Glioma stem cells: a midterm exam.

Malignant glioma: lessons from genomics, mouse models, and stem cells. Cell (2012) 2.85

Metabotropic glutamate receptors: from the workbench to the bedside. Neuropharmacology (2010) 2.31

Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell (2009) 2.14

The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain. Dev Cell (2009) 2.04

Non-stem cell origin for oligodendroglioma. Cancer Cell (2010) 1.95

The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. Cancer Cell (2011) 1.92

Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype. PLoS One (2011) 1.77

Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes. EMBO J (2009) 1.66

A neurocentric perspective on glioma invasion. Nat Rev Neurosci (2014) 1.61

The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation. Genes Dev (2010) 1.45

Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner. Genes Dev (2010) 1.43

Genetic mechanisms regulating stem cell self-renewal and differentiation in the central nervous system of Drosophila. Cell Adh Migr (2009) 1.42

Metzincin proteases and their inhibitors: foes or friends in nervous system physiology? J Neurosci (2010) 1.41

Identification of diverse astrocyte populations and their malignant analogs. Nat Neurosci (2017) 1.39

Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases. Oncogene (2011) 1.38

ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. Cell Rep (2014) 1.34

Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. Genes Cancer (2010) 1.33

Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A. Genes Dev (2013) 1.31

The perivascular niche microenvironment in brain tumor progression. Cell Cycle (2010) 1.30

CXCR4 mediates the proliferation of glioblastoma progenitor cells. Cancer Lett (2008) 1.27

Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone. J Neurooncol (2009) 1.26

Brain cancer propagating cells: biology, genetics and targeted therapies. Trends Mol Med (2009) 1.23

Therapeutic potential of AZD1480 for the treatment of human glioblastoma. Mol Cancer Ther (2011) 1.22

Glioblastoma Multiforme Oncogenomics and Signaling Pathways. Clin Med Oncol (2009) 1.21

Glioblastoma multiforme: State of the art and future therapeutics. Surg Neurol Int (2014) 1.18

Toward brain tumor gene therapy using multipotent mesenchymal stromal cell vectors. Mol Ther (2010) 1.18

Candidate pathways for promoting differentiation or quiescence of oligodendrocyte progenitor-like cells in glioma. Cancer Res (2012) 1.15

Dual blocking of mTor and PI3K elicits a prodifferentiation effect on glioblastoma stem-like cells. Neuro Oncol (2010) 1.15

Oncogenic extracellular vesicles in brain tumor progression. Front Physiol (2012) 1.15

Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development (2012) 1.13

A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas. J Exp Med (2011) 1.13

Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4 protein. J Biol Chem (2011) 1.10

Krüppel-like family of transcription factor 9, a differentiation-associated transcription factor, suppresses Notch1 signaling and inhibits glioblastoma-initiating stem cells. Stem Cells (2011) 1.09

GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma. Mol Cancer Res (2009) 1.09

Epigenetic regulation by chromatin activation mark H3K4me3 in primate progenitor cells within adult neurogenic niche. Sci Rep (2014) 1.07

Cancer-Specific requirement for BUB1B/BUBR1 in human brain tumor isolates and genetically transformed cells. Cancer Discov (2012) 1.07

Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes. Nat Neurosci (2014) 1.07

Brain Tumor Stem-Like Cells Identified by Neural Stem Cell Marker CD15. Transl Oncol (2009) 1.06

Activation of postnatal neural stem cells requires nuclear receptor TLX. J Neurosci (2011) 1.04

The cellular origin for malignant glioma and prospects for clinical advancements. Expert Rev Mol Diagn (2012) 1.02

Glioblastoma-initiating cells: relationship with neural stem cells and the micro-environment. Cancers (Basel) (2013) 1.01

Loss of heterozygosity of TRIM3 in malignant gliomas. BMC Cancer (2009) 1.01

A syngeneic glioma model to assess the impact of neural progenitor target cell age on tumor malignancy. Aging Cell (2009) 1.01

REST regulates oncogenic properties of glioblastoma stem cells. Stem Cells (2012) 1.00

Cancer Stem Cells: A Minor Cancer Subpopulation that Redefines Global Cancer Features. Front Oncol (2013) 0.99

Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis. J Clin Invest (2012) 0.98

Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells. Proc Natl Acad Sci U S A (2012) 0.98

Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry. Cell Death Dis (2012) 0.97

Applications of neural and mesenchymal stem cells in the treatment of gliomas. Expert Rev Anticancer Ther (2009) 0.97

Targeting JNK for therapeutic depletion of stem-like glioblastoma cells. Sci Rep (2012) 0.96

Immune therapeutic targeting of glioma cancer stem cells. Target Oncol (2010) 0.95

Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression. Differentiation (2011) 0.94

Isolation of glioma cancer stem cells in relation to histological grades in glioma specimens. Childs Nerv Syst (2012) 0.94

Direct isolation and RNA-seq reveal environment-dependent properties of engrafted neural stem/progenitor cells. Nat Commun (2012) 0.94

The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche. Mol Cell Biol (2012) 0.93

Porous chitosan-hyaluronic acid scaffolds as a mimic of glioblastoma microenvironment ECM. Biomaterials (2013) 0.93

The miR-223/nuclear factor I-A axis regulates glial precursor proliferation and tumorigenesis in the CNS. J Neurosci (2013) 0.91

L1 stimulation of human glioma cell motility correlates with FAK activation. J Neurooncol (2011) 0.91

MiR-330-mediated regulation of SH3GL2 expression enhances malignant behaviors of glioblastoma stem cells by activating ERK and PI3K/AKT signaling pathways. PLoS One (2014) 0.90

Nrf2 is required to maintain the self-renewal of glioma stem cells. BMC Cancer (2013) 0.90

Type-3 metabotropic glutamate receptors regulate chemoresistance in glioma stem cells, and their levels are inversely related to survival in patients with malignant gliomas. Cell Death Differ (2012) 0.90

Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells. Mol Cancer (2011) 0.90

Polysialic acid neural cell adhesion molecule (PSA-NCAM) is an adverse prognosis factor in glioblastoma, and regulates olig2 expression in glioma cell lines. BMC Cancer (2010) 0.89

Breast cancer biology: the multifaceted roles of mesenchymal stem cells. J Oncol (2008) 0.89

TRAIL conjugated to nanoparticles exhibits increased anti-tumor activities in glioma cells and glioma stem cells in vitro and in vivo. Neuro Oncol (2012) 0.88

Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth. J Clin Invest (2013) 0.88

Antigenic and Genotypic Similarity between Primary Glioblastomas and Their Derived Neurospheres. J Oncol (2011) 0.88

Association of stem cell marker CD133 expression with dissemination of glioblastomas. Neurosurg Rev (2010) 0.88

Transcription factors FOXG1 and Groucho/TLE promote glioblastoma growth. Nat Commun (2013) 0.88

The bright and the dark sides of DNA repair in stem cells. J Biomed Biotechnol (2010) 0.87

Rindopepimut: a promising immunotherapeutic for the treatment of glioblastoma multiforme. Immunotherapy (2014) 0.87

Molecular Characteristics in MRI-Classified Group 1 Glioblastoma Multiforme. Front Oncol (2013) 0.87

Extracellular vesicles and intercellular communication within the nervous system. J Clin Invest (2016) 0.87

Novel Perspectives on p53 Function in Neural Stem Cells and Brain Tumors. J Oncol (2010) 0.86

HMMR maintains the stemness and tumorigenicity of glioblastoma stem-like cells. Cancer Res (2014) 0.86

Induced interleukin-33 expression enhances the tumorigenic activity of rat glioma cells. Neuro Oncol (2013) 0.86

Temozolomide downregulates P-glycoprotein expression in glioblastoma stem cells by interfering with the Wnt3a/glycogen synthase-3 kinase/β-catenin pathway. Neuro Oncol (2013) 0.85

Analysis of neuronal proliferation, migration and differentiation in the postnatal brain using equine infectious anemia virus-based lentiviral vectors. Gene Ther (2009) 0.85

The good, the bad and the ugly: epigenetic mechanisms in glioblastoma. Mol Aspects Med (2012) 0.84

Cell of origin determines tumor phenotype in an oncogenic Ras/p53 knockout transgenic model of high-grade glioma. J Neuropathol Exp Neurol (2012) 0.82

The impact of age on oncogenic potential: tumor-initiating cells and the brain microenvironment. Aging Cell (2013) 0.82

PML: a tumor suppressor essential for neocortical development. Nat Neurosci (2009) 0.82

