Published in Cell on April 05, 2002
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell (2008) 4.68
Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron (2007) 4.47
Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res (2008) 3.99
The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Genes Dev (2003) 3.46
Regulation of innate immune responses in the brain. Nat Rev Immunol (2009) 3.41
MicroRNA-mediated control of oligodendrocyte differentiation. Neuron (2010) 3.24
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci (2009) 3.18
Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells. Nature (2009) 2.87
Mash1 specifies neurons and oligodendrocytes in the postnatal brain. EMBO J (2004) 2.55
Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells (2008) 2.54
Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube. Cell (2012) 2.54
Developmental genetics of vertebrate glial-cell specification. Nature (2010) 2.44
Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells. Genes Dev (2005) 2.40
Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome. Genome Res (2004) 2.29
Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain. Neuron (2007) 2.23
Regulation of motor neuron specification by phosphorylation of neurogenin 2. Neuron (2008) 2.20
Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell (2009) 2.18
Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair. Proc Natl Acad Sci U S A (2005) 2.09
Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome. Nat Neurosci (2010) 2.08
Development of NG2 neural progenitor cells requires Olig gene function. Proc Natl Acad Sci U S A (2006) 2.04
Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth. Proc Natl Acad Sci U S A (2005) 1.93
The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. Cancer Cell (2011) 1.92
Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects. Development (2009) 1.90
Directed differentiation of hippocampal stem/progenitor cells in the adult brain. Nat Neurosci (2008) 1.89
Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia. Brain Pathol (2008) 1.87
Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci U S A (2008) 1.84
Phosphorylation state of Olig2 regulates proliferation of neural progenitors. Neuron (2011) 1.83
Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis. Cell (2014) 1.83
Oligodendrocytes: biology and pathology. Acta Neuropathol (2009) 1.81
Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code. Cell (2008) 1.79
Induced neuronal cells: how to make and define a neuron. Cell Stem Cell (2011) 1.77
Phosphorylation regulates OLIG2 cofactor choice and the motor neuron-oligodendrocyte fate switch. Neuron (2011) 1.72
Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile. Mol Cancer (2008) 1.72
Epidermal growth factor induces the progeny of subventricular zone type B cells to migrate and differentiate into oligodendrocytes. Stem Cells (2009) 1.71
Activation of the subventricular zone in multiple sclerosis: evidence for early glial progenitors. Proc Natl Acad Sci U S A (2007) 1.71
A dlx2- and pax6-dependent transcriptional code for periglomerular neuron specification in the adult olfactory bulb. J Neurosci (2008) 1.69
Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell (2013) 1.66
The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord. Genes Dev (2005) 1.66
Notch1 control of oligodendrocyte differentiation in the spinal cord. J Cell Biol (2002) 1.65
Potential therapeutic implications of cancer stem cells in glioblastoma. Biochem Pharmacol (2010) 1.60
Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors. Genes Dev (2003) 1.60
The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nat Neurosci (2009) 1.60
Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves. FASEB J (2008) 1.60
A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells. Stem Cells (2009) 1.59
Characterization of Müller glia and neuronal progenitors during adult zebrafish retinal regeneration. Exp Eye Res (2008) 1.50
Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma. Cancer Cell (2016) 1.49
Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube. Philos Trans R Soc Lond B Biol Sci (2008) 1.48
Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination. Ann Neurol (2010) 1.47
Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination. Proc Natl Acad Sci U S A (2009) 1.46
Cancer stem cells in glioblastoma--molecular signaling and therapeutic targeting. Protein Cell (2010) 1.45
MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes. PLoS Biol (2013) 1.45
A regulatory network to segregate the identity of neuronal subtypes. Dev Cell (2008) 1.41
Paracrine control of oligodendrocyte differentiation by SRF-directed neuronal gene expression. Nat Neurosci (2009) 1.41
Common origins of hippocampal Ivy and nitric oxide synthase expressing neurogliaform cells. J Neurosci (2010) 1.39
Differential modulation of BMP signaling promotes the elaboration of cerebral cortical GABAergic neurons or oligodendrocytes from a common sonic hedgehog-responsive ventral forebrain progenitor species. Proc Natl Acad Sci U S A (2002) 1.37
Epigenetic regulation of oligodendrocyte identity. Trends Neurosci (2010) 1.36
Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate. Proc Natl Acad Sci U S A (2002) 1.33
Turning cancer stem cells inside out: an exploration of glioma stem cell signaling pathways. J Biol Chem (2009) 1.33
The interface between glial progenitors and gliomas. Acta Neuropathol (2008) 1.33
Ascl1 (Mash1) lineage cells contribute to discrete cell populations in CNS architecture. Mol Cell Neurosci (2008) 1.31
Oligodendrocyte development and the onset of myelination in the human fetal brain. Front Neuroanat (2009) 1.29
Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2. Genes Dev (2012) 1.28
Down syndrome: searching for the genetic culprits. Dis Model Mech (2011) 1.28
Bone morphogenetic protein signaling and olig1/2 interact to regulate the differentiation and maturation of adult oligodendrocyte precursor cells. Stem Cells (2007) 1.27
