R Poulsom

Author PubWeight™ 122.25‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum Mol Genet 2005 4.12
2 Hepatocytes from non-hepatic adult stem cells. Nature 2000 3.27
3 Epidermal growth factor (EGF/URO) induces expression of regulatory peptides in damaged human gastrointestinal tissues. J Pathol 1990 2.29
4 Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Lab Invest 1999 2.10
5 A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. J Biol Chem 1999 2.09
6 Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease. Gastroenterology 1993 1.97
7 E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study. Am J Pathol 1993 1.89
8 Bcl-2 expression in adult and embryonic non-haematopoietic tissues. J Pathol 1993 1.78
9 CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer. Gut 2010 1.63
10 Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon. Gut 2002 1.60
11 Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa. Gut 2000 1.59
12 Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule. Genomics 1995 1.59
13 Wnt5a cloning, expression, and up-regulation in human primary breast cancers. Clin Cancer Res 1995 1.56
14 Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach. Gastroenterology 1993 1.55
15 Experimental ulceration leads to sequential expression of spasmolytic polypeptide, intestinal trefoil factor, epidermal growth factor and transforming growth factor alpha mRNAs in rat stomach. J Pathol 1995 1.51
16 hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus. Proc Natl Acad Sci U S A 1993 1.48
17 The epidermal growth factor receptor in human pancreatic cancer. J Pathol 1992 1.47
18 Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types. J Pathol 1998 1.41
19 Trefoil peptides. Gut 1999 1.41
20 Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer. Cancer Res 1995 1.40
21 Transgenic mice that overexpress the human trefoil peptide pS2 have an increased resistance to intestinal damage. Proc Natl Acad Sci U S A 1996 1.29
22 Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome. Br J Cancer 1995 1.26
23 An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas. Glycobiology 1999 1.23
24 The ulceration-associated cell lineage (UACL) reiterates the Brunner's gland differentiation programme but acquires the proliferative organization of the gastric gland. J Pathol 1994 1.23
25 Stromelysin 3: an independent prognostic factor for relapse-free survival in node-positive breast cancer and demonstration of novel breast carcinoma cell expression. Am J Pathol 1998 1.20
26 Up-regulation of macrophage wnt gene expression in adenoma-carcinoma progression of human colorectal cancer. Br J Cancer 1999 1.19
27 Interactions between stromal cell--derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia. J Clin Invest 1998 1.19
28 Paneth cell granule depletion in the human small intestine under infective and nutritional stress. Clin Exp Immunol 2004 1.18
29 The expression of the trefoil peptides pS2 and human spasmolytic polypeptide (hSP) in 'gastric metaplasia' of the proximal duodenum: implications for the nature of 'gastric metaplasia'. J Pathol 1993 1.17
30 The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer. Br J Cancer 2002 1.16
31 Differential expression of vascular endothelial growth factor mRNA vs protein isoform expression in human breast cancer and relationship to eIF-4E. Br J Cancer 1998 1.16
32 Update on hepatic stem cells. Liver 2001 1.15
33 Bone marrow transplantation ameliorates pathology in interleukin-10 knockout colitic mice. J Pathol 2006 1.12
34 Allelic loss at SMAD4 in polyps from juvenile polyposis patients and use of fluorescence in situ hybridization to demonstrate clonal origin of the epithelium. Cancer Res 2000 1.11
35 The new stem cell biology: something for everyone. Mol Pathol 2003 1.10
36 MT1-MMP and MMP-2 mRNA expression in human ovarian tumors: possible implications for the role of desmoplastic fibroblasts. Hum Pathol 1998 1.09
37 Keratinocyte growth factor in inflammatory bowel disease. Increased mRNA transcripts in ulcerative colitis compared with Crohn's disease in biopsies and isolated mucosal myofibroblasts. Am J Pathol 1997 1.07
38 Cell behavior in the acetylaminofluorene-treated regenerating rat liver. Light and electron microscopic observations. Am J Pathol 1994 1.06
39 Duodenal-content reflux esophagitis induces the development of glandular metaplasia and adenosquamous carcinoma in rats. Carcinogenesis 2000 1.06
40 Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer. Carcinogenesis 2006 1.04
41 Expression of beta-catenin in basal cell carcinoma. Br J Dermatol 2003 1.04
42 Invasive lobular and invasive ductal carcinoma of the breast show distinct patterns of vascular endothelial growth factor expression and angiogenesis. J Pathol 1998 1.04
43 Differential expression of oestrogen receptor and oestrogen inducible genes in gastric mucosa and cancer. Gut 1997 1.02
44 Repopulation of human pulmonary epithelium by bone marrow cells: a potential means to promote repair. Tissue Eng 2005 1.02
