Published in J Virol on July 02, 2008
NF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ. PLoS Pathog (2011) 1.23
Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis. Retrovirology (2009) 1.21
Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells. Proc Natl Acad Sci U S A (2012) 1.15
HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes. Blood (2010) 1.13
APOBEC3G generates nonsense mutations in human T-cell leukemia virus type 1 proviral genomes in vivo. J Virol (2010) 1.12
Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein. J Biol Chem (2014) 0.98
Imaging spontaneous tumorigenesis: inflammation precedes development of peripheral NK tumors. Blood (2008) 0.95
Hematopoietic stem cells and retroviral infection. Retrovirology (2010) 0.91
Induction of p21(CIP1/WAF1) expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization. Retrovirology (2009) 0.90
HTLV-I p30 inhibits multiple S phase entry checkpoints, decreases cyclin E-CDK2 interactions and delays cell cycle progression. Mol Cancer (2010) 0.89
Complex cell cycle abnormalities caused by human T-lymphotropic virus type 1 Tax. J Virol (2011) 0.88
Regulation of human T-lymphotropic virus type I latency and reactivation by HBZ and Rex. PLoS Pathog (2014) 0.87
How the DNA damage response determines the fate of HTLV-1 Tax-expressing cells. Retrovirology (2012) 0.87
HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA. J Virol (2012) 0.86
Move or die: the fate of the Tax oncoprotein of HTLV-1. Viruses (2011) 0.85
Controversies in targeted therapy of adult T cell leukemia/lymphoma: ON target or OFF target effects? Viruses (2011) 0.84
Human T-cell leukemia virus type 1 Tax-deregulated autophagy pathway and c-FLIP expression contribute to resistance against death receptor-mediated apoptosis. J Virol (2013) 0.83
The human T-cell leukemia virus type 1 oncoprotein tax controls forkhead box O4 activity through degradation by the proteasome. J Virol (2011) 0.83
HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma-A Tale of Two Proteins: Tax and HBZ. Viruses (2016) 0.82
HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation. PLoS Pathog (2015) 0.81
Functional Comparison of HBZ and the Related APH-2 Protein Provides Insight into Human T-Cell Leukemia Virus Type 1 Pathogenesis. J Virol (2016) 0.80
Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules. Retrovirology (2008) 0.79
Human T-lymphotropic virus proteins and post-translational modification pathways. World J Virol (2012) 0.79
KSHV vCyclin counters the senescence/G1 arrest response triggered by NF-κB hyperactivation. Oncogene (2014) 0.78
Permissive Sense and Antisense Transcription from the 5' and 3' Long Terminal Repeats of Human T-Cell Leukemia Virus Type 1. J Virol (2016) 0.76
NF-κB inhibition facilitates the establishment of cell lines that chronically produce human T-lymphotropic virus type 1 viral particles. J Virol (2014) 0.76
Visualizing spatiotemporal dynamics of apoptosis after G1 arrest by human T cell leukemia virus type 1 Tax and insights into gene expression changes using microarray-based gene expression analysis. BMC Genomics (2012) 0.76
NOTCH1 Activation Depletes the Pool of Side Population Stem Cells in ATL. J Cancer Sci (2017) 0.75
CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev (1999) 24.83
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev (1994) 8.52
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med (2002) 5.79
Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J (2000) 5.61
The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J (1999) 5.44
Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton. Science (2003) 5.19
Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci (2004) 4.40
The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science (1987) 4.01
HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Proc Natl Acad Sci U S A (2006) 3.11
The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV. Cell (2003) 2.28
Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line. Science (1983) 2.26
Human T-cell leukemia virus (HTLV-I) transcripts in fresh and cultured cells of patients with adult T-cell leukemia. Proc Natl Acad Sci U S A (1984) 2.17
Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response. Oncogene (2005) 1.74
Examining human T-lymphotropic virus type 1 infection and replication by cell-free infection with recombinant virus vectors. J Virol (2001) 1.73
Induction of Bcl-x(L) expression by human T-cell leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax. J Virol (1999) 1.48
Engagement of specific T-cell surface molecules regulates cytoskeletal polarization in HTLV-1-infected lymphocytes. Blood (2005) 1.44
