1
|
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations.
|
Hum Mol Genet
|
2005
|
4.12
|
2
|
Hepatocytes from non-hepatic adult stem cells.
|
Nature
|
2000
|
3.27
|
3
|
Epidermal growth factor (EGF/URO) induces expression of regulatory peptides in damaged human gastrointestinal tissues.
|
J Pathol
|
1990
|
2.29
|
4
|
Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma.
|
Lab Invest
|
1999
|
2.10
|
5
|
A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer.
|
J Biol Chem
|
1999
|
2.09
|
6
|
Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease.
|
Gastroenterology
|
1993
|
1.97
|
7
|
E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study.
|
Am J Pathol
|
1993
|
1.89
|
8
|
Bcl-2 expression in adult and embryonic non-haematopoietic tissues.
|
J Pathol
|
1993
|
1.78
|
9
|
CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer.
|
Gut
|
2010
|
1.63
|
10
|
Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon.
|
Gut
|
2002
|
1.60
|
11
|
Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa.
|
Gut
|
2000
|
1.59
|
12
|
Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule.
|
Genomics
|
1995
|
1.59
|
13
|
Wnt5a cloning, expression, and up-regulation in human primary breast cancers.
|
Clin Cancer Res
|
1995
|
1.56
|
14
|
Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach.
|
Gastroenterology
|
1993
|
1.55
|
15
|
Experimental ulceration leads to sequential expression of spasmolytic polypeptide, intestinal trefoil factor, epidermal growth factor and transforming growth factor alpha mRNAs in rat stomach.
|
J Pathol
|
1995
|
1.51
|
16
|
hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus.
|
Proc Natl Acad Sci U S A
|
1993
|
1.48
|
17
|
The epidermal growth factor receptor in human pancreatic cancer.
|
J Pathol
|
1992
|
1.47
|
18
|
Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types.
|
J Pathol
|
1998
|
1.41
|
19
|
Trefoil peptides.
|
Gut
|
1999
|
1.41
|
20
|
Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer.
|
Cancer Res
|
1995
|
1.40
|
21
|
Transgenic mice that overexpress the human trefoil peptide pS2 have an increased resistance to intestinal damage.
|
Proc Natl Acad Sci U S A
|
1996
|
1.29
|
22
|
Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome.
|
Br J Cancer
|
1995
|
1.26
|
23
|
An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas.
|
Glycobiology
|
1999
|
1.23
|
24
|
The ulceration-associated cell lineage (UACL) reiterates the Brunner's gland differentiation programme but acquires the proliferative organization of the gastric gland.
|
J Pathol
|
1994
|
1.23
|
25
|
Stromelysin 3: an independent prognostic factor for relapse-free survival in node-positive breast cancer and demonstration of novel breast carcinoma cell expression.
|
Am J Pathol
|
1998
|
1.20
|
26
|
Up-regulation of macrophage wnt gene expression in adenoma-carcinoma progression of human colorectal cancer.
|
Br J Cancer
|
1999
|
1.19
|
27
|
Interactions between stromal cell--derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia.
|
J Clin Invest
|
1998
|
1.19
|
28
|
Paneth cell granule depletion in the human small intestine under infective and nutritional stress.
|
Clin Exp Immunol
|
2004
|
1.18
|
29
|
The expression of the trefoil peptides pS2 and human spasmolytic polypeptide (hSP) in 'gastric metaplasia' of the proximal duodenum: implications for the nature of 'gastric metaplasia'.
|
J Pathol
|
1993
|
1.17
|
30
|
The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer.
|
Br J Cancer
|
2002
|
1.16
|
31
|
Differential expression of vascular endothelial growth factor mRNA vs protein isoform expression in human breast cancer and relationship to eIF-4E.
|
Br J Cancer
|
1998
|
1.16
|
32
|
Update on hepatic stem cells.
|
Liver
|
2001
|
1.15
|
33
|
Bone marrow transplantation ameliorates pathology in interleukin-10 knockout colitic mice.
|
J Pathol
|
2006
|
1.12
|
34
|
Allelic loss at SMAD4 in polyps from juvenile polyposis patients and use of fluorescence in situ hybridization to demonstrate clonal origin of the epithelium.
|
Cancer Res
|
2000
|
1.11
|
35
|
The new stem cell biology: something for everyone.
|
Mol Pathol
|
2003
|
1.10
|
36
|
MT1-MMP and MMP-2 mRNA expression in human ovarian tumors: possible implications for the role of desmoplastic fibroblasts.
