Published in J Biol Chem on August 05, 1991
The p2 domain of human immunodeficiency virus type 1 Gag regulates sequential proteolytic processing and is required to produce fully infectious virions. J Virol (1994) 3.95
Sequential steps in human immunodeficiency virus particle maturation revealed by alterations of individual Gag polyprotein cleavage sites. J Virol (1998) 3.84
The spacer peptide between human immunodeficiency virus capsid and nucleocapsid proteins is essential for ordered assembly and viral infectivity. J Virol (1995) 3.80
Cytoskeletal proteins inside human immunodeficiency virus type 1 virions. J Virol (1996) 2.65
Prediction of O-glycosylation of mammalian proteins: specificity patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase. Biochem J (1995) 1.81
Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease. J Virol (2002) 1.71
Drug resistance in HIV-1 protease: Flexibility-assisted mechanism of compensatory mutations. Protein Sci (2002) 1.54
Proteolytic processing of Ty3 proteins is required for transposition. J Virol (1993) 1.49
Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2. Proc Natl Acad Sci U S A (1996) 1.48
Mutational analysis of the hydrophobic tail of the human immunodeficiency virus type 1 p6(Gag) protein produces a mutant that fails to package its envelope protein. J Virol (1999) 1.25
Cleavage of human immunodeficiency virus type 1 proteinase from the N-terminally adjacent p6* protein is essential for efficient Gag polyprotein processing and viral infectivity. J Virol (1998) 1.25
A preference-based free-energy parameterization of enzyme-inhibitor binding. Applications to HIV-1-protease inhibitor design. Protein Sci (1995) 1.21
Mutational analysis of the C-terminal gag cleavage sites in human immunodeficiency virus type 1. J Virol (2007) 1.18
Prediction of protein domain with mRMR feature selection and analysis. PLoS One (2012) 1.12
Human immunodeficiency virus type-1 reverse transcriptase and ribonuclease H as substrates of the viral protease. Protein Sci (1993) 0.99
Structural basis for distinctions between substrate and inhibitor specificities for feline immunodeficiency virus and human immunodeficiency virus proteases. J Virol (2003) 0.97
Active-site mobility in human immunodeficiency virus, type 1, protease as demonstrated by crystal structure of A28S mutant. Protein Sci (1998) 0.96
Alteration of substrate and inhibitor specificity of feline immunodeficiency virus protease. J Virol (2000) 0.94
A sequence-coupled vector-projection model for predicting the specificity of GalNAc-transferase. Protein Sci (1995) 0.94
Molecular analysis of the feline immunodeficiency virus protease: generation of a novel form of the protease by autoproteolysis and construction of cleavage-resistant proteases. J Virol (1997) 0.94
Comprehensive bioinformatic analysis of the specificity of human immunodeficiency virus type 1 protease. J Virol (2005) 0.93
Analysis of cleavage site mutations between the NC and PR Gag domains of Rous sarcoma virus. J Virol (1997) 0.90
iEzy-drug: a web server for identifying the interaction between enzymes and drugs in cellular networking. Biomed Res Int (2013) 0.85
Comparative studies on retroviral proteases: substrate specificity. Viruses (2010) 0.85
Local and spatial factors determining HIV-1 protease substrate recognition. Biochem J (2001) 0.84
Cloning and sequence analysis of a Bothrops jararaca cDNA encoding a precursor of seven bradykinin-potentiating peptides and a C-type natriuretic peptide. Proc Natl Acad Sci U S A (1997) 0.84
Synergistic binding of inhibitors to the protease from HIV type 1. Biochem J (1996) 0.84
A novel method for evaluation and screening of caspase inhibitory peptides by the amino acid positional fitness score. BMC Pharmacol (2004) 0.81
A PDZ domain-based assay for measuring HIV protease activity: assay design considerations. Protein Sci (2003) 0.79
Coevolutionary analysis of resistance-evading peptidomimetic inhibitors of HIV-1 protease. Proc Natl Acad Sci U S A (1999) 0.77
How to find simple and accurate rules for viral protease cleavage specificities. BMC Bioinformatics (2009) 0.77
Predicting sulfotyrosine sites using the random forest algorithm with significantly improved prediction accuracy. BMC Bioinformatics (2009) 0.76
Characterization of the protease domain of Rice tungro bacilliform virus responsible for the processing of the capsid protein from the polyprotein. Virol J (2005) 0.75
Amino acid analysis by reverse-phase high-performance liquid chromatography: precolumn derivatization with phenylisothiocyanate. Anal Biochem (1984) 5.85
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature (1999) 5.48
Amino acid sequence of human platelet factor 4. Proc Natl Acad Sci U S A (1977) 4.04
Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease. J Biol Chem (1993) 3.52