Salinomycin inhibits the tumor growth of glioma stem cells by selectively suppressing glioma-initiating cells. Mol Med Rep (2014) 0.81

The probable cell of origin of NF1- and PDGF-driven glioblastomas. PLoS One (2011) 0.81

miRNA-182 and the regulation of the glioblastoma phenotype - toward miRNA-based precision therapeutics. Cell Cycle (2015) 0.81

Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus. J Biol Chem (2012) 0.81

Downregulation of BRCA1-BRCA2-containing complex subunit 3 sensitizes glioma cells to temozolomide. Oncotarget (2014) 0.80

Translational potential of astrocytes in brain disorders. Prog Neurobiol (2015) 0.80

A microRNA Link to Glioblastoma Heterogeneity. Cancers (Basel) (2012) 0.80

In vivo RNAi screen identifies NLK as a negative regulator of mesenchymal activity in glioblastoma. Oncotarget (2015) 0.80

Aberrant mesenchymal differentiation of glioma stem-like cells: implications for therapeutic targeting. Oncotarget (2015) 0.80

Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance. J Neurooncol (2014) 0.79

Decreasing glioma recurrence through adjuvant cancer stem cell inhibition. Biologics (2010) 0.79

Targeting NF-κB in glioblastoma: A therapeutic approach. Sci Adv (2016) 0.79

Brain cancer: Tumour cells on neighbourhood watch. Nature (2015) 0.78

The potential origin of glioblastoma initiating cells. Front Biosci (Schol Ed) (2012) 0.78

Id2 mediates oligodendrocyte precursor cell maturation arrest and is tumorigenic in a PDGF-rich microenvironment. Cancer Res (2014) 0.78

Breast cancer stem cells, pathways and therapeutic perspectives 2011. Indian J Surg (2012) 0.77

Differences among brain tumor stem cell types and fetal neural stem cells in focal regions of histone modifications and DNA methylation, broad regions of modifications, and bivalent promoters. BMC Genomics (2014) 0.77

Frequency of NFKBIA deletions is low in glioblastomas and skewed in glioblastoma neurospheres. Mol Cancer (2013) 0.77

Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature (2010) 9.81

Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell (2002) 5.64

Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell (2002) 5.11

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell (2008) 5.06

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell (2008) 4.68

Mouse brain organization revealed through direct genome-scale TF expression analysis. Science (2004) 4.55

Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron (2007) 4.47

Corridors of migrating neurons in the human brain and their decline during infancy. Nature (2011) 4.12

Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors. Development (2003) 3.88

bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science (2004) 3.20

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev (2009) 2.96

The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropathol Exp Neurol (2004) 2.66

Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci U S A (2003) 2.64

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. Nat Neurosci (2011) 2.61

Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Cancer Res (2010) 2.56

Regional astrocyte allocation regulates CNS synaptogenesis and repair. Science (2012) 2.53

Development of mice expressing a single D-type cyclin. Genes Dev (2002) 2.43

Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development (2003) 2.42

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc Natl Acad Sci U S A (2009) 2.41

CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination. Cell Stem Cell (2010) 2.40

Astrocytes and disease: a neurodevelopmental perspective. Genes Dev (2012) 2.28

Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain. Neuron (2007) 2.23

Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell (2009) 2.18

Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev (2004) 2.16

Development of NG2 neural progenitor cells requires Olig gene function. Proc Natl Acad Sci U S A (2006) 2.04

Neural stem cell engraftment and myelination in the human brain. Sci Transl Med (2012) 1.96

The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. Cancer Cell (2011) 1.92

Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia. Brain Pathol (2008) 1.87

Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Proc Natl Acad Sci U S A (2011) 1.86

Phosphorylation state of Olig2 regulates proliferation of neural progenitors. Neuron (2011) 1.83

Targeted therapy for BRAFV600E malignant astrocytoma. Clin Cancer Res (2011) 1.79

Olig gene function in CNS development and disease. Glia (2006) 1.77

Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A (2004) 1.77

Molecular diversity of astrocytes with implications for neurological disorders. Proc Natl Acad Sci U S A (2004) 1.76

Myelin regeneration: a recapitulation of development? Annu Rev Neurosci (2011) 1.70

Oligodendrocyte regeneration after neonatal hypoxia requires FoxO1-mediated p27Kip1 expression. J Neurosci (2012) 1.68