|
Hum Pathol
|
1998
|
1.09
|
37
|
Keratinocyte growth factor in inflammatory bowel disease. Increased mRNA transcripts in ulcerative colitis compared with Crohn's disease in biopsies and isolated mucosal myofibroblasts.
|
Am J Pathol
|
1997
|
1.07
|
38
|
Cell behavior in the acetylaminofluorene-treated regenerating rat liver. Light and electron microscopic observations.
|
Am J Pathol
|
1994
|
1.06
|
39
|
Duodenal-content reflux esophagitis induces the development of glandular metaplasia and adenosquamous carcinoma in rats.
|
Carcinogenesis
|
2000
|
1.06
|
40
|
Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer.
|
Carcinogenesis
|
2006
|
1.04
|
41
|
Expression of beta-catenin in basal cell carcinoma.
|
Br J Dermatol
|
2003
|
1.04
|
42
|
Invasive lobular and invasive ductal carcinoma of the breast show distinct patterns of vascular endothelial growth factor expression and angiogenesis.
|
J Pathol
|
1998
|
1.04
|
43
|
Differential expression of oestrogen receptor and oestrogen inducible genes in gastric mucosa and cancer.
|
Gut
|
1997
|
1.02
|
44
|
Repopulation of human pulmonary epithelium by bone marrow cells: a potential means to promote repair.
|
Tissue Eng
|
2005
|
1.02
|
45
|
Expression of the trefoil peptides pS2 and human spasmolytic polypeptide (hSP) in Barrett's metaplasia and the native oesophageal epithelium: delineation of epithelial phenotype.
|
J Pathol
|
1994
|
1.02
|
46
|
Distribution and expression of pancreatic secretory trypsin inhibitor and its possible role in epithelial restitution.
|
Am J Pathol
|
1996
|
1.02
|
47
|
Roles of hepatocyte growth factor and its receptor Met during gastric ulcer healing in rats.
|
Gastroenterology
|
1997
|
1.02
|
48
|
The production and characterization of a new monoclonal antibody to the trefoil peptide human spasmolytic polypeptide.
|
Histochem J
|
1994
|
1.01
|
49
|
The mucous neck cell in the human gastric corpus: a distinctive, functional cell lineage.
|
J Pathol
|
1999
|
1.01
|
50
|
Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract.
|
Am J Pathol
|
1996
|
1.00
|
51
|
Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line.
|
Cell Growth Differ
|
1994
|
1.00
|
52
|
The expression of E-cadherin and catenins in sporadic colorectal carcinoma.
|
Hum Pathol
|
2001
|
0.99
|
53
|
Identification of transmembrane proteins as potential prognostic markers and therapeutic targets in breast cancer by a screen for signal sequence encoding transcripts.
|
J Pathol
|
2006
|
0.98
|
54
|
Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland.
|
J Cell Sci
|
1997
|
0.98
|
55
|
The pattern of expression of the microtubule-binding protein RHAMM/IHABP in mammary carcinoma suggests a role in the invasive behaviour of tumour cells.
|
J Pathol
|
2001
|
0.97
|
56
|
Expression and purification of a trefoil peptide motif in a beta-galactosidase fusion protein and its use to search for trefoil-binding sites.
|
Eur J Biochem
|
1993
|
0.96
|
57
|
Primary mucinous carcinomas of the skin express TFF1, TFF3, estrogen receptor, and progesterone receptors.
|
Am J Surg Pathol
|
1998
|
0.95
|
58
|
Localization of intestinal trefoil-factor mRNA in rat stomach and intestine by hybridization in situ.
|
Biochem J
|
1992
|
0.95
|
59
|
Nonuniform expression of a mouse mammary tumor virus-driven int-2/Fgf-3 transgene in pregnancy-responsive breast tumors.
|
Cell Growth Differ
|
1992
|
0.94
|
60
|
Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation.
|
Oncogene
|
2012
|
0.93
|
61
|
Hyperplastic polyps: a cell lineage which both synthesizes and secretes trefoil-peptides and has phenotypic similarity with the ulcer-associated cell lineage.
|
Am J Pathol
|
1993
|
0.93
|
62
|
Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.
|
Xenobiotica
|
1997
|
0.93
|
63
|
Expression of trefoil peptides in the gastric mucosa of transgenic mice overexpressing transforming growth factor-alpha.
|
Growth Factors
|
1996
|
0.92
|
64
|
Basal cell carcinoma development is associated with induction of the expression of the transcription factor Gli-1.
|
Br J Dermatol
|
1998
|
0.92
|
65
|
mRNA expression profiling of phyllodes tumours of the breast: identification of genes important in the development of borderline and malignant phyllodes tumours.
