Published in FASEB J on June 03, 2008
Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity. Annu Rev Biophys (2010) 3.76
The Ectocarpus genome and the independent evolution of multicellularity in brown algae. Nature (2010) 3.60
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions. ASN Neuro (2009) 2.85
Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity. Proc Natl Acad Sci U S A (2010) 1.46
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1. PLoS Genet (2012) 1.29
A comparative study of Lrrk2 function in primary neuronal cultures. Parkinsonism Relat Disord (2010) 1.23
Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers. PLoS One (2012) 1.09
Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau. Bioessays (2010) 1.06
Genetics and genomics of Parkinson's disease. Genome Med (2014) 1.04
Saccharina genomes provide novel insight into kelp biology. Nat Commun (2015) 1.02
Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways. J Neurochem (2014) 0.95
Characterization of the Roco protein family in Dictyostelium discoideum. Eukaryot Cell (2010) 0.91
The ROCO kinase QkgA is necessary for proliferation inhibition by autocrine signals in Dictyostelium discoideum. Eukaryot Cell (2010) 0.90
Dual regulation of a Dictyostelium STAT by cGMP and Ca2+ signalling. J Cell Sci (2010) 0.90
Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation. Front Mol Neurosci (2014) 0.89
Contribution of GTPase activity to LRRK2-associated Parkinson disease. Small GTPases (2013) 0.87
Highly dynamic exon shuffling in candidate pathogen receptors ... what if brown algae were capable of adaptive immunity? Mol Biol Evol (2011) 0.87
Current understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor design. Future Med Chem (2012) 0.86
Parkinson's disease and low frequency alleles found together throughout LRRK2. Ann Hum Genet (2009) 0.86
GTP binding to the ROC domain of DAP-kinase regulates its function through intramolecular signalling. EMBO Rep (2011) 0.85
Heterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease. Mech Ageing Dev (2010) 0.85
LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization. PLoS One (2013) 0.84
Multiple regulatory mechanisms for the Dictyostelium Roco protein GbpC. J Biol Chem (2011) 0.84
LRRK2: an éminence grise of Wnt-mediated neurogenesis? Front Cell Neurosci (2013) 0.83
The regulation and deregulation of Wnt signaling by PARK genes in health and disease. J Mol Cell Biol (2013) 0.82
Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts. Proc Natl Acad Sci U S A (2016) 0.81
LRRK2 G2019S mutation: frequency and haplotype data in South African Parkinson's disease patients. J Neural Transm (Vienna) (2010) 0.81
SILAC-based proteomic quantification of chemoattractant-induced cytoskeleton dynamics on a second to minute timescale. Nat Commun (2014) 0.80
No dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblasts. PLoS One (2015) 0.79
The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research. Biochem J (2016) 0.79
Evolution of neurodegeneration. Curr Biol (2012) 0.79
Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's Disease. Parkinsons Dis (2016) 0.78
Genetic, structural, and molecular insights into the function of ras of complex proteins domains. Chem Biol (2014) 0.78
Rare variants in LRRK1 and Parkinson's disease. Neurogenetics (2013) 0.78
The common PARK8 mutation LRRK2G²⁰¹⁹S is not a risk factor for breast cancer in the absence of Parkinson's disease. J Neurol (2013) 0.78
Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations. Biosci Rep (2015) 0.77
Metabolic labeling of leucine rich repeat kinases 1 and 2 with radioactive phosphate. J Vis Exp (2013) 0.77
The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. PLoS Genet (2015) 0.76
A phylogenetic survey of myotubularin genes of eukaryotes: distribution, protein structure, evolution, and gene expression. BMC Evol Biol (2010) 0.76
Sequences located within the N-terminus of the PD-linked LRRK2 lead to increased aggregation and attenuation of 6-hydroxydopamine-induced cell death. PLoS One (2012) 0.75
A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway. Mol Neurodegener (2017) 0.75
Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase. Mol Biol Cell (2006) 1.67
Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour. PLoS Biol (2011) 1.49
The regulation of myosin II in Dictyostelium. Eur J Cell Biol (2006) 1.41
Analysis of cell movement by simultaneous quantification of local membrane displacement and fluorescent intensities using Quimp2. Cell Motil Cytoskeleton (2009) 1.36
Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis. Proc Natl Acad Sci U S A (2013) 1.34
Highlighting the role of Ras and Rap during Dictyostelium chemotaxis. Cell Signal (2008) 1.28
RasGEF-containing proteins GbpC and GbpD have differential effects on cell polarity and chemotaxis in Dictyostelium. J Cell Sci (2005) 1.16
Intramolecular activation mechanism of the Dictyostelium LRRK2 homolog Roco protein GbpC. J Biol Chem (2008) 1.11
Switching direction in electric-signal-induced cell migration by cyclic guanosine monophosphate and phosphatidylinositol signaling. Proc Natl Acad Sci U S A (2009) 1.11
Phosducin-like proteins in Dictyostelium discoideum: implications for the phosducin family of proteins. EMBO J (2003) 1.05
Diversification of the cullin family. BMC Evol Biol (2009) 1.02
The phosducin-like protein PhLP1 is essential for G{beta}{gamma} dimer formation in Dictyostelium discoideum. Mol Cell Biol (2005) 1.00
Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proc Natl Acad Sci U S A (2012) 0.99
Regulation of phagocytosis in Dictyostelium by the inositol 5-phosphatase OCRL homolog Dd5P4. Traffic (2007) 0.97
Pleckstrin homology domain diffusion in Dictyostelium cytoplasm studied using fluorescence correlation spectroscopy. J Biol Chem (2003) 0.96
A 60-kilodalton protein component of the counting factor complex regulates group size in Dictyostelium discoideum. Eukaryot Cell (2006) 0.95
Mathematics of experimentally generated chemoattractant gradients. Methods Mol Biol (2009) 0.92
The role of cGMP and the rear of the cell in Dictyostelium chemotaxis and cell streaming. J Cell Sci (2007) 0.92
Characterization of the Roco protein family in Dictyostelium discoideum. Eukaryot Cell (2010) 0.91
Dual regulation of a Dictyostelium STAT by cGMP and Ca2+ signalling. J Cell Sci (2010) 0.90
Ancient origin of animal U-box ubiquitin ligases. BMC Evol Biol (2010) 0.87
A diverse family of inositol 5-phosphatases playing a role in growth and development in Dictyostelium discoideum. J Biol Chem (2002) 0.87
Diversification and Specialization of Plant RBR Ubiquitin Ligases. PLoS One (2010) 0.86
Multiple regulatory mechanisms for the Dictyostelium Roco protein GbpC. J Biol Chem (2011) 0.84
GIN transposons: genetic elements linking retrotransposons and genes. Mol Biol Evol (2010) 0.83
Reply to Tall et al.: Dictyostelium Ric8 does not have a chaperoning function during development and chemotaxis. Proc Natl Acad Sci U S A (2013) 0.76
Cultivation of immobilized Dictyostelium discoideum for the production of soluble human Fas ligand. Appl Microbiol Biotechnol (2004) 0.75