Deiodinase-mediated thyroid hormone inactivation minimizes thyroid hormone signaling in the early development of fetal skeleton.

PubWeight™: 0.92‹?›

🔗 View Article (PMID 18682303)

Published in Bone on July 17, 2008

Authors

Luciane P Capelo1, Eduardo H Beber, Stephen A Huang, Telma M T Zorn, Antonio C Bianco, Cecília H A Gouveia

Author Affiliations

1: Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, 05508-000, Brazil.

Articles cited by this

Thyroid hormone homeostasis and action in the type 2 deiodinase-deficient rodent brain during development. Endocrinology (2007) 2.15

Type 3 deiodinase is critical for the maturation and function of the thyroid axis. J Clin Invest (2006) 1.95

The use of antithyroid drugs in pregnancy and lactation. J Clin Endocrinol Metab (2001) 1.81

The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. Nat Cell Biol (2005) 1.78

Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med (2000) 1.72

Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase. Proc Natl Acad Sci U S A (2004) 1.68

Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes. Proc Natl Acad Sci U S A (2007) 1.54

Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues, before and after onset of fetal thyroid function. Endocrinology (1985) 1.42

Thyroid hormone regulation of gene expression. Annu Rev Physiol (1991) 1.39

The molecular actions of thyroid hormone in bone. Trends Endocrinol Metab (2003) 1.38

Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism. Endocrinology (2006) 1.36

The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. Diabetes (2007) 1.30

Pregnant rat uterus expresses high levels of the type 3 iodothyronine deiodinase. J Clin Invest (1999) 1.21

Contrasting skeletal phenotypes in mice with an identical mutation targeted to thyroid hormone receptor alpha1 or beta. Mol Endocrinol (2005) 1.12

Thyroid hormone acts directly on growth plate chondrocytes to promote hypertrophic differentiation and inhibit clonal expansion and cell proliferation. Endocrinology (2000) 1.12

The type 2 and type 3 iodothyronine deiodinases play important roles in coordinating development in Rana catesbeiana tadpoles. Endocrinology (1997) 1.11

The placental transfer of propylthiouracil, methimazole and carbimazole. J Clin Endocrinol Metab (1977) 1.10

Expression profiles of the three iodothyronine deiodinases, D1, D2, and D3, in the developing rat. Endocrinology (1999) 1.08

Thyroid status during skeletal development determines adult bone structure and mineralization. Mol Endocrinol (2007) 1.08

Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes. J Clin Invest (1998) 1.07

The roles of the iodothyronine deiodinases in mammalian development. Thyroid (2005) 1.06

Thyroid hormones regulate hypertrophic chondrocyte differentiation and expression of parathyroid hormone-related peptide and its receptor during endochondral bone formation. J Bone Miner Res (2000) 1.05

Ontogenesis of thyroid function and interactions with maternal function. Endocr Dev (2007) 1.01

The expression of thyroid hormone receptors in human bone. Bone (1997) 1.00

[Bone maturation in the fetus and newborn infant]. Arch Fr Pediatr (1977) 0.99

Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation. Endocrinology (2004) 0.98

Thyroid hormones and 5'-deiodinase in the rat fetus late in gestation: effects of maternal hypothyroidism. Endocrinology (1991) 0.93

The rat placenta and the transfer of thyroid hormones from the mother to the fetus. Effects of maternal thyroid status. Endocrinology (1992) 0.93

Effect of thyroid hormone and growth hormone on recovery from hypothyroidism of epiphyseal growth plate cartilage and its adjacent bone. Endocrinology (1989) 0.92

The thyroid hormone receptor beta-specific agonist GC-1 selectively affects the bone development of hypothyroid rats. J Bone Miner Res (2004) 0.92

L-thyroxine and 3,5,3'-triiodo-L-thyronine in rat embryos before onset of fetal thyroid function. Endocrinology (1984) 0.89

Thyroid hormones promote chondrocyte differentiation in mouse ATDC5 cells and stimulate endochondral ossification in fetal mouse tibias through iodothyronine deiodinases in the growth plate. J Bone Miner Res (2002) 0.89

Transfer of thyroxine from the mother to the rat fetus near term: effects on brain 3,5,3'-triiodothyronine deficiency. Endocrinology (1988) 0.88

Thyroid hormone stimulates alkaline phosphatase activity in cultured rat osteoblastic cells (ROS 17/2.8) through 3,5,3'-triiodo-L-thyronine nuclear receptors. Endocrinology (1987) 0.88

Thyroid hormones and bone. J Endocrinol (1993) 0.87

A novel interaction between thyroid hormones and 1,25(OH)(2)D(3) in osteoclast formation. Biochem Biophys Res Commun (2002) 0.86