|
J Pathol
|
2008
|
0.92
|
66
|
The gene encoding mouse intestinal trefoil factor: structural organization, partial sequence analysis and mapping to murine chromosome 17q.
|
Gene
|
1996
|
0.92
|
67
|
Comprehensive analysis of SMAD4 mutations and protein expression in juvenile polyposis: evidence for a distinct genetic pathway and polyp morphology in SMAD4 mutation carriers.
|
Am J Pathol
|
2001
|
0.92
|
68
|
The cellular origin and proliferative status of regenerating renal parenchyma after mercuric chloride damage and erythropoietin treatment.
|
Cell Prolif
|
2007
|
0.92
|
69
|
In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours.
|
J Pathol
|
2000
|
0.92
|
70
|
BAG-i expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data.
|
J Pathol
|
2002
|
0.91
|
71
|
Top down or bottom up? Competing management structures in the morphogenesis of colorectal neoplasms.
|
Gut
|
2002
|
0.91
|
72
|
Trefoil factor expression in normal and diseased human salivary glands.
|
Hum Pathol
|
2000
|
0.90
|
73
|
Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse.
|
Gastroenterology
|
2001
|
0.90
|
74
|
The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse.
|
J Pathol
|
2008
|
0.90
|
75
|
Analysis of foetal expression sites of human type II DNA topoisomerase alpha and beta mRNAs by in situ hybridisation.
|
Biochim Biophys Acta
|
1996
|
0.90
|
76
|
Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease.
|
Scand J Gastroenterol Suppl
|
1992
|
0.89
|
77
|
Tumour-promoting activity of altered WWP1 expression in breast cancer and its utility as a prognostic indicator.
|
J Pathol
|
2008
|
0.88
|
78
|
Regulation of stromal cell cyclooxygenase-2 in the ApcMin/+ mouse model of intestinal tumorigenesis.
|
Carcinogenesis
|
2005
|
0.88
|
79
|
Ulcer associated cell lineage glands expressing trefoil peptide genes are induced by chronic ulceration in ileal pouch mucosa.
|
Gut
|
2001
|
0.87
|
80
|
Effect of ectopic expression of rat trefoil factor family 3 (intestinal trefoil factor) in the jejunum of transgenic mice.
|
J Biol Chem
|
2001
|
0.87
|
81
|
Haematopoietic lineage-committed bone marrow cells, but not cloned cultured mesenchymal stem cells, contribute to regeneration of renal tubular epithelium after HgCl 2 -induced acute tubular injury.
|
Cell Prolif
|
2008
|
0.87
|
82
|
Expression of oestrogen receptor and oestrogen-inducible genes in pancreatic cancer.
|
Br J Surg
|
1997
|
0.87
|
83
|
Hepatic and renal differentiation from blood-borne stem cells.
|
Gene Ther
|
2002
|
0.86
|
84
|
H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer.
|
Mol Med
|
1996
|
0.86
|
85
|
Expression of hepatocyte growth factor mRNA during oval cell activation in the rat liver.
|
J Pathol
|
1993
|
0.86
|
86
|
The cloning, mapping and expression of a novel gene, BRL, related to the AF10 leukaemia gene.
|
Oncogene
|
1999
|
0.85
|
87
|
Expression of two related viral early genes in Epstein-Barr virus-associated tumors.
|
J Virol
|
2000
|
0.84
|
88
|
Keratinocyte growth factor and coeliac disease.
|
Gut
|
2001
|
0.83
|
89
|
Trefoil peptides: mitogens, motogens, or mirages?
|
J Clin Gastroenterol
|
1997
|
0.83
|
90
|
Expression of oestrogen receptor and oestrogen-inducible genes pS2 and ERD5 in large bowel mucosa and cancer.
|
J Pathol
|
1998
|
0.82
|
91
|
Inhibition of hexonate dehydrogenase and aldose reductase from bovine retina by sorbinil, statil, M79175 and valproate.
|
Biochem Pharmacol
|
1986
|
0.82
|
92
|
Proliferative populations in intestinal metaplasia: evidence of deregulation in Paneth and goblet cells, but not endocrine cells.
|
J Pathol
|
2000
|
0.82
|
93
|
Morphological changes of organs after sucrose or fructose feeding.
|
Prog Biochem Pharmacol
|
1986
|
0.82
|
94
|
Lysozyme gene expression in inflammatory bowel disease.