The determination of the concentration of hydrolytic enzyme solutions: alpha-chymotrypsin, trypsin, papain, elastase, subtilisin, and acetylcholinesterase. J Am Chem Soc (1966) 3.09
Platelet factor 4 is chemotactic for neutrophils and monocytes. Proc Natl Acad Sci U S A (1981) 3.03
A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation. Science (1990) 2.80
Amphiphilic secondary structure: design of peptide hormones. Science (1984) 2.71
An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection. Proc Natl Acad Sci U S A (1990) 2.32
Secondary structures of proteins and peptides in amphiphilic environments. (A review). Proc Natl Acad Sci U S A (1983) 2.26
Kinetics and mechanism of hemolysis induced by melittin and by a synthetic melittin analogue. Biophys J (1982) 2.03
Structure of human serum lipoproteins inferred from compositional analysis. Proc Natl Acad Sci U S A (1977) 1.95
Cation binding to the integrin CD11b I domain and activation model assessment. Structure (1998) 1.90
Amino acid sequence of phospholipase A2-alpha from the venom of Crotalus adamanteus. A new classification of phospholipases A2 based upon structural determinants. J Biol Chem (1977) 1.81
Nucleotide sequence and expression of the capsid protein gene of feline calicivirus. J Virol (1991) 1.78
The role of surface in the biological activities of trehalose 6,6'-dimycolate. Surface properties and development of a model system. J Biol Chem (1981) 1.66
The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13. J Biol Chem (1992) 1.63
Peptides with affinity for membranes. Annu Rev Biophys Biophys Chem (1987) 1.63
Effect of point mutations on the kinetics and the inhibition of human immunodeficiency virus type 1 protease: relationship to drug resistance. Biochemistry (1995) 1.56
The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase. J Biol Chem (1992) 1.55
The atomic-resolution structure of human caspase-8, a key activator of apoptosis. Structure (1999) 1.54
Evolution of phosphofructokinase--gene duplication and creation of new effector sites. Nature (1984) 1.52
The mechanism of activation of lecithin:cholesterol acyltransferase by apolipoprotein A-I and an amphiphilic peptide. J Biol Chem (1980) 1.50
Structure at 2.5-A resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene-based inhibitor. Biochemistry (1991) 1.48
The selective S-methylation of sulfhydryl groups in proteins and peptides with methyl-p-nitrobenzenesulfonate. J Biol Chem (1971) 1.41
The covalent and tertiary structure of bovine liver rhodanese. Nature (1978) 1.41
A new class of phospholipases A2 with lysine in place of aspartate 49. Functional consequences for calcium and substrate binding. J Biol Chem (1984) 1.38
Complete amino acid sequence of pig kidney fructose-1,6-bisphosphatase. Proc Natl Acad Sci U S A (1982) 1.37
Sequence of the bacteriophage SP01 gene coding for transcription factor 1, a viral homologue of the bacterial type II DNA-binding proteins. Proc Natl Acad Sci U S A (1984) 1.36
Amino acid sequence and characterization of a protein inhibitor of protein kinase C. J Biol Chem (1990) 1.32
Dissociative inhibition of dimeric enzymes. Kinetic characterization of the inhibition of HIV-1 protease by its COOH-terminal tetrapeptide. J Biol Chem (1991) 1.29
Interaction of the HpaI endonuclease with synthetic oligonucleotides. Biochemistry (1982) 1.29
Specificity and inhibition of proteases from human immunodeficiency viruses 1 and 2. J Biol Chem (1990) 1.29
Evidence for transbilayer, tail-to-tail cholesterol dimers in dipalmitoylglycerophosphocholine liposomes. Biochemistry (1995) 1.27
Substrate analogue inhibition and active site titration of purified recombinant HIV-1 protease. Biochemistry (1990) 1.26
The specificity of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase as inferred from a database of in vivo substrates and from the in vitro glycosylation of proteins and peptides. J Biol Chem (1993) 1.25
Active site cysteinyl and arginyl residues of rhodanese. A novel formation of disulfide bonds in the active site promoted by phenylglyoxal. J Biol Chem (1978) 1.24
Gene duplication in the evolution of the two complementing domains of gram-negative bacterial tetracycline efflux proteins. Gene (1990) 1.24
Purification and characterization of the principal inhibitor of calcium oxalate monohydrate crystal growth in human urine. J Biol Chem (1983) 1.22
Applications of thermolysin in protein structural analysis. Methods Enzymol (1977) 1.22
The covalent protein structure of insecticyanin, a blue biliprotein from the hemolymph of the tobacco hornworm, Manduca sexta L. J Biol Chem (1984) 1.21
Predicting human immunodeficiency virus protease cleavage sites in proteins by a discriminant function method. Proteins (1996) 1.20
Structural relationships in the adenylate kinase family. Eur J Biochem (1986) 1.18
Alpha-chymotrypsin: enzyme concentration and kinetics. J Chem Educ (1967) 1.18
Purification and properties of methionyl-transfer-ribonucleic acid synthetase from Escherichia coli. Biochem J (1967) 1.18
