Published in Annu Rev Biophys on January 01, 2010
Chemotaxis in cancer. Nat Rev Cancer (2011) 3.68
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
Integrins in cell migration. Cold Spring Harb Perspect Biol (2011) 3.15
Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis. Cell (2012) 2.98
Cells navigate with a local-excitation, global-inhibition-biased excitable network. Proc Natl Acad Sci U S A (2010) 2.54
Designing synthetic regulatory networks capable of self-organizing cell polarization. Cell (2012) 2.28
Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCγ/PKCα pathway. Dev Cell (2014) 1.79
Understanding eukaryotic chemotaxis: a pseudopod-centred view. Nat Rev Mol Cell Biol (2010) 1.73
Generation and dynamics of an endogenous, self-generated signaling gradient across a migrating tissue. Cell (2013) 1.62
Incoherent feedforward control governs adaptation of activated ras in a eukaryotic chemotaxis pathway. Sci Signal (2012) 1.53
Neutrophils scan for activated platelets to initiate inflammation. Science (2014) 1.50
Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour. PLoS Biol (2011) 1.49
Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells. Nat Cell Biol (2016) 1.47
Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases. Nat Immunol (2012) 1.43
Rescaling of Spatio-Temporal Sensing in Eukaryotic Chemotaxis. PLoS One (2016) 1.40
Tracking shallow chemical gradients by actin-driven wandering of the polarization site. Curr Biol (2012) 1.37
Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis. Proc Natl Acad Sci U S A (2013) 1.34
Activated membrane patches guide chemotactic cell motility. PLoS Comput Biol (2011) 1.32
'Dicty dynamics': Dictyostelium motility as persistent random motion. Phys Biol (2011) 1.26
Group choreography: mechanisms orchestrating the collective movement of border cells. Nat Rev Mol Cell Biol (2012) 1.25
Biased excitable networks: how cells direct motion in response to gradients. Curr Opin Cell Biol (2011) 1.24
Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism. J Cell Biol (2012) 1.20
Cell signaling during development of Dictyostelium. Dev Biol (2014) 1.20
Review series: TOR kinase complexes and cell migration. J Cell Biol (2011) 1.19
Regulation of PCP by the Fat signaling pathway. Genes Dev (2013) 1.17
Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet. Curr Opin Cell Biol (2014) 1.17
Excitable actin dynamics in lamellipodial protrusion and retraction. Biophys J (2012) 1.17
Morphogen transport. Development (2013) 1.16
Moving in the right direction: how eukaryotic cells migrate along chemical gradients. Semin Cell Dev Biol (2011) 1.15
Adhesion dynamics at a glance. J Cell Sci (2011) 1.13
Myosin I links PIP3 signaling to remodeling of the actin cytoskeleton in chemotaxis. Sci Signal (2012) 1.10
Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells. PLoS Comput Biol (2013) 1.10
Impact of microscopic motility on the swimming behavior of parasites: straighter trypanosomes are more directional. PLoS Comput Biol (2011) 1.09
Evidence for a fence that impedes the diffusion of phosphatidylinositol 4,5-bisphosphate out of the forming phagosomes of macrophages. Mol Biol Cell (2011) 1.09
Electrophoresis of cellular membrane components creates the directional cue guiding keratocyte galvanotaxis. Curr Biol (2013) 1.08
Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification. EMBO Rep (2011) 1.08
Bleb-driven chemotaxis of Dictyostelium cells. J Cell Biol (2014) 1.06
Biogenesis of the posterior pole is mediated by the exosome/microvesicle protein-sorting pathway. J Biol Chem (2011) 1.05
Signaling mechanisms for chemotaxis. Dev Growth Differ (2011) 1.04
Two distinct functions for PI3-kinases in macropinocytosis. J Cell Sci (2013) 1.03
Gradient sensing in defined chemotactic fields. Integr Biol (Camb) (2010) 1.03
Generation of membrane structures during phagocytosis and chemotaxis of macrophages: role and regulation of the actin cytoskeleton. Immunol Rev (2013) 1.01
Evolutionary crossroads in developmental biology: Dictyostelium discoideum. Development (2011) 1.01
Cellular memory in eukaryotic chemotaxis. Proc Natl Acad Sci U S A (2014) 1.01
Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation. Mol Biol Cell (2011) 1.01
Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN. Mol Biol Cell (2010) 1.00
Molecular mechanism of fascin function in filopodial formation. J Biol Chem (2012) 0.99
Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics. PLoS One (2012) 0.97
Rectified directional sensing in long-range cell migration. Nat Commun (2014) 0.97
Blurred line between chemotactic chase and phagocytic consumption: an immunophysical single-cell perspective. J Cell Sci (2011) 0.96
Delineating the core regulatory elements crucial for directed cell migration by examining folic-acid-mediated responses. J Cell Sci (2012) 0.96
A stochastic model for chemotaxis based on the ordered extension of pseudopods. Biophys J (2010) 0.96
Excitable signal transduction induces both spontaneous and directional cell asymmetries in the phosphatidylinositol lipid signaling system for eukaryotic chemotaxis. Biophys J (2014) 0.94
Dipeptidyl peptidase IV is a human and murine neutrophil chemorepellent. J Immunol (2013) 0.93
Lateral diffusion of peripheral membrane proteins on supported lipid bilayers is controlled by the additive frictional drags of (1) bound lipids and (2) protein domains penetrating into the bilayer hydrocarbon core. Chem Phys Lipids (2013) 0.93
Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion. Proc Natl Acad Sci U S A (2012) 0.93
A model for a correlated random walk based on the ordered extension of pseudopodia. PLoS Comput Biol (2010) 0.93
Biased migration of confined neutrophil-like cells in asymmetric hydraulic environments. Proc Natl Acad Sci U S A (2013) 0.92
Repelled from the wound, or randomly dispersed? Reverse migration behaviour of neutrophils characterized by dynamic modelling. J R Soc Interface (2012) 0.92
The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration. J Biol Chem (2011) 0.91
Interactions of phosphatase and tensin homologue (PTEN) proteins with phosphatidylinositol phosphates: insights from molecular dynamics simulations of PTEN and voltage sensitive phosphatase. Biochemistry (2014) 0.91
Temporal sampling, resetting, and adaptation orchestrate gradient sensing in sperm. J Cell Biol (2012) 0.91
Gradient generation platforms: new directions for an established microfluidic technology. Lab Chip (2014) 0.91
Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway. Biophys J (2016) 0.90
The physics of eukaryotic chemotaxis. Phys Today (2013) 0.89
How blebs and pseudopods cooperate during chemotaxis. Proc Natl Acad Sci U S A (2014) 0.89
Intracellular encoding of spatiotemporal guidance cues in a self-organizing signaling system for chemotaxis in Dictyostelium cells. Biophys J (2013) 0.89
Mouse macrophages completely lacking Rho subfamily GTPases (RhoA, RhoB, and RhoC) have severe lamellipodial retraction defects, but robust chemotactic navigation and altered motility. J Biol Chem (2014) 0.88
Different roles of membrane potentials in electrotaxis and chemotaxis of dictyostelium cells. Eukaryot Cell (2011) 0.88
Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Rep (2013) 0.88
Cell-cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis. Proc Natl Acad Sci U S A (2016) 0.87
A PIP5 kinase essential for efficient chemotactic signaling. Curr Biol (2014) 0.87
Chemotaxis in densely populated tissue determines germinal center anatomy and cell motility: a new paradigm for the development of complex tissues. PLoS One (2011) 0.86
Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics. J Biomech Eng (2016) 0.85
Rho GTPases orient directional sensing in chemotaxis. Proc Natl Acad Sci U S A (2013) 0.85
Nogo-B is associated with cytoskeletal structures in human monocyte-derived macrophages. BMC Res Notes (2011) 0.85
WD40-repeat proteins control the flow of Gβγ signaling for directional cell migration. Cell Adh Migr (2013) 0.84
Coccidioides Endospores and Spherules Draw Strong Chemotactic, Adhesive, and Phagocytic Responses by Individual Human Neutrophils. PLoS One (2015) 0.84
Rho GTPases and regulation of cell migration and polarization in human corneal epithelial cells. PLoS One (2013) 0.84
Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis. Nat Commun (2014) 0.84
