Published in Biochemistry on August 06, 1991
Principles of protein folding--a perspective from simple exact models. Protein Sci (1995) 7.54
Cooperativity in protein-folding kinetics. Proc Natl Acad Sci U S A (1993) 2.87
How native-state topology affects the folding of dihydrofolate reductase and interleukin-1beta. Proc Natl Acad Sci U S A (2000) 2.11
Early events in protein folding explored by rapid mixing methods. Chem Rev (2006) 1.50
Early intermediates in the folding of dihydrofolate reductase from Escherichia coli detected by hydrogen exchange and NMR. Protein Sci (1995) 1.16
Stopped-flow NMR spectroscopy: real-time unfolding studies of 6-19F-tryptophan-labeled Escherichia coli dihydrofolate reductase. Proc Natl Acad Sci U S A (1995) 1.14
Gauging a hydrocarbon ruler by an intrinsic exciton probe. Biochemistry (2007) 1.14
Native-like structure of a protein-folding intermediate bound to the chaperonin GroEL. Proc Natl Acad Sci U S A (1997) 1.10
Probing minimal independent folding units in dihydrofolate reductase by molecular dissection. Protein Sci (1997) 1.09
Fast photochemical oxidation of proteins and mass spectrometry follow submillisecond protein folding at the amino-acid level. J Am Chem Soc (2012) 1.04
Identifying the structural boundaries of independent folding domains in the alpha subunit of tryptophan synthase, a beta/alpha barrel protein. Protein Sci (1999) 1.02
Folding thermodynamics and kinetics of the leucine-rich repeat domain of the virulence factor Internalin B. Protein Sci (2008) 1.02
An essential intermediate in the folding of dihydrofolate reductase. Proc Natl Acad Sci U S A (2000) 0.98
NMR and protein folding: equilibrium and stopped-flow studies. Protein Sci (1993) 0.95
Structure of a rapidly formed intermediate in ribonuclease T1 folding. Protein Sci (1992) 0.95
Testing the role of chain connectivity on the stability and structure of dihydrofolate reductase from E. coli: fragment complementation and circular permutation reveal stable, alternatively folded forms. Protein Sci (2001) 0.93
Tryptophan replacements in the trp aporepressor from Escherichia coli: probing the equilibrium and kinetic folding models. Protein Sci (1993) 0.93
Activation of chicken liver dihydrofolate reductase by urea and guanidine hydrochloride is accompanied by conformational change at the active site. Biochem J (1996) 0.91
Folding kinetics of staphylococcal nuclease studied by tryptophan engineering and rapid mixing methods. J Mol Biol (2007) 0.88
Probing the role of aromatic residues at the secondary saccharide-binding sites of human salivary alpha-amylase in substrate hydrolysis and bacterial binding. J Mol Biol (2008) 0.88
Mitochondrial 3β-hydroxysteroid dehydrogenase enzyme activity requires reversible pH-dependent conformational change at the intermembrane space. J Biol Chem (2012) 0.88
Structure of a partially unfolded form of Escherichia coli dihydrofolate reductase provides insight into its folding pathway. Protein Sci (2014) 0.83
Comparative study on dihydrofolate reductases from Shewanella species living in deep-sea and ambient atmospheric-pressure environments. Extremophiles (2010) 0.81
Molecular dynamics simulation of Escherichia coli dihydrofolate reductase and its protein fragments: relative stabilities in experiment and simulations. Protein Sci (2001) 0.81
Folding pathway of a multidomain protein depends on its topology of domain connectivity. Proc Natl Acad Sci U S A (2014) 0.81
Geofold: topology-based protein unfolding pathways capture the effects of engineered disulfides on kinetic stability. Proteins (2011) 0.80
Slow-folding kinetics of ribonuclease-A by volume change and circular dichroism: evidence for two independent reactions. Protein Sci (1994) 0.79
Unique fluorophores in the dimeric archaeal histones hMfB and hPyA1 reveal the impact of nonnative structure in a monomeric kinetic intermediate. Protein Sci (2007) 0.79
Comparison of kinetics of formation of helices and hydrophobic core during the folding of staphylococcal nuclease from acid. Biophys J (1994) 0.76
A semi-empirical approach for the simulation of circular dichroism spectra of gramicidin A in a model membrane. Biophys J (1992) 0.76
Systematic alanine insertion reveals the essential regions that encode structure formation and activity of dihydrofolate reductase. Biophysics (Nagoya-shi) (2011) 0.75
