Published in Respir Res on July 11, 2008
Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses. J Immunol (2012) 1.35
Imbalances between interleukin-1 and tumor necrosis factor agonists and antagonists in stable COPD. J Clin Immunol (2009) 1.10
Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency. Respir Res (2012) 0.88
Alpha1-antitrypsin deficiency: a clinical-genetic overview. Appl Clin Genet (2011) 0.77
The rs361525 polymorphism does not increase production of tumor necrosis factor alpha by monocytes from alpha-1 antitrypsin deficient subjects with chronic obstructive pulmonary disease - a pilot study. J Negat Results Biomed (2015) 0.77
Chronic productive cough and extensive cysts in left lung. Int J Gen Med (2011) 0.75
Inflammatory cytokine response to exercise in alpha-1-antitrypsin deficient COPD patients 'on' or 'off' augmentation therapy. BMC Pulm Med (2014) 0.75
Identification of Novel Short C-Terminal Transcripts of Human SERPINA1 Gene. PLoS One (2017) 0.75
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (2004) 125.23
The natural history of chronic airflow obstruction. Br Med J (1977) 13.04
Problems of reporting genetic associations with complex outcomes. Lancet (2003) 8.11
Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med (1996) 5.53
"Density mask". An objective method to quantitate emphysema using computed tomography. Chest (1988) 4.24
Computed tomography of bronchiectasis. J Comput Assist Tomogr (1982) 3.01
Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Am J Hum Genet (2001) 2.61
Local and systemic inflammation in patients with chronic obstructive pulmonary disease: soluble tumor necrosis factor receptors are increased in sputum. Am J Respir Crit Care Med (2002) 2.32
An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles. J Exp Med (1993) 2.30
Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol (2005) 2.08
Tumor necrosis factor-alpha levels and weight loss in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1994) 2.06
Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 1.88
Prevalence and impact of bronchiectasis in alpha1-antitrypsin deficiency. Am J Respir Crit Care Med (2007) 1.88
Oxidants/antioxidants and COPD. Chest (2000) 1.85
High-resolution computed tomography scanning in alpha1-antitrypsin deficiency: relationship to lung function and health status. Eur Respir J (2001) 1.71
The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2007) 1.70
Tumor necrosis factor-alpha gene polymorphism in chronic bronchitis. Am J Respir Crit Care Med (1997) 1.63
Familial prevalence of chronic obstructive pulmonary disease in a matched pair study. Am J Med (1977) 1.63
Chronic Obstructive Pulmonary Disease, inflammation and co-morbidity--a common inflammatory phenotype? Respir Res (2006) 1.51
Evidence for excessive bronchial inflammation during an acute exacerbation of chronic obstructive pulmonary disease in patients with alpha(1)-antitrypsin deficiency (PiZ). Am J Respir Crit Care Med (1999) 1.45
Cigarette smoking and health. American Thoracic Society. Am J Respir Crit Care Med (1996) 1.39
Different transcriptional activity and in vitro TNF-alpha production in psoriasis patients carrying the TNF-alpha 238A promoter polymorphism. J Invest Dermatol (2000) 1.32
The -308 tumour necrosis factor-alpha gene polymorphism predicts therapeutic response to TNFalpha-blockers in rheumatoid arthritis and spondyloarthritis patients. Rheumatology (Oxford) (2006) 1.31
Neutrophils and protease/antiprotease imbalance. Am J Respir Crit Care Med (1999) 1.30
Association of tumor necrosis factor alpha gene promoter polymorphism with the presence of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2001) 1.26
Longitudinal follow-up study of smoking-induced lung density changes by high-resolution computed tomography. Am J Respir Crit Care Med (2000) 1.21
Alpha 1-antitrypsin deficiency. 3: Clinical manifestations and natural history. Thorax (2004) 1.15
Genetic and environmental determinants of level of pulmonary function. Am J Epidemiol (1984) 1.14
Association of tumor necrosis factor-alpha gene promoter polymorphism with low attenuation areas on high-resolution CT in patients with COPD. Chest (2002) 1.11
Alpha1-antitrypsin suppresses TNF-alpha and MMP-12 production by cigarette smoke-stimulated macrophages. Am J Respir Cell Mol Biol (2007) 1.10
IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency. Am J Respir Cell Mol Biol (2007) 1.08
Endothelial nitric oxide synthase as a potential susceptibility gene in the pathogenesis of emphysema in alpha1-antitrypsin deficiency. Am J Respir Cell Mol Biol (1999) 1.06
Different cytokine patterns in bronchial biopsies in asthma and chronic bronchitis. Respir Med (1996) 1.05
Functional analysis of linker-scan mutants spanning the -376, -308, -244, and -238 polymorphic sites of the TNF-alpha promoter. Cytokine (2001) 1.04
Peculiarities of the GSTM1 0/0 genotype in French heavy smokers with various types of chronic bronchitis. Hum Genet (1997) 1.03
Inter-relationships between inflammatory markers in patients with stable COPD with bronchitis: intra-patient and inter-patient variability. Thorax (2007) 1.01
