Published in Nature on November 11, 2007
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MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing. PLoS Biol (2010) 1.68
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UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9. Nat Commun (2013) 1.61
SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV. PLoS Genet (2011) 1.61
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Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance. PLoS Genet (2011) 1.56
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Three SRA-domain methylcytosine-binding proteins cooperate to maintain global CpG methylation and epigenetic silencing in Arabidopsis. PLoS Genet (2008) 1.54
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DNMT3L modulates significant and distinct flanking sequence preference for DNA methylation by DNMT3A and DNMT3B in vivo. PLoS Genet (2010) 1.41
DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation. Blood (2011) 1.40
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The human proteins MBD5 and MBD6 associate with heterochromatin but they do not bind methylated DNA. PLoS One (2010) 1.37
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Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing. Proc Natl Acad Sci U S A (2011) 1.35
Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication. Nature (2013) 1.35
The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. Nucleic Acids Res (2011) 1.32
M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. Proc Natl Acad Sci U S A (2012) 1.32
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Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation. Genes Dev (2013) 1.30
Keeping it in the family: diverse histone recognition by conserved structural folds. Crit Rev Biochem Mol Biol (2010) 1.29
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The KRAB-ZFP/KAP1 system contributes to the early embryonic establishment of site-specific DNA methylation patterns maintained during development. Cell Rep (2012) 1.28
The epigenome as a therapeutic target in prostate cancer. Nat Rev Urol (2010) 1.28
Constitutive heterochromatin formation and transcription in mammals. Epigenetics Chromatin (2015) 1.26
Structure and hemimethylated CpG binding of the SRA domain from human UHRF1. J Biol Chem (2008) 1.26
Connections between TET proteins and aberrant DNA modification in cancer. Trends Genet (2014) 1.24
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet (2008) 11.17
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature (2004) 7.42
Identification of a factor that links apoptotic cells to phagocytes. Nature (2002) 6.76
Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. Nat Cell Biol (2007) 6.30
A promoter-level mammalian expression atlas. Nature (2014) 6.25
Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev Cell (2004) 5.72
Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Genes Cells (2006) 5.68
Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development (2002) 4.72
Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell (2002) 4.68
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J (2006) 4.16
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol (2007) 4.12
QUMA: quantification tool for methylation analysis. Nucleic Acids Res (2008) 3.73
CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. Nat Cell Biol (2002) 3.71
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc Natl Acad Sci U S A (2006) 3.51
Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation. Nat Genet (2004) 3.47
Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse. Hum Mol Genet (2007) 3.27
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DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction. J Biol Chem (2004) 3.25
Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev (2008) 2.99
Arabidopsis transcriptome analysis under drought, cold, high-salinity and ABA treatment conditions using a tiling array. Plant Cell Physiol (2008) 2.84
A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons. Mol Cell Biol (2005) 2.57
Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity. Development (2008) 2.53
De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J Exp Med (2007) 2.50
SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes. Blood (2012) 2.50
Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1. Nat Med (2002) 2.45
The exocyst complex binds the small GTPase RalA to mediate filopodia formation. Nat Cell Biol (2002) 2.40
Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr Biol (2003) 2.38
PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet (2008) 2.37
Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest (2010) 2.29
In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses. J Exp Med (2005) 2.28
Genome-wide analysis of alternative pre-mRNA splicing in Arabidopsis thaliana based on full-length cDNA sequences. Nucleic Acids Res (2004) 2.19
Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science (2011) 2.17
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A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. J Cell Biol (2004) 2.14
Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization. J Biol Chem (2005) 2.10
SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling. Nature (2002) 2.08
Dynamic reprogramming of DNA methylation at an epigenetically sensitive allele in mice. PLoS Genet (2006) 2.07
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis. Cancer Cell (2011) 2.01
Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation. Cell Stem Cell (2013) 2.01
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands. Elife (2012) 1.99
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J (2007) 1.99
ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency. Cell Stem Cell (2010) 1.98
Novel regulation of MHC class II function in B cells. EMBO J (2007) 1.98
SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing. Dev Cell (2013) 1.97
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Large-scale comparative phosphoproteomics identifies conserved phosphorylation sites in plants. Plant Physiol (2010) 1.93
Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1. Genes Dev (2005) 1.93
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Alterations of lysine modifications on the histone H3 N-tail under drought stress conditions in Arabidopsis thaliana. Plant Cell Physiol (2008) 1.76
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DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. Genes Dev (2006) 1.76
Mouse Phenotype Database Integration Consortium: integration [corrected] of mouse phenome data resources. Mamm Genome (2007) 1.75
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CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration. Arterioscler Thromb Vasc Biol (2010) 1.60
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Co-expression of de novo DNA methyltransferases Dnmt3a2 and Dnmt3L in gonocytes of mouse embryos. Gene Expr Patterns (2004) 1.59
Gateways to the FANTOM5 promoter level mammalian expression atlas. Genome Biol (2015) 1.58
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Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia. Blood (2012) 1.56
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