N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Res (2006) 1.64

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev (2012) 1.64

Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube. Nature (2005) 1.62

Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination. Proc Natl Acad Sci U S A (2011) 1.57

Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination. Ann Neurol (2010) 1.47

Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination. Proc Natl Acad Sci U S A (2009) 1.46

Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors. Mol Cell Biol (2007) 1.38

Transcription factor co-expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord. Glia (2006) 1.35

A dramatic increase of C1q protein in the CNS during normal aging. J Neurosci (2013) 1.35

A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury. Sci Transl Med (2011) 1.35

Histology-based expression profiling yields novel prognostic markers in human glioblastoma. J Neuropathol Exp Neurol (2005) 1.34

The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. Dev Cell (2005) 1.34

Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice. Dev Biol (2003) 1.29

Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex. Cell (2012) 1.28

Beta-catenin function is required for cerebellar morphogenesis. Brain Res (2006) 1.28

Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach. Proc Natl Acad Sci U S A (2002) 1.27

A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci (2009) 1.27

Hedgehog signaling has a protective effect in glucocorticoid-induced mouse neonatal brain injury through an 11betaHSD2-dependent mechanism. J Clin Invest (2009) 1.23

Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2. Nat Rev Neurosci (2012) 1.22

Medulloblastoma: a problem of developmental biology. Cancer Cell (2002) 1.21

NIH Consensus Development Conference statement: inhaled nitric-oxide therapy for premature infants. Pediatrics (2011) 1.20

Overcoming remyelination failure in multiple sclerosis and other myelin disorders. Exp Neurol (2010) 1.20

Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proc Natl Acad Sci U S A (2012) 1.15

Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development (2012) 1.13

Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex. J Neurosci (2003) 1.13

Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development (2012) 1.13

Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma. J Clin Invest (2012) 1.12

Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2. J Neuropathol Exp Neurol (2006) 1.10

Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem. Acta Neuropathol (2012) 1.05

Towards improved animal models of neonatal white matter injury associated with cerebral palsy. Dis Model Mech (2010) 1.05

Evolving concepts of gliogenesis: a look way back and ahead to the next 25 years. Neuron (2013) 1.00

Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia. Development (2003) 0.99

Myelin regeneration in multiple sclerosis: targeting endogenous stem cells. Neurotherapeutics (2011) 0.93

Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity. PLoS One (2012) 0.92

STAT3-mediated astrogliosis protects myelin development in neonatal brain injury. Ann Neurol (2012) 0.91

Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions. Glia (2013) 0.90

Olig1 function is required for remyelination potential of transplanted neural progenitor cells in a model of viral-induced demyelination. Exp Neurol (2012) 0.90

Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes. Mech Dev (2002) 0.89

Expression and function of Nkx6.3 in vertebrate hindbrain. Brain Res (2008) 0.88

Cerebellar 'transcriptome' reveals cell-type and stage-specific expression during postnatal development and tumorigenesis. Mol Cell Neurosci (2006) 0.88

Dexamethasone destabilizes Nmyc to inhibit the growth of hedgehog-associated medulloblastoma. Cancer Res (2010) 0.86

Missense mutation in mouse GALC mimics human gene defect and offers new insights into Krabbe disease. Hum Mol Genet (2013) 0.86

Myelin restoration: progress and prospects for human cell replacement therapies. Arch Immunol Ther Exp (Warsz) (2011) 0.85

Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. PLoS One (2013) 0.85

Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube. Dev Biol (2006) 0.85

Evidence that nuclear factor IA inhibits repair after white matter injury. Ann Neurol (2012) 0.85

Cerebellar abnormalities following hypoxia alone compared to hypoxic-ischemic forebrain injury in the developing rat brain. Neurobiol Dis (2010) 0.84

NIH consensus development conference: Inhaled nitric oxide therapy for premature infants. NIH Consens State Sci Statements (2010) 0.84

Postnatal growth of the human pons: a morphometric and immunohistochemical analysis. J Comp Neurol (2014) 0.83

Role of academic medical centers in cell-based therapeutic clinical trials. Transl Res (2011) 0.75

Synchronization of goat fibroblast cells at quiescent stage and determination of their transition from G0 to G1 by detection of cyclin D1 mRNA. Cloning Stem Cells (2004) 0.75