Genetic control of morphogenesis in Dictyostelium. Dev Biol (2015) 0.84
Actin cross-linking proteins cortexillin I and II are required for cAMP signaling during Dictyostelium chemotaxis and development. Mol Biol Cell (2011) 0.84
Role of Polarized G Protein Signaling in Tracking Pheromone Gradients. Dev Cell (2015) 0.84
Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range. Proc Natl Acad Sci U S A (2014) 0.83
From lipid second messengers to molecular motors: microtubule-organizing center reorientation in T cells. Immunol Rev (2013) 0.83
Calumenin-15 facilitates filopodia formation by promoting TGF-β superfamily cytokine GDF-15 transcription. Cell Death Dis (2013) 0.83
The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton. Mol Biol Cell (2011) 0.83
Direct biochemical measurements of signal relay during Dictyostelium development. J Biol Chem (2011) 0.83
Asymmetric PTEN distribution regulated by spatial heterogeneity in membrane-binding state transitions. PLoS Comput Biol (2013) 0.82
Identification of a Chemoattractant G-Protein-Coupled Receptor for Folic Acid that Controls Both Chemotaxis and Phagocytosis. Dev Cell (2016) 0.82
Chemotaxis of Dictyostelium discoideum: collective oscillation of cellular contacts. PLoS One (2013) 0.81
Amplification and temporal filtering during gradient sensing by nerve growth cones probed with a microfluidic assay. Biophys J (2012) 0.80
The IplA Ca2+ channel of Dictyostelium discoideum is necessary for chemotaxis mediated through Ca2+, but not through cAMP, and has a fundamental role in natural aggregation. J Cell Sci (2012) 0.80
Interplay between phosphoinositide lipids and calcium signals at the leading edge of chemotaxing ameboid cells. Chem Phys Lipids (2014) 0.80
Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay. J Cell Sci (2013) 0.80
The neutrophil's eye-view: inference and visualisation of the chemoattractant field driving cell chemotaxis in vivo. PLoS One (2012) 0.80
The exocytic gene secA is required for Dictyostelium cell motility and osmoregulation. J Cell Sci (2010) 0.80
A continuum model of actin waves in Dictyostelium discoideum. PLoS One (2013) 0.80
The role of phosphoinositide-regulated actin reorganization in chemotaxis and cell migration. Br J Pharmacol (2014) 0.80
SILAC-based proteomic quantification of chemoattractant-induced cytoskeleton dynamics on a second to minute timescale. Nat Commun (2014) 0.80
The genome of the social amoeba Dictyostelium discoideum. Nature (2005) 9.18
Making sense of it all: bacterial chemotaxis. Nat Rev Mol Cell Biol (2004) 6.83
G protein signaling events are activated at the leading edge of chemotactic cells. Cell (1998) 6.60
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell (2002) 6.36
Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell (2002) 6.06
A cell's sense of direction. Science (1999) 6.00
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol (2002) 5.58
Receptor-mediated activation of heterotrimeric G-proteins in living cells. Science (2001) 4.04
Eukaryotic chemotaxis: distinctions between directional sensing and polarization. J Biol Chem (2003) 3.95
Changing directions in the study of chemotaxis. Nat Rev Mol Cell Biol (2008) 3.61
Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions. Nat Cell Biol (2007) 3.52
Cell motility and chemotaxis in Dictyostelium amebae lacking myosin heavy chain. Dev Biol (1988) 3.48
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J Cell Biol (2004) 3.44
Migration of zebrafish primordial germ cells: a role for myosin contraction and cytoplasmic flow. Dev Cell (2006) 3.39
An actin-based wave generator organizes cell motility. PLoS Biol (2007) 3.36
Orientation of chemotactic cells and growth cones: models and mechanisms. J Cell Sci (1999) 3.31
PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. Nat Cell Biol (2006) 3.12
PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr Biol (2008) 3.06
Actin dynamics at the leading edge: from simple machinery to complex networks. Dev Cell (2009) 3.06
Single-molecule analysis of chemotactic signaling in Dictyostelium cells. Science (2001) 2.89
Localization of the G protein betagamma complex in living cells during chemotaxis. Science (2000) 2.87
Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation. J Cell Biol (1997) 2.78
TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol Biol Cell (2005) 2.76
Chemotaxis in the absence of PIP3 gradients. Curr Biol (2007) 2.73
Dictyostelium myosin heavy chain phosphorylation sites regulate myosin filament assembly and localization in vivo. Cell (1993) 2.61
Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. J Biol Chem (2004) 2.60
Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development. Cell (1992) 2.60
Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. Mol Biol Cell (2003) 2.56
PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Dev Cell (2007) 2.53
Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci U S A (2004) 2.52
Leading the way: Directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. J Cell Sci (2003) 2.49
EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells. J Cell Biol (2007) 2.48
The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium. J Cell Biol (1995) 2.40
Temporal and spatial regulation of chemotaxis. Dev Cell (2002) 2.35
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A (2008) 2.34
Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration. PLoS One (2008) 2.21
Signaling at zero G: G-protein-independent functions for 7-TM receptors. Trends Biochem Sci (2001) 2.20
Navigating through models of chemotaxis. Curr Opin Cell Biol (2008) 2.19
Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis. Mol Biol Cell (2003) 2.19
Regulation of actin polymerization in cell-free systems by GTPgammaS and Cdc42. J Cell Biol (1997) 2.14
Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol Cell (2001) 2.07
Understanding PTEN regulation: PIP2, polarity and protein stability. Oncogene (2008) 2.07
Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis. Dev Cell (2005) 2.06
A diffusion-translocation model for gradient sensing by chemotactic cells. Biophys J (2001) 2.04
Cell motility and cytoskeletal regulation in invasion and metastasis. J Mammary Gland Biol Neoplasia (2007) 2.03
The ordered extension of pseudopodia by amoeboid cells in the absence of external cues. PLoS One (2009) 2.03
Dictyostelium development in the absence of cAMP. Science (1997) 2.01
Adenylyl cyclase localization regulates streaming during chemotaxis. Cell (2003) 2.00
Directional sensing in eukaryotic chemotaxis: a balanced inactivation model. Proc Natl Acad Sci U S A (2006) 1.98
Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. Proc Natl Acad Sci U S A (2006) 1.96
Periodic signaling controlled by an oscillatory circuit that includes protein kinases ERK2 and PKA. Science (2004) 1.90
PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis. J Cell Biol (1999) 1.89
Moving towards a better understanding of chemotaxis. Curr Biol (2008) 1.88
Activation of Galphai3 triggers cell migration via regulation of GIV. J Cell Biol (2008) 1.88
A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium. EMBO J (2002) 1.87
The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium. Curr Biol (1996) 1.86
Directional sensing during chemotaxis. FEBS Lett (2008) 1.84
A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium. Genes Dev (1997) 1.82
Visualization of G protein betagamma dimers using bimolecular fluorescence complementation demonstrates roles for both beta and gamma in subcellular targeting. J Biol Chem (2004) 1.81
Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis. J Cell Biol (2007) 1.80
Quantitative imaging of single live cells reveals spatiotemporal dynamics of multistep signaling events of chemoattractant gradient sensing in Dictyostelium. Mol Biol Cell (2004) 1.76
Local and spatially coordinated movements in Dictyostelium discoideum amoebae during chemotaxis. Cell (1982) 1.75
Molecular genetic analysis of two G alpha protein subunits in Dictyostelium. J Biol Chem (1991) 1.72
In silico reconstitution of actin-based symmetry breaking and motility. PLoS Biol (2009) 1.66
Chemoattractant-induced Ras activation during Dictyostelium aggregation. EMBO Rep (2004) 1.63
Spatiotemporal regulation of Ras activity provides directional sensing. Curr Biol (2008) 1.60