Stimulation of cyclin-dependent kinase activity and G1- to S-phase transition in human lymphocytes by the human T-cell leukemia/lymphotropic virus type 1 Tax protein. J Virol (1998) 1.43
Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence. EMBO J (2006) 1.40
Human T-cell leukemia virus-I tax oncoprotein functionally targets a subnuclear complex involved in cellular DNA damage-response. J Biol Chem (2003) 1.33
Human T-lymphotropic virus type 1 oncoprotein tax promotes S-phase entry but blocks mitosis. J Virol (2002) 1.28
HBZ, a new important player in the mystery of adult T-cell leukemia. Blood (2006) 1.27
Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation. Mol Cell Biol (2000) 1.26
Alteration of phosphatidylinositol 3-kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL). Proc Natl Acad Sci U S A (2005) 1.25
Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein. Proc Natl Acad Sci U S A (2005) 1.24
HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule. Proc Natl Acad Sci U S A (2004) 1.23
Multi-step carcinogenesis model for adult T-cell leukemia. Jpn J Cancer Res (1989) 1.23
Induction of micronuclei by HTLV-I Tax: a cellular assay for function. Virology (1993) 1.20
Phosphoinositide-3 kinase-PKB/Akt pathway activation is involved in fibroblast Rat-1 transformation by human T-cell leukemia virus type I tax. Oncogene (2001) 1.17
Cell type-specific E2F activation and cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I. J Biol Chem (2000) 1.15
Human T-lymphotropic virus type 1 oncoprotein tax promotes unscheduled degradation of Pds1p/securin and Clb2p/cyclin B1 and causes chromosomal instability. Mol Cell Biol (2003) 1.15
Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line. J Virol (1999) 1.12
Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I. Oncogene (2001) 1.12
Differences in the ability of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 tax to inhibit p53 function. J Virol (2000) 1.04
Tax-dependent stimulation of G1 phase-specific cyclin-dependent kinases and increased expression of signal transduction genes characterize HTLV type 1-transformed T cells. AIDS Res Hum Retroviruses (2000) 1.03
The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication. Nat Cell Biol (2006) 1.02
Limiting amounts of p27Kip1 correlates with constitutive activation of cyclin E-CDK2 complex in HTLV-I-transformed T-cells. Oncogene (1999) 1.02
Clastogenic effect of the human T-cell leukemia virus type I Tax oncoprotein correlates with unstabilized DNA breaks. J Biol Chem (2000) 1.02
Human T-cell leukemia virus type 1 Tax attenuates gamma-irradiation-induced apoptosis through physical interaction with Chk2. Oncogene (2006) 1.01
Versatile reporter systems show that transactivation by human T-cell leukemia virus type 1 Tax occurs independently of chromatin remodeling factor BRG1. J Virol (2006) 0.96
Experimental acute adult T cell leukemia-lymphoma is associated with thymic atrophy in human T cell leukemia virus type I infection. Lab Invest (1996) 0.94
Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes. Blood (2006) 0.94
Insights into the molecular mechanism of p53 inhibition by HTLV type 1 Tax. AIDS Res Hum Retroviruses (2000) 0.92
Phosphoinositide 3-kinase and Forkhead, a switch for cell division. Biochem Soc Trans (2004) 0.91
Genomic instability driven by the human T-cell leukemia virus type I (HTLV-I) oncoprotein, Tax. Oncogene (2002) 0.91
Infectious transmission and replication of human T-cell leukemia virus type 1. Front Biosci (2004) 0.91
Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. Nat Med (2010) 4.23
Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Res (2006) 3.12
Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology (2011) 3.05
JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. J Neurosci (2009) 2.64
Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis. Mol Cell (2013) 2.61
VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. Neuron (2010) 2.54
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest (2009) 2.52
Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov (2013) 2.43
Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts. Cancer Res (2010) 2.13
STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood (2006) 2.12
Human immunodeficiency virus (HIV)-negative plasmablastic lymphoma: a single institutional experience and literature review. Leuk Res (2011) 2.10
Risk Factors for Central Compartment Lymph Node Metastasis in Papillary Thyroid Microcarcinoma: A Meta-Analysis. World J Surg (2015) 2.09
HS2 enhancer function is blocked by a transcriptional terminator inserted between the enhancer and the promoter. J Biol Chem (2004) 2.01
Enhancement of learning and memory by elevating brain magnesium. Neuron (2010) 2.00
Atomic origins of the high catalytic activity of nanoporous gold. Nat Mater (2012) 1.87
Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging. Genes Dev (2014) 1.81
Efficient lentiviral vector-mediated control of HIV-1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load. Mol Ther (2004) 1.80
Enrichment of cancer cells using aptamers immobilized on a microfluidic channel. Anal Chem (2009) 1.78
Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium. J Biol Chem (2004) 1.72
Methylation-mediated repression of microRNA 129-2 enhances oncogenic SOX4 expression in HCC. Liver Int (2013) 1.71
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP. Hum Mol Genet (2011) 1.68
Vaccine-induced myeloid cell population dampens protective immunity to SIV. J Clin Invest (2014) 1.64
Moderate cardiac-selective overexpression of angiotensin II type 2 receptor protects cardiac functions from ischaemic injury. Exp Physiol (2011) 1.61
A facilitated tracking and transcription mechanism of long-range enhancer function. Nucleic Acids Res (2007) 1.60
Mortality rates among prevalent hemodialysis patients in Beijing: a comparison with USRDS data. Nephrol Dial Transplant (2012) 1.59
Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients. Clin Cancer Res (2009) 1.59
Development of polydimethylsiloxane substrates with tunable elastic modulus to study cell mechanobiology in muscle and nerve. PLoS One (2012) 1.54
Loss of melanopsin-containing retinal ganglion cells in a rat glaucoma model. Chin Med J (Engl) (2008) 1.48
A molecular and functional analysis of large granular lymphocyte expansions in patients with chronic myelogenous leukemia treated with tyrosine kinase inhibitors. Leuk Lymphoma (2011) 1.47
Effects of a dental adhesive incorporating antibacterial monomer on the growth, adherence and membrane integrity of Streptococcus mutans. J Dent (2009) 1.46
Among 46 near full length HIV type 1 genome sequences from Rakai District, Uganda, subtype D and AD recombinants predominate. AIDS Res Hum Retroviruses (2002) 1.46
TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. J Clin Invest (2012) 1.44
Matrix metalloproteinases in human sclerotic dentine of attrited molars. Arch Oral Biol (2012) 1.42
Dual function of Arabidopsis ATAF1 in abiotic and biotic stress responses. Cell Res (2009) 1.41
Single molecule detection from a large-scale SERS-active Au₇₉Ag₂₁ substrate. Sci Rep (2011) 1.41
Homozygous hemoglobin C disease. Blood (2013) 1.41
Long noncoding RNAs associated with liver regeneration 1 accelerates hepatocyte proliferation during liver regeneration by activating Wnt/β-catenin signaling. Hepatology (2013) 1.40
Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering RNAs suppresses growth of human prostate tumor in vivo. Clin Cancer Res (2005) 1.40
Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence. EMBO J (2006) 1.40
Neonatal Type II Alveolar Epithelial Cell Transplant Facilitates Lung Reparation in Piglets With Acute Lung Injury and Extracorporeal Life Support. Pediatr Crit Care Med (2016) 1.39
Requirement of hCenexin for proper mitotic functions of polo-like kinase 1 at the centrosomes. Mol Cell Biol (2006) 1.36
Cutting edge: in vivo blockade of human IL-2 receptor induces expansion of CD56(bright) regulatory NK cells in patients with active uveitis. J Immunol (2005) 1.36
Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4. Arthritis Rheum (2010) 1.36
The clinical significance of twist expression in nasopharyngeal carcinoma. Cancer Lett (2006) 1.35
Fabrication and Structural Design of Micro Pressure Sensors for Tire Pressure Measurement Systems (TPMS). Sensors (Basel) (2009) 1.33
SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens. Blood (2010) 1.33
K-bZIP of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) binds KSHV/HHV-8 Rta and represses Rta-mediated transactivation. J Virol (2003) 1.32
Manufacture of clinical-grade CD19-specific T cells stably expressing chimeric antigen receptor using Sleeping Beauty system and artificial antigen presenting cells. PLoS One (2013) 1.32
Local delivery of interleukin-12 using T cells targeting VEGF receptor-2 eradicates multiple vascularized tumors in mice. Clin Cancer Res (2012) 1.32
miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway. Hepatology (2010) 1.31
Effects of long-term low-dose cadmium exposure on genomic DNA methylation in human embryo lung fibroblast cells. Toxicology (2007) 1.31
Safe two-plasmid production for the first clinical lentivirus vector that achieves >99% transduction in primary cells using a one-step protocol. J Gene Med (2004) 1.29
Myelodysplastic syndromes classification and risk stratification. Hematol Oncol Clin North Am (2010) 1.29
IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis. J Clin Invest (2002) 1.29
Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice. Am J Physiol Endocrinol Metab (2004) 1.29