Radiologic and clinical features of COPD patients with discordant pulmonary physiology: lessons from alpha1-antitrypsin deficiency. Chest (2007) 0.99
TNFalpha polymorphisms and risk of psoriatic arthritis. Ann Rheum Dis (2005) 0.99
Tag SNP screening of the PDCD1 gene for association with Graves' disease. Clin Endocrinol (Oxf) (2007) 0.98
Variability of pulmonary function in alpha-1-antitrypsin deficiency: residual family resemblance beyond the effect of the Pi locus. Hum Hered (1990) 0.98
Synthetic serine elastase inhibitor reduces cigarette smoke-induced emphysema in guinea pigs. Am J Respir Crit Care Med (2002) 0.93
A systematic approach to the assessment of known TNF-alpha polymorphisms in Graves' disease. Genes Immun (2004) 0.91
Glutathione S-transferase P1 and lung function in patients with alpha1-antitrypsin deficiency and COPD. Chest (2005) 0.90
Linkage analysis of alpha 1-antitrypsin deficiency: lessons for complex diseases. Hum Hered (2001) 0.76
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med (2012) 22.96
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide. Am J Respir Crit Care Med (2007) 8.06
Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. Am J Med (2010) 3.24
Augmentation therapy for alpha1 antitrypsin deficiency: a meta-analysis. COPD (2009) 2.41
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genet (2011) 2.25
Prevalence and impact of bronchiectasis in alpha1-antitrypsin deficiency. Am J Respir Crit Care Med (2007) 1.88
Systemic inflammation and comorbidity in COPD: a result of 'overspill' of inflammatory mediators from the lungs? Review of the evidence. Thorax (2010) 1.82
Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature (2013) 1.79
Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood (2013) 1.73
A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians. Clin Endocrinol (Oxf) (2004) 1.64
An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2015) 1.63
Seven newly identified loci for autoimmune thyroid disease. Hum Mol Genet (2012) 1.57
Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis. J Clin Endocrinol Metab (2007) 1.57
Wnt signalling in lung development and diseases. Respir Res (2006) 1.55
Assessment of pulmonary neutrophilic inflammation in emphysema by quantitative positron emission tomography. Am J Respir Crit Care Med (2012) 1.53
Chronic Obstructive Pulmonary Disease, inflammation and co-morbidity--a common inflammatory phenotype? Respir Res (2006) 1.51
Association of the TSHR gene with Graves' disease: the first disease specific locus. Eur J Hum Genet (2005) 1.49
Pattern of emphysema distribution in alpha1-antitrypsin deficiency influences lung function impairment. Am J Respir Crit Care Med (2004) 1.43
Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nat Genet (2011) 1.30
Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Hum Mol Genet (2009) 1.26
Progression parameters for emphysema: a clinical investigation. Respir Med (2007) 1.22
Variability in densitometric assessment of pulmonary emphysema with computed tomography. Invest Radiol (2005) 1.19
The effect of augmentation therapy on bronchial inflammation in alpha1-antitrypsin deficiency. Am J Respir Crit Care Med (2002) 1.12
Influence of calibration on densitometric studies of emphysema progression using computed tomography. Am J Respir Crit Care Med (2004) 1.11
Imbalances between interleukin-1 and tumor necrosis factor agonists and antagonists in stable COPD. J Clin Immunol (2009) 1.10
Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure. JAMA (2010) 1.07
Inflammation in sputum relates to progression of disease in subjects with COPD: a prospective descriptive study. Respir Res (2006) 1.05
Association of PTPN22 haplotypes with Graves' disease. J Clin Endocrinol Metab (2006) 1.05
Early donor management increases the retrieval rate of lungs for transplantation. Ann Thorac Surg (2008) 1.01
Radiologic and clinical features of COPD patients with discordant pulmonary physiology: lessons from alpha1-antitrypsin deficiency. Chest (2007) 0.99
Donor ABCB1 variant associates with increased risk for kidney allograft failure. J Am Soc Nephrol (2012) 0.98
A randomized, placebo-controlled trial of a leukotriene synthesis inhibitor in patients with COPD. Chest (2002) 0.98
IgA1 protease. Int J Biochem Cell Biol (2005) 0.95
The genetics of chronic obstructive pulmonary disease. Respir Res (2006) 0.95
Alpha-1-antitrypsin replacement therapy: current status. Curr Opin Pulm Med (2006) 0.95
Detection of emphysema progression in alpha 1-antitrypsin deficiency using CT densitometry; methodological advances. Respir Res (2008) 0.93
Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2011) 0.92
Comparison of the sensitivities of 5 different computed tomography scanners for the assessment of the progression of pulmonary emphysema: a phantom study. Invest Radiol (2004) 0.92
Exploring the optimum approach to the use of CT densitometry in a randomised placebo-controlled study of augmentation therapy in alpha 1-antitrypsin deficiency. Respir Res (2009) 0.91
Thyroid stimulating hormone receptor (TSHR) intron 1 variants are major risk factors for Graves' disease in three European Caucasian cohorts. PLoS One (2010) 0.90