Purification, physical characterization, and NH2-terminal sequence of glutamine synthetase from the cyanobacterium Anabaena 7120. J Biol Chem (1981) 1.18
Structure of the complex of yeast adenylate kinase with the inhibitor P1,P5-di(adenosine-5'-)pentaphosphate at 2.6 A resolution. J Mol Biol (1987) 1.18
B- to Z-DNA transition probed by oligonucleotides containing methylphosphonates. Proc Natl Acad Sci U S A (1986) 1.17
Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus. J Biol Chem (1991) 1.16
Processing of the human heparanase precursor and evidence that the active enzyme is a heterodimer. J Biol Chem (1999) 1.16
Binding of amphiphilic peptides to phospholipid/cholesterol unilamellar vesicles: a model for protein--cholesterol interaction. Proc Natl Acad Sci U S A (1981) 1.15
Large scale purification and refolding of HIV-1 protease from Escherichia coli inclusion bodies. J Protein Chem (1993) 1.14
Crystal structure of a complex of HIV-1 protease with a dihydroxyethylene-containing inhibitor: comparisons with molecular modeling. Protein Sci (1992) 1.13
Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase. Mol Pharmacol (1993) 1.13
Apolipoproteins and the structural organization of plasma lipoproteins: human plasma high density lipoprotein-3. J Lipid Res (1979) 1.13
Anthranilate synthetase component II from Pseudomonas putida. Covalent structure and identification of the cysteine residue involved in catalysis. J Biol Chem (1978) 1.12
Silkmoth chorion proteins. Their diversity, amino acid composition, and the NH-terminal sequence of one component. J Biol Chem (1978) 1.12
Detection and kinetic behavior of preproinsulin in pancreatic islets. Proc Natl Acad Sci U S A (1978) 1.12
The complete amino acid sequence of adenylate kinase from baker's yeast. Eur J Biochem (1986) 1.11
Structural and functional properties of a phospholipase A2 purified from an inflammatory exudate. Biochemistry (1986) 1.11
Purification and characterization of a low molecular weight acid phosphatase from bovine liver. J Biol Chem (1969) 1.09
Purification and characterization of heterodimeric human immunodeficiency virus type 1 (HIV-1) reverse transcriptase produced by in vitro processing of p66 with recombinant HIV-1 protease. J Biol Chem (1992) 1.08
Covalent structural analysis of yeast inorganic pyrophosphatase. J Biol Chem (1978) 1.07
CXC chemokines connective tissue activating peptide-III and neutrophil activating peptide-2 are heparin/heparan sulfate-degrading enzymes. J Biol Chem (1995) 1.07
Molecular mechanism for dominance of a mutant allele of an ATP-dependent protease. J Mol Biol (1982) 1.06
Purification and characterization of a calcium oxalate monohydrate crystal growth inhibitor from human kidney tissue culture medium. J Biol Chem (1981) 1.05
Chain length-function correlation of amphiphilic peptides. Synthesis and surface properties of a tetratetracontapeptide segment of apolipoprotein A-I. J Biol Chem (1980) 1.04
On the alkylation of amino acid residues at the active site of ribonuclease. J Biol Chem (1966) 1.04
The Juvenile Hormone Binding Protein in the Hemolymph of Manduca sexta Johannson (Lepidoptera: Sphingidae). Proc Natl Acad Sci U S A (1974) 1.04
Specificity of retroviral proteases: an analysis of viral and nonviral protein substrates. Methods Enzymol (1994) 1.03
Targeting the HIV-protease in AIDS therapy: a current clinical perspective. Biochim Biophys Acta (2000) 1.03
Interdomain hydrolysis of a truncated Pseudomonas exotoxin by the human immunodeficiency virus-1 protease. J Biol Chem (1990) 1.03
Molecular structure of deoxycytidyl-3'-methylphosphonate (RP) 5'-deoxyguanidine, d[Cp(CH3)G]. A neutral dinucleotide with Watson-Crick base pairing and a right handed helical twist. Nucleic Acids Res (1990) 1.01
Chloroplast and cytoplasmic enzymes 1, 2, 3. Subunit structure of pea leaf aldolases. Arch Biochem Biophys (1975) 1.01
The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic transition state analog inhibitors. J Biol Chem (1993) 1.01
The kinetics of the Escherichia coli alkaline phosphatase catalyzed hydrolysis of 2,4-dinitrophenyl phosphate. J Am Chem Soc (1967) 1.00
Human immunodeficiency virus type-1 reverse transcriptase and ribonuclease H as substrates of the viral protease. Protein Sci (1993) 0.99
Surface properties of an amphiphilic peptide hormone and of its analog: corticotropin-releasing factor and sauvagine. Proc Natl Acad Sci U S A (1983) 0.99
Phosphorylation of rat hepatic fructose-1,6-bisphosphatase and pyruvate kinase. J Biol Chem (1980) 0.98
Catalysis by adsorbed enzymes. The hydrolysis of tripropionin by pancreatic lipase adsorbed to siliconized glass beads. J Biol Chem (1973) 0.97
HIV-1 protease cleaves actin during acute infection of human T-lymphocytes. AIDS Res Hum Retroviruses (1992) 0.97
Sequence analysis of bovine lens aldose reductase. J Biol Chem (1990) 0.97