PubRank

Douglas R Green

Author PubWeight™ 330.60‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004 9.52
2 BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell 2005 8.73
3 Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 2002 8.38
4 Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol 2010 7.95
5 The BCL-2 family reunion. Mol Cell 2010 7.32
6 Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature 2007 7.21
7 Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell 2006 7.18
8 c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell 2012 6.49
9 Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 2011 6.31
10 A unified model for apical caspase activation. Mol Cell 2003 6.12
11 How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol 2008 6.02
12 The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 2011 6.00
13 HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med 2011 5.99
14 Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell 2008 5.67
15 PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 2005 5.49
16 The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity 2002 5.38
17 Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein. Immunity 2008 4.37
18 GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell 2007 4.22
19 CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature 2005 3.81
20 Dynamic programming of CD8+ T lymphocyte responses. Nat Immunol 2003 3.73
21 A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell 2011 3.72
22 Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell 2004 3.49
23 Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis. Cell 2012 3.23
24 Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 2008 3.15
25 Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. Proc Natl Acad Sci U S A 2011 3.11
26 The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nat Immunol 2011 3.03
27 Cytochrome c: functions beyond respiration. Nat Rev Mol Cell Biol 2008 2.95
28 Necroptosis. N Engl J Med 2014 2.71
29 Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. Proc Natl Acad Sci U S A 2008 2.67
30 Metabolic checkpoints in activated T cells. Nat Immunol 2012 2.47
31 Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis. J Cell Biol 2003 2.47
32 T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc Natl Acad Sci U S A 2010 2.41
33 The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J 2005 2.38
34 Caspase 8 inhibits programmed necrosis by processing CYLD. Nat Cell Biol 2011 2.37
35 Correlated three-dimensional light and electron microscopy reveals transformation of mitochondria during apoptosis. Nat Cell Biol 2007 2.34
36 Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. Proc Natl Acad Sci U S A 2013 2.33
37 The multidomain proapoptotic molecules Bax and Bak are directly activated by heat. Proc Natl Acad Sci U S A 2005 2.30
38 Do inducers of apoptosis trigger caspase-independent cell death? Nat Rev Mol Cell Biol 2005 2.25
39 Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration. Nat Cell Biol 2012 2.25
40 Regional analysis of p53 mutations in rheumatoid arthritis synovium. Proc Natl Acad Sci U S A 2002 2.19
41 The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell 2011 2.18
42 Characterization of cytoplasmic caspase-2 activation by induced proximity. Mol Cell 2009 2.18
43 Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature 2006 2.17
44 In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis. Nat Cell Biol 2005 2.11
45 Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. Proc Natl Acad Sci U S A 2013 2.10
46 Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Rep 2012 2.06
47 Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation. J Biol Chem 2010 1.99
48 RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100. J Biol Chem 2003 1.96
49 Mitochondrial dysfunction in ataxia-telangiectasia. Blood 2011 1.93
50 FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes. J Immunol 2014 1.89
51 Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. Cancer Cell 2003 1.88
52 Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell 2011 1.87
53 Cell death and tissue remodeling in planarian regeneration. Dev Biol 2009 1.87
54 Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration. Proc Natl Acad Sci U S A 2006 1.87
55 Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Immunity 2013 1.83
56 Uptake of apoptotic antigen-coupled cells by lymphoid dendritic cells and cross-priming of CD8(+) T cells produce active immune unresponsiveness. J Immunol 2002 1.79
57 It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival. Nat Rev Mol Cell Biol 2011 1.76
58 PB1-F2 proteins from H5N1 and 20 century pandemic influenza viruses cause immunopathology. PLoS Pathog 2010 1.75
59 Noncanonical autophagy promotes the visual cycle. Cell 2013 1.74
60 Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis. Science 2005 1.73
61 Apoptosis and oncogenesis: give and take in the BCL-2 family. Curr Opin Genet Dev 2011 1.71
62 Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner. J Immunol 2012 1.71
63 The role of ARK in stress-induced apoptosis in Drosophila cells. J Cell Biol 2002 1.68
