) 0.84
Increased synaptophysin is involved in inflammation-induced heat hyperalgesia mediated by cyclin-dependent kinase 5 in rats. PLoS One (2012) 0.83
Bacterial toxins and the nervous system: neurotoxins and multipotential toxins interacting with neuronal cells. Toxins (Basel) (2010) 0.81
Phosphatidylinositol transfer proteins and protein kinase C make separate but non-interacting contributions to the phosphorylation state necessary for secretory competence in rat mast cells. Biochem J (2001) 0.79
In search of the molecular mechanism of intracellular membrane fusion and neurotransmitter release. Nat Med (2013) 0.78
Synaptotagmin 1 and Ca2+ drive trans SNARE zippering. Sci Rep (2014) 0.78
Two-photon fluorescence lifetime imaging of primed SNARE complexes in presynaptic terminals and β cells. Nat Commun (2015) 0.78
Chronic treatment with agomelatine or venlafaxine reduces depolarization-evoked glutamate release from hippocampal synaptosomes. BMC Neurosci (2013) 0.78
Drosophila SNAP-29 is an essential SNARE that binds multiple proteins involved in membrane traffic. PLoS One (2014) 0.77
Dopamine Release Suppression Dependent on an Increase of Intracellular Ca(2+) Contributed to Rotenone-induced Neurotoxicity in PC12 Cells. J Toxicol Pathol (2013) 0.77
Richard Scheller and Thomas Südhof receive the 2013 Albert Lasker Basic Medical Research Award. J Clin Invest (2013) 0.75
The Rab3A-22A Chimera Prevents Sperm Exocytosis by Stabilizing Open Fusion Pores. J Biol Chem (2016) 0.75
Genetic associations with reflexive visual attention in infancy and childhood. Dev Sci (2015) 0.75
Steric hindrance of SNARE transmembrane domain organization impairs the hemifusion-to-fusion transition. EMBO Rep (2016) 0.75
Energetics, kinetics, and pathway of SNARE folding and assembly revealed by optical tweezers. Protein Sci (2017) 0.75
Model of SNARE-mediated membrane adhesion kinetics. PLoS One (2009) 0.75
A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion. Cell (1993) 10.66
Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. Nature (2000) 6.96
Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. Science (1992) 6.50
SNARE-mediated membrane fusion. Nat Rev Mol Cell Biol (2001) 5.58
Chemical synthesis of restriction enzyme recognition sites useful for cloning. Science (1977) 4.81
Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells. Cell (1998) 4.80
A genomic perspective on membrane compartment organization. Nature (2001) 4.80
Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci (1988) 4.36
The molecular machinery for secretion is conserved from yeast to neurons. Proc Natl Acad Sci U S A (1993) 4.22
The syntaxin family of vesicular transport receptors. Cell (1993) 4.14
Specificity and regulation of a synaptic vesicle docking complex. Neuron (1994) 4.02
Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell (1996) 3.88
VAMP-1: a synaptic vesicle-associated integral membrane protein. Proc Natl Acad Sci U S A (1988) 3.76
Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking. Science (1994) 3.08
n-Sec1: a neural-specific syntaxin-binding protein. Proc Natl Acad Sci U S A (1994) 2.95
Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. Neuron (1998) 2.70
Syntaxin 6 functions in trans-Golgi network vesicle trafficking. Mol Biol Cell (1997) 2.70
SNAREs and NSF in targeted membrane fusion. Curr Opin Cell Biol (1997) 2.66
Mechanisms of synaptic vesicle exocytosis. Annu Rev Cell Dev Biol (2000) 2.66
Structural organization of the synaptic exocytosis core complex. Neuron (1997) 2.64
SNARE interactions are not selective. Implications for membrane fusion specificity. J Biol Chem (1999) 2.60
Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes. J Cell Biol (1998) 2.59
Functional impact of syntaxin on gating of N-type and Q-type calcium channels. Nature (1995) 2.46
nSec1 binds a closed conformation of syntaxin1A. J Cell Biol (2000) 2.44
The mammalian brain rsec6/8 complex. Neuron (1996) 2.44
Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process. Neuron (1998) 2.36
Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Cell (1997) 2.26
Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A). Proc Natl Acad Sci U S A (1999) 2.25
Seven novel mammalian SNARE proteins localize to distinct membrane compartments. J Biol Chem (1998) 2.25
Two vesicle-associated membrane protein genes are differentially expressed in the rat central nervous system. J Biol Chem (1989) 2.23
Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit. Proc Natl Acad Sci U S A (1999) 2.23
A role for synaptotagmin (p65) in regulated exocytosis. Cell (1993) 2.22
A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes. Mol Cell (2000) 2.21
A molecular description of synaptic vesicle membrane trafficking. Annu Rev Biochem (1994) 2.13
Botulinum neurotoxin type C cleaves a single Lys-Ala bond within the carboxyl-terminal region of syntaxins. J Biol Chem (1995) 2.06
VAMP-7 mediates vesicular transport from endosomes to lysosomes. J Cell Biol (1999) 2.01
Distinct domains of syntaxin are required for synaptic vesicle fusion complex formation and dissociation. Neuron (1995) 1.94
The ability of agrin to cluster AChRs depends on alternative splicing and on cell surface proteoglycans. Neuron (1993) 1.91
Three SNARE complexes cooperate to mediate membrane fusion. Proc Natl Acad Sci U S A (2001) 1.91
SNAREs contribute to the specificity of membrane fusion. Neuron (2000) 1.88
Subunit structure of the mammalian exocyst complex. Proc Natl Acad Sci U S A (1997) 1.87
