Published in Genes Dev on August 01, 2008
DNA hypomethylation in cancer cells. Epigenomics (2009) 3.71
VEZF1 elements mediate protection from DNA methylation. PLoS Genet (2010) 1.42
Endothelin-1 gene regulation. FASEB J (2010) 1.32
Chromatin domains, insulators, and the regulation of gene expression. Biochim Biophys Acta (2012) 1.11
A novel DNMT3B splice variant expressed in tumor and pluripotent cells modulates genomic DNA methylation patterns and displays altered DNA binding. Mol Cancer Res (2009) 1.10
Roles of chromatin insulator proteins in higher-order chromatin organization and transcription regulation. Nucleus (2011) 1.02
Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma. Epigenetics (2011) 0.91
Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II. Proc Natl Acad Sci U S A (2012) 0.89
Association between acquired uniparental disomy and homozygous mutations and HER2/ER/PR status in breast cancer. PLoS One (2010) 0.83
Complete biallelic insulation at the H19/Igf2 imprinting control region position results in fetal growth retardation and perinatal lethality. PLoS One (2010) 0.80
Poly(ADP-ribose) polymerase-1 (PARP-1) contributes to the barrier function of a vertebrate chromatin insulator. J Biol Chem (2010) 0.79
Gene dates, parties and galas. Symposium on Chromatin Dynamics and Higher Order Organization. EMBO Rep (2009) 0.76
Yeast one-hybrid screen of a thymus epithelial library identifies ZBTB7A as a regulator of thymic insulin expression. Mol Immunol (2013) 0.75
Targeted Vezf1-null mutation impairs vascular structure formation during embryonic stem cell differentiation. Arterioscler Thromb Vasc Biol (2010) 0.75
Testicular Dnmt3 expression and global DNA methylation are down-regulated by gonadotropin releasing hormones in the ricefield eel Monopterus albus. Sci Rep (2017) 0.75
Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A (2001) 132.88
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell (1999) 25.75
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet (2007) 20.22
Eukaryotic cytosine methyltransferases. Annu Rev Biochem (2005) 15.45
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet (2005) 15.37
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature (2000) 14.91
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. Nature (2007) 8.17
UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science (2007) 7.90
Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature (1999) 6.42
Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. Cell (1993) 5.22
The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res (1999) 4.74
Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci. EMBO J (2001) 4.28
The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. Proc Natl Acad Sci U S A (1999) 4.13
Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line. Genes Dev (1992) 4.02
Use of a HpaII-polymerase chain reaction assay to study DNA methylation in the Pgk-1 CpG island of mouse embryos at the time of X-chromosome inactivation. Mol Cell Biol (1990) 3.78
Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activities. Proc Natl Acad Sci U S A (2002) 3.46
Detection and measurement of PCR bias in quantitative methylation analysis of bisulphite-treated DNA. Nucleic Acids Res (1997) 3.34
DNA methylation: the nuts and bolts of repression. J Cell Physiol (2007) 3.00
Lsh, a member of the SNF2 family, is required for genome-wide methylation. Genes Dev (2001) 2.96
CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. J Biol Chem (2005) 2.86
Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells. EMBO J (1997) 2.34
Aberrant DNA methylation as a cancer-inducing mechanism. Annu Rev Pharmacol Toxicol (2005) 2.34
An erythrocyte-specific protein that binds to the poly(dG) region of the chicken beta-globin gene promoter. Genes Dev (1988) 1.82
MAZ-dependent termination between closely spaced human complement genes. EMBO J (1994) 1.76
Whole-genome methylation scan in ICF syndrome: hypomethylation of non-satellite DNA repeats D4Z4 and NBL2. Hum Mol Genet (2000) 1.73
Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. Proc Natl Acad Sci U S A (2002) 1.73
Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins. Oncogene (2007) 1.70
Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation. Mol Cancer Res (2004) 1.68
DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. Hum Mol Genet (2007) 1.65
Escape from gene silencing in ICF syndrome: evidence for advanced replication time as a major determinant. Hum Mol Genet (2000) 1.61
DNMT3B mutations and DNA methylation defect define two types of ICF syndrome. Hum Mutat (2005) 1.59