Halophilic mechanism of the enzymatic function of a moderately halophilic dihydrofolate reductase from Haloarcula japonica strain TR-1. Extremophiles (2017) 0.75
The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. Proteins (1989) 5.72
American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken) (2012) 4.82
Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis (2008) 3.77
Stable amplified DNA in drug-resistant Leishmania exists as extrachromosomal circles. Science (1986) 2.84
IgD multiple myeloma. Review of 133 cases. Arch Intern Med (1975) 2.10
Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor. Nature (1995) 2.09
Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo. Nat Genet (1996) 2.09
Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89. Antimicrob Agents Chemother (1997) 1.88
Aminoacyl-transfer RNA populations in mammalian cells chromatographic profiles and patterns of codon recognition. Biochim Biophys Acta (1979) 1.87
Effect of point mutations on the folding of globular proteins. Methods Enzymol (1987) 1.87
Probing the folding mechanism of a leucine zipper peptide by stopped-flow circular dichroism spectroscopy. Biochemistry (1995) 1.78
A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa. Mol Biochem Parasitol (1984) 1.71
Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica. Biochemistry (1985) 1.71
Rapid formation of secondary structure framework in protein folding studied by stopped-flow circular dichroism. FEBS Lett (1987) 1.70
Folding and stability of trp aporepressor from Escherichia coli. Biochemistry (1990) 1.59
Resolution of the fluorescence equilibrium unfolding profile of trp aporepressor using single tryptophan mutants. Protein Sci (1993) 1.56
MR sialography in patients with Sjögren syndrome. AJNR Am J Neuroradiol (1998) 1.56
Folding of dihydrofolate reductase from Escherichia coli. Biochemistry (1986) 1.51
Chronic active hepatitis in transgenic mice expressing interferon-gamma in the liver. Proc Natl Acad Sci U S A (1994) 1.49
Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline. J Biol Chem (1994) 1.48
Folding of staphylococcal nuclease A studied by equilibrium and kinetic circular dichroism spectra. Biochemistry (1991) 1.44
A reexamination of the folding mechanism of dihydrofolate reductase from Escherichia coli: verification and refinement of a four-channel model. Biochemistry (1993) 1.40
Folding mechanism of the alpha-subunit of tryptophan synthase, an alpha/beta barrel protein: global analysis highlights the interconversion of multiple native, intermediate, and unfolded forms through parallel channels. Biochemistry (1999) 1.40
Response of the septic vasculature to prolonged vasopressor therapy with N(omega)-monomethyl-L-arginine and epinephrine in canines. Crit Care Med (1998) 1.39
Collapse of coherent quasiparticle states in theta-(BEDT-TTF)2I3 observed by optical spectroscopy. Phys Rev Lett (2005) 1.39
Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine. Biochemistry (1993) 1.35
Evidence for identity between the equilibrium unfolding intermediate and a transient folding intermediate: a comparative study of the folding reactions of alpha-lactalbumin and lysozyme. Biochemistry (1986) 1.32
Comparison of the transient folding intermediates in lysozyme and alpha-lactalbumin. Biochemistry (1985) 1.32
Establishment of two interleukin 6 (B cell stimulatory factor 2/interferon beta 2)-dependent human bone marrow-derived myeloma cell lines. J Exp Med (1989) 1.28
Characterization of the critical state in protein folding. Effects of guanidine hydrochloride and specific Ca2+ binding on the folding kinetics of alpha-lactalbumin. J Mol Biol (1989) 1.28
Three-state denaturation of alpha-lactalbumin by guanidine hydrochloride. J Mol Biol (1976) 1.26
Barriers in protein folding reactions. Adv Protein Chem (2000) 1.24
Structure and stability of an early folding intermediate of Escherichia coli trp aporepressor measured by far-UV stopped-flow circular dichroism and 8-anilino-1-naphthalene sulfonate binding. Biochemistry (1993) 1.24
Kinetics of disulfide bond reduction in alpha-lactalbumin by dithiothreitol and molecular basis of superreactivity of the Cys6-Cys120 disulfide bond. Biochemistry (1990) 1.23