Differential expression of synaptic vesicle protein 2 (SV2) isoforms. J Neurosci (1994) 1.84
SV2, a brain synaptic vesicle protein homologous to bacterial transporters. Science (1992) 1.83
A role for dystrophin-associated glycoproteins and utrophin in agrin-induced AChR clustering. Cell (1994) 1.80
The sec6/8 complex is located at neurite outgrowth and axonal synapse-assembly domains. J Neurosci (1999) 1.78
Vesicle-associated membrane protein and synaptophysin are associated on the synaptic vesicle. J Biol Chem (1994) 1.77
Generation and maintenance of neuronal polarity: mechanisms of transport and targeting. Neuron (1999) 1.77
Targeting vesicles to specific sites on the plasma membrane: the role of the sec6/8 complex. Trends Cell Biol (1999) 1.76
A single gene encodes multiple neuropeptides mediating a stereotyped behavior. Cell (1983) 1.75
Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs. J Cell Biol (1998) 1.74
Isolation and characterization of a Drosophila neuropeptide gene. Neuron (1988) 1.74
Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins. J Biol Chem (2001) 1.70
Three novel proteins of the syntaxin/SNAP-25 family. J Biol Chem (1998) 1.67
Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking. Mol Biol Cell (1999) 1.67
Cellular and molecular biology of neuropeptide processing and packaging. Neuron (1989) 1.66
A new syntaxin family member implicated in targeting of intracellular transport vesicles. J Biol Chem (1996) 1.66
Synaptic vesicle biogenesis, docking, and fusion: a molecular description. Physiol Rev (1996) 1.65
Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin. J Biol Chem (1996) 1.65
Synaptic vesicle membrane proteins interact to form a multimeric complex. J Cell Biol (1992) 1.64
Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking. Mol Biol Cell (1999) 1.64
The Di-leucine motif of vesicle-associated membrane protein 4 is required for its localization and AP-1 binding. J Biol Chem (2001) 1.57
Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes. Curr Biol (1999) 1.54
Mammalian vesicle trafficking proteins of the endoplasmic reticulum and Golgi apparatus. J Biol Chem (1996) 1.51
Structure and expression of a rat agrin. Neuron (1991) 1.49
Dynamics of tubulovesicular recycling endosomes in hippocampal neurons. J Neurosci (1999) 1.49
Two rat homologs of clathrin-associated adaptor proteins. Gene (1994) 1.47
The rat brain synucleins; family of proteins transiently associated with neuronal membrane. Brain Res Mol Brain Res (1991) 1.46
Regulation of membrane trafficking: structural insights from a Rab/effector complex. Cell (1999) 1.46
Localization of synaptotagmin-binding domains on syntaxin. J Neurosci (1996) 1.44
Syntaxin 18, a SNAP receptor that functions in the endoplasmic reticulum, intermediate compartment, and cis-Golgi vesicle trafficking. J Biol Chem (2000) 1.44
RNA splicing regulates agrin-mediated acetylcholine receptor clustering activity on cultured myotubes. Neuron (1992) 1.44
Sequential SNARE assembly underlies priming and triggering of exocytosis. Neuron (2001) 1.41
Identification and characterization of Drosophila genes for synaptic vesicle proteins. J Neurosci (1993) 1.40
Cellular and molecular biology of the presynaptic nerve terminal. Annu Rev Neurosci (1991) 1.38
The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells. Proc Natl Acad Sci U S A (2001) 1.38
Developmental regulation of highly active alternatively spliced forms of agrin. Neuron (1993) 1.38
The biochemistry of neurotransmitter secretion. J Biol Chem (1995) 1.37
Brain contains two forms of synaptic vesicle protein 2. Proc Natl Acad Sci U S A (1993) 1.36
Identification of synaptic proteins and their isoform mRNAs in compartments of pancreatic endocrine cells. Proc Natl Acad Sci U S A (1994) 1.35
Multiple neuropeptides derived from a common precursor are differentially packaged and transported. Cell (1988) 1.35
The cysteine string secretory vesicle protein activates Hsc70 ATPase. J Biol Chem (1996) 1.34
Tomosyn binds t-SNARE proteins via a VAMP-like coiled coil. Neuron (1998) 1.33
Phosphorylation of synaptic vesicle proteins: modulation of the alpha SNAP interaction with the core complex. Proc Natl Acad Sci U S A (1996) 1.33
Quantitative measurement of mast cell degranulation using a novel flow cytometric annexin-V binding assay. Cytometry (1999) 1.32
A family of genes that codes for ELH, a neuropeptide eliciting a stereotyped pattern of behavior in Aplysia. Cell (1982) 1.30
Association of three small GTP-binding proteins with cholinergic synaptic vesicles. FEBS Lett (1993) 1.26
VAMP/synaptobrevin isoforms 1 and 2 are widely and differentially expressed in nonneuronal tissues. J Cell Biol (1996) 1.24
Hrs-2 is an ATPase implicated in calcium-regulated secretion. Nature (1997) 1.24
Self-association of the H3 region of syntaxin 1A. Implications for intermediates in SNARE complex assembly. J Biol Chem (2000) 1.24
Distinct patterns of expression of two VAMP genes within the rat brain. J Neurosci (1990) 1.22
Specific representation of cloned repetitive DNA sequences in sea urchin RNAs. Cell (1978) 1.22
Cysteine string protein, a DnaJ family member, is present on diverse secretory vesicles. Neuropharmacology (1995) 1.22
Sorting within the regulated secretory pathway occurs in the trans-Golgi network. J Cell Biol (1990) 1.21
Prohormone processing and the secretory pathway. J Biol Chem (1988) 1.20
Differential expression of the p65 gene family. Neuron (1991) 1.20
Nitric oxide modulates synaptic vesicle docking fusion reactions. Neuron (1996) 1.19