Published in Eur Respir J on June 14, 2012
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Longer telomere length in COPD patients with α1-antitrypsin deficiency independent of lung function. PLoS One (2014) 0.87
Inflammatory cytokine response to exercise in alpha-1-antitrypsin deficient COPD patients 'on' or 'off' augmentation therapy. BMC Pulm Med (2014) 0.75
Neutrophil Fates in Bronchiectasis and Alpha-1 Antitrypsin Deficiency. Ann Am Thorac Soc (2016) 0.75
Therapy with plasma purified alpha1-antitrypsin (Prolastin®) induces time-dependent changes in plasma levels of MMP-9 and MPO. PLoS One (2015) 0.75
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Repurposing Treatments to Enhance Innate Immunity. Can Statins Improve Neutrophil Functions and Clinical Outcomes in COPD? J Clin Med (2016) 0.75
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Augmentation therapy for alpha1 antitrypsin deficiency: a meta-analysis. COPD (2009) 2.41
Human innate immunosenescence: causes and consequences for immunity in old age. Trends Immunol (2009) 2.00
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Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood (2013) 1.73
An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2015) 1.63
Vascular adhesion protein-1 mediates adhesion and transmigration of lymphocytes on human hepatic endothelial cells. J Immunol (2002) 1.55
Wnt signalling in lung development and diseases. Respir Res (2006) 1.55
Assessment of pulmonary neutrophilic inflammation in emphysema by quantitative positron emission tomography. Am J Respir Crit Care Med (2012) 1.53
Chronic Obstructive Pulmonary Disease, inflammation and co-morbidity--a common inflammatory phenotype? Respir Res (2006) 1.51
Pattern of emphysema distribution in alpha1-antitrypsin deficiency influences lung function impairment. Am J Respir Crit Care Med (2004) 1.43
Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses. J Immunol (2012) 1.35
Progression parameters for emphysema: a clinical investigation. Respir Med (2007) 1.22
Variability in densitometric assessment of pulmonary emphysema with computed tomography. Invest Radiol (2005) 1.19
Influence of calibration on densitometric studies of emphysema progression using computed tomography. Am J Respir Crit Care Med (2004) 1.11
Imbalances between interleukin-1 and tumor necrosis factor agonists and antagonists in stable COPD. J Clin Immunol (2009) 1.10
Statins for sepsis: distinguishing signal from the noise when designing clinical trials. Am J Respir Crit Care Med (2013) 1.07
Inflammation in sputum relates to progression of disease in subjects with COPD: a prospective descriptive study. Respir Res (2006) 1.05
Early donor management increases the retrieval rate of lungs for transplantation. Ann Thorac Surg (2008) 1.01
Radiologic and clinical features of COPD patients with discordant pulmonary physiology: lessons from alpha1-antitrypsin deficiency. Chest (2007) 0.99
A randomized, placebo-controlled trial of a leukotriene synthesis inhibitor in patients with COPD. Chest (2002) 0.98
Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals. Aging Cell (2014) 0.95
An age-related numerical and functional deficit in CD19(+) CD24(hi) CD38(hi) B cells is associated with an increase in systemic autoimmunity. Aging Cell (2013) 0.95
IgA1 protease. Int J Biochem Cell Biol (2005) 0.95
The genetics of chronic obstructive pulmonary disease. Respir Res (2006) 0.95
Alpha-1-antitrypsin replacement therapy: current status. Curr Opin Pulm Med (2006) 0.95
Detection of emphysema progression in alpha 1-antitrypsin deficiency using CT densitometry; methodological advances. Respir Res (2008) 0.93
Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2011) 0.92
The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency. Respir Res (2008) 0.92
Comparison of the sensitivities of 5 different computed tomography scanners for the assessment of the progression of pulmonary emphysema: a phantom study. Invest Radiol (2004) 0.92
Exploring the optimum approach to the use of CT densitometry in a randomised placebo-controlled study of augmentation therapy in alpha 1-antitrypsin deficiency. Respir Res (2009) 0.91
Tumor necrosis factor-{alpha} rs361525 polymorphism is associated with increased local production and downstream inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 0.90
Reported and unreported exacerbations of COPD: analysis by diary cards. Chest (2007) 0.90
Polyclonal free light chains: a biomarker of inflammatory disease or treatment target? F1000 Med Rep (2013) 0.90
Exacerbations of COPD diagnosed in primary care: changes in spirometry and relationship to symptoms. COPD (2005) 0.89
Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency. Respir Res (2012) 0.88
Myeloid related protein-8/14 stimulates interleukin-8 production in airway epithelial cells. Am J Respir Cell Mol Biol (2003) 0.88
The relationship of chronic sputum expectoration to physiologic, radiologic, and health status characteristics in alpha(1)-antitrypsin deficiency (PiZ). Chest (2002) 0.87
Alpha one antitrypsin deficiency: from gene to treatment. Respiration (2007) 0.87
Aα-Val360: a marker of neutrophil elastase and COPD disease activity. Eur Respir J (2012) 0.86
Outdoor air pollution is associated with rapid decline of lung function in alpha-1-antitrypsin deficiency. Occup Environ Med (2010) 0.86