45 Expression of the trefoil peptides pS2 and human spasmolytic polypeptide (hSP) in Barrett's metaplasia and the native oesophageal epithelium: delineation of epithelial phenotype. J Pathol 1994 1.02
46 Distribution and expression of pancreatic secretory trypsin inhibitor and its possible role in epithelial restitution. Am J Pathol 1996 1.02
47 Roles of hepatocyte growth factor and its receptor Met during gastric ulcer healing in rats. Gastroenterology 1997 1.02
48 The production and characterization of a new monoclonal antibody to the trefoil peptide human spasmolytic polypeptide. Histochem J 1994 1.01
49 The mucous neck cell in the human gastric corpus: a distinctive, functional cell lineage. J Pathol 1999 1.01
50 Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract. Am J Pathol 1996 1.00
51 Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line. Cell Growth Differ 1994 1.00
52 The expression of E-cadherin and catenins in sporadic colorectal carcinoma. Hum Pathol 2001 0.99
53 Identification of transmembrane proteins as potential prognostic markers and therapeutic targets in breast cancer by a screen for signal sequence encoding transcripts. J Pathol 2006 0.98
54 Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland. J Cell Sci 1997 0.98
55 The pattern of expression of the microtubule-binding protein RHAMM/IHABP in mammary carcinoma suggests a role in the invasive behaviour of tumour cells. J Pathol 2001 0.97
56 Expression and purification of a trefoil peptide motif in a beta-galactosidase fusion protein and its use to search for trefoil-binding sites. Eur J Biochem 1993 0.96
57 Primary mucinous carcinomas of the skin express TFF1, TFF3, estrogen receptor, and progesterone receptors. Am J Surg Pathol 1998 0.95
58 Localization of intestinal trefoil-factor mRNA in rat stomach and intestine by hybridization in situ. Biochem J 1992 0.95
59 Nonuniform expression of a mouse mammary tumor virus-driven int-2/Fgf-3 transgene in pregnancy-responsive breast tumors. Cell Growth Differ 1992 0.94
60 Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation. Oncogene 2012 0.93
61 Hyperplastic polyps: a cell lineage which both synthesizes and secretes trefoil-peptides and has phenotypic similarity with the ulcer-associated cell lineage. Am J Pathol 1993 0.93
62 Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization. Xenobiotica 1997 0.93
63 Expression of trefoil peptides in the gastric mucosa of transgenic mice overexpressing transforming growth factor-alpha. Growth Factors 1996 0.92
64 Basal cell carcinoma development is associated with induction of the expression of the transcription factor Gli-1. Br J Dermatol 1998 0.92
65 mRNA expression profiling of phyllodes tumours of the breast: identification of genes important in the development of borderline and malignant phyllodes tumours. J Pathol 2008 0.92
66 The gene encoding mouse intestinal trefoil factor: structural organization, partial sequence analysis and mapping to murine chromosome 17q. Gene 1996 0.92
67 Comprehensive analysis of SMAD4 mutations and protein expression in juvenile polyposis: evidence for a distinct genetic pathway and polyp morphology in SMAD4 mutation carriers. Am J Pathol 2001 0.92
68 The cellular origin and proliferative status of regenerating renal parenchyma after mercuric chloride damage and erythropoietin treatment. Cell Prolif 2007 0.92
69 In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours. J Pathol 2000 0.92
70 BAG-i expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data. J Pathol 2002 0.91
71 Top down or bottom up? Competing management structures in the morphogenesis of colorectal neoplasms. Gut 2002 0.91
72 Trefoil factor expression in normal and diseased human salivary glands. Hum Pathol 2000 0.90
73 Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse. Gastroenterology 2001 0.90
74 The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse. J Pathol 2008 0.90
75 Analysis of foetal expression sites of human type II DNA topoisomerase alpha and beta mRNAs by in situ hybridisation. Biochim Biophys Acta 1996 0.90
76 Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease. Scand J Gastroenterol Suppl 1992 0.89
77 Tumour-promoting activity of altered WWP1 expression in breast cancer and its utility as a prognostic indicator. J Pathol 2008 0.88
78 Regulation of stromal cell cyclooxygenase-2 in the ApcMin/+ mouse model of intestinal tumorigenesis. Carcinogenesis 2005 0.88
79 Ulcer associated cell lineage glands expressing trefoil peptide genes are induced by chronic ulceration in ileal pouch mucosa. Gut 2001 0.87
80 Effect of ectopic expression of rat trefoil factor family 3 (intestinal trefoil factor) in the jejunum of transgenic mice. J Biol Chem 2001 0.87
81 Haematopoietic lineage-committed bone marrow cells, but not cloned cultured mesenchymal stem cells, contribute to regeneration of renal tubular epithelium after HgCl 2 -induced acute tubular injury. Cell Prolif 2008 0.87