Lsh is involved in de novo methylation of DNA. EMBO J (2006) 1.57
Hypomethylation of pericentromeric DNA in breast adenocarcinomas. Int J Cancer (1998) 1.55
Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome. Development (2006) 1.44
Genomewide DNA hypomethylation is associated with alterations on chromosome 8 in prostate carcinoma. Genes Chromosomes Cancer (2002) 1.28
Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein. Mol Cell Biol (2005) 1.26
Hypomethylation of chromosome 1 heterochromatin DNA correlates with q-arm copy gain in human hepatocellular carcinoma. Am J Pathol (2001) 1.19
Properties of BGP1, a poly(dG)-binding protein from chicken erythrocytes. Nucleic Acids Res (1990) 1.16
DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearrangements. J Nutr (2002) 1.14
Lsh, a guardian of heterochromatin at repeat elements. Biochem Cell Biol (2005) 1.11
Transcriptional regulation of the human DNA methyltransferase 3A and 3B genes by Sp3 and Sp1 zinc finger proteins. Biochem J (2005) 1.07
Satellite DNA hypomethylation in karyotyped Wilms tumors. Cancer Genet Cytogenet (2003) 1.05
Developmental changes in methylation of spermatogenesis-specific genes include reprogramming in the epididymis. Nat Genet (1994) 1.03
Vezf1: A Zn finger transcription factor restricted to endothelial cells and their precursors. Dev Biol (1999) 1.02
Vezf1/DB1 is an endothelial cell-specific transcription factor that regulates expression of the endothelin-1 promoter. J Biol Chem (2001) 1.00
p68RacGAP is a novel GTPase-activating protein that interacts with vascular endothelial zinc finger-1 and modulates endothelial cell capillary formation. J Biol Chem (2004) 0.96
Dosage-dependent requirement for mouse Vezf1 in vascular system development. Dev Biol (2005) 0.96
Molecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoter. Mol Cell Biol (1994) 0.95
Correlation of DNA hypomethylation at pericentromeric heterochromatin regions of chromosomes 16 and 1 with histological features and chromosomal abnormalities of human breast carcinomas. Am J Pathol (2002) 0.94
Functional interaction between RhoB and the transcription factor DB1. Cell Adhes Commun (1998) 0.91
The human promoter methylome. Nat Genet (2007) 0.85
Vascular endothelial zinc finger 1 is involved in the regulation of angiogenesis: possible contribution of stathmin/OP18 as a downstream target gene. Arterioscler Thromb Vasc Biol (2004) 0.85
Genomic organization and promoter analysis of the Dnmt3b gene. Gene (2003) 0.79
Insulators: exploiting transcriptional and epigenetic mechanisms. Nat Rev Genet (2006) 6.43
H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions. Nat Genet (2009) 5.82
We gather together: insulators and genome organization. Curr Opin Genet Dev (2007) 5.81
CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species. Mol Cell (2004) 5.51
Insulators: many functions, many mechanisms. Genes Dev (2002) 5.36
Nucleosome stability mediated by histone variants H3.3 and H2A.Z. Genes Dev (2007) 4.19
Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activities. Proc Natl Acad Sci U S A (2002) 3.46
Recruitment of histone modifications by USF proteins at a vertebrate barrier element. Mol Cell (2004) 3.08
Conserved CTCF insulator elements flank the mouse and human beta-globin loci. Mol Cell Biol (2002) 2.69
The insulation of genes from external enhancers and silencing chromatin. Proc Natl Acad Sci U S A (2002) 2.60
Critical DNA binding interactions of the insulator protein CTCF: a small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci. J Biol Chem (2007) 2.49
Viral nanoparticles as tools for intravital vascular imaging. Nat Med (2006) 2.46
Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9. EMBO J (2003) 2.43
The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151. Cancer Cell (2008) 2.27
Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells. Dev Dyn (2004) 2.12
The 5'-HS4 chicken beta-globin insulator is a CTCF-dependent nuclear matrix-associated element. Proc Natl Acad Sci U S A (2004) 2.05
Methylation of histone H4 by arginine methyltransferase PRMT1 is essential in vivo for many subsequent histone modifications. Genes Dev (2005) 2.01
The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation. Genes Dev (2002) 1.89
Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA. Genes Dev (2010) 1.88
CD98hc (SLC3A2) mediates integrin signaling. Proc Natl Acad Sci U S A (2004) 1.88
Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7. Blood (2010) 1.84
USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier. Mol Cell Biol (2007) 1.68