Preformed secondary structure drives the association reaction of GCN4-p1, a model coiled-coil system. J Mol Biol (2000) 1.23
Effect of single amino acid replacements on the folding and stability of dihydrofolate reductase from Escherichia coli. Biochemistry (1987) 1.22
Multistate equilibrium unfolding of Escherichia coli dihydrofolate reductase: thermodynamic and spectroscopic description of the native, intermediate, and unfolded ensembles. Biochemistry (2000) 1.19
The pentaammineruthenium(III)-histidine complex in ribonuclease A as an optical probe of conformational change. Biochim Biophys Acta (1980) 1.18
Early intermediates in the folding of dihydrofolate reductase from Escherichia coli detected by hydrogen exchange and NMR. Protein Sci (1995) 1.16
An early immunoreactive folding intermediate of the tryptophan synthease beta 2 subunit is a 'molten globule'. FEBS Lett (1990) 1.16
The progressive development of structure and stability during the equilibrium folding of the alpha subunit of tryptophan synthase from Escherichia coli. Protein Sci (1999) 1.15
Selection and properties of Leishmania tropica resistant to 10-propargyl-5,8-dideazafolate, an inhibitor of thymidylate synthetase. Mol Biochem Parasitol (1985) 1.12
Role of diffusion in the folding of the alpha subunit of tryptophan synthase from Escherichia coli. Biochemistry (1990) 1.10
Native-like structure of a protein-folding intermediate bound to the chaperonin GroEL. Proc Natl Acad Sci U S A (1997) 1.10
Development of nonpolar surfaces in the folding of Escherichia coli dihydrofolate reductase detected by 1-anilinonaphthalene-8-sulfonate binding. Biochemistry (1994) 1.10
Probing minimal independent folding units in dihydrofolate reductase by molecular dissection. Protein Sci (1997) 1.09
Effects of multiple replacements at a single position on the folding and stability of dihydrofolate reductase from Escherichia coli. Biochemistry (1989) 1.06
Local and global dynamics during the folding of Escherichia coli dihydrofolate reductase by time-resolved fluorescence spectroscopy. Biochemistry (1995) 1.05
Appropriateness of DSS and TSP as internal references for (1)H NMR studies of molten globule proteins in aqueous media. J Biomol NMR (1994) 1.05
Long-range electrostatic interactions can influence the folding, stability, and cooperativity of dihydrofolate reductase. Biochemistry (1989) 1.04
The Pro117 to glycine mutation of staphylococcal nuclease simplifies the unfolding-folding kinetics. FEBS Lett (1991) 1.04
Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity. J Biol Chem (1992) 1.03
Identifying the structural boundaries of independent folding domains in the alpha subunit of tryptophan synthase, a beta/alpha barrel protein. Protein Sci (1999) 1.02
Monoclonal macroglobulinemia in NZB-NZW F1 mice. J Exp Med (1973) 1.02
Controlled vaporization of the superconducting condensate in cuprate superconductors by femtosecond photoexcitation. Phys Rev Lett (2008) 1.01
The burst-phase intermediate in the refolding of beta-lactoglobulin studied by stopped-flow circular dichroism and absorption spectroscopy. J Mol Biol (1996) 1.01
Interleukin-6 (B-cell stimulatory factor 2)-dependent growth of a Lennert's lymphoma-derived T-cell line (KT-3). Blood (1988) 1.01
A strategy for testing the suitability of cysteine replacements in dihydrofolate reductase from Escherichia coli. J Biochem (1995) 1.00
Urea and thermal equilibrium denaturation studies on the dimerization domain of Escherichia coli Trp repressor. Biochemistry (1997) 1.00
Molten globule state of equine beta-lactoglobulin. Proteins (1997) 1.00
Thymus-antigen- and immunoglobulin- positive cells in lymph-nodes, thymus, and malignant lymphomas of NZB/NZW mice. Clin Immunol Immunopathol (1974) 0.99
Intramolecular catalysis of a proline isomerization reaction in the folding of dihydrofolate reductase. Biochemistry (1992) 0.98
Contribution of the 6-120 disulfide bond of alpha-lactalbumin to the stabilities of its native and molten globule states. Biochemistry (1992) 0.98
Ligand binding is the principal determinant of stability for the p21(H)-ras protein. Biochemistry (1998) 0.98
Rehospitalization among home healthcare patients: results of a prospective study. Home Healthc Nurse (2001) 0.98
