Published in Proc Natl Acad Sci U S A on July 09, 2009
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Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens. Proc Natl Acad Sci U S A (2011) 2.05
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Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation. Chem Biol (2011) 1.59
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Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics. Angew Chem Int Ed Engl (2010) 1.22
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Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropica. Chembiochem (2013) 1.15
The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery. Nat Prod Rep (2015) 1.11
Carboxylases in natural and synthetic microbial pathways. Appl Environ Microbiol (2011) 1.10
Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica. J Med Chem (2009) 1.10
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The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution. Chembiochem (2011) 1.07
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Structure and biosynthesis of the marine streptomycete ansamycin ansalactam A and its distinctive branched chain polyketide extender unit. J Am Chem Soc (2011) 1.01
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Complexity generation during natural product biosynthesis using redox enzymes. Curr Opin Chem Biol (2012) 0.96
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Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A. ACS Chem Biol (2011) 0.90
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Designed biosynthesis of 36-methyl-FK506 by polyketide precursor pathway engineering. ACS Synth Biol (2012) 0.83
A tandem chemoenzymatic methylation by S-adenosyl-L-methionine. Chembiochem (2013) 0.82
Flavin-linked oxidase catalyzes pyrrolizine formation of dichloropyrrole-containing polyketide extender unit in chlorizidine A. J Am Chem Soc (2013) 0.82
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Identification of Middle Chain Fatty Acyl-CoA Ligase Responsible for the Biosynthesis of 2-Alkylmalonyl-CoAs for Polyketide Extender Unit. J Biol Chem (2015) 0.80
Characterization of 5-chloro-5-deoxy-D-ribose 1-dehydrogenase in chloroethylmalonyl coenzyme A biosynthesis: substrate and reaction profiling. J Biol Chem (2010) 0.80
Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess. J Ind Microbiol Biotechnol (2011) 0.79
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Using Molecular Networking for Microbial Secondary Metabolite Bioprospecting. Metabolites (2016) 0.78
Identification and characterization of the biosynthetic gene cluster of polyoxypeptin A, a potent apoptosis inducer. BMC Microbiol (2014) 0.76
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Crystallization and preliminary X-ray diffraction analysis of AntE, a crotonyl-CoA carboxylase/reductase from Streptomyces sp. NRRL 2288. Acta Crystallogr F Struct Biol Commun (2014) 0.75
Biosynthesis of akaeolide and lorneic acids and annotation of type I polyketide synthase gene clusters in the genome of Streptomyces sp. NPS554. Mar Drugs (2015) 0.75
Coupled Biosynthesis of Volatiles and Salinosporamide A in Salinispora tropica. Chembiochem (2016) 0.75
A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nat Commun (2016) 0.75
β-Lactone formation during product release from a nonribosomal peptide synthetase. Nat Chem Biol (2017) 0.75
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The chalcone synthase superfamily of type III polyketide synthases. Nat Prod Rep (2003) 3.71
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Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms. Curr Opin Chem Biol (2003) 2.36
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Halogenation strategies in natural product biosynthesis. Chem Biol (2008) 2.08
Biosynthesis and attachment of novel bacterial polyketide synthase starter units. Nat Prod Rep (2002) 2.05
Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding. J Am Chem Soc (2006) 1.96
Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nat Chem Biol (2007) 1.85
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Structural analyses reveal two distinct families of nucleoside phosphorylases. Biochem J (2002) 1.69
Biosynthesis of polyketide synthase extender units. Nat Prod Rep (2009) 1.66
The structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa. J Biol Chem (2004) 1.58
Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units. Proc Natl Acad Sci U S A (2006) 1.56
Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations. Biochemistry (2001) 1.55
The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2007) 1.49
Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica. Org Lett (2007) 1.44
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Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome. Angew Chem Int Ed Engl (2008) 1.39
Crystal structures of the key anaerobic enzyme pyruvate:ferredoxin oxidoreductase, free and in complex with pyruvate. Nat Struct Biol (1999) 1.30
The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A. Chem Biol (2006) 1.27
Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26. Gene (2002) 1.22
Identification, characterization, and inhibition of Plasmodium falciparum beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ). J Biol Chem (2003) 1.14
Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ). J Biol Chem (2007) 1.11
Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome. J Nat Prod (2007) 1.11
The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase. J Biol Chem (2002) 1.11
Structure-function relationships in the 2-oxo acid dehydrogenase family: substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins. Proteins (2008) 1.09
In vitro reconstituted biotransformation of 4-fluorothreonine from fluoride ion: application of the fluorinase. Chem Biol (2008) 1.09
Multiple pathways for acetate assimilation in Streptomyces cinnamonensis. J Ind Microbiol Biotechnol (2005) 1.07
Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya. Nat Prod Rep (2004) 1.04
Structure and function of Rv0130, a conserved hypothetical protein from Mycobacterium tuberculosis. Protein Sci (2006) 1.00
From genetic diversity to metabolic unity: studies on the biosynthesis of aurafurones and aurafuron-like structures in myxobacteria and streptomycetes. J Mol Biol (2007) 0.95
S-adenosyl-L-methionine:hydroxide adenosyltransferase: a SAM enzyme. Angew Chem Int Ed Engl (2008) 0.89
Precursor supply for polyketide biosynthesis: the role of crotonyl-CoA reductase. Metab Eng (2001) 0.87
S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases. Chembiochem (2008) 0.85
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Prognostic or predictive plasma cytokines and angiogenic factors for patients treated with pazopanib for metastatic renal-cell cancer: a retrospective analysis of phase 2 and phase 3 trials. Lancet Oncol (2012) 4.58
Molecular evidence for a uniform microbial community in sponges from different oceans. Appl Environ Microbiol (2002) 4.24
Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc Natl Acad Sci U S A (2007) 4.04
Genomic basis for natural product biosynthetic diversity in the actinomycetes. Nat Prod Rep (2009) 3.74
Mass spectral molecular networking of living microbial colonies. Proc Natl Acad Sci U S A (2012) 3.56
High-speed graphene transistors with a self-aligned nanowire gate. Nature (2010) 3.48
Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL. Cancer Res (2009) 3.10
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Lessons from the past and charting the future of marine natural products drug discovery and chemical biology. Chem Biol (2012) 2.29
Algal genomes reveal evolutionary mosaicism and the fate of nucleomorphs. Nature (2012) 2.15
Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. Hepatology (2011) 2.13
MS/MS networking guided analysis of molecule and gene cluster families. Proc Natl Acad Sci U S A (2013) 2.12
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Low prevalence of knee and back pain in southeast China; the Shantou COPCORD study. J Rheumatol (2004) 2.06
A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nat Chem Biol (2011) 2.05
Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase. Nat Chem Biol (2006) 2.02
Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria. ISME J (2009) 1.94
Therapeutic misconception, misestimation, and optimism in participants enrolled in phase 1 trials. Cancer (2012) 1.94
Proarrhythmic risk of embryonic stem cell-derived cardiomyocyte transplantation in infarcted myocardium. Heart Rhythm (2010) 1.89
Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration. J Exp Med (2004) 1.85
Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nat Chem Biol (2007) 1.85
Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc Natl Acad Sci U S A (2014) 1.78
Enzymatic total synthesis of enterocin polyketides. Nat Chem Biol (2007) 1.78
Highly efficient gate-tunable photocurrent generation in vertical heterostructures of layered materials. Nat Nanotechnol (2013) 1.72
Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster. J Biol Chem (2007) 1.71
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Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation. Chem Biol (2011) 1.59
Genome-wide signatures of convergent evolution in echolocating mammals. Nature (2013) 1.59
Ten years' experience with needle biopsy in the early diagnosis of sacroiliitis. Arthritis Rheum (2012) 1.59
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Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils. Mol Biol Cell (2005) 1.57
Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora. Proc Natl Acad Sci U S A (2014) 1.56
BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc Natl Acad Sci U S A (2013) 1.55
Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates. J Biol Chem (2004) 1.54
Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin. J Am Chem Soc (2008) 1.54
Effects of cellulose crystallinity, hemicellulose, and lignin on the enzymatic hydrolysis of Miscanthus sinensis to monosaccharides. Biosci Biotechnol Biochem (2008) 1.54
Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. J Biol Chem (2005) 1.52
Production of branched-chain alkylprodiginines in S. coelicolor by replacement of the 3-ketoacyl ACP synthase III initiation enzyme, RedP. Chem Biol (2005) 1.50
HMGB1 is a cofactor in mammalian base excision repair. Mol Cell (2007) 1.49
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Structural insights into functional and pathological amyloid. J Biol Chem (2011) 1.39
Engineering fluorometabolite production: fluorinase expression in Salinispora tropica Yields Fluorosalinosporamide. J Nat Prod (2010) 1.39
Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome. Angew Chem Int Ed Engl (2008) 1.39
Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation. Int J Cancer (2011) 1.39
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Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization. Biochemistry (2007) 1.19
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Targeted sequencing of 179 genes associated with hereditary retinal dystrophies and 10 candidate genes identifies novel and known mutations in patients with various retinal diseases. Invest Ophthalmol Vis Sci (2013) 1.19
Merochlorins A-D, cyclic meroterpenoid antibiotics biosynthesized in divergent pathways with vanadium-dependent chloroperoxidases. J Am Chem Soc (2012) 1.18
Survival After Sublobar Resection versus Lobectomy for Clinical Stage IA Lung Cancer: An Analysis from the National Cancer Data Base. J Thorac Oncol (2015) 1.18
Advances in and applications of proteasome inhibitors. Curr Opin Chem Biol (2008) 1.17
Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains. ACS Chem Biol (2009) 1.17
Mutasynthesis of enterocin and wailupemycin analogues. J Am Chem Soc (2003) 1.16
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