Specific sites in the C terminus of CTCF interact with the SA2 subunit of the cohesin complex and are required for cohesin-dependent insulation activity. Mol Cell Biol (2011) 1.68
Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. Proc Natl Acad Sci U S A (2002) 1.64
EGFL7 is a chemoattractant for endothelial cells and is up-regulated in angiogenesis and arterial injury. Am J Pathol (2005) 1.62
Antagonism between DNA hypermethylation and enhancer-blocking activity at the H19 DMD is uncovered by CpG mutations. Nat Genet (2004) 1.60
Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects. Hum Gene Ther (2007) 1.55
Distribution of histone H3.3 in hematopoietic cell lineages. Proc Natl Acad Sci U S A (2006) 1.51
Hydrazone ligation strategy to assemble multifunctional viral nanoparticles for cell imaging and tumor targeting. Nano Lett (2010) 1.42
VEZF1 elements mediate protection from DNA methylation. PLoS Genet (2010) 1.42
Intravital imaging of embryonic and tumor neovasculature using viral nanoparticles. Nat Protoc (2010) 1.34
Hydrodynamic studies on defined heterochromatin fragments support a 30-nm fiber having six nucleosomes per turn. J Mol Biol (2008) 1.33
EGFL7: a unique angiogenic signaling factor in vascular development and disease. Blood (2011) 1.33
Human beta-globin locus control region HS5 contains CTCF- and developmental stage-dependent enhancer-blocking activity in erythroid cells. Mol Cell Biol (2003) 1.30
Chromatin remodeling by RNA polymerases. Trends Biochem Sci (2004) 1.30
Physical properties of a genomic condensed chromatin fragment. J Mol Biol (2004) 1.22
Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues. Biochem J (2003) 1.18
The human insulin gene is part of a large open chromatin domain specific for human islets. Proc Natl Acad Sci U S A (2009) 1.17
Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes. Blood (2011) 1.17
Epigenetic control of the variable expression of a Plasmodium falciparum receptor protein for erythrocyte invasion. Proc Natl Acad Sci U S A (2010) 1.17
Mammalian septins nomenclature. Mol Biol Cell (2002) 1.16
Both CTCF-dependent and -independent insulators are found between the mouse T cell receptor alpha and Dad1 genes. J Biol Chem (2004) 1.14
Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription. Nat Struct Mol Biol (2011) 1.14
H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation. Blood (2010) 1.14
Maintenance of a constitutive heterochromatin domain in vertebrates by a Dicer-dependent mechanism. Nat Cell Biol (2009) 1.12
Chromatin domains, insulators, and the regulation of gene expression. Biochim Biophys Acta (2012) 1.11
The human insulin gene displays transcriptionally active epigenetic marks in islet-derived mesenchymal precursor cells in the absence of insulin expression. Stem Cells (2007) 1.09
Dosage-dependent requirement for mouse Vezf1 in vascular system development. Dev Biol (2005) 0.96
Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locus. Proc Natl Acad Sci U S A (2008) 0.93
Expression of EGFL7 in primordial germ cells and in adult ovaries and testes. Gene Expr Patterns (2008) 0.92
A role for Egfl7 during endothelial organization in the embryoid body model system. J Angiogenes Res (2010) 0.90
Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II. Proc Natl Acad Sci U S A (2012) 0.89
Transcription of Ig germline genes in single human B cells and the role of cytokines in isotype determination. J Immunol (2004) 0.86
RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription. Nat Commun (2013) 0.84
Chromatin structure outside and inside the nucleus. Biopolymers (2013) 0.83
Identifying early vascular genes through gene trapping in mouse embryonic stem cells. Curr Top Dev Biol (2004) 0.81
Epidermal growth factor-like domain 7 is a marker of the endothelial lineage and active angiogenesis. Genesis (2014) 0.80
High resolution analysis of the chromatin landscape of the IgE switch region in human B cells. PLoS One (2011) 0.79
Genome architecture and expression. Curr Opin Genet Dev (2012) 0.78
In vitro imaging of angiogenesis using embryonic stem cell-derived endothelial cells. Stem Cells Dev (2011) 0.78
Physical chemistry of nucleic acids and their complexes. Biopolymers (2013) 0.77
Order from chaos in the nucleus. Mol Cell (2012) 0.76
The evolution of epigenetics. Perspect Biol Med (2014) 0.75
Targeted Vezf1-null mutation impairs vascular structure formation during embryonic stem cell differentiation. Arterioscler Thromb Vasc Biol (2010) 0.75
Obituary. Robert Simpson. Nucleic Acids Res (2004) 0.75