Thermodynamic properties of the transition state for the rate-limiting step in the folding of the alpha subunit of tryptophan synthase. Biochemistry (1994) 0.97
Increased in situ expression of nitric oxide synthase in human colorectal cancer. Virchows Arch (2000) 0.97
Apparent radii of the native, stable intermediates and unfolded conformers of the alpha-subunit of tryptophan synthase from E. coli, a TIM barrel protein. Biochemistry (1999) 0.97
Expression of a dominant negative SHP-2 in transgenic mice induces insulin resistance. J Biol Chem (1999) 0.97
Granulocytic sarcoma of megakaryoblastic differentiation in the lymph nodes terminating as acute megakaryoblastic leukemia in a case of chronic idiopathic myelofibrosis persisting for 16 years. Eur J Haematol (2001) 0.97
Folding-unfolding equilibrium and kinetics of equine beta-lactoglobulin: equivalence between the equilibrium molten globule state and a burst-phase folding intermediate. Biochemistry (1999) 0.97
Mutagenic and thermodynamic analyses of residual structure in the alpha subunit of tryptophan synthase. Biochemistry (1996) 0.95
Characterization of a slow folding reaction for the alpha subunit of tryptophan synthase. Proteins (1987) 0.95
The barriers in the bimolecular and unimolecular folding reactions of the dimeric core domain of Escherichia coli Trp repressor are dominated by enthalpic contributions. Biochemistry (1998) 0.94
Ethnic difference in the pattern of K-ras oncogene mutations in human colorectal cancers. Hum Mutat (1996) 0.94
Mapping the energy surface for the folding reaction of the coiled-coil peptide GCN4-p1. Biochemistry (2001) 0.94
Ca2+-induced alteration in the unfolding behavior of alpha-lactalbumin. J Biochem (1986) 0.94
Nuclear magnetic resonance study of the thermal denaturation of ribonuclease A: implications for multistate behavior at low pH. Proc Natl Acad Sci U S A (1973) 0.93
Testing the role of chain connectivity on the stability and structure of dihydrofolate reductase from E. coli: fragment complementation and circular permutation reveal stable, alternatively folded forms. Protein Sci (2001) 0.93
Interresidue distance measurements in proteins. Fluorescent energy transfer between tryptophans and a Ru(III)(NH3)5-histidine complex in alpha-lytic protease and lysozyme. Biochim Biophys Acta (1982) 0.93
Effect of single amino acid substitutions on the thermal stability of the alpha subunit of tryptophan synthase. Biochemistry (1980) 0.93
Absence of genetic alteration at codon 531 of the human c-src gene in 479 advanced colorectal cancers from Japanese and Caucasian patients. Cancer Res (1999) 0.93
Increased soluble CD4 and decreased soluble CD8 molecules in patients with Sjögren's syndrome. Am J Med (1992) 0.93
Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val577), with susceptibility to Sjögren's syndrome. Arthritis Rheum (1997) 0.93
Tryptophan replacements in the trp aporepressor from Escherichia coli: probing the equilibrium and kinetic folding models. Protein Sci (1993) 0.93
Mechanism of folding of the dimeric core domain of Escherichia coli trp repressor: a nearly diffusion-limited reaction leads to the formation of an on-pathway dimeric intermediate. Biochemistry (1998) 0.92
Effect of a single amino acid substitution on the folding of the alpha subunit of tryptophan synthase. Biochemistry (1983) 0.92
alpha-Lactalbumin: a calcium metalloprotein. Biochem Biophys Res Commun (1980) 0.92
Association of the glutathione S-transferase M1 homozygous null genotype with susceptibility to Sjögren's syndrome in Japanese individuals. Arthritis Rheum (1999) 0.92
Non-IgM monoclonal gammopathy in patients with Sjögren's syndrome. Am J Med (1980) 0.91
Hydrophobic core substitutions in calbindin D9k: effects on stability and structure. Biochemistry (1998) 0.91
Hydrophobic core substitutions in calbindin D9k: effects on Ca2+ binding and dissociation. Biochemistry (1998) 0.91
Protective and cellular immune responses to idiotypic determinants on cells from a spontaneous lymphoma of NZB-NZW F1 mice. J Exp Med (1974) 0.91
The pentaammineruthenium(III)histidine complex in ribonuclease A: application to the assignment of histidine proton resonances. Anal Biochem (1981) 0.91
Construction and characterization of monomeric tryptophan repressor: a model for an early intermediate in the folding of a dimeric protein. Biochemistry (1997) 0.90