Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity.

PubWeight™: 1.17‹?› | Rank: Top 10%

🔗 View Article (PMC 1951476)

Published in Mol Cell Biol on April 23, 2007

Authors

G D Vivek Sagar1, Balázs Gereben, Isabelle Callebaut, Jean-Paul Mornon, Anikó Zeöld, Wagner S da Silva, Cristina Luongo, Monica Dentice, Susana M Tente, Beatriz C G Freitas, John W Harney, Ann Marie Zavacki, Antonio C Bianco

Author Affiliations

1: Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Articles citing this

Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev (2008) 2.98

Thyroid hormone regulation of metabolism. Physiol Rev (2014) 1.70

American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models. Thyroid (2013) 1.41

Minireview: Defining the roles of the iodothyronine deiodinases: current concepts and challenges. Endocrinology (2009) 1.40

Reawakened interest in type III iodothyronine deiodinase in critical illness and injury. Nat Clin Pract Endocrinol Metab (2008) 1.22

The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase. Mol Cell Biol (2009) 1.09

Minireview: cracking the metabolic code for thyroid hormone signaling. Endocrinology (2011) 1.04

Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine. J Clin Invest (2015) 1.03

The thyroid hormone-inactivating deiodinase functions as a homodimer. Mol Endocrinol (2008) 0.98

Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling. Biochim Biophys Acta (2012) 0.98

Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes. J Clin Endocrinol Metab (2015) 0.98

Defending plasma T3 is a biological priority. Clin Endocrinol (Oxf) (2014) 0.97

KISS1R intracellular trafficking and degradation: effect of the Arg386Pro disease-associated mutation. Endocrinology (2011) 0.95

Small ubiquitin-related modifier (SUMO)-1 promotes glycolysis in hypoxia. J Biol Chem (2010) 0.95

Thyroid hormone signaling in energy homeostasis and energy metabolism. Ann N Y Acad Sci (2014) 0.92

Iodothyronine deiodinase enzyme activities in bone. Bone (2008) 0.91

The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. FEBS Lett (2011) 0.90

Type 2 deiodinase at the crossroads of thyroid hormone action. Int J Biochem Cell Biol (2011) 0.87

Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities. Oncotarget (2014) 0.86

Thyroid function in critically ill patients. Lancet Diabetes Endocrinol (2015) 0.85

AUF1 and HuR: possible implications of mRNA stability in thyroid function and disorders. Thyroid Res (2011) 0.85

E3Net: a system for exploring E3-mediated regulatory networks of cellular functions. Mol Cell Proteomics (2011) 0.84

The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex. Mol Endocrinol (2013) 0.84

Thyroid hormone and the neuroglia: both source and target. J Thyroid Res (2011) 0.84

Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism. Proc Natl Acad Sci U S A (2014) 0.83

Scope and limitations of iodothyronine deiodinases in hypothyroidism. Nat Rev Endocrinol (2015) 0.82

Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis. Mol Endocrinol (2011) 0.82

Selenium. Role of the essential metalloid in health. Met Ions Life Sci (2013) 0.82

Regulation of CTP Synthase Filament Formation During DNA Endoreplication in Drosophila. Genetics (2015) 0.80

Disruption of type 2 iodothyronine deiodinase activity in cultured human glial cells by polybrominated diphenyl ethers. Chem Res Toxicol (2015) 0.77

Coupling between Nutrient Availability and Thyroid Hormone Activation. J Biol Chem (2015) 0.76

WSB1: from homeostasis to hypoxia. J Biomed Sci (2016) 0.76

Cracking the code for thyroid hormone signaling. Trans Am Clin Climatol Assoc (2013) 0.75

The pineal gland: A model for adrenergic modulation of ubiquitin ligases. PLoS One (2017) 0.75

Catalysis leads to posttranslational inactivation of the type 1 deiodinase and alters its conformation. J Endocrinol (2012) 0.75

Knockdown of the type 3 iodothyronine deiodinase (D3) interacting protein peroxiredoxin 3 decreases D3-mediated deiodination in intact cells. Endocrinology (2009) 0.75