|
Gastroenterology
|
1992
|
0.81
|
95
|
Vascular endothelial growth factor transgenic mice exhibit reduced male fertility and placental rejection.
|
Mol Hum Reprod
|
2001
|
0.81
|
96
|
Expression of trefoil peptides pS2 and human spasmolytic polypeptide in gastric metaplasia at the margin of duodenal ulcers.
|
Gut
|
1995
|
0.81
|
97
|
Advantages of in situ hybridisation over direct or indirect in situ reverse transcriptase-polymerase chain reaction for localisation of galanin mRNA expression in rat small intestine and pituitary.
|
Histochem J
|
2001
|
0.80
|
98
|
Identification by differential display of a protein phosphatase-2A regulatory subunit preferentially expressed in malignant melanoma cells.
|
Int J Cancer
|
1999
|
0.80
|
99
|
Recipes for adult stem cell plasticity: fusion cuisine or readymade?
|
J Clin Pathol
|
2004
|
0.79
|
100
|
The effects of an aldose reductase inhibitor upon the sorbitol pathway, fructose-1-phosphate and lactate in the retina and nerve of streptozotocin-diabetic rats.
|
Exp Eye Res
|
1983
|
0.79
|
101
|
Persistent hyaloid vasculature and vitreal haemorrhage in albino rats: a morphological and histological study.
|
Exp Eye Res
|
1985
|
0.79
|
102
|
Exogenous bone marrow cells do not rescue non-irradiated mice from acute renal tubular damage caused by HgCl2, despite establishment of chimaerism and cell proliferation in bone marrow and spleen.
|
Cell Prolif
|
2008
|
0.79
|
103
|
The gene encoding human intestinal trefoil factor (TFF3) is located on chromosome 21q22.3 clustered with other members of the trefoil peptide family.
|
Genomics
|
1996
|
0.78
|
104
|
Duodenal content reflux esophagitis in the rat: an animal model for the ulcer-associated cell lineage (UACL)?
|
Am J Pathol
|
1997
|
0.78
|
105
|
Comparison of isotopic and non-isotopic labelling for in situ hybridisation of various mRNA targets with cRNA probes.
|
Eur J Histochem
|
1998
|
0.77
|
106
|
Distinct roles for S100a8 in early embryo development and in the maternal deciduum.
|
Dev Dyn
|
2011
|
0.77
|
107
|
The effects of long-term treatment of streptozotocin-diabetic rats with an aldose reductase inhibitor.
|
Exp Eye Res
|
1983
|
0.77
|
108
|
Trefoil peptides and surgical disease.
|
Br J Surg
|
1999
|
0.77
|
109
|
Upregulation of keratinocyte growth factor during T-cell immunity in the gut mucosa.
|
Ann N Y Acad Sci
|
1998
|
0.76
|
110
|
Antibody targeting studies in a transgenic murine model of spontaneous colorectal tumors.
|
Proc Natl Acad Sci U S A
|
2001
|
0.76
|
111
|
Inhibition of aldose reductase in five tissues of the streptozotocin-diabetic rat.
|
Biochem Pharmacol
|
1983
|
0.76
|
112
|
COX-2 in murine intestinal tumors.
|
Gastroenterology
|
2000
|
0.75
|
113
|
Streptozotocin-diabetes but not galactose-feeding increases the serum concentration of type IV collagen antigens in rats.
|
Diabetes Res
|
1990
|
0.75
|
114
|
Inhibition of aldose reductase from human retina.
|
Curr Eye Res
|
1987
|
0.75
|
115
|
[The cell line associated with ulcer and trefoil peptides: a system of gastrointestinal mucosal repair].
|
Gastroenterol Hepatol
|
2000
|
0.75
|
116
|
Comparison of aldose reductase inhibitors in vitro. Effects of enzyme purification and substrate type.
|
Biochem Pharmacol
|
1987
|
0.75
|
117
|
Making sense out of in situ PCR.
|
J Pathol
|
1997
|
0.75
|
118
|
The anti-proliferative effect of plasma from rats with acute fulminant hepatic failure.
|
Scand J Gastroenterol
|
1997
|
0.75
|
119
|
Some effects of aldose reductase inhibition upon the eyes of long-term streptozotocin-diabetic rats.
|
Curr Eye Res
|
1983
|
0.75
|
120
|
Aldose reductases from human retina and bovine lens: dependence of inhibition upon the choice of enzyme substrate.
|
Prog Clin Biol Res
|
1987
|
0.75
|
121
|
A new computer method for the measurement of the thickness of basement membranes.
|
Comput Biol Med
|
1989
|
0.75
|