Published in Angew Chem Int Ed Engl on January 01, 2008
Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proc Natl Acad Sci U S A (2009) 1.91
Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics. Angew Chem Int Ed Engl (2010) 1.22
S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases. Chembiochem (2008) 0.85
Independent Evolution of Six Families of Halogenating Enzymes. PLoS One (2016) 0.76
Insights into enzymatic halogenation from computational studies. Front Chem (2014) 0.75
Salvadenosine, a 5'-deoxy-5'-(methylthio) nucleoside from the Bahamian tunicate Didemnum sp. J Org Chem (2014) 0.75
Methane emissions from terrestrial plants under aerobic conditions. Nature (2006) 4.49
The interaction of Alba, a conserved archaeal chromatin protein, with Sir2 and its regulation by acetylation. Science (2002) 2.69
Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding. Nucleic Acids Res (2005) 2.51
Methoxyl groups of plant pectin as a precursor of atmospheric methane: evidence from deuterium labelling studies. New Phytol (2008) 1.84
Creatine kinase is physically associated with the cardiac ATP-sensitive K+ channel in vivo. FASEB J (2001) 1.72
Crystal structure and mechanism of a bacterial fluorinating enzyme. Nature (2004) 1.70
The Scottish Structural Proteomics Facility: targets, methods and outputs. J Struct Funct Genomics (2010) 1.66
The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain. Nat Struct Mol Biol (2012) 1.53
Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease. J Neurochem (2013) 1.51
Biochemistry: biosynthesis of an organofluorine molecule. Nature (2002) 1.41
Engineering fluorometabolite production: fluorinase expression in Salinispora tropica Yields Fluorosalinosporamide. J Nat Prod (2010) 1.39
Analysis of CF···FC interactions on cyclohexane and naphthalene frameworks. J Phys Chem A (2014) 1.39
The 3D structure of a periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli. Proc Natl Acad Sci U S A (2007) 1.36
The observation of a large gauche preference when 2-fluoroethylamine and 2-fluoroethanol become protonated. Org Biomol Chem (2004) 1.30
Chloromethane, a Novel Methyl Donor for Biosynthesis of Esters and Anisoles in Phellinus pomaceus. Appl Environ Microbiol (1989) 1.27
The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A. Chem Biol (2006) 1.27
CDK/ERK-mediated phosphorylation of the human influenza A virus NS1 protein at threonine-215. Virology (2008) 1.26
Evidence of a new role for the high-osmolarity glycerol mitogen-activated protein kinase pathway in yeast: regulating adaptation to citric acid stress. Mol Cell Biol (2004) 1.22
AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis. Nat Chem Biol (2009) 1.21
A comparison of the accuracy of iTRAQ quantification by nLC-ESI MSMS and nLC-MALDI MSMS methods. J Proteomics (2010) 1.20
The cyanobactin heterocyclase enzyme: a processive adenylase that operates with a defined order of reaction. Angew Chem Int Ed Engl (2013) 1.20
PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells. PLoS One (2012) 1.14
The fluorinase from Streptomyces cattleya is also a chlorinase. Angew Chem Int Ed Engl (2006) 1.13
Catalytic asymmetric fluorination comes of age. Angew Chem Int Ed Engl (2008) 1.13
Crystal structure of the NanB sialidase from Streptococcus pneumoniae. J Mol Biol (2008) 1.12
Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway. EMBO J (2014) 1.11
In vitro reconstituted biotransformation of 4-fluorothreonine from fluoride ion: application of the fluorinase. Chem Biol (2008) 1.09
Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase. Nat Commun (2010) 1.08
Isolation and characterisation of 5'-fluorodeoxyadenosine synthase, a fluorination enzyme from Streptomyces cattleya. FEBS Lett (2003) 1.06
Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya. Nat Prod Rep (2004) 1.04
CC1, a novel crenarchaeal DNA binding protein. J Bacteriol (2006) 1.03