Hypomethylation of the IL17RC promoter associates with age-related macular degeneration. Cell Rep (2012) 1.28
Human T-lymphotropic virus type 1 oncoprotein tax promotes S-phase entry but blocks mitosis. J Virol (2002) 1.28
Microarray analysis of temperature-induced transcriptome of Yersinia pestis. Microbiol Immunol (2004) 1.28
Molecular epidemiology of human Blastocystis in a village in Yunnan province, China. Parasitol Int (2007) 1.25
Structure-function analysis of barley NLR immune receptor MLA10 reveals its cell compartment specific activity in cell death and disease resistance. PLoS Pathog (2012) 1.25
Human T-lymphotropic virus type I tax activates I-kappa B kinase by inhibiting I-kappa B kinase-associated serine/threonine protein phosphatase 2A. J Biol Chem (2002) 1.25
p62/SQSTM1 involved in cisplatin resistance in human ovarian cancer cells by clearing ubiquitinated proteins. Eur J Cancer (2011) 1.25
Age-related macular degeneration: an immunologically driven disease. Curr Opin Investig Drugs (2009) 1.23
NF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ. PLoS Pathog (2011) 1.23
The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists. Protein Cell (2013) 1.23
HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule. Proc Natl Acad Sci U S A (2004) 1.23
Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus: role of JAK/STAT signaling. J Virol (2006) 1.22
Aging brain microenvironment decreases hippocampal neurogenesis through Wnt-mediated survivin signaling. Aging Cell (2012) 1.22
Complete SHOX deficiency causes Langer mesomelic dysplasia. Am J Med Genet (2002) 1.22
Circulating miR-17-5p and miR-20a: molecular markers for gastric cancer. Mol Med Rep (2012) 1.22
The onco-embryonic antigen ROR1 is expressed by a variety of human cancers. Am J Pathol (2012) 1.20
UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting. Curr Biol (2011) 1.19
Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails. Cancer Immunol Immunother (2012) 1.19
Comprehensive assessment of heavy metal contamination in sediment of the Pearl River Estuary and adjacent shelf. Mar Pollut Bull (2012) 1.19
Prevention of cartilage degeneration and gait asymmetry by lubricin tribosupplementation in the rat following anterior cruciate ligament transection. Arthritis Rheum (2011) 1.18
Engineering secondary cell wall deposition in plants. Plant Biotechnol J (2012) 1.18
Evidence for cancer stem cells in human endometrial carcinoma. Cancer Res (2009) 1.17
The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity. Genes Dev (2011) 1.17
Modulation of the unfolded protein response is the core of microRNA-122-involved sensitivity to chemotherapy in hepatocellular carcinoma. Neoplasia (2011) 1.16
Loss of the Y chromosome: an age-related or clonal phenomenon in acute myelogenous leukemia/myelodysplastic syndrome? Arch Pathol Lab Med (2008) 1.16
Downregulation of BMI-1 enhances 5-fluorouracil-induced apoptosis in nasopharyngeal carcinoma cells. Biochem Biophys Res Commun (2008) 1.16
Synthesis of hyperbranched polyethylene amphiphiles by chain walking polymerization in tandem with RAFT polymerization and supramolecular self-assembly vesicles. Macromol Rapid Commun (2012) 1.16
Induction of myelodysplasia by myeloid-derived suppressor cells. J Clin Invest (2013) 1.15
Human T-lymphotropic virus type 1 oncoprotein tax promotes unscheduled degradation of Pds1p/securin and Clb2p/cyclin B1 and causes chromosomal instability. Mol Cell Biol (2003) 1.15
A randomized pilot study of systemic immunosuppression in the treatment of age-related macular degeneration with choroidal neovascularization. Retina (2010) 1.14
ERCC1, RRM1 and BRCA1 mRNA expression levels and clinical outcome of advanced non-small cell lung cancer. Med Oncol (2010) 1.14
Effects of supplemental intra-articular lubricin and hyaluronic acid on the progression of posttraumatic arthritis in the anterior cruciate ligament-deficient rat knee. Am J Sports Med (2010) 1.14
Computer-assisted lip diagnosis on Traditional Chinese Medicine using multi-class support vector machines. BMC Complement Altern Med (2012) 1.14
Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival. Clin Cancer Res (2007) 1.13
Sleeping beauty system to redirect T-cell specificity for human applications. J Immunother (2013) 1.13
Concanavalin A-captured glycoproteins in healthy human urine. Mol Cell Proteomics (2005) 1.13
Gene expression profiling in autoimmune noninfectious uveitis disease. J Immunol (2008) 1.12
(S)-2-(3-Nitro-phen-yl)-1,2-dihydro-quinazolin-4(3H)-one. Acta Crystallogr Sect E Struct Rep Online (2008) 1.11
Distribution of sphingosine kinase activity and mRNA in rodent brain. J Neurochem (2007) 1.11
A practical guide to treatment of infantile hemangiomas of the head and neck. Int J Clin Exp Med (2013) 1.11