Rac regulation of chemotaxis and morphogenesis in Dictyostelium. EMBO J (2004) 1.56
Recruitment of a myosin heavy chain kinase to actin-rich protrusions in Dictyostelium. Curr Biol (2001) 1.54
The Roco protein family: a functional perspective. FASEB J (2008) 1.52
In vivo analysis of 3-phosphoinositide dynamics during Dictyostelium phagocytosis and chemotaxis. J Cell Sci (2004) 1.51
Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells. Proc Natl Acad Sci U S A (2000) 1.46
Rap1 controls cell adhesion and cell motility through the regulation of myosin II. J Cell Biol (2007) 1.45
Actin polymerization and pseudopod extension during amoeboid chemotaxis. Cell Motil Cytoskeleton (1988) 1.45
Eukaryotic chemotaxis at a glance. J Cell Sci (2008) 1.44
Navigating signaling networks: chemotaxis in Dictyostelium discoideum. Curr Opin Genet Dev (2006) 1.43
The regulation of myosin II in Dictyostelium. Eur J Cell Biol (2006) 1.41
Signaling through chemoattractant receptors in Dictyostelium. Trends Genet (1996) 1.40
Delineation of the roles played by RasG and RasC in cAMP-dependent signal transduction during the early development of Dictyostelium discoideum. Mol Biol Cell (2006) 1.36
Mechanisms of gradient sensing and chemotaxis: conserved pathways, diverse regulation. Cell Cycle (2006) 1.36
The PI3K-mediated activation of CRAC independently regulates adenylyl cyclase activation and chemotaxis. Curr Biol (2005) 1.31
Two cAMP receptors activate common signaling pathways in Dictyostelium. Mol Biol Cell (1994) 1.31
Ligand-induced phosphorylation of the cAMP receptor from Dictyostelium discoideum. J Biol Chem (1988) 1.27
Phosphorylation of chemoattractant receptors is not essential for chemotaxis or termination of G-protein-mediated responses. J Biol Chem (1997) 1.27
cGMP as second messenger during Dictyostelium chemotaxis. FEBS Lett (1997) 1.25
Reaction-diffusion waves of actin filament polymerization/depolymerization in Dictyostelium pseudopodium extension and cell locomotion. Biophys Chem (2000) 1.22
PTEN plays a role in the suppression of lateral pseudopod formation during Dictyostelium motility and chemotaxis. J Cell Sci (2007) 1.21
Differential localization in cells of myosin II heavy chain kinases during cytokinesis and polarized migration. BMC Cell Biol (2002) 1.21
Dictyostelium LIS1 is a centrosomal protein required for microtubule/cell cortex interactions, nucleus/centrosome linkage, and actin dynamics. Mol Biol Cell (2005) 1.20
Signaling pathways controlling primordial germ cell migration in zebrafish. J Cell Sci (2004) 1.18
Roles played by Ras subfamily proteins in the cell and developmental biology of microorganisms. Cell Signal (2003) 1.17
Ggamma in dictyostelium: its role in localization of gbetagamma to the membrane is required for chemotaxis in shallow gradients. Mol Biol Cell (2001) 1.16
RasGEF-containing proteins GbpC and GbpD have differential effects on cell polarity and chemotaxis in Dictyostelium. J Cell Sci (2005) 1.16
Chemotaxis: navigating by multiple signaling pathways. Sci STKE (2007) 1.15
Characterization of the GbpD-activated Rap1 pathway regulating adhesion and cell polarity in Dictyostelium discoideum. J Biol Chem (2006) 1.14
Guanine nucleotides modulate cell surface cAMP-binding sites in membranes from Dictyostelium discoideum. Biochem Biophys Res Commun (1984) 1.14
Phospholipase C regulation of phosphatidylinositol 3,4,5-trisphosphate-mediated chemotaxis. Mol Biol Cell (2007) 1.12
Intramolecular activation mechanism of the Dictyostelium LRRK2 homolog Roco protein GbpC. J Biol Chem (2008) 1.11
The surface cyclic AMP receptors, cAR1, cAR2, and cAR3, promote Ca2+ influx in Dictyostelium discoideum by a G alpha 2-independent mechanism. Mol Biol Cell (1993) 1.10
Mechanically induced actin-mediated rocketing of phagosomes. Mol Biol Cell (2006) 1.10
Dictyostelium PAKc is required for proper chemotaxis. Mol Biol Cell (2004) 1.09
Chemotaxis: signalling the way forward. Nat Rev Mol Cell Biol (2004) 4.96
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature (2006) 4.09
PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr Biol (2008) 3.06
A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. Proc Natl Acad Sci U S A (2009) 2.85
Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. J Biol Chem (2004) 2.60
Cells navigate with a local-excitation, global-inhibition-biased excitable network. Proc Natl Acad Sci U S A (2010) 2.54
PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Dev Cell (2007) 2.53
Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci U S A (2004) 2.52
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A (2008) 2.34
G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J Cell Biol (2007) 2.34
Navigating through models of chemotaxis. Curr Opin Cell Biol (2008) 2.19
Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis. Mol Biol Cell (2003) 2.19
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. Proc Natl Acad Sci U S A (2006) 1.96
Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells. Biophys J (2004) 1.91
Visualization of G protein betagamma dimers using bimolecular fluorescence complementation demonstrates roles for both beta and gamma in subcellular targeting. J Biol Chem (2004) 1.81
Chemoattractant signaling in dictyostelium discoideum. Annu Rev Cell Dev Biol (2004) 1.77
Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase. Mol Biol Cell (2006) 1.67
Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis. J Cell Biol (2010) 1.64
Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer. Science (2014) 1.64
Structural comparisons of class I phosphoinositide 3-kinases. Nat Rev Cancer (2008) 1.42
An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration. Nat Cell Biol (2013) 1.34
Biased excitable networks: how cells direct motion in response to gradients. Curr Opin Cell Biol (2011) 1.24
Visualizing PI3 kinase-mediated cell-cell signaling during Dictyostelium development. Curr Biol (2002) 1.21
Leading-edge research: PtdIns(3,4,5)P3 and directed migration. Nat Cell Biol (2007) 1.20
Signaling pathways mediating chemotaxis in the social amoeba, Dictyostelium discoideum. Eur J Cell Biol (2006) 1.20
Moving in the right direction: how eukaryotic cells migrate along chemical gradients. Semin Cell Dev Biol (2011) 1.15
Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes. Cell Mol Life Sci (2014) 1.15
Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis. J Biol Chem (2010) 1.14
Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells. PLoS Comput Biol (2013) 1.10
Automated characterization of cell shape changes during amoeboid motility by skeletonization. BMC Syst Biol (2010) 1.08
tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis. Genes Dev (2008) 1.03
Genetic analysis of the role of G protein-coupled receptor signaling in electrotaxis. J Cell Biol (2002) 1.02
Single-molecule analysis of chemoattractant-stimulated membrane recruitment of a PH-domain-containing protein. J Cell Sci (2006) 0.99
Analysis of chemotaxis in Dictyostelium. Methods Mol Biol (2012) 0.96
Moving forward: mechanisms of chemoattractant gradient sensing. Physiology (Bethesda) (2004) 0.95
Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion. Proc Natl Acad Sci U S A (2012) 0.93
Assessment of development and chemotaxis in Dictyostelium discoideum mutants. Methods Mol Biol (2011) 0.92
Extracellular cAMP inhibits proximal reabsorption: are plasma membrane cAMP receptors involved? Am J Physiol Renal Physiol (2002) 0.90
Different roles of membrane potentials in electrotaxis and chemotaxis of dictyostelium cells. Eukaryot Cell (2011) 0.88
Structural effects of oncogenic PI3Kα mutations. Curr Top Microbiol Immunol (2010) 0.87
Multiple host kinases contribute to Akt activation during Salmonella infection. PLoS One (2013) 0.79
Hippo on the move: tumor suppressor regulates adhesion and migration. Cell Cycle (2013) 0.78
Analyzing chemotaxis using Dictyostelium discoideum as a model system. Methods Mol Biol (2004) 0.78
Regulation of adenylyl cyclases by a region outside the minimally functional cytoplasmic domains. J Biol Chem (2001) 0.78
3D arrays for high throughput assay of cell migration and electrotaxis. Cell Biol Int (2013) 0.77
Ege A, a novel C2 domain containing protein, is essential for GPCR-mediated gene expression in dictyostelium. Dev Biol (2002) 0.76
QnAs with Peter N. Devreotes. Interview by Prashant Nair. Proc Natl Acad Sci U S A (2010) 0.75