The fluorine gauche effect. Langmuir isotherms report the relative conformational stability of (+/-)-erythro- and (+/-)-threo-9,10-difluorostearic acids. Chem Commun (Camb) (2002) 1.03
Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity. J Med Chem (2009) 1.02
Enzymatic fluorination in Streptomyces cattleya takes place with an inversion of configuration consistent with an SN2 reaction mechanism. Chembiochem (2004) 1.00
Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticles in vitro and in vivo. Nanomedicine (Lond) (2012) 1.00
Stepwise adaptations of citrate synthase to survival at life's extremes. From psychrophile to hyperthermophile. Eur J Biochem (2002) 0.99
The fluorinase, the chlorinase and the duf-62 enzymes. Curr Opin Chem Biol (2008) 0.99
Mechanism of enzymatic fluorination in Streptomyces cattleya. J Am Chem Soc (2007) 0.98
Alicyclic ring structure: conformational influence of the CF2 group in cyclododecanes. Angew Chem Int Ed Engl (2011) 0.98
Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site. Chem Biol (2006) 0.98
Egr1 signaling in prostate cancer. Cancer Biol Ther (2003) 0.98
Synthesis and structure of stereoisomeric multivicinal hexafluoroalkanes. Angew Chem Int Ed Engl (2009) 0.97
Synthesis and structure of all-syn-1,2,3,4-tetrafluorocyclohexane. Chem Commun (Camb) (2011) 0.97
Enantioselective synthesis of an all-syn four vicinal fluorine motif. J Am Chem Soc (2006) 0.96
An acetylase with relaxed specificity catalyses protein N-terminal acetylation in Sulfolobus solfataricus. Mol Microbiol (2007) 0.95
alpha,beta,gamma-Trifluoroalkanes: a stereoselective synthesis placing three vicinal fluorines along a hydrocarbon chain. J Am Chem Soc (2005) 0.95
The identification of 5'-fluoro-5-deoxyinosine as a shunt product in cell free extracts of Streptomyces cattleya. Bioorg Chem (2005) 0.95
Insights into the biosynthesis of the Vibrio cholerae major autoinducer CAI-1 from the crystal structure of the PLP-dependent enzyme CqsA. J Mol Biol (2009) 0.94
Prins fluorination cyclisations: Preparation of 4-fluoro-pyran and -piperidine heterocycles. Beilstein J Org Chem (2010) 0.93
Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the gamma-amino-alpha-hydroxybutyryl (haba) group. Biochimie (2006) 0.93
Insight into enzymatic C-F bond formation from QM and QM/MM calculations. J Am Chem Soc (2005) 0.93
Accelerating influence of the gem-difluoromethylene group in a ring-closing olefin metathesis reaction. A Thorpe-Ingold effect? Chem Commun (Camb) (2013) 0.92
Proteomic and functional characterization of the outer membrane vesicles from the gastric pathogen Helicobacter pylori. Proteomics Clin Appl (2009) 0.91
Synthesis and elaboration of all-cis-1,2,4,5-tetrafluoro-3-phenylcyclohexane: a polar cyclohexane motif. Chemistry (2014) 0.91
Fluorinase mediated C-(18)F bond formation, an enzymatic tool for PET labelling. Chem Commun (Camb) (2006) 0.90
Displacement of the canonical single-stranded DNA-binding protein in the Thermoproteales. Proc Natl Acad Sci U S A (2011) 0.90
Conformation-specific crosslinking of mitochondrial complex I. FEBS Lett (2013) 0.90
An enzymatic route to selenazolines. Chembiochem (2013) 0.90
Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus. BMC Syst Biol (2011) 0.89
Structural basis for a class of nanomolar influenza A neuraminidase inhibitors. Sci Rep (2013) 0.88
Fluorocyclohexanes: synthesis and structure of all-syn-1,2,4,5-tetrafluorocyclohexane. Chem Commun (Camb) (2012) 0.88
IDENTIFICATION OF CONOIDIN A AS A COVALENT INHIBITOR OF PEROXIREDOXIN II. Org Biomol Chem (2009) 0.87
Stereoelectronic interactions and the one-bond C-F coupling constant in sevoflurane. J Phys Chem A (2012) 0.86
Multi-vicinal fluoroalkanes: a new class of organofluorine compounds. Org Biomol Chem (2008) 0.86
Bacterial dioxygenase- and monooxygenase-catalysed sulfoxidation of benzo[b]thiophenes. Org Biomol Chem (2011) 0.86
Diastereoselective synthesis of 2,3,4,5,6-pentafluoroheptanes. J Org Chem (2009) 0.85
Synthesis and conformation of multi-vicinal fluoroalkane diastereoisomers. Angew Chem Int Ed Engl (2007) 0.85
Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA. Org Biomol Chem (2011) 0.85
Fluorine containing amino acids: synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif. Org Biomol Chem (2015) 0.85
Liquid crystals carrying stereodefined vicinal difluoro- and trifluoro- alkyl motifs. Chem Commun (Camb) (2007) 0.85
Fluorinase-coupled base swaps: synthesis of [18F]-5'-deoxy-5'-fluorouridines. Angew Chem Int Ed Engl (2008) 0.85
Stable hydrogen isotope ratios of lignin methoxyl groups as a paleoclimate proxy and constraint of the geographical origin of wood. New Phytol (2007) 0.84
Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya. Chemosphere (2003) 0.84
Cloning, characterization and regulation of a family of phi class glutathione transferases from wheat. Plant Mol Biol (2003) 0.84
An electrostatic gauche effect in beta-fluoro- and beta-hydroxy-N-ethylpyridinium cations. Angew Chem Int Ed Engl (2007) 0.84
Identification of a PLP-Dependent Threonine Transaldolase: A Novel Enzyme Involved in 4-Fluorothreonine Biosynthesis in Streptomyces cattleya This work was supported by the Biotechnological and Biological Sciences Research Council and the University of St Andrews. Angew Chem Int Ed Engl (2001) 0.84
Stepwise preparation of all-cis 1,3,4-trifluoro-2-phenylcyclohexane, avoiding a phenonium intermediate. J Org Chem (2014) 0.84
Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: implications for angiogenic regulation. Blood (2014) 0.83
The rare fluorinated natural products and biotechnological prospects for fluorine enzymology. Methods Enzymol (2012) 0.83
Cell-free biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya. Angew Chem Int Ed Engl (2002) 0.83
Unusual chromophore and cross-links in ranasmurfin: a blue protein from the foam nests of a tropical frog. Angew Chem Int Ed Engl (2008) 0.83
Synthesis of phosphonate and phostone analogues of ribose-1-phosphates. Beilstein J Org Chem (2009) 0.83
Optimisation of conoidin A, a peroxiredoxin inhibitor. ChemMedChem (2010) 0.82
Identification of 5-fluoro-5-deoxy-D-ribose-1-phosphate as an intermediate in fluorometabolite biosynthesis in Streptomyces cattleya. Chem Commun (Camb) (2004) 0.82
Rapid enrichment and analysis of yeast phosphoproteins using affinity chromatography, 2D-PAGE and peptide mass fingerprinting. Yeast (2005) 0.82
Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates. Org Biomol Chem (2006) 0.81
The identification of (3R,4S)-5-fluoro-5-deoxy-D-ribulose-1-phosphate as an intermediate in fluorometabolite biosynthesis in Streptomyces cattleya. Bioorg Chem (2007) 0.81
Purification, crystallization and data collection of methicillin-resistant Staphylococcus aureus Sar2676, a pantothenate synthetase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.81
Expression, purification, crystallization, data collection and preliminary biochemical characterization of methicillin-resistant Staphylococcus aureus Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.81
Fluorosugars: synthesis of the 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of D-glucose and D-altrose and assessment of their erythrocyte transmembrane transport. Chem Commun (Camb) (2010) 0.81
Synthesis and vanilloid receptor (TRPV1) activity of the enantiomers of alpha-fluorinated capsaicin. Chembiochem (2009) 0.81
A functional approach to uncover the low-temperature adaptation strategies of the archaeon Methanosarcina barkeri. Appl Environ Microbiol (2013) 0.81
Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility. Org Biomol Chem (2012) 0.80
Crystallization and X-ray diffraction of 5'-fluoro-5'-deoxyadenosine synthase, a fluorination enzyme from Streptomyces cattleya. Acta Crystallogr D Biol Crystallogr (2003) 0.80
Insights into fluorometabolite biosynthesis in Streptomyces cattleya DSM46488 through genome sequence and knockout mutants. Bioorg Chem (2012) 0.80
The mechanisms of radical SAM/cobalamin methylations: an evolving working hypothesis. Chembiochem (2013) 0.80