Published in Clin Cancer Res on September 01, 2005
Targeting STAT3 in cancer: how successful are we? Expert Opin Investig Drugs (2009) 2.58
STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Res (2008) 2.46
Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530. Oncogene (2008) 1.57
STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation. J Clin Pathol (2007) 1.46
The PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells. J Biol Chem (2008) 1.46
Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells. J Biol Chem (2010) 1.28
Role of EMT in Metastasis and Therapy Resistance. J Clin Med (2016) 1.20
STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines. Br J Cancer (2006) 1.08
Prostate cancer and neuroendocrine differentiation: more neuronal, less endocrine? Front Oncol (2015) 1.01
Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection. Mol Cancer (2010) 0.98
Differential expression of RBM5, EGFR and KRAS mRNA and protein in non-small cell lung cancer tissues. J Exp Clin Cancer Res (2012) 0.97
Interleukin-6: a bone marrow stromal cell paracrine signal that induces neuroendocrine differentiation and modulates autophagy in bone metastatic PCa cells. Autophagy (2012) 0.94
Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesis. Cytokine Growth Factor Rev (2012) 0.92
Enhanced tumor suppression in vitro and in vivo by co-expression of survivin-specific siRNA and wild-type p53 protein. Cancer Gene Ther (2010) 0.90
Cytokine-induced tumor suppressors: a GRIM story. Cytokine (2010) 0.88
ERRβ splice variants differentially regulate cell cycle progression. Cell Cycle (2015) 0.88
Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer. Int J Oncol (2009) 0.85
Silencing of signal transducer and activator of transcription 3 expression by RNA interference suppresses growth of human hepatocellular carcinoma in tumor-bearing nude mice. World J Gastroenterol (2009) 0.84
Small RNA and its application in andrology and urology. Transl Androl Urol (2012) 0.84
Radiotherapy-induced plasticity of prostate cancer mobilizes stem-like non-adherent, Erk signaling-dependent cells. Cell Death Differ (2014) 0.83
Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA. ACS Chem Biol (2011) 0.81
Knockdown of stat3 expression by RNAi inhibits in vitro growth of human ovarian cancer. Radiol Oncol (2011) 0.81
Identification of a structural motif in the tumor-suppressive protein GRIM-19 required for its antitumor activity. Am J Pathol (2010) 0.81
Targeted therapy via oral administration of attenuated Salmonella expression plasmid-vectored Stat3-shRNA cures orthotopically transplanted mouse HCC. Cancer Gene Ther (2012) 0.80
Inhibition of ICAM2 induces radiosensitization in oral squamous cell carcinoma cells. Br J Cancer (2008) 0.80
Off-target effects of plasmid-transcribed shRNAs on NFκB signaling pathway and cell survival of human melanoma cells. Mol Biol Rep (2013) 0.80
Delivery of the co-expression plasmid pEndo-Si-Stat3 by attenuated Salmonella serovar typhimurium for prostate cancer treatment. J Cancer Res Clin Oncol (2013) 0.79
A membrane penetrating peptide aptamer inhibits STAT3 function and suppresses the growth of STAT3 addicted tumor cells. JAKSTAT (2012) 0.79
Plasmid-based Stat3 siRNA delivered by hydroxyapatite nanoparticles suppresses mouse prostate tumour growth in vivo. Asian J Androl (2011) 0.79
Detection of novel amplicons in prostate cancer by comprehensive genomic profiling of prostate cancer cell lines using oligonucleotide-based arrayCGH. PLoS One (2007) 0.79
Tumor suppressor gene RBM5 delivered by attenuated Salmonella inhibits lung adenocarcinoma through diverse apoptotic signaling pathways. World J Surg Oncol (2013) 0.78
Plasmid-based Survivin shRNA and GRIM-19 carried by attenuated Salmonella suppresses tumor cell growth. Asian J Androl (2012) 0.76
GRIM-19: A Double-edged Sword that Regulates Anti-Tumor and Innate Immune Responses. Transl Oncogenomics (2008) 0.76
The efficiency of silencing expression of the gene coding STAT3 transcriptional factor and susceptibility of bladder cancer cells to apoptosis. Contemp Oncol (Pozn) (2012) 0.76
The relationship between total and phosphorylated STAT1 and STAT3 tumour cell expression, components of tumour microenvironment and survival in patients with invasive ductal breast cancer. Oncotarget (2016) 0.75
Total glucosides of paeony inhibits lipopolysaccharide-induced proliferation, migration and invasion in androgen insensitive prostate cancer cells. PLoS One (2017) 0.75
Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines. J Chem Biol (2017) 0.75
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell (2010) 7.94
The c-Myc target gene network. Semin Cancer Biol (2006) 5.98
Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell (2009) 5.49
HIF-dependent antitumorigenic effect of antioxidants in vivo. Cancer Cell (2007) 4.81
MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell (2009) 4.47
Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. Nat Med (2010) 4.23
Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing. Proc Natl Acad Sci U S A (2004) 3.85
Melamine-contaminated powdered formula and urolithiasis in young children. N Engl J Med (2009) 3.46
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol (2002) 3.23
Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Res (2006) 3.12
Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology (2011) 3.05
Advanced materials for energy storage. Adv Mater (2010) 3.04
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet (2010) 2.95
Genetic evidence supports demic diffusion of Han culture. Nature (2004) 2.92
Fatty liver and the metabolic syndrome among Shanghai adults. J Gastroenterol Hepatol (2005) 2.67
JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. J Neurosci (2009) 2.64
Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis. Mol Cell (2013) 2.61
VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. Neuron (2010) 2.54
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest (2009) 2.52
Mechanism of induction and suppression of antiviral immunity directed by virus-derived small RNAs in Drosophila. Cell Host Microbe (2008) 2.48
Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol (2002) 2.45
Suppression of antiviral silencing by cucumber mosaic virus 2b protein in Arabidopsis is associated with drastically reduced accumulation of three classes of viral small interfering RNAs. Plant Cell (2007) 2.43
Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov (2013) 2.43
Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci U S A (2003) 2.32
Global surveillance of emerging Influenza virus genotypes by mass spectrometry. PLoS One (2007) 2.29
Controllable self-assembly of nanoparticles for specific delivery of multiple therapeutic molecules to cancer cells using RNA nanotechnology. Nano Lett (2005) 2.22
Prevalence of and risk factors for fatty liver in a general population of Shanghai, China. J Hepatol (2005) 2.21
Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts. Cancer Res (2010) 2.13
Global regulation of nucleotide biosynthetic genes by c-Myc. PLoS One (2008) 2.12
STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood (2006) 2.12
Human immunodeficiency virus (HIV)-negative plasmablastic lymphoma: a single institutional experience and literature review. Leuk Res (2011) 2.10
Risk Factors for Central Compartment Lymph Node Metastasis in Papillary Thyroid Microcarcinoma: A Meta-Analysis. World J Surg (2015) 2.09
Analysis of MiR-195 and MiR-497 expression, regulation and role in breast cancer. Clin Cancer Res (2011) 2.08
HS2 enhancer function is blocked by a transcriptional terminator inserted between the enhancer and the promoter. J Biol Chem (2004) 2.01
Enhancement of learning and memory by elevating brain magnesium. Neuron (2010) 2.00
GGA proteins mediate the recycling pathway of memapsin 2 (BACE). J Biol Chem (2004) 1.99
Atomic origins of the high catalytic activity of nanoporous gold. Nat Mater (2012) 1.87
Isolation of a novel swine influenza virus from Oklahoma in 2011 which is distantly related to human influenza C viruses. PLoS Pathog (2013) 1.83
High-energy MnO2 nanowire/graphene and graphene asymmetric electrochemical capacitors. ACS Nano (2010) 1.81
Complexin cross-links prefusion SNAREs into a zigzag array. Nat Struct Mol Biol (2011) 1.81
The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3. Proc Natl Acad Sci U S A (2003) 1.80
Ribosome dysfunction is an early event in Alzheimer's disease. J Neurosci (2005) 1.80
Integrating multiple 'omics' analysis for microbial biology: application and methodologies. Microbiology (2009) 1.79
Rapid identification of emerging infectious agents using PCR and electrospray ionization mass spectrometry. Ann N Y Acad Sci (2007) 1.79
Graphene anchored with co(3)o(4) nanoparticles as anode of lithium ion batteries with enhanced reversible capacity and cyclic performance. ACS Nano (2010) 1.78
Characterization of a novel influenza virus in cattle and Swine: proposal for a new genus in the Orthomyxoviridae family. MBio (2014) 1.75
Generation of PPARγ mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning. Cell Res (2011) 1.74
NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells. J Biol Chem (2004) 1.73
Genotypic variation and mixtures of Lyme Borrelia in Ixodes ticks from North America and Europe. PLoS One (2010) 1.73
Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium. J Biol Chem (2004) 1.72
Methylation-mediated repression of microRNA 129-2 enhances oncogenic SOX4 expression in HCC. Liver Int (2013) 1.71
In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (Bevirimat). J Virol (2006) 1.70
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP. Hum Mol Genet (2011) 1.68