Cardiovascular and musculskeletal co-morbidities in patients with alpha 1 antitrypsin deficiency. Respir Res (2010) 0.86
Effect of expectoration on inflammation in induced sputum in alpha-1-antitrypsin deficiency. Respir Med (2005) 0.84
CT scan appearance, densitometry, and health status in protease inhibitor SZ alpha1-antitrypsin deficiency. Chest (2009) 0.84
Randomised controlled trial for emphysema with a selective agonist of the γ-type retinoic acid receptor. Eur Respir J (2012) 0.83
The link between chronic periodontitis and COPD: a common role for the neutrophil? BMC Med (2013) 0.83
Modification of gene expression and increase in alpha1-antitrypsin (alpha1-AT) secretion after homologous recombination in alpha1-AT-deficient monocytes. Hum Gene Ther (2007) 0.83
TargetCOPD: a pragmatic randomised controlled trial of targeted case finding for COPD versus routine practice in primary care: protocol. BMC Pulm Med (2014) 0.83
Gamma-glutamyl transferase: the silent partner? COPD (2010) 0.83
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α-1-antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol (2015) 0.83
Standardization of CT densitometry. Radiology (2004) 0.82
3-Chlorotyrosine in sputum of COPD patients: relationship with airway inflammation. COPD (2010) 0.82
The fibrinogen cleavage product Aα-Val360, a specific marker of neutrophil elastase activity in vivo. Thorax (2011) 0.82
Recent advances in α-1-antitrypsin deficiency-related lung disease. Expert Rev Respir Med (2013) 0.82
Phenotypic differences in alpha 1 antitrypsin-deficient sibling pairs may relate to genetic variation. COPD (2008) 0.82
Aberrant neutrophil functions in stable chronic obstructive pulmonary disease: the neutrophil as an immunotherapeutic target. Int Immunopharmacol (2013) 0.81
Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex. Respir Res (2008) 0.81
The cleavage specificity of an IgA1 protease from Haemophilus influenzae. Virulence (2011) 0.81
Global Initiative for Chronic Obstructive Lung Disease 2011 symptom/risk assessment in α1-antitrypsin deficiency. Chest (2013) 0.81
Simvastatin to modify neutrophil function in older patients with septic pneumonia (SNOOPI): study protocol for a randomised placebo-controlled trial. Trials (2014) 0.80
The interaction of host and pathogen factors in chronic obstructive pulmonary disease exacerbations and their role in tissue damage. Proc Am Thorac Soc (2007) 0.79
Progranulin is a substrate for neutrophil-elastase and proteinase-3 in the airway and its concentration correlates with mediators of airway inflammation in COPD. Am J Physiol Lung Cell Mol Physiol (2013) 0.79
Proteinase 3 activity in sputum from subjects with alpha-1-antitrypsin deficiency and COPD. Eur Respir J (2012) 0.79
Relationship of sputum color to nature and outpatient management of acute exacerbations of COPD. 2000. Chest (2009) 0.79
Studies of gamma-glutamyl transferase in alpha-1 antitrypsin deficiency. COPD (2010) 0.78
Auto-antibodies and inflammation. A case of the chicken and the egg? Am J Respir Crit Care Med (2011) 0.78
Relationship between frequency, length, and treatment outcome of exacerbations to baseline lung function and lung density in alpha-1 antitrypsin-deficient COPD. Int J Chron Obstruct Pulmon Dis (2012) 0.78
Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency. Ther Adv Respir Dis (2009) 0.78
Bronchiectasis with chronic obstructive pulmonary disease: association or a further phenotype? Am J Respir Crit Care Med (2013) 0.78
Relationship of the 2011 Global Initiative for Chronic Obstructive Lung Disease strategy to clinically relevant outcomes in individuals with α1-antitrypsin deficiency. Ann Am Thorac Soc (2014) 0.78
Bacterial load and exacerbations of COPD. Am J Respir Crit Care Med (2008) 0.77
An evaluation of measured and calculated serum free cortisol in a group of patients with known adrenal suppression. Ann Clin Biochem (2010) 0.77
Age related development of respiratory abnormalities in non-index α-1 antitrypsin deficient studies. Respir Med (2012) 0.76
Inflammatory markers in bacterial exacerbations of COPD. Am J Respir Crit Care Med (2002) 0.76
A novel model and molecular therapy for Z alpha-1 antitrypsin deficiency. Mamm Genome (2011) 0.76
Vitamin D Deficiency in Human and Murine Sepsis. Crit Care Med (2017) 0.76
Re-evaluating COPD risk: just a matter of definition. Am J Respir Crit Care Med (2011) 0.75
Eureka? Radiology (2011) 0.75
Computed tomography: a new gold standard for the clinical assessment of emphysema. Am J Respir Crit Care Med (2006) 0.75
Chronic obstructive pulmonary disease: towards pharmacogenetics. Genome Med (2009) 0.75
"Knock-out" mouse: down but not out. Am J Respir Crit Care Med (2003) 0.75
Authors' response to 'TAP deficiency is also a cause of bronchiectasis'. Thorax (2013) 0.75
Children must be protected from the tobacco industry's marketing tactics. BMJ (2013) 0.75
The Relationship of the Fibrinogen Cleavage Biomarker Aα-Val360 With Disease Severity and Activity in α1-Antitrypsin Deficiency. Chest (2015) 0.75
Unifying the genetics, co-morbidities and management of COPD. Ther Adv Respir Dis (2008) 0.75
Bronchiectasis in older patients with chronic obstructive pulmonary disease : prevalence, diagnosis and therapeutic management. Drugs Aging (2013) 0.75
α1-antitrypsin deficiency: what has it ever done for us? Chest (2013) 0.75
Prevalence and radiological outcomes of lung nodules in alpha 1-antitrypsin deficiency. Respir Med (2013) 0.75