64 A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. Proc Natl Acad Sci U S A 2005 1.65
65 Role of proteolysis in caspase-8 activation and stabilization. Biochemistry 2007 1.64
66 Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis. Am J Pathol 2002 1.58
67 The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization. Nat Immunol 2011 1.58
68 Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death. Mol Biol Cell 2006 1.57
69 Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains. Nature 2008 1.55
70 Resistance to caspase-independent cell death requires persistence of intact mitochondria. Dev Cell 2010 1.54
71 Mitochondria and cell signalling. J Cell Sci 2012 1.52
72 Non-apoptotic role of BID in inflammation and innate immunity. Nature 2011 1.49
73 Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol 2013 1.47
74 BID-induced structural changes in BAK promote apoptosis. Nat Struct Mol Biol 2013 1.45
75 And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosis. Biochimie 2002 1.39
76 Transcription, apoptosis and p53: catch-22. Trends Genet 2005 1.39
77 Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway. Mol Cell 2011 1.38
78 Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils. Nat Med 2002 1.38
79 Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol 2014 1.35
80 Toll-like receptor signaling in the lysosomal pathways. Immunol Rev 2009 1.35
81 Apoptotic cells induce tolerance by generating helpless CD8+ T cells that produce TRAIL. J Immunol 2007 1.33
82 Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-α-induced shock. Mol Med 2012 1.31
83 HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells. J Biol Chem 2002 1.31
84 PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis. Cell Cycle 2009 1.29
85 PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat Chem Biol 2013 1.28
86 Regulation of arthritis by p53: critical role of adaptive immunity. Arthritis Rheum 2005 1.26
87 Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. J Biol Chem 2001 1.25
88 Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival. Blood 2009 1.24
89 Protective roles for caspase-8 and cFLIP in adult homeostasis. Cell Rep 2013 1.23
90 Mitochondrial pathway of apoptosis is ancestral in metazoans. Proc Natl Acad Sci U S A 2012 1.21
91 Cytoplasmic p53: bax and forward. Cell Cycle 2004 1.21
92 TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. J Biol Chem 2011 1.21
93 Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity. Cell Host Microbe 2008 1.20
94 Mitochondrial regulation of cell death. Cold Spring Harb Perspect Biol 2013 1.19
95 Metabolic reprogramming and metabolic dependency in T cells. Immunol Rev 2012 1.18
96 Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation. J Cell Biol 2004 1.18
97 Dynamic regulation of FoxP3 expression controls the balance between CD4+ T cell activation and cell death. Eur J Immunol 2005 1.14
98 Minimal BH3 peptides promote cell death by antagonizing anti-apoptotic proteins. J Biol Chem 2003 1.14
99 Ripped to death. Trends Cell Biol 2011 1.14
100 Measuring apoptosis at the single cell level. Methods 2008 1.13
101 Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy. Genes Dev 2012 1.13
102 Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage. Blood 2011 1.12
103 Cell death and immune privilege. Int Rev Immunol 2002 1.10
104 Acridine Orange/Ethidium Bromide (AO/EB) Staining to Detect Apoptosis. CSH Protoc 2006 1.10
105 Manipulation of apoptosis in the host-parasite interaction. Trends Parasitol 2004 1.10
106 Highly conserved caspase and Bcl-2 homologues from the sea anemone Aiptasia pallida: lower metazoans as models for the study of apoptosis evolution. J Mol Evol 2006 1.08
107 Remodeling for demolition: changes in mitochondrial ultrastructure during apoptosis. Mol Cell 2002 1.06
108 p53's believe it or not: lessons on transcription-independent death. J Clin Immunol 2003 1.06
109 Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses. Mol Cell Biol 2003 1.05
110 NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2. Proc Natl Acad Sci U S A 2010 1.03
111 Mitochondria in cell death. Essays Biochem 2010 1.03
112 HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation. Blood 2005 1.02
113 Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis. EMBO J 2012 1.01
114 Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells. Proc Natl Acad Sci U S A 2009 1.00
115 Knockdown of actin and caspase gene expression by RNA interference in the symbiotic anemone Aiptasia pallida. Biol Bull 2007 1.00
116 Armed response: how dying cells influence T-cell functions. Immunol Rev 2011 0.99
117 Metalloproteinase shedding of Fas ligand regulates beta-amyloid neurotoxicity. Curr Biol 2002 0.98
118 Apoptosis: Stabbed in the BAX. Nature 2008 0.98
119 Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy. Cancer Res 2013 0.97
120 p53 tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis. Arthritis Res Ther 2004 0.95
121 Eating for good health: linking autophagy and phagocytosis in host defense. Autophagy 2008 0.95
122 Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells. Oncotarget 2014 0.94