Budding of equine infectious anemia virus is insensitive to proteasome inhibitors. J Virol (2002) 1.67
EUS and survival in patients with pancreatic cancer: a population-based study. Gastrointest Endosc (2010) 1.66
Lung cancer: performance of automated lung nodule detection applied to cancers missed in a CT screening program. Radiology (2002) 1.66
3D aperiodic hierarchical porous graphitic carbon material for high-rate electrochemical capacitive energy storage. Angew Chem Int Ed Engl (2008) 1.64
The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Cancer Cell (2006) 1.63
Computer-aided diagnosis in thoracic CT. Semin Ultrasound CT MR (2005) 1.63
Photoperiod- and thermo-sensitive genic male sterility in rice are caused by a point mutation in a novel noncoding RNA that produces a small RNA. Cell Res (2012) 1.63
Identification of miniature inverted-repeat transposable elements (MITEs) and biogenesis of their siRNAs in the Solanaceae: new functional implications for MITEs. Genome Res (2008) 1.63
Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression. Hepatology (2009) 1.62
Bacterial effector binding to ribosomal protein s3 subverts NF-kappaB function. PLoS Pathog (2009) 1.61
Moderate cardiac-selective overexpression of angiotensin II type 2 receptor protects cardiac functions from ischaemic injury. Exp Physiol (2011) 1.61
A facilitated tracking and transcription mechanism of long-range enhancer function. Nucleic Acids Res (2007) 1.60
Crystal structure of the T315I mutant of AbI kinase. Chem Biol Drug Des (2007) 1.60
Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients. Clin Cancer Res (2009) 1.59
Digital image analysis of EUS images accurately differentiates pancreatic cancer from chronic pancreatitis and normal tissue. Gastrointest Endosc (2008) 1.59
Mortality rates among prevalent hemodialysis patients in Beijing: a comparison with USRDS data. Nephrol Dial Transplant (2012) 1.59
3-O-(3',3'-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 Gag precursor assembled in vitro. J Virol (2006) 1.58
IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain. Sci Signal (2009) 1.57
Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease. J Am Soc Nephrol (2008) 1.56
p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2). J Biol Chem (2012) 1.55
Development of polydimethylsiloxane substrates with tunable elastic modulus to study cell mechanobiology in muscle and nerve. PLoS One (2012) 1.54
RNA silencing: a conserved antiviral immunity of plants and animals. Virus Res (2004) 1.54
Determinants of the incidence of hand, foot and mouth disease in China using geographically weighted regression models. PLoS One (2012) 1.52
Direct broad-range detection of alphaviruses in mosquito extracts. Virology (2007) 1.52
Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. J Biol Chem (2007) 1.52
Functional inactivation of a transcriptional corepressor by a signaling kinase. Nat Struct Biol (2003) 1.50
Loss of melanopsin-containing retinal ganglion cells in a rat glaucoma model. Chin Med J (Engl) (2008) 1.48
Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice. Cell Res (2011) 1.48
Mass screening for prostate cancer: a comparative study in Natori, Japan and Changchun, China. Urology (2003) 1.47
A molecular and functional analysis of large granular lymphocyte expansions in patients with chronic myelogenous leukemia treated with tyrosine kinase inhibitors. Leuk Lymphoma (2011) 1.47
Fabrication of Graphene/Polyaniline Composite Paper via In Situ Anodic Electropolymerization for High-Performance Flexible Electrode. ACS Nano (2009) 1.47
MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma. Proc Natl Acad Sci U S A (2002) 1.47
Efficacy of catheter ablation and surgical CryoMaze procedure in patients with long-lasting persistent atrial fibrillation and rheumatic heart disease: a randomized trial. Eur Heart J (2010) 1.47
Effects of a dental adhesive incorporating antibacterial monomer on the growth, adherence and membrane integrity of Streptococcus mutans. J Dent (2009) 1.46
TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. J Clin Invest (2012) 1.44
Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma. J Biol Chem (2005) 1.43
Doped graphene sheets as anode materials with superhigh rate and large capacity for lithium ion batteries. ACS Nano (2011) 1.43
Matrix metalloproteinases in human sclerotic dentine of attrited molars. Arch Oral Biol (2012) 1.42
Morphological and physiological responses to sediment type and light availability in roots of the submerged plant Myriophyllum spicatum. Ann Bot (2007) 1.42
Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera. Gastroenterology (2007) 1.42
Dual function of Arabidopsis ATAF1 in abiotic and biotic stress responses. Cell Res (2009) 1.41
Single molecule detection from a large-scale SERS-active Au₇₉Ag₂₁ substrate. Sci Rep (2011) 1.41