Ubiquitination-mediated interaction among domains is responsible for inhibition of RNA endonuclease activity of mRNA cycling sequence binding protein from L. donovani (LdCSBP). Parasitol Res (2014) 0.75

Articles cited by this

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis (1997) 57.27

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature (2006) 9.36

Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat Rev Mol Cell Biol (2005) 4.84

Hydrophobic cluster analysis: an efficient new way to compare and analyse amino acid sequences. FEBS Lett (1987) 4.71

A dissection of specific and non-specific protein-protein interfaces. J Mol Biol (2004) 3.77

Deciphering protein sequence information through hydrophobic cluster analysis (HCA): current status and perspectives. Cell Mol Life Sci (1997) 2.83

Fluorescence resonance energy transfer from cyan to yellow fluorescent protein detected by acceptor photobleaching using confocal microscopy and a single laser. J Microsc (2003) 2.74

Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways. EMBO J (2006) 2.58

Deiodinases: implications of the local control of thyroid hormone action. J Clin Invest (2006) 2.56

Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer. Structure (1996) 2.07

Adrenergic activation of triiodothyronine production in brown adipose tissue. Nature (1983) 1.97

Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation. Endocrinology (1992) 1.80

The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. Nat Cell Biol (2005) 1.78

Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase. Proc Natl Acad Sci U S A (2004) 1.68

Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. J Clin Invest (2003) 1.67

Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds. Nature (2003) 1.67

The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure. J Biol Chem (2003) 1.45

Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation. Mol Endocrinol (2000) 1.35

In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases. Endocrinology (2003) 1.34

The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. Diabetes (2007) 1.30

Type 2 iodothyronine deiodinase expression in the cochlea before the onset of hearing. Proc Natl Acad Sci U S A (2000) 1.30

Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes. J Biol Chem (2002) 1.26

The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line. J Biol Chem (2001) 1.23

Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy. Endocrinology (2000) 1.23

Proteolysis: anytime, any place, anywhere? Nat Cell Biol (2005) 1.12

Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2. Mol Endocrinol (2003) 1.11

Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center. Endocrinology (2000) 1.10

Biochemical and biophysical characterization of serotonin 5-HT2C receptor homodimers on the plasma membrane of living cells. Biochemistry (2004) 1.09

A novel retinoid X receptor-independent thyroid hormone response element is present in the human type 1 deiodinase gene. Mol Cell Biol (1995) 1.09

Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes. J Clin Invest (1998) 1.07

A ratiometric expressible FRET sensor for phosphoinositides displays a signal change in highly dynamic membrane structures in fibroblasts. Biochemistry (2004) 0.95

Fluorescence Resonance Energy Transfer (FRET) as a method to calculate the dimerization strength of basic Helix-Loop-Helix (bHLH) proteins. Biol Proced Online (2004) 0.92

Characterization of the protein dimerization domain responsible for assembly of functional selenodeiodinases. J Biol Chem (2005) 0.81

Articles by these authors

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature (2006) 9.36

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell (2004) 8.58

Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev (2002) 5.15

Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3). Cell (2003) 4.94

betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science (2002) 4.47

Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring) (2009) 3.15

Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev (2008) 2.98

Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid (2014) 2.77

Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family. Nucleic Acids Res (2002) 2.76

LXRs regulate the balance between fat storage and oxidation. Cell Metab (2005) 2.75

Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging. Mol Imaging (2003) 2.68

NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly. J Cell Biol (2006) 2.38

Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. J Biol Chem (2006) 2.15

Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU. Blood (2003) 2.11

Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis. Endocrinology (2010) 1.81

Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans. J Clin Invest (2005) 1.81

Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1. J Biol Chem (2006) 1.79

The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. Nat Cell Biol (2005) 1.78

Toxoplasma sortilin-like receptor regulates protein transport and is essential for apical secretory organelle biogenesis and host infection. Cell Host Microbe (2012) 1.78

Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem (2007) 1.77

Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. J Clin Invest (2003) 1.67

Supramolecular complexes mediate selenocysteine incorporation in vivo. Mol Cell Biol (2006) 1.65

The Ig-like structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy. Structure (2002) 1.64

Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis. Diabetes (2004) 1.62

The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab (2005) 1.62

Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features. Trends Endocrinol Metab (2011) 1.60

Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality. Diabetes (2011) 1.55

Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes. Proc Natl Acad Sci U S A (2007) 1.54

Prediction of the general transcription factors associated with RNA polymerase II in Plasmodium falciparum: conserved features and differences relative to other eukaryotes. BMC Genomics (2005) 1.53

Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity. Thyroid (2010) 1.52

The Tudor tandem of 53BP1: a new structural motif involved in DNA and RG-rich peptide binding. Structure (2004) 1.51

Molecular models of the open and closed states of the whole human CFTR protein. Cell Mol Life Sci (2009) 1.50

Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations. J Clin Invest (2014) 1.50

The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure. J Biol Chem (2003) 1.45

Thyroid hormone-related regulation of gene expression in human fatty liver. J Clin Endocrinol Metab (2009) 1.44

Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats. J Clin Invest (2008) 1.43

American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models. Thyroid (2013) 1.41

Multiple pathways inhibit NHEJ at telomeres. Genes Dev (2008) 1.40

Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse. Endocrinology (2004) 1.38

The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases. J Biol Chem (2002) 1.38

Coupled tRNA(Sec)-dependent assembly of the selenocysteine decoding apparatus. Mol Cell (2003) 1.37

Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism. Endocrinology (2006) 1.36

In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases. Endocrinology (2003) 1.34

Molecular basis of methylmalonyl-CoA mutase apoenzyme defect in 40 European patients affected by mut(o) and mut- forms of methylmalonic acidemia: identification of 29 novel mutations in the MUT gene. Hum Mutat (2005) 1.32

The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. Diabetes (2007) 1.30

Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome. Endocrinology (2003) 1.29

Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells. J Clin Invest (2010) 1.29

Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study. Endocrinology (2007) 1.28

Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes. J Biol Chem (2002) 1.26

Characterization of a Type III secretion substrate specificity switch (T3S4) domain in YscP from Yersinia enterocolitica. Mol Microbiol (2005) 1.25

Myofiber integrity depends on desmin network targeting to Z-disks and costameres via distinct plectin isoforms. J Cell Biol (2008) 1.25

The discovery of SycO highlights a new function for type III secretion effector chaperones. EMBO J (2006) 1.23

Human RTEL1 deficiency causes Hoyeraal-Hreidarsson syndrome with short telomeres and genome instability. Hum Mol Genet (2013) 1.23

Reawakened interest in type III iodothyronine deiodinase in critical illness and injury. Nat Clin Pract Endocrinol Metab (2008) 1.22

Thyroid hormone promotes postnatal rat pancreatic β-cell development and glucose-responsive insulin secretion through MAFA. Diabetes (2013) 1.22

Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes. Endocrinology (2008) 1.20

The A14-A43 heterodimer subunit in yeast RNA pol I and their relationship to Rpb4-Rpb7 pol II subunits. Proc Natl Acad Sci U S A (2002) 1.20

The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Cell Metab (2011) 1.19

Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining. Proc Natl Acad Sci U S A (2011) 1.18

Atypical structure and phylogenomic evolution of the new eutherian oocyte- and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family. Genomics (2007) 1.16

The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination. J Exp Med (2004) 1.16

Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity. PLoS One (2011) 1.15

Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations. Endocrinology (2006) 1.14

An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP. Mol Cell Biol (2003) 1.14

The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane. Blood (2011) 1.14

The multifunctional protein PEA-15 is involved in the control of apoptosis and cell cycle in astrocytes. Biochem Pharmacol (2003) 1.13

Function of Apollo (SNM1B) at telomere highlighted by a splice variant identified in a patient with Hoyeraal-Hreidarsson syndrome. Proc Natl Acad Sci U S A (2010) 1.12