A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci (2009) 1.27
Nuclear export of OLIG2 in neural stem cells is essential for ciliary neurotrophic factor-induced astrocyte differentiation. J Cell Biol (2004) 1.25
Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Proc Natl Acad Sci U S A (2006) 1.25
Is Pax6 critical for neurogenesis in the human fetal brain? Cereb Cortex (2007) 1.22
Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2. Nat Rev Neurosci (2012) 1.22
Specification of CNS glia from neural stem cells in the embryonic neuroepithelium. Philos Trans R Soc Lond B Biol Sci (2008) 1.21
Transplanted oligodendrocytes and motoneuron progenitors generated from human embryonic stem cells promote locomotor recovery after spinal cord transection. Stem Cells (2010) 1.21
NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination. J Neurosci (2011) 1.18
Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system. Neuron (2012) 1.18
Transcription factor Olig2 defines subpopulations of retinal progenitor cells biased toward specific cell fates. Proc Natl Acad Sci U S A (2012) 1.17
Fibroblast growth factor receptor signaling in oligodendrocytes regulates myelin sheath thickness. J Neurosci (2012) 1.17
Two-tier transcriptional control of oligodendrocyte differentiation. Curr Opin Neurobiol (2009) 1.17
Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformation. Mech Dev (2005) 1.17
Sustained activation of ERK1/2 MAPK in oligodendrocytes and schwann cells enhances myelin growth and stimulates oligodendrocyte progenitor expansion. J Neurosci (2013) 1.16
The basic helix-loop-helix transcription factor olig2 is critical for reactive astrocyte proliferation after cortical injury. J Neurosci (2008) 1.16
Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer. Nucleic Acids Res (2010) 1.15
Transplantation of human neural stem cells transduced with Olig2 transcription factor improves locomotor recovery and enhances myelination in the white matter of rat spinal cord following contusive injury. BMC Neurosci (2009) 1.13
Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anesthetics. J Neurosci (2010) 1.13
Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging. EMBO J (2014) 1.12
Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS. J Neurosci (2012) 1.12
Glial development: the crossroads of regeneration and repair in the CNS. Neuron (2014) 1.12
The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. Nat Med (2014) 1.11
Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly. Neuron (2012) 1.11
MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cord. J Neurosci (2010) 1.10
Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system. Nat Neurosci (2009) 1.08
NG2 cells are not a major source of reactive astrocytes after neocortical stab wound injury. Glia (2011) 1.06
BMP signaling mutant mice exhibit glial cell maturation defects. Mol Cell Neurosci (2007) 1.06
Olig2-dependent developmental fate switch of NG2 cells. Development (2012) 1.06
The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes. PLoS Genet (2013) 1.05
Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene. Hum Mol Genet (2010) 1.04
Delayed myelination in an intrauterine growth retardation model is mediated by oxidative stress upregulating bone morphogenetic protein 4. J Neuropathol Exp Neurol (2012) 1.03
Tumor progression and oncogene addiction in a PDGF-B-induced model of gliomagenesis. Neoplasia (2008) 1.03
ZFP191 is required by oligodendrocytes for CNS myelination. Genes Dev (2010) 1.01
Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities. Neural Plast (2012) 1.00
The role of CXCR4 signaling in the migration of transplanted oligodendrocyte progenitors into the cerebral white matter. Neurobiol Dis (2011) 1.00
Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature (2010) 9.81
Profiling critical cancer gene mutations in clinical tumor samples. PLoS One (2009) 5.63
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell (2002) 5.11
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell (2008) 5.06
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell (2008) 4.68
Mouse brain organization revealed through direct genome-scale TF expression analysis. Science (2004) 4.55
Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron (2007) 4.47
Corridors of migrating neurons in the human brain and their decline during infancy. Nature (2011) 4.12
Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors. Development (2003) 3.88
Basic helix-loop-helix factors in cortical development. Neuron (2003) 3.21
bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science (2004) 3.20
Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev (2009) 2.96
A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. PLoS Genet (2005) 2.85
Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ Res (2009) 2.82
Glioma stem cells: a midterm exam. Neuron (2008) 2.69
The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropathol Exp Neurol (2004) 2.66
Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci U S A (2003) 2.64
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. Nat Neurosci (2011) 2.61
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell (2011) 2.58
Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Cancer Res (2010) 2.56
Regional astrocyte allocation regulates CNS synaptogenesis and repair. Science (2012) 2.53
Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia. Cell (2005) 2.52
Cysteine cathepsins: from structure, function and regulation to new frontiers. Biochim Biophys Acta (2011) 2.50
Bcl-2 engineered MSCs inhibited apoptosis and improved heart function. Stem Cells (2007) 2.45
Gold nanocages as contrast agents for spectroscopic optical coherence tomography. Opt Lett (2005) 2.44
Development of mice expressing a single D-type cyclin. Genes Dev (2002) 2.43
Molecular mechanisms controlling cortical gliogenesis. Curr Opin Neurobiol (2002) 2.43
Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development (2003) 2.42
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc Natl Acad Sci U S A (2009) 2.41
CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination. Cell Stem Cell (2010) 2.40
Astrocytes and disease: a neurodevelopmental perspective. Genes Dev (2012) 2.28
Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain. Neuron (2007) 2.23
Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes. Kidney Int (2010) 2.18
Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell (2009) 2.18
Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev (2004) 2.16
A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. BMC Dev Biol (2005) 2.08
Development of NG2 neural progenitor cells requires Olig gene function. Proc Natl Acad Sci U S A (2006) 2.04
Neural stem cell engraftment and myelination in the human brain. Sci Transl Med (2012) 1.96
Blockade of TNF-α rapidly inhibits pain responses in the central nervous system. Proc Natl Acad Sci U S A (2011) 1.95
The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. Cancer Cell (2011) 1.92
Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia. Brain Pathol (2008) 1.87
Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Proc Natl Acad Sci U S A (2011) 1.86
Phosphorylation state of Olig2 regulates proliferation of neural progenitors. Neuron (2011) 1.83
Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system. Dev Dyn (2009) 1.83
Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Mol Cell Biol (2002) 1.81
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol (2013) 1.79
Targeted therapy for BRAFV600E malignant astrocytoma. Clin Cancer Res (2011) 1.79
Olig gene function in CNS development and disease. Glia (2006) 1.77
Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A (2004) 1.77
Molecular diversity of astrocytes with implications for neurological disorders. Proc Natl Acad Sci U S A (2004) 1.76
Violence against doctors in China. BMJ (2012) 1.75
Myelin regeneration: a recapitulation of development? Annu Rev Neurosci (2011) 1.70
Oligodendrocyte regeneration after neonatal hypoxia requires FoxO1-mediated p27Kip1 expression. J Neurosci (2012) 1.68
N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Res (2006) 1.64
Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev (2012) 1.64
Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube. Nature (2005) 1.62
Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination. Proc Natl Acad Sci U S A (2011) 1.57
Is the intravascular administration of mesenchymal stem cells safe? Mesenchymal stem cells and intravital microscopy. Microvasc Res (2009) 1.51
Compression and aggregation-resistant particles of crumpled soft sheets. ACS Nano (2011) 1.49
Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination. Ann Neurol (2010) 1.47
Carbon monoxide releasing molecules inhibit cell death resulting from renal transplantation related stress. J Urol (2012) 1.46
Real-time in vivo blood-flow imaging by moving-scatterer-sensitive spectral-domain optical Doppler tomography. Opt Lett (2006) 1.46
Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination. Proc Natl Acad Sci U S A (2009) 1.46
Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis. J Exp Clin Cancer Res (2010) 1.44
Application of attitude jitter detection based on short-time asynchronous images and compensation methods for Chinese mapping satellite-1. Opt Express (2015) 1.39
Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors. Mol Cell Biol (2007) 1.38
Mesenchymal stem cells and cardiac repair. J Cell Mol Med (2008) 1.37
Transcription factor co-expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord. Glia (2006) 1.35
A dramatic increase of C1q protein in the CNS during normal aging. J Neurosci (2013) 1.35
Serological prevalence of echinococcosis and risk factors for infection among children in rural communities of southern Ningxia, China. Trop Med Int Health (2008) 1.35
A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury. Sci Transl Med (2011) 1.35
Histology-based expression profiling yields novel prognostic markers in human glioblastoma. J Neuropathol Exp Neurol (2005) 1.34
The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. Dev Cell (2005) 1.34
How to track cellular aging of mesenchymal stromal cells? Aging (Albany NY) (2010) 1.34
The effects of TLR activation on T-cell development and differentiation. Clin Dev Immunol (2012) 1.33
RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells. J Cell Sci (2010) 1.33
Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci U S A (2013) 1.33
Functional significance of VEGF-a in human ovarian carcinoma: role in vasculogenic mimicry. Cancer Biol Ther (2008) 1.32
RIP1, a member of an Arabidopsis protein family, interacts with the protein RARE1 and broadly affects RNA editing. Proc Natl Acad Sci U S A (2012) 1.32
Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08). Neuro Oncol (2009) 1.30
A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist. Anal Biochem (2004) 1.29
Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice. Dev Biol (2003) 1.29
Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex. Cell (2012) 1.28
Promotion of hepatocellular carcinoma metastasis through matrix metalloproteinase activation by epithelial-mesenchymal transition regulator Twist1. J Cell Mol Med (2011) 1.28
Beta-catenin function is required for cerebellar morphogenesis. Brain Res (2006) 1.28
Functions of noncoding RNAs in neural development and neurological diseases. Mol Neurobiol (2011) 1.27
Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach. Proc Natl Acad Sci U S A (2002) 1.27
A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci (2009) 1.27
Engineering central metabolic modules of Escherichia coli for improving β-carotene production. Metab Eng (2013) 1.26
Solexa sequencing of novel and differentially expressed microRNAs in testicular and ovarian tissues in Holstein cattle. Int J Biol Sci (2011) 1.26