Tumor necrosis factor-{alpha} rs361525 polymorphism is associated with increased local production and downstream inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 0.90
Reported and unreported exacerbations of COPD: analysis by diary cards. Chest (2007) 0.90
Polyclonal free light chains: a biomarker of inflammatory disease or treatment target? F1000 Med Rep (2013) 0.90
Exacerbations of COPD diagnosed in primary care: changes in spirometry and relationship to symptoms. COPD (2005) 0.89
Myeloid related protein-8/14 stimulates interleukin-8 production in airway epithelial cells. Am J Respir Cell Mol Biol (2003) 0.88
Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency. Respir Res (2012) 0.88
Alpha one antitrypsin deficiency: from gene to treatment. Respiration (2007) 0.87
The relationship of chronic sputum expectoration to physiologic, radiologic, and health status characteristics in alpha(1)-antitrypsin deficiency (PiZ). Chest (2002) 0.87
Outdoor air pollution is associated with rapid decline of lung function in alpha-1-antitrypsin deficiency. Occup Environ Med (2010) 0.86
Confirmation of association of chromosome 5q31-33 with United Kingdom Caucasian Graves' disease. Thyroid (2010) 0.86
Genetic developments in autoimmune thyroid disease: an evolutionary process. Clin Endocrinol (Oxf) (2007) 0.86
Skewed X chromosome inactivation and female preponderance in autoimmune thyroid disease: an association study and meta-analysis. J Clin Endocrinol Metab (2013) 0.86
Aα-Val360: a marker of neutrophil elastase and COPD disease activity. Eur Respir J (2012) 0.86
Cardiovascular and musculskeletal co-morbidities in patients with alpha 1 antitrypsin deficiency. Respir Res (2010) 0.86
Effect of expectoration on inflammation in induced sputum in alpha-1-antitrypsin deficiency. Respir Med (2005) 0.84
CT scan appearance, densitometry, and health status in protease inhibitor SZ alpha1-antitrypsin deficiency. Chest (2009) 0.84
The link between chronic periodontitis and COPD: a common role for the neutrophil? BMC Med (2013) 0.83
Modification of gene expression and increase in alpha1-antitrypsin (alpha1-AT) secretion after homologous recombination in alpha1-AT-deficient monocytes. Hum Gene Ther (2007) 0.83
TargetCOPD: a pragmatic randomised controlled trial of targeted case finding for COPD versus routine practice in primary care: protocol. BMC Pulm Med (2014) 0.83
Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. Eur J Hum Genet (2010) 0.83
Randomised controlled trial for emphysema with a selective agonist of the γ-type retinoic acid receptor. Eur Respir J (2012) 0.83
Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. Clin Endocrinol (Oxf) (2010) 0.83
Gamma-glutamyl transferase: the silent partner? COPD (2010) 0.83
Chronic obstructive pulmonary disease: an update of treatment related to frequently associated comorbidities. Ther Adv Chronic Dis (2010) 0.83
α-1-antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol (2015) 0.83
The fibrinogen cleavage product Aα-Val360, a specific marker of neutrophil elastase activity in vivo. Thorax (2011) 0.82
Standardization of CT densitometry. Radiology (2004) 0.82
3-Chlorotyrosine in sputum of COPD patients: relationship with airway inflammation. COPD (2010) 0.82
Phenotypic differences in alpha 1 antitrypsin-deficient sibling pairs may relate to genetic variation. COPD (2008) 0.82
Recent advances in α-1-antitrypsin deficiency-related lung disease. Expert Rev Respir Med (2013) 0.82
Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex. Respir Res (2008) 0.81
Variability of sputum inflammatory mediators in COPD and α1-antitrypsin deficiency. Eur Respir J (2012) 0.81
Global Initiative for Chronic Obstructive Lung Disease 2011 symptom/risk assessment in α1-antitrypsin deficiency. Chest (2013) 0.81
The cleavage specificity of an IgA1 protease from Haemophilus influenzae. Virulence (2011) 0.81
Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression. Clin Endocrinol (Oxf) (2010) 0.80
A nonsense mutation in exon 2 of the DNase I gene is not present in UK subjects with systemic lupus erythematosus and Graves' disease: Comment on the article by Rood et al. Arthritis Rheum (2002) 0.80
Impact of month of birth on the development of autoimmune thyroid disease in the United Kingdom and Europe. J Clin Endocrinol Metab (2014) 0.79
Relationship of sputum color to nature and outpatient management of acute exacerbations of COPD. 2000. Chest (2009) 0.79
The interaction of host and pathogen factors in chronic obstructive pulmonary disease exacerbations and their role in tissue damage. Proc Am Thorac Soc (2007) 0.79
Progranulin is a substrate for neutrophil-elastase and proteinase-3 in the airway and its concentration correlates with mediators of airway inflammation in COPD. Am J Physiol Lung Cell Mol Physiol (2013) 0.79
Proteinase 3 activity in sputum from subjects with alpha-1-antitrypsin deficiency and COPD. Eur Respir J (2012) 0.79
Relationship between frequency, length, and treatment outcome of exacerbations to baseline lung function and lung density in alpha-1 antitrypsin-deficient COPD. Int J Chron Obstruct Pulmon Dis (2012) 0.78
Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency. Ther Adv Respir Dis (2009) 0.78