Concentrations of triiodo-L-thyronine in the plasma and tissues of normal rats, as determined by radioimmunoassay: comparison with results obtained by an isotopic equilibrium technique. Endocrinology (1978) 0.86

Thyroxine inner ring monodeiodinating activity in fetal tissues of the rat. Pediatr Res (1988) 0.86

Stimulation of alkaline phosphatase activity by thyroid hormone in mouse osteoblast-like cells (MC3T3-E1): a possible mechanism of hyperalkaline phosphatasia in hyperthyroidism. Bone Miner (1988) 0.85

Effects of selenium deficiency on tissue selenium content, deiodinase activity, and thyroid hormone economy in the rat during development. Endocrinology (2000) 0.82

Thyroid hormone 5'-deiodinase activity, nuclear binding, and effects on mitogenesis in UMR-106 osteoblastic osteosarcoma cells. J Bone Miner Res (1989) 0.82

Maternal-fetal thyroid hormone relationships and the fetal brain. Acta Med Austriaca (1988) 0.79

Increase of adenylate cyclase catalytic-unit activity by dexamethasone in rat osteoblast-like cells. Biochem J (1986) 0.77

Maternal thyroid hormones during pregnancy: effects on the fetus in congenital hypothyroidism and in iodine deficiency. Adv Exp Med Biol (1991) 0.77

The isoform-specific expression of the tri-iodothyronine receptor in osteoblasts and osteoclasts. Eur J Clin Invest (1996) 0.77

Articles by these authors

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature (2006) 9.36

betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science (2002) 4.47

Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring) (2009) 3.15

Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev (2008) 2.98

Thyroid hormone inactivation in gastrointestinal stromal tumors. N Engl J Med (2014) 2.80

Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid (2014) 2.77

LXRs regulate the balance between fat storage and oxidation. Cell Metab (2005) 2.75

Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging. Mol Imaging (2003) 2.68

Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. J Biol Chem (2006) 2.15

Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis. Endocrinology (2010) 1.81

Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans. J Clin Invest (2005) 1.81

The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. Nat Cell Biol (2005) 1.78

Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem (2007) 1.77

Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. J Clin Invest (2003) 1.67

Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis. Diabetes (2004) 1.62

The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab (2005) 1.62

Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features. Trends Endocrinol Metab (2011) 1.60

Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality. Diabetes (2011) 1.55

Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes. Proc Natl Acad Sci U S A (2007) 1.54

Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity. Thyroid (2010) 1.52

A randomized, double-blind, placebo-controlled pilot trial of triiodothyronine in neonatal heart surgery. J Thorac Cardiovasc Surg (2005) 1.45

The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure. J Biol Chem (2003) 1.45

Thyroid hormone-related regulation of gene expression in human fatty liver. J Clin Endocrinol Metab (2009) 1.44

Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats. J Clin Invest (2008) 1.43

Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse. Endocrinology (2004) 1.38

Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism. Endocrinology (2006) 1.36

In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases. Endocrinology (2003) 1.34

The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. Diabetes (2007) 1.30

Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome. Endocrinology (2003) 1.29

Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells. J Clin Invest (2010) 1.29

Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study. Endocrinology (2007) 1.28

Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes. J Biol Chem (2002) 1.26

Reawakened interest in type III iodothyronine deiodinase in critical illness and injury. Nat Clin Pract Endocrinol Metab (2008) 1.22

A standardized assessment of thyroid nodules in children confirms higher cancer prevalence than in adults. J Clin Endocrinol Metab (2013) 1.22

Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes. Endocrinology (2008) 1.20

Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity. Mol Cell Biol (2007) 1.17

Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations. Endocrinology (2006) 1.14

Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2. Mol Endocrinol (2003) 1.11

Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue. J Lipid Res (2009) 1.10

Ubc6p and ubc7p are required for normal and substrate-induced endoplasmic reticulum-associated degradation of the human selenoprotein type 2 iodothyronine monodeiodinase. Mol Endocrinol (2002) 1.09

The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase. Mol Cell Biol (2009) 1.09

Consumptive hypothyroidism caused by paraneoplastic production of type 3 iodothyronine deiodinase. Thyroid (2005) 1.09

Characterization of the nuclear factor-kappa B responsiveness of the human dio2 gene. Endocrinology (2006) 1.08

Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. J Endocrinol (2007) 1.08

Type 2 iodothyronine deiodinase levels are higher in slow-twitch than fast-twitch mouse skeletal muscle and are increased in hypothyroidism. Endocrinology (2010) 1.06

S-nitrosoglutathione reductase-dependent PPARγ denitrosylation participates in MSC-derived adipogenesis and osteogenesis. J Clin Invest (2015) 1.06

Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis. Endocrinology (2009) 1.06

Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine. J Clin Invest (2015) 1.03

Anti-inflammatory effect of atorvastatin ameliorates insulin resistance in monosodium glutamate-treated obese mice. Metabolism (2009) 1.02

Coordination of hypothalamic and pituitary T3 production regulates TSH expression. J Clin Invest (2013) 1.01

A TRbeta-selective agonist confers resistance to diet-induced obesity. J Endocrinol (2009) 1.01

Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis. Endocrinology (2002) 1.00

The thyroid hormone-inactivating deiodinase functions as a homodimer. Mol Endocrinol (2008) 0.98

Double disruption of α2A- and α2C-adrenoceptors results in sympathetic hyperactivity and high-bone-mass phenotype. J Bone Miner Res (2011) 0.98

Rapid resolution of consumptive hypothyroidism in a child with hepatic hemangioendothelioma following liver transplantation. Ann Clin Lab Sci (2007) 0.98

Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue. J Lipid Res (2007) 0.98

Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling. Biochim Biophys Acta (2012) 0.98

Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism. J Neurosci (2012) 0.98

Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation. Endocrinology (2004) 0.98

Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis. Endocrinology (2002) 0.98

Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes. J Clin Endocrinol Metab (2015) 0.98

Defending plasma T3 is a biological priority. Clin Endocrinol (Oxf) (2014) 0.97

Metabolic instability of type 2 deiodinase is transferable to stable proteins independently of subcellular localization. J Biol Chem (2006) 0.94

Ultrastructural and autoradiographical analysis show a faster skin repair in He-Ne laser-treated wounds. J Photochem Photobiol B (2006) 0.94

Thyroid hormone signaling in energy homeostasis and energy metabolism. Ann N Y Acad Sci (2014) 0.92

Responsiveness to thyroid hormone and to ambient temperature underlies differences between brown adipose tissue and skeletal muscle thermogenesis in a mouse model of diet-induced obesity. Endocrinology (2011) 0.92

Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1. Am J Physiol Endocrinol Metab (2003) 0.92

The thyroid hormone receptor beta-specific agonist GC-1 selectively affects the bone development of hypothyroid rats. J Bone Miner Res (2004) 0.92

β(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice. J Endocrinol (2012) 0.92

Thyroid nodules and cancer in children with PTEN hamartoma tumor syndrome. J Clin Endocrinol Metab (2010) 0.92

Thyroid surgery at Children's Hospital Boston: a 35-year single-institution experience. J Pediatr Surg (2011) 0.92

Inhibition of the type 2 iodothyronine deiodinase underlies the elevated plasma TSH associated with amiodarone treatment. Endocrinology (2010) 0.91

The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion. Endocrinology (2011) 0.91

Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus. Endocrinology (2005) 0.91

The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. FEBS Lett (2011) 0.90

Soy protein diet alters expression of hepatic genes regulating fatty acid and thyroid hormone metabolism in the male rat. J Nutr Biochem (2009) 0.90

The estrous cycle modulates small leucine-rich proteoglycans expression in mouse uterine tissues. Anat Rec (Hoboken) (2009) 0.89

ETA receptor mediates altered leukocyte-endothelial cell interaction and adhesion molecules expression in DOCA-salt rats. Hypertension (2004) 0.89

Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain. Endocrinology (2007) 0.89

Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis. Endocrinology (2005) 0.89

Feeding and metabolism in mice lacking pituitary adenylate cyclase-activating polypeptide. Endocrinology (2007) 0.89

Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels. Brain Res (2005) 0.88

Tissue-specific inactivation of type 2 deiodinase reveals multilevel control of fatty acid oxidation by thyroid hormone in the mouse. Diabetes (2014) 0.88

Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway. J Endocrinol (2010) 0.88

A novel pathway regulates thyroid hormone availability in rat and human hypothalamic neurosecretory neurons. PLoS One (2012) 0.87

Mice lacking brain-type creatine kinase activity show defective thermoregulation. Physiol Behav (2009) 0.87

Type 2 deiodinase at the crossroads of thyroid hormone action. Int J Biochem Cell Biol (2011) 0.87

Modulation of small leucine-rich proteoglycans (SLRPs) expression in the mouse uterus by estradiol and progesterone. Reprod Biol Endocrinol (2011) 0.86

Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage. J Neurosci (2013) 0.86

Distribution of collagen types I, III, and V in pregnant mouse endometrium. Connect Tissue Res (2007) 0.85

Differential effects of refeeding on melanocortin-responsive neurons in the hypothalamic paraventricular nucleus. Endocrinology (2008) 0.85

Differential expression of glycosaminoglycans and proteoglycans in the migratory pathway of the primordial germ cells of the mouse. Histochem Cell Biol (2002) 0.85