123 Autophagy is a cell survival program for female germ cells in the murine ovary. Reproduction 2011 0.94
124 Cutting edge: regulatory T cells do not mediate suppression via programmed cell death pathways. J Immunol 2011 0.93
125 Role of Bcl-2 family members in immunity and disease. Biochim Biophys Acta 2004 0.93
126 The relationship between metabolism and the autophagy machinery during the innate immune response. Cell Metab 2013 0.93
127 Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control. Cell Metab 2011 0.92
128 Cancer: A wolf in wolf's clothing. Nature 2010 0.91
129 Addendum: defective Dock2 expression in a subset of ASC-deficient mouse lines. Nat Immunol 2012 0.91
130 Apoptosis therapy: driving cancers down the road to ruin. Nat Med 2013 0.91
131 Apoptosis: letting slip the dogs of war. Curr Biol 2002 0.91
132 Analysis of DNA fragmentation using agarose gel electrophoresis. CSH Protoc 2006 0.90
133 Nonlymphoid Fas ligand in peptide-induced peripheral lymphocyte deletion. Proc Natl Acad Sci U S A 2002 0.88
134 Confocal restricted-height imaging of suspension cells (CRISC) in a PDMS microdevice during apoptosis. Lab Chip 2005 0.87
135 Death fold domain interaction in apoptosis. Cell Death Differ 2003 0.87
136 The immune diet: meeting the metabolic demands of lymphocyte activation. F1000 Biol Rep 2012 0.86
137 MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis. Mol Cell Biol 2011 0.86
138 Tumor necrosis factor alpha up-regulates non-lymphoid Fas-ligand following superantigen-induced peripheral lymphocyte activation. J Biol Chem 2002 0.86
139 Real time with caspase-2. Cell Cycle 2010 0.85
140 Introduction: apoptosis in the development and function of the immune system. Semin Immunol 2003 0.85
141 Lymphocyte apoptosis: refining the paths to perdition. Curr Opin Hematol 2002 0.85
142 Duration of CTL activation regulates IL-2 production required for autonomous clonal expansion. Eur J Immunol 2006 0.85
143 DUB-le Trouble for Cell Survival. Cancer Cell 2010 0.84
144 Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression. Blood 2011 0.84
145 Staining of suspension cells with hoechst 33258 to detect apoptosis. CSH Protoc 2006 0.84
146 Apoptosis in the regulation of immune responses. J Rheumatol Suppl 2005 0.83
147 Life support: the alpha4 phosphatase subunit in cell survival and apoptosis. Trends Cell Biol 2005 0.83
148 Interleukin-2 rescues helpless effector CD8+ T cells by diminishing the susceptibility to TRAIL mediated death. Immunol Lett 2011 0.82
149 The role of p53 and Fas in a model of acute murine graft-versus-host disease. J Immunol 2005 0.82
150 Metabolic activation of CaMKII by coenzyme A. Mol Cell 2013 0.82
151 Regulation of activation-induced Fas (CD95/Apo-1) ligand expression in T cells by the cyclin B1/Cdk1 complex. J Biol Chem 2004 0.82
152 T cell metabolism and the immune response. Semin Immunol 2013 0.81
153 The suicide in the thymus, a twisted trail. Nat Immunol 2003 0.81
154 Distinct roles of cytolytic effector molecules for antigen-restricted killing by CTL in vivo. Immunol Cell Biol 2010 0.81
155 Mitochondria, apoptosis and autoimmunity. Curr Dir Autoimmun 2006 0.80
156 Presence of a transcriptionally active glucocorticoid receptor alpha in lens epithelial cells. Invest Ophthalmol Vis Sci 2003 0.80
157 Live to dead cell imaging. Methods Mol Biol 2009 0.79
158 Propidium Iodide (PI) Uptake Assay to Detect Apoptosis. CSH Protoc 2006 0.78
159 Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy 2014 0.77
160 Cell survival in tough times: The mitochondrial recovery plan. Cell Cycle 2010 0.77
161 Detection of phosphatidylserine externalization during apoptosis. CSH Protoc 2006 0.77
162 Mitochondria and apoptosis: a quick take on a long view. F1000 Biol Rep 2009 0.77
163 Corrigendum: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells. Nature 2016 0.76
164 The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis. Mol Cell 2016 0.76
165 Death receptors and mitochondria: life depends on the liver. Hepatology 2011 0.75
166 Granzyme A: the road less traveled. Nat Immunol 2003 0.75
167 Immunology: A heavyweight knocked out. Nature 2011 0.75
168 Microscopic Analysis of Mitochondrial Transmembrane Potential ({Delta}{Psi}m). CSH Protoc 2006 0.75
169 Analysis of TUNEL Staining by Flow Cytometry to Detect Apoptosis. CSH Protoc 2006 0.75
170 Flow Cytometric Analysis of Mitochondrial Transmembrane Potential ({Delta}{Psi}m). CSH Protoc 2006 0.75
171 Metabolism and immunity: the old and the new. Semin Immunol 2012 0.75
172 TUNEL Staining of Tissue Sections to Detect Apoptosis. CSH Protoc 2006 0.75
173 Analysis of DNA Fragmentation Using Propidium Iodide (PI) Fluorescence of Individual Nuclei. CSH Protoc 2006 0.75
174 Analysis of DNA Fragmentation Using the JAM Assay. CSH Protoc 2006 0.75
175 TUNEL Staining of Adherent Cells to Detect Apoptosis. CSH Protoc 2006 0.75
176 Analysis of DNA Fragmentation Using Propidium Iodide (PI) Staining After Ethanol Fixation. CSH Protoc 2006 0.75
177 Biochemical analysis of cell death using colorimetric quantification of caspase activation. CSH Protoc 2006 0.75
178 Leukostat staining of cytospin preparations to detect apoptosis. CSH Protoc 2006 0.75