82 Expression of oestrogen receptor and oestrogen-inducible genes in pancreatic cancer. Br J Surg 1997 0.87
83 Hepatic and renal differentiation from blood-borne stem cells. Gene Ther 2002 0.86
84 H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer. Mol Med 1996 0.86
85 Expression of hepatocyte growth factor mRNA during oval cell activation in the rat liver. J Pathol 1993 0.86
86 The cloning, mapping and expression of a novel gene, BRL, related to the AF10 leukaemia gene. Oncogene 1999 0.85
87 Expression of two related viral early genes in Epstein-Barr virus-associated tumors. J Virol 2000 0.84
88 Keratinocyte growth factor and coeliac disease. Gut 2001 0.83
89 Trefoil peptides: mitogens, motogens, or mirages? J Clin Gastroenterol 1997 0.83
90 Expression of oestrogen receptor and oestrogen-inducible genes pS2 and ERD5 in large bowel mucosa and cancer. J Pathol 1998 0.82
91 Inhibition of hexonate dehydrogenase and aldose reductase from bovine retina by sorbinil, statil, M79175 and valproate. Biochem Pharmacol 1986 0.82
92 Proliferative populations in intestinal metaplasia: evidence of deregulation in Paneth and goblet cells, but not endocrine cells. J Pathol 2000 0.82
93 Morphological changes of organs after sucrose or fructose feeding. Prog Biochem Pharmacol 1986 0.82
94 Lysozyme gene expression in inflammatory bowel disease. Gastroenterology 1992 0.81
95 Vascular endothelial growth factor transgenic mice exhibit reduced male fertility and placental rejection. Mol Hum Reprod 2001 0.81
96 Expression of trefoil peptides pS2 and human spasmolytic polypeptide in gastric metaplasia at the margin of duodenal ulcers. Gut 1995 0.81
97 Advantages of in situ hybridisation over direct or indirect in situ reverse transcriptase-polymerase chain reaction for localisation of galanin mRNA expression in rat small intestine and pituitary. Histochem J 2001 0.80
98 Identification by differential display of a protein phosphatase-2A regulatory subunit preferentially expressed in malignant melanoma cells. Int J Cancer 1999 0.80
99 Recipes for adult stem cell plasticity: fusion cuisine or readymade? J Clin Pathol 2004 0.79
100 The effects of an aldose reductase inhibitor upon the sorbitol pathway, fructose-1-phosphate and lactate in the retina and nerve of streptozotocin-diabetic rats. Exp Eye Res 1983 0.79
101 Persistent hyaloid vasculature and vitreal haemorrhage in albino rats: a morphological and histological study. Exp Eye Res 1985 0.79
102 Exogenous bone marrow cells do not rescue non-irradiated mice from acute renal tubular damage caused by HgCl2, despite establishment of chimaerism and cell proliferation in bone marrow and spleen. Cell Prolif 2008 0.79
103 The gene encoding human intestinal trefoil factor (TFF3) is located on chromosome 21q22.3 clustered with other members of the trefoil peptide family. Genomics 1996 0.78
104 Duodenal content reflux esophagitis in the rat: an animal model for the ulcer-associated cell lineage (UACL)? Am J Pathol 1997 0.78
105 Comparison of isotopic and non-isotopic labelling for in situ hybridisation of various mRNA targets with cRNA probes. Eur J Histochem 1998 0.77
106 Distinct roles for S100a8 in early embryo development and in the maternal deciduum. Dev Dyn 2011 0.77
107 The effects of long-term treatment of streptozotocin-diabetic rats with an aldose reductase inhibitor. Exp Eye Res 1983 0.77
108 Trefoil peptides and surgical disease. Br J Surg 1999 0.77
109 Upregulation of keratinocyte growth factor during T-cell immunity in the gut mucosa. Ann N Y Acad Sci 1998 0.76
110 Antibody targeting studies in a transgenic murine model of spontaneous colorectal tumors. Proc Natl Acad Sci U S A 2001 0.76
111 Inhibition of aldose reductase in five tissues of the streptozotocin-diabetic rat. Biochem Pharmacol 1983 0.76
112 COX-2 in murine intestinal tumors. Gastroenterology 2000 0.75
113 Streptozotocin-diabetes but not galactose-feeding increases the serum concentration of type IV collagen antigens in rats. Diabetes Res 1990 0.75
114 Inhibition of aldose reductase from human retina. Curr Eye Res 1987 0.75
115 [The cell line associated with ulcer and trefoil peptides: a system of gastrointestinal mucosal repair]. Gastroenterol Hepatol 2000 0.75
116 Comparison of aldose reductase inhibitors in vitro. Effects of enzyme purification and substrate type. Biochem Pharmacol 1987 0.75
117 Making sense out of in situ PCR. J Pathol 1997 0.75
118 The anti-proliferative effect of plasma from rats with acute fulminant hepatic failure. Scand J Gastroenterol 1997 0.75
119 Some effects of aldose reductase inhibition upon the eyes of long-term streptozotocin-diabetic rats. Curr Eye Res 1983 0.75
120 Aldose reductases from human retina and bovine lens: dependence of inhibition upon the choice of enzyme substrate. Prog Clin Biol Res 1987 0.75
121 A new computer method for the measurement of the thickness of basement membranes. Comput Biol Med 1989 0.75